MY135652A - NEW PROCESS FOR THE SYNTHESIS OF (2S, 3aS, 7aS)-PERHYDROINDOLE-2-CARBOXYLIC ACID AND ESTERS THEREOF, AND APPLICATION IN THE SYNTHESIS OF PERINDOPRIL - Google Patents
NEW PROCESS FOR THE SYNTHESIS OF (2S, 3aS, 7aS)-PERHYDROINDOLE-2-CARBOXYLIC ACID AND ESTERS THEREOF, AND APPLICATION IN THE SYNTHESIS OF PERINDOPRILInfo
- Publication number
- MY135652A MY135652A MYPI20040882A MYPI20040882A MY135652A MY 135652 A MY135652 A MY 135652A MY PI20040882 A MYPI20040882 A MY PI20040882A MY PI20040882 A MYPI20040882 A MY PI20040882A MY 135652 A MY135652 A MY 135652A
- Authority
- MY
- Malaysia
- Prior art keywords
- synthesis
- perindopril
- application
- perhydroindole
- esters
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title abstract 2
- 229960002582 perindopril Drugs 0.000 title abstract 2
- CQYBNXGHMBNGCG-FXQIFTODSA-N (2s,3as,7as)-2,3,3a,4,5,6,7,7a-octahydro-1h-indol-1-ium-2-carboxylate Chemical compound C1CCC[C@@H]2[NH2+][C@H](C(=O)[O-])C[C@@H]21 CQYBNXGHMBNGCG-FXQIFTODSA-N 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical group [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCESS FOR THE SYNTHESIS OF COMPOUNDS OF FORMULA (I): WHEREIN R REPRESENTS A HYDROGEN ATOM OR A PROTECTING GROUP FOR THE ACID FUNCTION.APPLICATION IN THE SYNTHESIS OF PERINDOPRIL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03290607A EP1323729B1 (en) | 2003-03-12 | 2003-03-12 | Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY135652A true MY135652A (en) | 2008-06-30 |
Family
ID=8185879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20040882A MY135652A (en) | 2003-03-12 | 2004-03-12 | NEW PROCESS FOR THE SYNTHESIS OF (2S, 3aS, 7aS)-PERHYDROINDOLE-2-CARBOXYLIC ACID AND ESTERS THEREOF, AND APPLICATION IN THE SYNTHESIS OF PERINDOPRIL |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1323729B1 (en) |
| AR (1) | AR043569A1 (en) |
| AT (1) | ATE281465T1 (en) |
| DE (1) | DE60300116T2 (en) |
| DK (1) | DK1323729T3 (en) |
| ES (1) | ES2231760T3 (en) |
| MY (1) | MY135652A (en) |
| PT (1) | PT1323729E (en) |
| WO (1) | WO2004083237A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004099138A2 (en) * | 2003-05-12 | 2004-11-18 | Cipla Limited | Process for the preparation of perindopril |
| DE602004005947T2 (en) | 2003-10-30 | 2008-01-17 | Sumitomo Chemical Co., Ltd. | Process for the preparation of an optically active octahydro-1H-indole-2-carboxylic acid |
| SI21800A (en) | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | New procedure of synthesis of perindopril |
| EP1866327A1 (en) * | 2005-02-14 | 2007-12-19 | Lupin Ltd. | Improved process for preparation of highly pure trandolapril |
| CN100391945C (en) * | 2005-05-31 | 2008-06-04 | 浙江大学 | A kind of synthetic method of S-(-)-indoline-2-carboxylic acid |
| US8558023B2 (en) | 2010-04-20 | 2013-10-15 | Chiral Quest, Inc. | Enantioselective process for cycloalkenyl β-substituted alanines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341296C (en) * | 1981-12-29 | 2001-09-25 | Hansjorg Urbach | 2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use |
| FR2807431B1 (en) * | 2000-04-06 | 2002-07-19 | Adir | NOVEL PROCESS FOR THE SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS |
| FR2827860B1 (en) * | 2001-07-24 | 2004-12-10 | Servier Lab | NOVEL PROCESS FOR SYNTHESIS OF ACID DERIVATIVES (2S, 3AS, 7AS) -1 - [(S) -ALANYL] -OCTAHYDRO-1H-INDOLE-2-CARBOXYLINE AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL |
-
2003
- 2003-03-12 ES ES03290607T patent/ES2231760T3/en not_active Expired - Lifetime
- 2003-03-12 PT PT03290607T patent/PT1323729E/en unknown
- 2003-03-12 EP EP03290607A patent/EP1323729B1/en not_active Expired - Lifetime
- 2003-03-12 DE DE60300116T patent/DE60300116T2/en not_active Expired - Lifetime
- 2003-03-12 AT AT03290607T patent/ATE281465T1/en active
- 2003-03-12 DK DK03290607T patent/DK1323729T3/en active
-
2004
- 2004-03-12 AR ARP040100806A patent/AR043569A1/en not_active Application Discontinuation
- 2004-03-12 WO PCT/FR2004/000592 patent/WO2004083237A1/en not_active Ceased
- 2004-03-12 MY MYPI20040882A patent/MY135652A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004083237A1 (en) | 2004-09-30 |
| EP1323729B1 (en) | 2004-11-03 |
| ES2231760T3 (en) | 2005-05-16 |
| DE60300116D1 (en) | 2004-12-09 |
| DK1323729T3 (en) | 2005-02-14 |
| EP1323729A1 (en) | 2003-07-02 |
| AR043569A1 (en) | 2005-08-03 |
| PT1323729E (en) | 2005-02-28 |
| ATE281465T1 (en) | 2004-11-15 |
| DE60300116T2 (en) | 2005-12-22 |
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