MY101815A - Heterocyclic oxophthalazinyl acetic acids. - Google Patents
Heterocyclic oxophthalazinyl acetic acids.Info
- Publication number
- MY101815A MY101815A MYPI87001337A MYPI19871337A MY101815A MY 101815 A MY101815 A MY 101815A MY PI87001337 A MYPI87001337 A MY PI87001337A MY PI19871337 A MYPI19871337 A MY PI19871337A MY 101815 A MY101815 A MY 101815A
- Authority
- MY
- Malaysia
- Prior art keywords
- heterocyclic
- alkylamino
- hydroxy
- hydrogen
- acetic acids
- Prior art date
Links
- 235000011054 acetic acid Nutrition 0.000 title 1
- 150000001243 acetic acids Chemical class 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- 229910052717 sulfur Chemical group 0.000 abstract 2
- 102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
- 108010053754 Aldehyde reductase Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
- 229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000651 prodrug Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A HETEROCYCLIC OXOPHTHALAZINYL ACETIC ACID HAVING ALDOSE REDUCTASE INHIBITORY ACTIVITY HAS THE FORMULA (FORMULA. 1) WHEREIN X IS OXYGEN OR SULFUR, Z IS A COVALENT BOND, O, S, NH OR CH2; R1 IS HYDROXY, OR A PRODRUG GROUP; R2 IS A HETEROCYCLIC GROUP, R3 AND R4 ARE HYDROGEN OR THE SAME OR A DIFFERENT SUBSTITUENT, AND R5 IS HYDROGEN OR METHYL. THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS OF THE ABOVE COMPOUNDS WHEREIN R1 IS DI (C1-C4) ALKYLAMINO OR (C1-C4) ALKOXY SUBSTITUTED BY N-MORPHOLINO OR DI (C1-C4) ALKYLAMINO AND THE PHARMACEUTICALLY ACTIVE BASE ADDITION SALTS OF THE ABOVE COMPOUNDS WHEREIN R1 IS HYDROXY ARE ALSO ALDOSE REDUCTASE INHIBITORS.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79603985A | 1985-11-07 | 1985-11-07 | |
| US06/796,359 US4723010A (en) | 1985-11-07 | 1985-11-07 | Process for preparing chloromethyl thiazoles or oxazoles, and intermediates for use therein |
| EP86308545A EP0222576B1 (en) | 1985-11-07 | 1986-11-03 | Heterocyclic oxophthalazinyl acetic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY101815A true MY101815A (en) | 1992-01-31 |
Family
ID=27229392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI87001337A MY101815A (en) | 1985-11-07 | 1987-08-14 | Heterocyclic oxophthalazinyl acetic acids. |
Country Status (2)
| Country | Link |
|---|---|
| AT (1) | ATE73801T1 (en) |
| MY (1) | MY101815A (en) |
-
1986
- 1986-11-03 AT AT86308545T patent/ATE73801T1/en not_active IP Right Cessation
-
1987
- 1987-08-14 MY MYPI87001337A patent/MY101815A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE73801T1 (en) | 1992-04-15 |
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