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MXPA06013125A - Enzima recombinante con sensibilidad alterada a la retroalimentacion. - Google Patents

Enzima recombinante con sensibilidad alterada a la retroalimentacion.

Info

Publication number
MXPA06013125A
MXPA06013125A MXPA06013125A MXPA06013125A MXPA06013125A MX PA06013125 A MXPA06013125 A MX PA06013125A MX PA06013125 A MXPA06013125 A MX PA06013125A MX PA06013125 A MXPA06013125 A MX PA06013125A MX PA06013125 A MXPA06013125 A MX PA06013125A
Authority
MX
Mexico
Prior art keywords
recombinant enzyme
feedback sensitivity
altered feedback
recombinant
altered
Prior art date
Application number
MXPA06013125A
Other languages
English (en)
Inventor
Michel Chateau
Gwenaelle Bestel-Corre
Rainer Martin Figge
Celine Raynaud
Philippe Noel Paul Soucaille
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of MXPA06013125A publication Critical patent/MXPA06013125A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invencion se refiere al uso de enzimas homoserina transsuccinilasa recombinantes con sensibilidad alterada a la retroalimentacion (MetA*), y enzimas S-adenosilmetionina sintetasa posiblemente recombinantes con actividad reducida (MetK*), para la produccion de metionina, sus precursores o derivados de la misma.
MXPA06013125A 2004-05-12 2005-05-12 Enzima recombinante con sensibilidad alterada a la retroalimentacion. MXPA06013125A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2004/001901 WO2005111202A1 (en) 2004-05-12 2004-05-12 Recombinant enzyme with altered feedback sensitivity
PCT/EP2005/052180 WO2005108561A2 (en) 2004-05-12 2005-05-12 Recombinant enzyme with altered feedback sensitivity

Publications (1)

Publication Number Publication Date
MXPA06013125A true MXPA06013125A (es) 2007-02-14

Family

ID=34957660

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA06013125A MXPA06013125A (es) 2004-05-12 2005-05-12 Enzima recombinante con sensibilidad alterada a la retroalimentacion.

Country Status (8)

Country Link
US (1) US8795990B2 (es)
EP (1) EP1747269B1 (es)
JP (1) JP5164566B2 (es)
CN (1) CN1954067B (es)
ES (1) ES2535816T3 (es)
MX (1) MXPA06013125A (es)
PL (1) PL1747269T3 (es)
WO (2) WO2005111202A1 (es)

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JP4110641B2 (ja) 1998-11-17 2008-07-02 味の素株式会社 発酵法によるｌ−メチオニンの製造法
WO2006082252A2 (en) * 2005-02-07 2006-08-10 Metabolic Explorer Method for the enzymatic production of alpha-ketobutyrate
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CN102703398B (zh) * 2007-04-11 2014-06-04 Cj第一制糖株式会社 组合物及甲硫氨酸的生产方法
PL2520645T3 (pl) 2007-04-11 2015-05-29 Cj Cheiljedang Corp Kompozycje i sposoby wytwarzania metioniny
CN103710320B (zh) * 2007-04-11 2015-11-18 Cj第一制糖株式会社 组合物及甲硫氨酸的生产方法
CA2687559A1 (en) * 2007-06-25 2009-04-02 Plant Bioscience Limited Enzymes involved in triterpene synthesis
WO2009043372A1 (en) 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield
US7851180B2 (en) * 2008-04-04 2010-12-14 Cj Cheiljedang Corporation Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism
US9005952B2 (en) 2008-04-04 2015-04-14 Cj Cheiljedang Corporation Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism
WO2010022763A1 (en) * 2008-08-25 2010-03-04 Metabolic Explorer Method for the preparation of 2-hydroxy-isobutyrate
KR101827230B1 (ko) 2008-12-31 2018-02-07 메타볼릭 익스플로러 디올의 제조 방법
US8609396B2 (en) * 2009-08-28 2013-12-17 Cj Cheiljedang Corporation Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
US8283152B2 (en) * 2009-08-28 2012-10-09 Cj Cheiljedang Corporation Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
FR2951195B1 (fr) 2009-10-14 2014-01-31 Roquette Freres Composition riche en methionine destinee a l'alimentation animale
BR112012012915B1 (pt) 2009-11-30 2020-12-01 Ajinomoto Co., Inc. método para produção de l-cisteína, l-cistina, um derivado das mesmas, ou uma mistura das mesmas
WO2011073738A1 (en) 2009-12-14 2011-06-23 Metabolic Explorer Use of inducible promoters in the production of methionine
CN102782137B (zh) 2009-12-30 2016-01-06 代谢探索者公司 用于甲硫氨酸生产的菌株和方法
MX2012007718A (es) 2009-12-30 2012-07-25 Metabolic Explorer Sa Aumento de la produccion de metionina mediante la sobreexpresion de succinato deshidrogenasa.
US8911978B2 (en) 2010-07-02 2014-12-16 Metabolic Explorer Method for the preparation of hydroxy acids
TWI500768B (zh) 2010-07-05 2015-09-21 Metabolic Explorer Sa 由蔗糖製備１，３－丙二醇之方法
WO2012014228A1 (en) 2010-07-28 2012-02-02 Abhishek Narain Singh A method to by-pass allosteric domain activity of an enzyme so as to alter its feedback or feed-forward inhibition or activation
EP2617808B1 (en) 2010-09-14 2016-06-15 Ajinomoto Co., Inc. Sulfur-containing amino acid-producing bacterium and method for producing sulfur-containing amino acids
AR083468A1 (es) * 2010-10-25 2013-02-27 Metabolic Explorer Sa Aumento de la disponibilidad de nadph para la produccion de metionina
DK2657250T3 (en) 2010-12-21 2017-12-11 Cj Cheiljedang Corp Polypeptide variant having homoserine acetyl transferase activity and microorganism expressing this
EP2658987B1 (en) * 2010-12-30 2014-12-10 Metabolic Explorer Fermentative production of methionine hydroxy analog (mha)
WO2012090021A1 (en) 2010-12-30 2012-07-05 Metabolic Explorer Recombinant microorganism for the fermentative production of methionine
JP2014087259A (ja) 2011-02-22 2014-05-15 Ajinomoto Co Inc Ｌ−システイン生産菌及びｌ−システインの製造法
JP6020443B2 (ja) 2011-04-01 2016-11-02 味の素株式会社 Ｌ−システインの製造法
US9234223B2 (en) 2011-04-01 2016-01-12 Ajinomoto Co., Inc. Method for producing L-cysteine
EP2540834A1 (en) 2011-06-29 2013-01-02 Metabolic Explorer Method for the preparation of 1,3-propanediol
EP2766492B1 (en) 2011-10-11 2018-06-06 Metabolic Explorer Fermentative production of prenol
FR2983870B1 (fr) 2011-12-08 2015-07-17 Roquette Freres Composition en methionine destinee a l'alimentation animale
EP2647718A3 (en) 2012-04-06 2014-12-24 Metabolic Explorer Process for producing 5-aminopentanoate empolying a recombinant microorganism
JP2012196222A (ja) * 2012-06-11 2012-10-18 Metabolic Explorer 硫酸透過酵素の発現が増強された微生物を用いてメチオニンおよびその前駆体ホモセリンまたはスクシニルホモセリンを製造するための方法
CN104411821B (zh) 2012-06-18 2017-08-08 代谢探索者公司 用于发酵生产甲硫氨酸的重组微生物
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WO2014049382A2 (en) 2012-09-26 2014-04-03 Metabolic Explorer Ethylenediamine fermentative production by a recombinant microorganism
BR112015007916B1 (pt) 2013-05-13 2023-04-04 Ajinomoto Co., Inc Método para produzir l-aminoácido
CA2922597A1 (en) 2013-08-30 2015-03-05 Metabolic Explorer Microorganism for methionine production with improved methionine synthase activity and methionine efflux
PL2886651T3 (pl) 2013-10-21 2018-11-30 Ajinomoto Co., Inc. Sposób wytwarzania l-aminokwasu
BR112016008830B1 (pt) 2013-10-23 2023-02-23 Ajinomoto Co., Inc Método para produzir uma substância alvo
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CN105505894A (zh) * 2014-09-24 2016-04-20 中国科学院天津工业生物技术研究所 天冬氨酸激酶/高丝氨酸脱氢酶突变体及其应用
WO2016179545A1 (en) * 2015-05-06 2016-11-10 Trelys, Inc. Compositions and methods for biological production of methionine
EP3095868A1 (en) 2015-05-19 2016-11-23 Evonik Degussa GmbH Methionine production
CN107787368A (zh) 2015-07-10 2018-03-09 赢创德固赛有限公司 氨基酸生产
US20180223319A1 (en) 2015-08-07 2018-08-09 Evonik Degussa Gmbh Protein thiocarboxylate-dependent l-methionine production by fermentation
CN108291243A (zh) 2015-11-27 2018-07-17 赢创德固赛有限公司 生产l-甲硫氨酸的方法
WO2017118871A1 (en) 2016-01-08 2017-07-13 Metabolic Explorer Method to produce l-methionine by a fermentative production
CN105838740B (zh) * 2016-05-03 2020-11-06 湖北大学 一种茶树内生草螺菌制备纳米红色元素硒的方法
JP7321089B2 (ja) 2016-07-08 2023-08-04 メタボリック エクスプローラー 糖ホスホトランスフェラーゼ系（ｐｔｓ）をコードする遺伝子を含んでなる微生物による目的分子の発酵生産法
EP3296404A1 (en) 2016-09-15 2018-03-21 Evonik Degussa GmbH Modified microorganism for production of methionine
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
EP3856918A1 (en) 2018-09-28 2021-08-04 Ajinomoto Co., Inc. Method for producing l-methionine using a bacterium
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
CN112725251B (zh) * 2019-10-14 2022-07-22 江南大学 一种生产亚精胺的工程菌
CN114107243B (zh) * 2021-12-09 2023-04-07 江南大学 一种甲硫氨酸腺苷转移酶突变体
CN117511903A (zh) * 2022-11-11 2024-02-06 山东理工大学 一种基于266位点的s-腺苷蛋氨酸合成酶突变体及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4110641B2 (ja) * 1998-11-17 2008-07-02 味の素株式会社 発酵法によるｌ−メチオニンの製造法
JP4622111B2 (ja) * 2001-02-09 2011-02-02 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
DE10247437A1 (de) * 2002-10-11 2004-04-29 Consortium für elektrochemische Industrie GmbH Feedback-resistente Homoserin-Transsuccinylasen
DE10249642A1 (de) * 2002-10-24 2004-05-13 Consortium für elektrochemische Industrie GmbH Feedback-resistente Homoserin-Transsuccinylasen mit modifiziertem C-Terminus

Also Published As

Publication number Publication date
WO2005111202A1 (en) 2005-11-24
WO2005108561A2 (en) 2005-11-17
EP1747269A2 (en) 2007-01-31
JP2007536921A (ja) 2007-12-20
US20090029424A1 (en) 2009-01-29
CN1954067A (zh) 2007-04-25
JP5164566B2 (ja) 2013-03-21
EP1747269B1 (en) 2015-03-25
US8795990B2 (en) 2014-08-05
ES2535816T3 (es) 2015-05-18
PL1747269T3 (pl) 2015-08-31
WO2005108561A3 (en) 2006-07-20
CN1954067B (zh) 2011-08-03

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