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MXPA05009849A - Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor. - Google Patents

Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor.

Info

Publication number
MXPA05009849A
MXPA05009849A MXPA05009849A MXPA05009849A MXPA05009849A MX PA05009849 A MXPA05009849 A MX PA05009849A MX PA05009849 A MXPA05009849 A MX PA05009849A MX PA05009849 A MXPA05009849 A MX PA05009849A MX PA05009849 A MXPA05009849 A MX PA05009849A
Authority
MX
Mexico
Prior art keywords
inhibitor
nemorubicin
cyclooxygenase
combined therapy
cox
Prior art date
Application number
MXPA05009849A
Other languages
Spanish (es)
Inventor
Antonino Suarato
Original Assignee
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa
Publication of MXPA05009849A publication Critical patent/MXPA05009849A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present Invention relates to the use of a morpholinyl anthracycline derivative, a pharmaceutically acceptable salt or a metabolite thereof, for the preparation of a medicament In combination with a Cox-2 Inhibitor for simultaneous, separate or sequential use for the treatment of cancer and to compositions or packaged units comprising a morpholinyl anthracycline derivative and a Cox-2 Inhibitor.
MXPA05009849A 2003-03-18 2004-03-04 Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor. MXPA05009849A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03075780 2003-03-18
PCT/EP2004/050251 WO2004082689A1 (en) 2003-03-18 2004-03-04 Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor

Publications (1)

Publication Number Publication Date
MXPA05009849A true MXPA05009849A (en) 2005-12-06

Family

ID=33016930

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05009849A MXPA05009849A (en) 2003-03-18 2004-03-04 Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor.

Country Status (6)

Country Link
EP (1) EP1605951A1 (en)
AU (1) AU2004222527A1 (en)
BR (1) BRPI0408518A (en)
CA (1) CA2519310A1 (en)
MX (1) MXPA05009849A (en)
WO (1) WO2004082689A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8742076B2 (en) 2008-02-01 2014-06-03 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
CN101555264B (en) * 2008-04-11 2014-09-03 天津和美生物技术有限公司 Derivative of highly active tetra cyclic anthroquinones antibiotics and preparation and application thereof
ES2655243T3 (en) 2008-04-11 2018-02-19 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
AR072804A1 (en) 2008-07-15 2010-09-22 Genentech Inc CONJUGATES DERIVED FROM ANTHRACICLINE, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE AS ANTITUMOR AGENTS.
BR112013013127B1 (en) 2010-12-02 2021-06-22 Nerviano Medical Sciences S.R.L. PROCESS FOR THE PREPARATION OF MORFOLINIL ANTHRACYCLINE DERIVATIVES, MORFOLINIL ANTHRACYCLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS
JP6622293B2 (en) 2014-09-12 2019-12-18 ジェネンテック， インコーポレイテッド Anthracycline disulfide intermediates, antibody-drug conjugates, and methods
JP7029957B2 (en) * 2014-10-03 2022-03-04 エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド Improved filling of small molecule compounds in intact bacterial vesicles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2094136T3 (en) * 1989-12-19 1997-01-16 Pharmacia Spa CHIRAL INTERMEDIARIES OF 1,5-DIYODO-2-METOXI OR BENCILOXI.
GB2296495B (en) * 1994-12-23 1998-04-15 Erba Carlo Spa Anthracycline derivatives
JP2002533404A (en) * 1998-12-23 2002-10-08 ジー・ディー・サール・アンド・カンパニー Methods of using integrin antagonists and radiation therapy as combination therapy in the treatment of neoplasia
GB9909925D0 (en) * 1999-04-29 1999-06-30 Pharmacia & Upjohn Spa Combined preparations comprising anthracycline derivatives

Also Published As

Publication number Publication date
AU2004222527A1 (en) 2004-09-30
WO2004082689A1 (en) 2004-09-30
BRPI0408518A (en) 2006-03-07
CA2519310A1 (en) 2004-09-30
EP1605951A1 (en) 2005-12-21

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