[go: up one dir, main page]

MXPA05008368A - 1,2,4-triazinas inhibidoras del virus de inmunodeficiencia humana. - Google Patents

1,2,4-triazinas inhibidoras del virus de inmunodeficiencia humana.

Info

Publication number
MXPA05008368A
MXPA05008368A MXPA05008368A MXPA05008368A MXPA05008368A MX PA05008368 A MXPA05008368 A MX PA05008368A MX PA05008368 A MXPA05008368 A MX PA05008368A MX PA05008368 A MXPA05008368 A MX PA05008368A MX PA05008368 A MXPA05008368 A MX PA05008368A
Authority
MX
Mexico
Prior art keywords
triazines
hiv inhibiting
hiv
inhibiting
medicine
Prior art date
Application number
MXPA05008368A
Other languages
English (en)
Inventor
Donald William Ludovici
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MXPA05008368A publication Critical patent/MXPA05008368A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furnace Details (AREA)

Abstract

La presente invencion se refiere a inhibidores de la duplicacion del VIH de formula (I), que se define en la especificacion, su uso como medicina, su procedimiento de preparacion y composiciones farmaceuticas que los comprenden (ver formula (I)).
MXPA05008368A 2003-02-07 2004-02-05 1,2,4-triazinas inhibidoras del virus de inmunodeficiencia humana. MXPA05008368A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0301289 2003-02-07
PCT/EP2004/050084 WO2004074266A1 (en) 2003-02-07 2004-02-05 Hiv inhibiting 1,2,4-triazines

Publications (1)

Publication Number Publication Date
MXPA05008368A true MXPA05008368A (es) 2005-11-04

Family

ID=32892827

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05008368A MXPA05008368A (es) 2003-02-07 2004-02-05 1,2,4-triazinas inhibidoras del virus de inmunodeficiencia humana.

Country Status (20)

Country Link
US (1) US7585861B2 (es)
EP (1) EP1597242B1 (es)
JP (1) JP4783725B2 (es)
KR (1) KR20050105190A (es)
CN (2) CN1747941A (es)
AP (1) AP2005003365A0 (es)
AT (1) ATE402152T1 (es)
AU (1) AU2004213173B2 (es)
BR (1) BRPI0407306A (es)
CA (1) CA2513123C (es)
DE (1) DE602004015254D1 (es)
EA (1) EA010379B1 (es)
ES (1) ES2311146T3 (es)
HR (1) HRP20050690A2 (es)
IL (1) IL170120A (es)
MX (1) MXPA05008368A (es)
NO (1) NO20054127L (es)
PL (1) PL232814B1 (es)
WO (1) WO2004074266A1 (es)
ZA (1) ZA200506254B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ551027A (en) 2004-04-08 2011-01-28 Targegen Inc Benzotriazine inhibitors of kinases
EP1797050B1 (en) * 2004-08-10 2013-10-23 Janssen Pharmaceutica NV Hiv inhibiting 1.2.4-triazin-6-one derivates
JP5275628B2 (ja) 2004-08-25 2013-08-28 ターゲジェン インコーポレーティッド 複素環式化合物および使用方法
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
EP1830837B1 (en) 2004-09-20 2013-09-04 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
JP5149009B2 (ja) 2004-09-20 2013-02-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体
AR051093A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa desaturasa
AR051090A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
MX2007003325A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa.
MX2007003332A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
EP2029138A1 (en) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
US8604042B2 (en) 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
US8133900B2 (en) 2005-11-01 2012-03-13 Targegen, Inc. Use of bi-aryl meta-pyrimidine inhibitors of kinases
MY167260A (en) 2005-11-01 2018-08-14 Targegen Inc Bi-aryl meta-pyrimidine inhibitors of kinases
EP2121613A2 (en) 2007-01-31 2009-11-25 Vertex Pharmaceuticals, Inc. 2-aminopyridine derivatives useful as kinase inhibitors
PT2300013T (pt) 2008-05-21 2017-10-31 Ariad Pharma Inc Derivados de fósforo como inibidores de cinases
WO2010011756A1 (en) 2008-07-23 2010-01-28 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
WO2010011768A1 (en) 2008-07-23 2010-01-28 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
CA2732765A1 (en) 2008-08-06 2010-02-11 Vertex Pharmaceuticals Incorporated Aminopyridine kinase inhibitors
EP2427464A1 (en) 2009-05-06 2012-03-14 Vertex Pharmaceuticals Incorporated Pyrazolopyridines
WO2011094273A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
MX2012008641A (es) 2010-01-27 2012-11-23 Vertex Pharma Inhibidores de cinasas de pirazolopirazinas.
EP2582702A1 (en) 2010-01-27 2013-04-24 Vertex Pharmaceuticals Incorporated Pyrazolopyrimidine kinase inhibitors
WO2012060847A1 (en) 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
US20170298055A1 (en) 2014-09-17 2017-10-19 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
EA202092442A3 (ru) 2016-06-07 2021-08-31 Джакобио Фармасьютикалс Ко., Лтд. Новые гетероциклические производные, применимые в качестве ингибиторов shp2
KR102317480B1 (ko) 2017-03-23 2021-10-25 자코바이오 파마슈티칼스 컴퍼니 리미티드 Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
WO2020063760A1 (en) 2018-09-26 2020-04-02 Jacobio Pharmaceuticals Co., Ltd. Novel heterocyclic derivatives useful as shp2 inhibitors
WO2021071984A1 (en) * 2019-10-08 2021-04-15 Skyhawk Therapeutics, Inc. Compounds for modulating splicing
CR20220325A (es) 2019-12-20 2022-08-19 Tenaya Therapeutics Inc Fluoroalquil-oxadiazoles y sus usos
CN111333543B (zh) * 2020-04-17 2022-09-16 武汉工程大学 一种利匹韦林中间体的合成方法
CA3216768A1 (en) 2021-05-04 2022-11-10 Jin Yang 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef
CN115745848A (zh) * 2022-12-07 2023-03-07 上海优合生物科技有限公司 一种氨基胍的加工合成工艺
CN117658936B (zh) * 2023-11-30 2025-06-06 上海予君生物科技发展有限公司 一种3,5,6-三氯-[1,2,4]-三嗪的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459731A (en) 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
HUP9900730A3 (en) 1995-11-23 2001-04-28 Janssen Pharmaceutica Nv Solid mixtures of cyclodextrins prepared via melt-extrusion
NO311614B1 (no) * 1996-10-01 2001-12-17 Janssen Pharmaceutica Nv Substituerte diamino-1,3,5-triazinderivater
ATE244707T1 (de) 1998-03-27 2003-07-15 Lg Chem Investment Ltd Polyethoxylierte ascorbinsäurederivate als neue antioxidantien und verfahren zu ihrer herstellung
EP0945447A1 (en) * 1998-03-27 1999-09-29 Janssen Pharmaceutica N.V. Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections
DK0945443T3 (da) 1998-03-27 2003-06-02 Janssen Pharmaceutica Nv HIV-hæmmende pyrimidinderivater
AU762523C (en) * 1998-11-10 2004-02-12 Janssen Pharmaceutica N.V. HIV replication inhibiting pyrimidines
ATE315031T1 (de) * 1998-11-10 2006-02-15 Janssen Pharmaceutica Nv 2,4-disubstierte triazinderivate mit anti-hiv aktivität
JP5230050B2 (ja) 2000-05-08 2013-07-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｈｉｖ複製阻害剤
DE60221368T2 (de) 2001-03-15 2008-04-17 Janssen Pharmaceutica N.V. Hiv hemmende pyrazinon-derivate
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز

Also Published As

Publication number Publication date
IL170120A (en) 2013-04-30
KR20050105190A (ko) 2005-11-03
AU2004213173A1 (en) 2004-09-02
CA2513123C (en) 2013-04-23
US20070037811A1 (en) 2007-02-15
CN102503903A (zh) 2012-06-20
EP1597242B1 (en) 2008-07-23
ES2311146T3 (es) 2009-02-01
BRPI0407306A (pt) 2006-02-21
EA200501268A1 (ru) 2006-02-24
WO2004074266A8 (en) 2004-11-11
JP4783725B2 (ja) 2011-09-28
EA010379B1 (ru) 2008-08-29
US7585861B2 (en) 2009-09-08
WO2004074266A1 (en) 2004-09-02
CA2513123A1 (en) 2004-09-02
AP2005003365A0 (en) 2005-09-30
AU2004213173B2 (en) 2010-07-29
ATE402152T1 (de) 2008-08-15
PL378107A1 (pl) 2006-03-06
CN1747941A (zh) 2006-03-15
JP2006516983A (ja) 2006-07-13
NO20054127L (no) 2005-09-05
ZA200506254B (en) 2008-02-27
HRP20050690A2 (en) 2006-08-31
DE602004015254D1 (de) 2008-09-04
EP1597242A1 (en) 2005-11-23
PL232814B1 (pl) 2019-07-31

Similar Documents

Publication Publication Date Title
MXPA05008368A (es) 1,2,4-triazinas inhibidoras del virus de inmunodeficiencia humana.
UA100005C2 (ru) Ингибиторы репликации вируса иммунодефицита человека
GB0114286D0 (en) Nucleoside Derivatives
GEP20125704B (en) Plk kinase inhibitors
AU2002218167A1 (en) N-phenyl-2-pyrimidine-amine derivatives
MXPA02007942A (es) Derivados de pirrolopirimidinona, procesos de preparacion y uso.
MXPA04004842A (es) Inhibidores de 11-(-hidroxiesteroide deshidrogenasa de tipo 1.
MXPA04004837A (es) Inhibidores de 11-??-hidroxiesteroide deshidrogenasa de tipo 1.
WO2003084539A3 (en) New pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors
IL161154A0 (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
MY138708A (en) Biaryloxymethylarenecarboxylic acids
MXPA05008867A (es) Pirimidinas y triazinas inhibidoras de la replicacion del virus de inmunodeficiencia humana.
TW200621737A (en) 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof
CA2499330A1 (en) New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
UA95715C2 (ru) Фосфадиазиновые производные, фармацевтическая композиция и их применение
UA104988C2 (uk) Похідні піроніндолу та спосіб їх отримання
MY135218A (en) 2,6-quinolinyl and 2,6-naphthyl derivatives and their use in the treatment of vla-4 dependent diseases
DE602004008959D1 (de) Benzoäbüä1,4üdioxepinderivate
WO2005040171A8 (en) Pyrazolo and imidazo-pyrimidine derivatives
TW200722081A (en) New therapeutic combinations for the treatment or prevention of depression
MX2009006010A (es) Derivados de amina y su uso en enfermedades mediadas por el adrenoreceptor beta 2.
TW200639156A (en) New compounds
IL191670A0 (en) Compounds for the inhibition of apoptosis
TW200640465A (en) New pharmaceutically active compounds for the treatment of respiratory diseases
WO2004004725A3 (en) Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases

Legal Events

Date Code Title Description
FG Grant or registration