MXPA05006178A - Modificacion de la actividad de la ciclooxigenasa y de la lipooxigenasa con extractos de asteridae y opcionalmente acido boswelico. - Google Patents
Modificacion de la actividad de la ciclooxigenasa y de la lipooxigenasa con extractos de asteridae y opcionalmente acido boswelico.Info
- Publication number
- MXPA05006178A MXPA05006178A MXPA05006178A MXPA05006178A MXPA05006178A MX PA05006178 A MXPA05006178 A MX PA05006178A MX PA05006178 A MXPA05006178 A MX PA05006178A MX PA05006178 A MXPA05006178 A MX PA05006178A MX PA05006178 A MXPA05006178 A MX PA05006178A
- Authority
- MX
- Mexico
- Prior art keywords
- extracts
- cox
- asteridae
- activity
- boswellic acid
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 5
- 239000000284 extract Substances 0.000 title abstract 4
- 241001233866 asterids Species 0.000 title abstract 3
- NBGQZFQREPIKMG-UHFFFAOYSA-N 3beta-hydroxy-beta-boswellic acid Natural products C1CC(O)C(C)(C(O)=O)C2CCC3(C)C4(C)CCC5(C)CCC(C)C(C)C5C4=CCC3C21C NBGQZFQREPIKMG-UHFFFAOYSA-N 0.000 title abstract 2
- NBGQZFQREPIKMG-PONOSELZSA-N Boswellic acid Chemical compound C1C[C@@H](O)[C@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C NBGQZFQREPIKMG-PONOSELZSA-N 0.000 title abstract 2
- 102000003820 Lipoxygenases Human genes 0.000 title 1
- 108090000128 Lipoxygenases Proteins 0.000 title 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 title 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 title 1
- 230000004048 modification Effects 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 abstract 3
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 102100038277 Prostaglandin G/H synthase 1 Human genes 0.000 abstract 2
- 108050003243 Prostaglandin G/H synthase 1 Proteins 0.000 abstract 2
- WLYGSPLCNKYESI-RSUQVHIMSA-N Carthamin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@]1(O)C(O)=C(C(=O)\C=C\C=2C=CC(O)=CC=2)C(=O)C(\C=C\2C([C@](O)([C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(O)=C(C(=O)\C=C\C=3C=CC(O)=CC=3)C/2=O)=O)=C1O WLYGSPLCNKYESI-RSUQVHIMSA-N 0.000 abstract 1
- 241000208809 Carthamus Species 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Los extractos de plantas de la sub-familia Asteridae, tales como Carthamus tinctorious, son efectivos para inhibir selectivamente la actividad de la COX-2 y/o potenciar la actividad de la COX-1. Cuando se combinan extractos de Asteridae con acido boswelico, la combinacion muestra un efecto inhibidor sinergico tanto en la COX-2 como en la LO. Estos extractos y combinaciones se usan en metodos para inhibir selectivamente la COX-2, inhibir la LO, y/o mejorar la actividad de la COX-1, asi como tambien en metodos para tratar condiciones que podrian responder favorablemente a cualquiera de estos efectos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43210102P | 2002-12-09 | 2002-12-09 | |
| US50765503P | 2003-09-30 | 2003-09-30 | |
| PCT/US2003/039183 WO2004052299A2 (en) | 2002-12-09 | 2003-12-09 | MODIFICATION OF CYCLOOXYGENASE AND LIPOXYGENASE ACTIVITY WITH ASTERIDAE EXTRACTS AND OPTIONALLy BOSWELLIC ACID |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05006178A true MXPA05006178A (es) | 2006-03-09 |
Family
ID=32511628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05006178A MXPA05006178A (es) | 2002-12-09 | 2003-12-09 | Modificacion de la actividad de la ciclooxigenasa y de la lipooxigenasa con extractos de asteridae y opcionalmente acido boswelico. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7195790B2 (es) |
| AU (1) | AU2003296417A1 (es) |
| CA (1) | CA2508766A1 (es) |
| MX (1) | MXPA05006178A (es) |
| WO (1) | WO2004052299A2 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4732454B2 (ja) * | 2004-07-08 | 2011-07-27 | ライラ ニュートラシューティカルズ | 抗糖尿病性および抗炎症性を有するコロソリン酸の新規構造類似体 |
| BRPI0405829A (pt) * | 2004-12-16 | 2006-08-22 | Anidro Do Brasil Extracoes Ltd | uso de extrato vegetal, formulação contento extrato vegetal, uso de formulação e método cosmético |
| KR100847439B1 (ko) * | 2006-07-03 | 2008-07-21 | 신일제약주식회사 | 낙석등 추출물을 함유하는 염증성 질환 예방 및 치료용약제 |
| WO2008004118A2 (en) * | 2006-07-06 | 2008-01-10 | Avestha Gengraine Technologies Pvt. Ltd. | Carthamus tinctoris plant extracts for treating osteoporosis and the extraction process thereof |
| DE102006053475A1 (de) * | 2006-11-14 | 2008-06-19 | Eberhard-Karls-Universität Tübingen | Zubereitungen zur Hemmung der Prostaglandin E2 Synthese |
| KR100847440B1 (ko) * | 2007-01-24 | 2008-07-21 | 신일제약주식회사 | 염증성 질환 예방 및 치료용 복합 생약제 |
| HRP20070230B1 (en) * | 2007-05-18 | 2010-05-31 | Leko Vlado | Herbal composition for the prevention and treatmentofdiabetes mellitus type (i) and type (ii) |
| EA025110B1 (ru) | 2008-09-15 | 2016-11-30 | Лайла Нутрасьютикалс | Синергичные противовоспалительные композиции, содержащие экстракты boswellia serrata |
| CA2754064C (en) * | 2009-03-03 | 2017-06-20 | Viva Pharmaceutical Inc. | Plant extract compositions for the treatment of influenza and inflammation |
| US8273387B2 (en) * | 2009-08-26 | 2012-09-25 | Mary Kay Inc. | Topical skin formulations comprising plant extracts |
| PH12012501787A1 (en) * | 2010-03-15 | 2012-12-10 | Laila Nutraceuticals | Boswellia oil, its fractions and compositions for enhancing brain function |
| WO2011139354A1 (en) * | 2010-05-05 | 2011-11-10 | Ayurvedic-Life International, Llc | Preparation for weight loss management |
| CN103889434B (zh) | 2011-06-21 | 2017-02-15 | Bvw控股公司 | 含有乳香酸的医疗装置 |
| CN108339120B (zh) * | 2017-01-25 | 2021-08-06 | 苏州大学 | 蛋白激酶a激活剂在制备治疗血小板数量减少相关疾病药物中的用途 |
| CN106729331A (zh) * | 2017-03-25 | 2017-05-31 | 成都海青生物科技有限公司 | 一种可有效治疗肾盂肾炎的内服药物及其制备方法 |
| US9975917B1 (en) | 2017-09-20 | 2018-05-22 | King Saud University | Pentacyclic triterpenoidal derivatives |
| CN115068486A (zh) * | 2021-03-15 | 2022-09-20 | 中国医学科学院药物研究所 | 乳香酸类化合物作为ltb4受体抑制剂的用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4466923A (en) * | 1982-04-01 | 1984-08-21 | The United States Of America As Represented By The Secretary Of Agriculture | Supercritical CO2 extraction of lipids from lipid-containing materials |
| US5288725A (en) * | 1992-10-15 | 1994-02-22 | Merck & Co., Inc. | Pyrroloquinoline Bradykinin antagonist |
| DE4445728A1 (de) * | 1994-12-21 | 1996-06-27 | Simmet Th Prof Dr | Verwendung von Boswelliasäure zur Behandlung von Hirntumoren |
| US5629351A (en) | 1995-04-13 | 1997-05-13 | Council Of Scientific & Industrial Research | Boswellic acid compositions and preparation thereof |
| US5753266A (en) * | 1996-12-03 | 1998-05-19 | Youssefyeh; Parvin | Safflower seed powder compositions for the treatment of rheumatoid based arthritic diseases |
| US6245340B1 (en) * | 1996-12-03 | 2001-06-12 | Parvin Youssefyeh | Method of improving the immune response and compositions therefor |
| US5972993A (en) * | 1998-03-20 | 1999-10-26 | Avon Products, Inc. | Composition and method for treating rosacea and sensitive skin with free radical scavengers |
| JP2000014354A (ja) | 1998-06-30 | 2000-01-18 | Maruho Co Ltd | 抗アレルギーまたは抗炎症作用を有する組成物 |
| US6746695B1 (en) * | 1998-10-02 | 2004-06-08 | Armadillo Pharmaceuticals, Inc. | Pharmaceutical preparations of bioactive substances extracted from natural sources |
| US20010024664A1 (en) * | 1999-03-19 | 2001-09-27 | Obukowicz Mark G. | Selective COX-2 inhibition from edible plant extracts |
| US6534086B1 (en) * | 2000-03-06 | 2003-03-18 | Metagenics, Inc. | Composition and method for treatment of inflammation and pain in mammals |
| US6264995B1 (en) * | 1999-10-19 | 2001-07-24 | Thomas Newmark | Herbal composition for reducing inflammation and methods of using same |
| US6541045B1 (en) * | 2002-01-04 | 2003-04-01 | Nutraceutical Corporation | Herbal composition and method for combating inflammation |
| ATE513553T1 (de) * | 2002-03-05 | 2011-07-15 | Laila Impex | Verfahren zur herstellung einer fraktion, die bis zu 100 mit 3-o-acetyl-11-keto-beta- boswellinsäure aus einem extrakt, der ein gemisch aus boswellinsäuren enthält, angereichert ist |
-
2003
- 2003-12-09 WO PCT/US2003/039183 patent/WO2004052299A2/en not_active Ceased
- 2003-12-09 CA CA002508766A patent/CA2508766A1/en not_active Abandoned
- 2003-12-09 AU AU2003296417A patent/AU2003296417A1/en not_active Abandoned
- 2003-12-09 US US10/732,182 patent/US7195790B2/en not_active Expired - Lifetime
- 2003-12-09 MX MXPA05006178A patent/MXPA05006178A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004052299A8 (en) | 2005-02-24 |
| US20040166182A1 (en) | 2004-08-26 |
| US7195790B2 (en) | 2007-03-27 |
| CA2508766A1 (en) | 2004-06-24 |
| AU2003296417A1 (en) | 2004-06-30 |
| WO2004052299B1 (en) | 2005-02-03 |
| AU2003296417A8 (en) | 2004-06-30 |
| WO2004052299A3 (en) | 2004-12-16 |
| WO2004052299A2 (en) | 2004-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |