MXPA05005781A - Combinacion de ibuprofeno y oxicodona para alivio de dolor agudo. - Google Patents
Combinacion de ibuprofeno y oxicodona para alivio de dolor agudo.Info
- Publication number
- MXPA05005781A MXPA05005781A MXPA05005781A MXPA05005781A MXPA05005781A MX PA05005781 A MXPA05005781 A MX PA05005781A MX PA05005781 A MXPA05005781 A MX PA05005781A MX PA05005781 A MXPA05005781 A MX PA05005781A MX PA05005781 A MXPA05005781 A MX PA05005781A
- Authority
- MX
- Mexico
- Prior art keywords
- ibuprofen
- oxycodone
- pain relief
- dosage form
- administration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invencion es un metodo para lograr un rapido inicio de alivio de dolor para dolor agudo en un paciente que necesita del mismo, que comprende administrar oralmente una formulacion unitaria (o forma de dosificacion oral) que contiene una cantidad analgesica efectiva de (a) oxicodona o una sal farmaceuticamente aceptable de la misma y (b) ibuprofeno o sal farmaceuticamente aceptable del mismo; preferiblemente, la formulacion unitaria contiene (a) oxicodona o una sal farmaceuticamente aceptable de la misma e (b) ibuprofeno o una sal farmaceuticamente aceptable del mismo en una relacion en peso de aproximadamente 1:20 a aproximadamente 1:100 y de preferencia a aproximadamente 1:40 a aproximadamente 1:80, con base en los pesos de equivalentes molares de clorhidrato de oxicodona e ibuprofeno, respectivamente; de preferencia, se administra una cantidad de oxicodona e ibuprofeno efectiva para proveer alivio parcial o completo del dolor en 30 minutos; preferiblemente, la cantidad es suficiente para proveer alivio parcial o completo del dolor en 25 minutos; se ha descubierto que la administracion de una forma de dosificacion oral que contiene tanto oxicodona como ibuprofeno, provee un inicio mas rapido de alivio de dolor que la administracion de cualquier ingrediente activo solo; ademas, el rapido inicio del alivio de dolor se puede atribuir al menos en parte a la administracion de una forma de dosificacion sencilla que contiene ambos ingredientes activos en lugar de administrar oxicodona e ibuprofeno en formas de dosificacion oral separadas (es decir, administracion de una primera forma de dosificacion que contiene oxicodona y una segunda forma de dosificacion que contiene ibuprofeno), el metodo de la presente invencion es particularmente util para tratar dolor postoperatorio agudo, que incluye sin limite, dolor postoperatorio agudo moderado y/o severo (tal como aquel que resulta de cirugia dental).
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42994402P | 2002-11-29 | 2002-11-29 | |
| US45304403P | 2003-03-07 | 2003-03-07 | |
| US50663203P | 2003-09-26 | 2003-09-26 | |
| PCT/US2003/038088 WO2004050025A2 (en) | 2002-11-29 | 2003-11-26 | Combination of ibuprofen and oxycodone for acute pain relief |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05005781A true MXPA05005781A (es) | 2005-12-12 |
Family
ID=32475405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05005781A MXPA05005781A (es) | 2002-11-29 | 2003-11-26 | Combinacion de ibuprofeno y oxicodona para alivio de dolor agudo. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20040186122A1 (es) |
| EP (1) | EP1575584A4 (es) |
| JP (1) | JP2006515861A (es) |
| AU (1) | AU2003293180A1 (es) |
| CA (1) | CA2507851A1 (es) |
| MX (1) | MXPA05005781A (es) |
| WO (1) | WO2004050025A2 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050038063A1 (en) * | 2002-11-29 | 2005-02-17 | Kenneth Newman | Method of treating acute pain with unitary dosage form comprising ibuprofen and oxycodone |
| TW201509943A (zh) | 2004-03-30 | 2015-03-16 | Euro Celtique Sa | 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
| US20060068009A1 (en) * | 2004-09-30 | 2006-03-30 | Scolr Pharma, Inc. | Modified release ibuprofen dosage form |
| US20070077297A1 (en) | 2004-09-30 | 2007-04-05 | Scolr Pharma, Inc. | Modified release ibuprofen dosage form |
| BRPI0518553A2 (pt) * | 2004-12-13 | 2008-11-25 | Mcneil Ppc Inc | composiÇço farmacÊutica estÁvel, mÉtodo para estabilizaÇço de pelo menos um ingrediente farmaceuticamente ativo e mÉtodo de uso de celulose microcristalina silicificada |
| WO2007130507A2 (en) * | 2006-05-03 | 2007-11-15 | Proethic Pharmaceuticals, Inc. | Acute pain medications based on fast acting diclofenac-opioid combinations |
| US7749537B2 (en) * | 2006-12-04 | 2010-07-06 | Scolr Pharma, Inc. | Method of forming a tablet |
| KR101864559B1 (ko) * | 2009-03-12 | 2018-06-04 | 큠버랜드 파마슈티컬즈 인코포레이티드 | 정맥 내 투여용 이부프로펜의 투여 |
| EP2588481B1 (en) | 2010-07-02 | 2017-11-15 | Johnson Matthey Public Limited Company | Process for the synthesis and purification of oxycodone |
| PL2912193T3 (pl) | 2012-10-29 | 2019-03-29 | Arizona Board Of Regents On Behalf Of University Of Arizona | Markery predykcyjne dla terapii przeciwnowotworowej z użyciem inhibitora poliaminy |
| CN104434918A (zh) * | 2013-09-16 | 2015-03-25 | 江苏恩华药业股份有限公司 | 盐酸羟考酮与布洛芬复方多层片及其制备方法 |
| CA2952771A1 (en) | 2014-06-18 | 2015-12-23 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Carcinoma diagnosis and treatment based on odc1 genotype |
| CN108366982A (zh) | 2015-10-30 | 2018-08-03 | 癌症预防制药股份有限公司 | 依氟鸟氨酸和舒林酸，固定剂量的组合制剂 |
| WO2017075576A1 (en) * | 2015-10-30 | 2017-05-04 | Cancer Prevention Pharmaceuticals, Inc. | Eflornithine and sulindac, fixed dose combination formulation |
| US10945981B2 (en) | 2019-05-17 | 2021-03-16 | Cancer Prevention Pharmaceuticals, Inc. | Methods for treating familial adenomatous polyposis |
| EP4337209A4 (en) * | 2021-05-11 | 2025-03-26 | Pharmazz, Inc. | Pharmaceutical composition and method for treatment of acute respiratory distress syndrome (ards) in corona virus disease (covid-19) |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12001A (en) * | 1854-11-28 | Improvement in breech-loading fire-arms | ||
| US186122A (en) * | 1877-01-09 | Improvement in scale-beams | ||
| US121001A (en) * | 1871-11-14 | Improvement in stove-pipe drums | ||
| US232787A (en) * | 1880-09-28 | Telephone-stand | ||
| US199439A (en) * | 1878-01-22 | Improvement in wagon-standards | ||
| US861239A (en) * | 1904-05-12 | 1907-07-23 | Gen Electric | Controlling-switch. |
| JPS584720A (ja) * | 1981-06-26 | 1983-01-11 | ザ・アツプジヨン・カンパニ− | 鎮痛用医薬組成物 |
| US4464376A (en) * | 1982-07-22 | 1984-08-07 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| US4569937A (en) * | 1985-02-11 | 1986-02-11 | E. I. Du Pont De Nemours And Company | Analgesic mixture of oxycodone and ibuprofen |
| DE3669103D1 (de) * | 1986-11-14 | 1990-04-05 | Puetter Medice Chem Pharm | Ibuprofen enthaltendes arzneimittel. |
| US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US6471994B1 (en) * | 1995-01-09 | 2002-10-29 | Edward Mendell Co., Inc. | Pharmaceutical excipient having improved compressibility |
| US5585115A (en) * | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
| FR2762513B1 (fr) * | 1997-04-23 | 2003-08-22 | Permatec Pharma Ag | Comprimes bioadhesifs |
| US6399101B1 (en) * | 2000-03-30 | 2002-06-04 | Mova Pharmaceutical Corp. | Stable thyroid hormone preparations and method of making same |
| US20030232787A1 (en) * | 2001-05-08 | 2003-12-18 | Dooley David James | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic |
| US20030199439A1 (en) * | 2002-04-22 | 2003-10-23 | Simon David Lew | Compositions of alpha3beta4 receptor antagonists and opioid agonist analgesics |
-
2003
- 2003-11-26 EP EP03790172A patent/EP1575584A4/en not_active Withdrawn
- 2003-11-26 CA CA002507851A patent/CA2507851A1/en not_active Abandoned
- 2003-11-26 MX MXPA05005781A patent/MXPA05005781A/es unknown
- 2003-11-26 WO PCT/US2003/038088 patent/WO2004050025A2/en not_active Ceased
- 2003-11-26 JP JP2004570976A patent/JP2006515861A/ja active Pending
- 2003-11-26 AU AU2003293180A patent/AU2003293180A1/en not_active Abandoned
- 2003-12-01 US US10/725,246 patent/US20040186122A1/en not_active Abandoned
-
2004
- 2004-08-23 US US10/925,783 patent/US20050059690A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006515861A (ja) | 2006-06-08 |
| EP1575584A2 (en) | 2005-09-21 |
| WO2004050025A3 (en) | 2004-12-09 |
| US20050059690A1 (en) | 2005-03-17 |
| US20040186122A1 (en) | 2004-09-23 |
| CA2507851A1 (en) | 2004-06-17 |
| WO2004050025A2 (en) | 2004-06-17 |
| AU2003293180A1 (en) | 2004-06-23 |
| EP1575584A4 (en) | 2006-02-01 |
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