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MXPA03011980A - Agonista de oxitocina. - Google Patents

Agonista de oxitocina.

Info

Publication number
MXPA03011980A
MXPA03011980A MXPA03011980A MXPA03011980A MXPA03011980A MX PA03011980 A MXPA03011980 A MX PA03011980A MX PA03011980 A MXPA03011980 A MX PA03011980A MX PA03011980 A MXPA03011980 A MX PA03011980A MX PA03011980 A MXPA03011980 A MX PA03011980A
Authority
MX
Mexico
Prior art keywords
oxytocin agonists
general formula
compounds
agonists
group
Prior art date
Application number
MXPA03011980A
Other languages
English (en)
Inventor
William Pitt Gary Robert
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of MXPA03011980A publication Critical patent/MXPA03011980A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Tea And Coffee (AREA)
  • Current-Collector Devices For Electrically Propelled Vehicles (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Los compuestos de acuerdo con la formula general 1: en donde G1 es NR6R7 o un grupo policiclico fusionado, son novedosos. Son agonistas de oxitocina selectivos y potentes. Las composiciones farmaceuticas de estos compuestos son utiles en el tratamiento de, entre otras cosas, disfuncion erectil.
MXPA03011980A 2001-06-25 2002-06-24 Agonista de oxitocina. MXPA03011980A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0115515.9A GB0115515D0 (en) 2001-06-25 2001-06-25 Oxytocin agonisys
PCT/GB2002/002872 WO2003000692A2 (en) 2001-06-25 2002-06-24 Oxytocin agonists

Publications (1)

Publication Number Publication Date
MXPA03011980A true MXPA03011980A (es) 2004-03-26

Family

ID=9917320

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03011980A MXPA03011980A (es) 2001-06-25 2002-06-24 Agonista de oxitocina.

Country Status (22)

Country Link
US (1) US20040235753A1 (es)
EP (1) EP1399436B1 (es)
JP (1) JP2005500317A (es)
KR (1) KR20040010762A (es)
CN (1) CN1606553A (es)
AT (1) ATE291021T1 (es)
CA (1) CA2450480A1 (es)
CZ (1) CZ20033414A3 (es)
DE (1) DE60203290T2 (es)
DK (1) DK1399436T3 (es)
ES (1) ES2239717T3 (es)
GB (1) GB0115515D0 (es)
HU (1) HUP0400368A3 (es)
IL (1) IL159289A0 (es)
MX (1) MXPA03011980A (es)
NO (1) NO20035772L (es)
NZ (1) NZ530035A (es)
PL (1) PL367538A1 (es)
PT (1) PT1399436E (es)
RU (1) RU2309156C2 (es)
WO (1) WO2003000692A2 (es)
ZA (1) ZA200309626B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001082492A1 (fr) 2000-04-26 2001-11-01 Fujitsu Limited Appareil radiorecepteur et systeme de radiocommunications
DK1480998T3 (da) 2002-02-27 2007-03-26 Ferring Bv Mellemprodukter og fremgangsmåder til fremstilling af heptapeptidoxytocinanaloger
EP1449844A1 (en) * 2003-02-14 2004-08-25 Ferring B.V. benzamide derivatives as oxytocin agonists and vasopressin antagonists
EP1512687A1 (en) * 2003-09-05 2005-03-09 Ferring B.V. Piperazines as oxytocin agonists
EP1632494A1 (en) 2004-08-24 2006-03-08 Ferring B.V. Vasopressin v1a antagonists
RU2008114374A (ru) * 2005-10-24 2009-12-10 Вайет (Us) Трициклические соединения, применяемые в качестве агонистов рецептора окситоцина
US9096546B2 (en) * 2007-05-10 2015-08-04 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
CA2691849A1 (en) * 2007-06-28 2008-12-31 Novartis Ag Kallikrein 7 modulators
WO2009043436A2 (en) * 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of af12198 as a therapeutic agent
WO2009033820A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
WO2009039966A2 (en) * 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
US20100190717A1 (en) * 2007-09-11 2010-07-29 Dorian Bevec Use of melanin concentrating hormone and met-enkephalin as therapeutic agents
CA2704724A1 (en) * 2007-09-11 2009-04-16 Mondobiotech Laboratories Ag 5use of a peptide as a therapeutic agent
AR068509A1 (es) * 2007-09-19 2009-11-18 Jerini Ag Antagosnistas del receptor de bradiquinina b1
WO2011147889A1 (en) 2010-05-25 2011-12-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the treatment of a feeding disorder with early-onset in a patient
GB201105537D0 (en) * 2011-03-31 2011-05-18 Vantia Ltd New process
CN103159641A (zh) * 2011-12-14 2013-06-19 天津泰普药品科技发展有限公司 托伐普坦中间体2-甲酸-5-(2-甲基苯甲酰氨基)甲苯的制备方法
US10442819B2 (en) 2014-12-05 2019-10-15 Merck Sharp & Dohme Corp. Tricyclic compounds as inhibitors of mutant IDH enzymes
AU2016289271B2 (en) 2015-07-06 2020-12-03 Kinoxis Therapeutics Pty Ltd Therapeutic compounds and compositions for treating social disorders and substance use disorders
PT3551631T (pt) * 2016-12-12 2024-12-10 Kinoxis Therapeutics Pty Ltd Agonistas de recetor de oxitocina não-peptídicos
KR20170035351A (ko) 2017-01-06 2017-03-30 셰플러코리아(유) 볼베어링용 케이지
US20220288060A1 (en) * 2019-09-06 2022-09-15 Kinoxis Therapeutics Pty Ltd Treatment of Opioid Withdrawal
EP4378526A1 (en) * 2022-11-30 2024-06-05 Université de Strasbourg Non peptidergic agonists of oxytocin receptor
EP4378525A1 (en) * 2022-11-30 2024-06-05 Université de Strasbourg Non peptidergic agonists of oxytocin receptor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665441B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.
DE60001054T2 (de) * 1999-02-04 2003-07-24 Wyeth, Madison Trizyclische pyridin n-oxide vasopressin agonisten
GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
GB0015601D0 (en) * 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents

Also Published As

Publication number Publication date
DK1399436T3 (da) 2005-05-30
DE60203290T2 (de) 2006-02-02
CN1606553A (zh) 2005-04-13
RU2003136152A (ru) 2005-05-20
ZA200309626B (en) 2004-05-12
ES2239717T3 (es) 2005-10-01
NZ530035A (en) 2004-06-25
WO2003000692A3 (en) 2003-05-15
NO20035772L (no) 2003-12-22
HUP0400368A3 (en) 2007-05-29
GB0115515D0 (en) 2001-08-15
EP1399436A2 (en) 2004-03-24
KR20040010762A (ko) 2004-01-31
WO2003000692A2 (en) 2003-01-03
US20040235753A1 (en) 2004-11-25
RU2309156C2 (ru) 2007-10-27
IL159289A0 (en) 2004-06-01
PL367538A1 (en) 2005-02-21
CZ20033414A3 (en) 2004-05-12
CA2450480A1 (en) 2003-01-03
HK1064666A1 (en) 2005-02-04
HUP0400368A2 (hu) 2004-08-30
EP1399436B1 (en) 2005-03-16
ATE291021T1 (de) 2005-04-15
DE60203290D1 (de) 2005-04-21
JP2005500317A (ja) 2005-01-06
PT1399436E (pt) 2005-07-29

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