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MXPA03011898A - Ensayo de seleccion in vitro para ?- secretasa. - Google Patents

Ensayo de seleccion in vitro para ?- secretasa.

Info

Publication number
MXPA03011898A
MXPA03011898A MXPA03011898A MXPA03011898A MXPA03011898A MX PA03011898 A MXPA03011898 A MX PA03011898A MX PA03011898 A MXPA03011898 A MX PA03011898A MX PA03011898 A MXPA03011898 A MX PA03011898A MX PA03011898 A MXPA03011898 A MX PA03011898A
Authority
MX
Mexico
Prior art keywords
gamma
secretase
vitro
substrate
secretase activity
Prior art date
Application number
MXPA03011898A
Other languages
English (en)
Inventor
Fuchs Klaus
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MXPA03011898A publication Critical patent/MXPA03011898A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

De acuerdo al metodo de seleccion de la invencion, se identifican substancias capaces de modular La actividad de ?-secretasa, incubando una fuente y un substrato de actividad de ?-secretasa con una substancia de prueba, y detectando un fragmento C-terminal liberado a partir del sustrato.
MXPA03011898A 2001-07-04 2002-06-27 Ensayo de seleccion in vitro para ?- secretasa. MXPA03011898A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10131899A DE10131899A1 (de) 2001-07-04 2001-07-04 In vitro-Screening-Assay für gamma-Secretase
PCT/EP2002/007095 WO2003008635A2 (en) 2001-07-04 2002-06-27 η-SECRETASE IN VITRO SCREENING ASSAY

Publications (1)

Publication Number Publication Date
MXPA03011898A true MXPA03011898A (es) 2004-03-26

Family

ID=7690254

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03011898A MXPA03011898A (es) 2001-07-04 2002-06-27 Ensayo de seleccion in vitro para ?- secretasa.

Country Status (6)

Country Link
EP (1) EP1407043A2 (es)
JP (1) JP2004535206A (es)
CA (1) CA2452832A1 (es)
DE (1) DE10131899A1 (es)
MX (1) MXPA03011898A (es)
WO (1) WO2003008635A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0229582D0 (en) * 2002-12-19 2003-01-22 Merck Sharp & Dohme Novel assay
PL1849762T3 (pl) 2006-04-21 2009-12-31 Cellzome Ltd Podstawione kwasy bifenylo-karboksylowe i ich pochodne
KR20090128454A (ko) 2007-03-07 2009-12-15 얀센 파마슈티카 엔.브이. 에스트로겐 관련 수용체-알파 조절제로서 치환된 페녹시 아미노티아졸론
EP2132188B1 (en) 2007-03-07 2011-12-14 Janssen Pharmaceutica N.V. Substituted phenoxy n-alkylated thiazoledinedione as estrogen related receptor-alpha modulators
JP2010533478A (ja) * 2007-07-13 2010-10-28 エラン ファーマシューティカルズ，インコーポレイテッド ガンマセクレターゼの阻害剤の基質特異性を同定するための組成物および方法
DK2215044T3 (da) 2007-10-17 2012-11-26 Cellzome Ltd Biphenylcarboxylsyrer og derivater deraf
CA2702959C (en) 2007-10-19 2016-07-26 Janssen Pharmaceutica Nv Carbon linked modulators of .gamma.-secretase
EP2212280B1 (en) 2007-10-19 2013-12-04 Janssen Pharmaceutica, N.V. Amide linked modulators of y-secretase
BRPI0817433A2 (pt) 2007-10-19 2015-06-16 Janssen Pharmaceutica Nv Moduladores de gama-secretase piperidinila e piperazinila
WO2009052350A1 (en) 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Amine linked modulators of y-secretase
US7968725B2 (en) 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase
US9023767B2 (en) 2009-05-07 2015-05-05 Memorial Sloan-Kettering Cancer Center γ-Secretase substrates and methods of use
US9632088B2 (en) 2010-09-07 2017-04-25 Memorial Sloan-Kettering Cancer Center Methods and compositions for gamma-secretase assay
WO2014062771A1 (en) * 2012-10-16 2014-04-24 The Johns Hopkins University An inducible reconstitution and real-time quantitative kinetic system for the study of intramembrane enzymes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4589297A (en) * 1996-10-07 1998-05-05 Scios Inc. Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase
DE19941039A1 (de) * 1999-08-28 2001-03-01 Boehringer Ingelheim Pharma gamma-Sekretase in vitro Testsystem

Also Published As

Publication number Publication date
WO2003008635A3 (en) 2004-01-29
WO2003008635A2 (en) 2003-01-30
EP1407043A2 (en) 2004-04-14
DE10131899A1 (de) 2003-02-27
WO2003008635A8 (en) 2003-10-30
CA2452832A1 (en) 2003-01-30
JP2004535206A (ja) 2004-11-25

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