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MXPA03010269A - Derivados de 2,5-disubstituida piridina, pirimidina, piridazina y 1,2,4-triazina para usarse como inhibidores de p38. - Google Patents

Derivados de 2,5-disubstituida piridina, pirimidina, piridazina y 1,2,4-triazina para usarse como inhibidores de p38.

Info

Publication number
MXPA03010269A
MXPA03010269A MXPA03010269A MXPA03010269A MXPA03010269A MX PA03010269 A MXPA03010269 A MX PA03010269A MX PA03010269 A MXPA03010269 A MX PA03010269A MX PA03010269 A MXPA03010269 A MX PA03010269A MX PA03010269 A MXPA03010269 A MX PA03010269A
Authority
MX
Mexico
Prior art keywords
inhibitors
pyridazine
pyrimidine
triazine derivatives
disubstituted pyridine
Prior art date
Application number
MXPA03010269A
Other languages
English (en)
Inventor
L Harbeson Scott
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MXPA03010269A publication Critical patent/MXPA03010269A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
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  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
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Abstract

La presente invencion se relaciona con inhibidores de P38, una proteina cinasa mamifera implicada en proliferacion celular, muerte celular y respuesta a estimulos extracelulares. La invencion tambien se relaciona con los metodos para producir estos inhibidores. La invencion tambien proporciona las composiciones farmaceuticas que comprenden los inhibidores de la invencion y los metodos para utilizar esas composiciones en el tratamiento y prevencion de diversos trastornos. Los inhibidores son de la formula (I), (II) o (III) en donde las variables son como se definen en las reivindicaciones.
MXPA03010269A 2001-05-11 2002-05-10 Derivados de 2,5-disubstituida piridina, pirimidina, piridazina y 1,2,4-triazina para usarse como inhibidores de p38. MXPA03010269A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29050401P 2001-05-11 2001-05-11
PCT/US2002/017673 WO2002092087A1 (en) 2001-05-11 2002-05-10 2,5-disubstituted pyridine, pyrimidine, pyridazine and 1, 2, 4-triazine derivatives for use as p38 inhibitors

Publications (1)

Publication Number Publication Date
MXPA03010269A true MXPA03010269A (es) 2004-05-05

Family

ID=23116303

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MXPA03010269A MXPA03010269A (es) 2001-05-11 2002-05-10 Derivados de 2,5-disubstituida piridina, pirimidina, piridazina y 1,2,4-triazina para usarse como inhibidores de p38.

Country Status (6)

Country Link
US (1) US7271181B2 (es)
EP (1) EP1392300A1 (es)
JP (1) JP2004536057A (es)
CA (1) CA2446879A1 (es)
MX (1) MXPA03010269A (es)
WO (1) WO2002092087A1 (es)

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US7271181B2 (en) 2007-09-18
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