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MXPA03008844A - Sustratos, preparacion y uso. - Google Patents

Sustratos, preparacion y uso.

Info

Publication number
MXPA03008844A
MXPA03008844A MXPA03008844A MXPA03008844A MXPA03008844A MX PA03008844 A MXPA03008844 A MX PA03008844A MX PA03008844 A MXPA03008844 A MX PA03008844A MX PA03008844 A MXPA03008844 A MX PA03008844A MX PA03008844 A MXPA03008844 A MX PA03008844A
Authority
MX
Mexico
Prior art keywords
reactive
bond
substrate
preferred
ies
Prior art date
Application number
MXPA03008844A
Other languages
English (en)
Inventor
Remacle Jose
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of MXPA03008844A publication Critical patent/MXPA03008844A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Graft Or Block Polymers (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Laminated Bodies (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Se describe un proceso para preparar un sustrato 1. Proceso para preparar un sustrato que tiene en el mismo sitios reactivos con los grupos reactivos de una sonda molecular, el proceso comprende los pasos de aplicar a la superficie del sustrato un material que comprende uno o mas sitios reactivos que tienen un enlace doble etilenicamente no saturado activado de la formula I: (ver formula) en donde, si n=0, m=1, X3 es carbono y X1 es nitrogeno, el enlace entre ellos es triple y X4 no existe; si n=1, m=1, X3 es carbono y X1 es oxigeno o azufre, el enlace entre ellos es doble y X2 es oxigeno o azufre o nitrogeno sustituido por un sustituyente organo; si n=1, m=1 o 2, X3 es azufre y X1 es oxigeno, el enlace entre ellos es doble y X2 es nitrogeno sustituido por un sustituyente organo; R1, R2, representan cada uno de manera independiente hidrogeno, hidroxilo o grupo organo, R3 y R4 representan cada uno de manera independiente hidrogeno o grupo organo, finalmente contiene un atomo de silicio y R1 y R2 no estan enlazados a R4, y, en otro paso, de unir en forma covalente el grupo reactivo de la sonda molecular al enlace doble etilenicamente no saturado activado de los sitios reactivos que tienen la formula I. La porcion o porciones no saturadas activadas preferidas comprenden porciones ester no saturadas tales como porciones de (met)acrilato. Las sondas preferidas comprenden grupos amino en las mismas. Los enlaces fuertes preferidos son enlaces covalentes. Las reacciones de enlace preferidas son reacciones de adicion de Michael. El sustrato que tiene sondas depositadas en el mismo se puede usar para interactuar con un blanco. Otros aspectos de la invencion se refieren a sustratos y sistemas multirreactivos (tal como micromatrices) asi preparados, usos de los mismos, y productos e informacion obtenidos a partir de los mismos.
MXPA03008844A 2001-03-30 2002-03-20 Sustratos, preparacion y uso. MXPA03008844A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01108134A EP1245272A1 (en) 2001-03-30 2001-03-30 Substrates, preparation and use
PCT/EP2002/003102 WO2002078835A2 (en) 2001-03-30 2002-03-20 Substrates, preparation and use

Publications (1)

Publication Number Publication Date
MXPA03008844A true MXPA03008844A (es) 2004-05-24

Family

ID=8177005

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03008844A MXPA03008844A (es) 2001-03-30 2002-03-20 Sustratos, preparacion y uso.

Country Status (12)

Country Link
US (1) US8304229B2 (es)
EP (2) EP1245272A1 (es)
JP (1) JP4184089B2 (es)
KR (1) KR100876256B1 (es)
CN (1) CN1310700C (es)
AT (1) ATE508793T1 (es)
AU (1) AU2002257687A1 (es)
CA (1) CA2441983C (es)
DK (1) DK1377369T3 (es)
MX (1) MXPA03008844A (es)
TW (1) TWI243072B (es)
WO (1) WO2002078835A2 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10262235B4 (de) 2002-11-12 2010-05-12 Kronotec Ag Spanplatte, insbesondere Fußbodenpaneel oder Möbelplatte, und Verfahren zu ihrer Herstellung
DE10252866B3 (de) 2002-11-12 2004-04-29 Kronotec Ag Paneel und Verfahren zur Herstellung eines Paneels
US7617651B2 (en) 2002-11-12 2009-11-17 Kronotec Ag Floor panel
ES2307840T3 (es) 2002-11-15 2008-12-01 Flooring Technologies Ltd. Equipo compuesto por dos placas de construccion que pueden unirse entre si y una pieza insertada para enclavar estas placas de construccion.
DE10306118A1 (de) 2003-02-14 2004-09-09 Kronotec Ag Bauplatte
US7678425B2 (en) 2003-03-06 2010-03-16 Flooring Technologies Ltd. Process for finishing a wooden board and wooden board produced by the process
DE20304761U1 (de) 2003-03-24 2004-04-08 Kronotec Ag Einrichtung zum Verbinden von Bauplatten, insbesondere Bodenpaneele
DE10362218B4 (de) 2003-09-06 2010-09-16 Kronotec Ag Verfahren zum Versiegeln einer Bauplatte
DE20315676U1 (de) 2003-10-11 2003-12-11 Kronotec Ag Paneel, insbesondere Bodenpaneel
US7506481B2 (en) 2003-12-17 2009-03-24 Kronotec Ag Building board for use in subfloors
DE102004005047B3 (de) 2004-01-30 2005-10-20 Kronotec Ag Verfahren und Einrichtung zum Einbringen eines die Feder einer Platte bildenden Streifens
DE102004011931B4 (de) 2004-03-11 2006-09-14 Kronotec Ag Dämmstoffplatte aus einem Holzwerkstoff-Bindemittelfaser-Gemisch
DE102005042658B3 (de) 2005-09-08 2007-03-01 Kronotec Ag Bauplatte, insbesondere Fußbodenpaneel
DE102005042657B4 (de) 2005-09-08 2010-12-30 Kronotec Ag Bauplatte und Verfahren zur Herstellung
US7854986B2 (en) 2005-09-08 2010-12-21 Flooring Technologies Ltd. Building board and method for production
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DE102005063034B4 (de) 2005-12-29 2007-10-31 Flooring Technologies Ltd. Paneel, insbesondere Bodenpaneel
DE102006006124A1 (de) 2006-02-10 2007-08-23 Flooring Technologies Ltd. Einrichtung zum Verriegeln zweier Bauplatten
DE102006007976B4 (de) 2006-02-21 2007-11-08 Flooring Technologies Ltd. Verfahren zur Veredelung einer Bauplatte
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CN101832996B (zh) * 2010-04-14 2013-01-09 南方医科大学 一种中药生物芯片的基片及其制备方法和用途
CN108503565B (zh) * 2018-04-04 2019-08-09 大连理工大学 一种生物芯片基片，其制备方法及应用
TW202019989A (zh) * 2018-08-06 2020-06-01 美商康寧公司 具有穩定聚合物塗層之流動槽及其用於基因定序之用途
CN112154757B (zh) * 2020-09-30 2022-08-30 福建泉智生物科技有限公司 枇杷有机-无机质平衡施肥方法

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Also Published As

Publication number Publication date
EP1377369A2 (en) 2004-01-07
JP4184089B2 (ja) 2008-11-19
CA2441983A1 (en) 2002-10-10
AU2002257687A1 (en) 2002-10-15
CA2441983C (en) 2011-08-02
CN1310700C (zh) 2007-04-18
DK1377369T3 (da) 2011-08-15
TWI243072B (en) 2005-11-11
EP1245272A1 (en) 2002-10-02
ATE508793T1 (de) 2011-05-15
WO2002078835A3 (en) 2002-11-28
JP2004534866A (ja) 2004-11-18
WO2002078835A2 (en) 2002-10-10
CN1505544A (zh) 2004-06-16
KR20030092041A (ko) 2003-12-03
US8304229B2 (en) 2012-11-06
EP1377369B1 (en) 2011-05-11
KR100876256B1 (ko) 2008-12-26
US20040092006A1 (en) 2004-05-13

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