MXPA03008338A - Derivados de piperazina. - Google Patents

Derivados de piperazina.

Info

Publication number: MXPA03008338A
Authority: MX; Mexico
Prior art keywords: piperazine derivatives; piperazine; derivatives
Prior art date: 2001-03-13

Application number

MXPA03008338A

Other languages

English (en)

Inventor

Paul Hebeisen

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-13

Filing date

2002-03-06

Publication date

2003-12-11

2002-03-06 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-12-11 Publication of MXPA03008338A publication Critical patent/MXPA03008338A/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Anesthesiology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MXPA03008338A 2001-03-13 2002-03-06 Derivados de piperazina. MXPA03008338A (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0106177.9A GB0106177D0 (en)	2001-03-13	2001-03-13	Piperazine derivatives
PCT/EP2002/002443 WO2002072584A2 (en)	2001-03-13	2002-03-06	Tetrahydro-pyrazino (1,2-a) indoles for the treatment of central nervous disorders

Publications (1)

Publication Number	Publication Date
MXPA03008338A true MXPA03008338A (es)	2003-12-11

Family

ID=9910578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MXPA03008338A MXPA03008338A (es)	2001-03-13	2002-03-06	Derivados de piperazina.

Country Status (20)

Country	Link
US (1)	US6844345B2 (es)
EP (1)	EP1370561B1 (es)
JP (1)	JP4230225B2 (es)
KR (1)	KR100618748B1 (es)
CN (1)	CN1245405C (es)
AR (1)	AR035945A1 (es)
AT (1)	ATE422498T1 (es)
AU (1)	AU2002304833B2 (es)
BR (1)	BR0208111A (es)
CA (1)	CA2438596C (es)
DE (1)	DE60231107D1 (es)
ES (1)	ES2320739T3 (es)
GB (1)	GB0106177D0 (es)
GT (1)	GT200200048A (es)
MX (1)	MXPA03008338A (es)
PA (1)	PA8540801A1 (es)
PE (1)	PE20021043A1 (es)
UY (1)	UY27204A1 (es)
WO (1)	WO2002072584A2 (es)
ZA (1)	ZA200306613B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6762132B1 (en) *	2000-08-31	2004-07-13	Micron Technology, Inc.	Compositions for dissolution of low-K dielectric films, and methods of use
MXPA04012711A (es)	2002-06-19	2005-03-23	Biovitrum Ab	Nuevos compuestos, su uso y preparacion.
CL2004000826A1 (es)	2003-04-25	2005-03-04	Pfizer	Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
ATE525354T1 (de) *	2004-05-03	2011-10-15	Janssen Pharmaceutica Nv	Benzofuranderivate als selektive androgenrezeptormodulatoren (sarms)
EP2248524A3 (en)	2004-08-25	2011-03-09	Takeda Pharmaceutical Company Limited	Preventives/remedies for stress urinary incontinence and method of screening the same
ATE485294T1 (de) *	2005-11-18	2010-11-15	Hoffmann La Roche	Azaindol-2-carboxamid-derivate
DE602006010433D1 (de) *	2005-12-09	2009-12-24	Hoffmann La Roche	Für die behandlung von obesitas geeignete tricyclische amidderivate
WO2007132841A1 (ja)	2006-05-16	2007-11-22	Takeda Pharmaceutical Company Limited	縮合複素環化合物およびその用途
JP5520051B2 (ja)	2007-11-15	2014-06-11	武田薬品工業株式会社	縮合ピリジン誘導体およびその用途
EP2254886B1 (en)	2008-03-28	2016-05-25	Nerviano Medical Sciences S.r.l.	3,4-dihydro-2h-pyrazino[1,2-a]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2011071136A1 (ja)	2009-12-11	2011-06-16	アステラス製薬株式会社	線維筋痛症治療剤
WO2011149036A1 (ja) *	2010-05-27	2011-12-01	国立大学法人東京大学	抗炎症薬
WO2012030953A1 (en)	2010-09-01	2012-03-08	Arena Pharmaceuticals, Inc.	5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
CN104203950B (zh)	2012-03-16	2016-08-24	生命医药公司	肝x受体调节剂
HUE029402T2 (en)	2012-03-16	2017-02-28	Vitae Pharmaceuticals Inc	Liver X receptor modulators
JP5974177B2 (ja) *	2012-08-06	2016-08-23	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	ピペラジノ［１，２−ａ］インドール−１−オン類及び［１，４］ジアゼピノ［１，２−ａ］インドール−１−オン
MX2015013915A (es) *	2013-04-02	2015-12-11	Hoffmann La Roche	Piperazino[1,2-a]indol-1-onas y [1,4]diazepino[1,2-a]indol-1-ona.
WO2015066344A1 (en)	2013-11-01	2015-05-07	Arena Pharmaceuticals, Inc.	5-ht2c receptor agonists and compositions and methods of use
CN106317058B (zh) *	2016-08-17	2018-10-02	广东省微生物研究所	化合物dichotocejpin A及其制备方法和在制备治疗糖尿病药物中的应用
JOP20190239A1 (ar)	2017-04-19	2019-10-09	Neurocrine Biosciences Inc	مركبات مثبطة لـ vmat2 وتركيبات منها
WO2019131902A1 (ja)	2017-12-27	2019-07-04	武田薬品工業株式会社	腹圧性尿失禁および便失禁の治療薬

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3317524A (en)	1965-02-04	1967-05-02	American Home Prod	Substituted 1, 2, 3, 4-tetrahydro-pyrazino[1, 2-a]indoles
CA1247547A (en)	1983-06-22	1988-12-28	Paul Hadvary	Leucine derivatives
CA1270837A (en)	1984-12-21	1990-06-26	Hoffmann-La Roche Limited	Oxetanones
CA1328881C (en)	1984-12-21	1994-04-26	Pierre Barbier	Process for the manufacture of oxetanones
CA2035972C (en)	1990-02-23	2006-07-11	Martin Karpf	Process for the preparation of oxetanones
US5274143A (en)	1991-07-23	1993-12-28	Hoffmann-La Roche Inc.	Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione
EP0572863A1 (de) *	1992-06-05	1993-12-08	F. Hoffmann-La Roche Ag	ZNS Pyrazinoindole
WO1996012721A1 (en) *	1994-10-20	1996-05-02	American Home Products Corporation	Indole derivatives useful as serotonergic agents
US5854245A (en) *	1996-06-28	1998-12-29	Merck & Co., Inc.	Fibrinogen receptor antagonists
US6004996A (en)	1997-02-05	1999-12-21	Hoffman-La Roche Inc.	Tetrahydrolipstatin containing compositions
US6267952B1 (en)	1998-01-09	2001-07-31	Geltex Pharmaceuticals, Inc.	Lipase inhibiting polymers
AU761351B2 (en)	1998-08-14	2003-06-05	Cheplapharm Arzneimittel Gmbh	Pharmaceutical compositions containing lipase inhibitors
DE69916288T2 (de)	1998-08-14	2005-03-24	F. Hoffmann-La Roche Ag	Lipasehemmer und chitosan enthaltende arzneimittel
GB9902047D0 (en) *	1999-01-29	1999-03-17	Cerebrus Ltd	Chemical compounds XI
DE60113865T2 (de) *	2000-07-31	2006-07-20	Vernalis Research Ltd., Winnersh	Piperazin derivate

2001
- 2001-03-13 GB GBGB0106177.9A patent/GB0106177D0/en not_active Ceased
2002
- 2002-03-06 CA CA002438596A patent/CA2438596C/en not_active Expired - Fee Related
- 2002-03-06 EP EP02732459A patent/EP1370561B1/en not_active Expired - Lifetime
- 2002-03-06 CN CNB028062876A patent/CN1245405C/zh not_active Expired - Fee Related
- 2002-03-06 BR BR0208111-3A patent/BR0208111A/pt not_active IP Right Cessation
- 2002-03-06 ES ES02732459T patent/ES2320739T3/es not_active Expired - Lifetime
- 2002-03-06 WO PCT/EP2002/002443 patent/WO2002072584A2/en not_active Ceased
- 2002-03-06 KR KR1020037011901A patent/KR100618748B1/ko not_active Expired - Fee Related
- 2002-03-06 AU AU2002304833A patent/AU2002304833B2/en not_active Ceased
- 2002-03-06 MX MXPA03008338A patent/MXPA03008338A/es not_active Application Discontinuation
- 2002-03-06 JP JP2002571500A patent/JP4230225B2/ja not_active Expired - Fee Related
- 2002-03-06 DE DE60231107T patent/DE60231107D1/de not_active Expired - Lifetime
- 2002-03-06 AT AT02732459T patent/ATE422498T1/de not_active IP Right Cessation
- 2002-03-07 PA PA20028540801A patent/PA8540801A1/es unknown
- 2002-03-07 US US10/092,751 patent/US6844345B2/en not_active Expired - Fee Related
- 2002-03-11 AR ARP020100877A patent/AR035945A1/es not_active Application Discontinuation
- 2002-03-12 UY UY27204A patent/UY27204A1/es not_active Application Discontinuation
- 2002-03-12 PE PE2002000197A patent/PE20021043A1/es not_active Application Discontinuation
- 2002-03-12 GT GT200200048A patent/GT200200048A/es unknown
2003
- 2003-08-25 ZA ZA200306613A patent/ZA200306613B/en unknown

Also Published As

Publication number	Publication date
AR035945A1 (es)	2004-07-28
BR0208111A (pt)	2004-03-02
CN1245405C (zh)	2006-03-15
PA8540801A1 (es)	2005-02-04
AU2002304833B2 (en)	2006-05-04
WO2002072584A2 (en)	2002-09-19
EP1370561A2 (en)	2003-12-17
ATE422498T1 (de)	2009-02-15
JP2004532823A (ja)	2004-10-28
ES2320739T3 (es)	2009-05-28
WO2002072584A3 (en)	2003-01-03
CN1529706A (zh)	2004-09-15
ZA200306613B (en)	2004-11-25
UY27204A1 (es)	2002-09-30
CA2438596C (en)	2008-07-08
PE20021043A1 (es)	2002-11-19
KR100618748B1 (ko)	2006-08-31
CA2438596A1 (en)	2002-09-19
US6844345B2 (en)	2005-01-18
EP1370561B1 (en)	2009-02-11
JP4230225B2 (ja)	2009-02-25
US20020169163A1 (en)	2002-11-14
KR20030080255A (ko)	2003-10-11
GT200200048A (es)	2002-11-15
GB0106177D0 (en)	2001-05-02
DE60231107D1 (de)	2009-03-26

Publication	Publication Date	Title
MXPA03005270A (es)	2003-09-25	Derivados de piperazina.
ZA200207827B (en)	2003-09-30	Novel piperazine derivatives.
AU8395501A (en)	2002-02-13	Piperazine derivatives
AP2005003198A0 (en)	2005-03-31	Spiroindolinepiperidine derivatives.
ZA200500170B (en)	2006-02-22	Indole-3-sulphur derivatives.
ZA200307646B (en)	2004-07-13	Benzamidine derivative.
ZA200400926B (en)	2005-02-04	Diamine derivatives.
ZA200309522B (en)	2005-02-23	Substituted cyclohexane-1-4diamine derivatives
IL160701A0 (en)	2004-08-31	3-substituted-4-pyrimidone derivatives
PL369076A1 (en)	2005-04-18	Piperazine derivative
ZA200208561B (en)	2003-05-19	Hydraulischer druckverstarker.
GB0202015D0 (en)	2002-03-13	Piperazine Derivatives
MXPA03008338A (es)	2003-12-11	Derivados de piperazina.
MXPA01009037A (es)	2003-11-18	I-bet.
MXPA03008140A (es)	2003-12-12	Amidas de acido benzofuran-2-carboxilico sustituidas.
MXPA03005286A (es)	2003-10-06	METODO Y APARATO PARA SUPERVISAR PULSACION DE INSTALACION DE ORDEnA.
MXPA03008139A (es)	2003-12-12	Fluoralcoxifenilsulfonilureas sustituidas.
HUP0401949A3 (en)	2009-07-28	4-imidazolin-2-one derivatives
HUP0303186A3 (en)	2007-06-28	4-aminobenzopyran derivatives
HUP0500026A3 (en)	2008-02-28	N-heteroarylnicotinamide derivatives
ZA200205482B (en)	2003-12-31	Aminosulfonylbiphenyl derivatives.
ZA200206151B (en)	2003-11-03	Substituted amionomethyl-phenyl-cyclohexane derivatives.
MXPA03004453A (es)	2003-08-19	Derivados de pirimidina.
MXPA03002737A (es)	2004-01-26	Derivados sustituidos de 1-aminobutan-3-ol.
MXPA03001269A (es)	2003-06-09	Nuevos derivados de aminociclohexano.

Legal Events

Date	Code	Title	Description
2013-09-30	FA	Abandonment or withdrawal