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MXPA03007766A - Emulsiones inyectables de agua en aceite. - Google Patents

Emulsiones inyectables de agua en aceite.

Info

Publication number
MXPA03007766A
MXPA03007766A MXPA03007766A MXPA03007766A MXPA03007766A MX PA03007766 A MXPA03007766 A MX PA03007766A MX PA03007766 A MXPA03007766 A MX PA03007766A MX PA03007766 A MXPA03007766 A MX PA03007766A MX PA03007766 A MXPA03007766 A MX PA03007766A
Authority
MX
Mexico
Prior art keywords
adjuvants
acid
atloxreg
arlacel
ooc
Prior art date
Application number
MXPA03007766A
Other languages
English (en)
Inventor
Theodorus Jansen
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of MXPA03007766A publication Critical patent/MXPA03007766A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Colloid Chemistry (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Cosmetics (AREA)

Abstract

La presente invencion proporciona adyuvantes, para su uso en la formulacion de vacunas, que comprende una emulsion de agua en aceite, caracterizada porque dicha emulsion comprende un emulsor polimerico que es un copolimero de bloque que tiene una formula general A-COO-B-OOC-A, en la cual B es el residuo bivalente de un glicol de polialquileno soluble en agua y A es el residuo de un acido monocarboxilico complejo soluble en aceite. Tal emulsor polimerico, asi como tambien la preparacion del mismo, se han descrito en GB 2002400 y WO9607689. Preferentemente en los copolimeros de bloque de la formula A-COO-B-OOC-A, el componente B se deriva de glicol de polietileno y los componentes A se derivan de acido polihidroxiestearico, preferentemente a partir de poli(acido 12-hidroxi-estearico). Los emulsores mas preferidos utilizados en los adyuvantes de acuerdo con la invencion son Arlacel P135, un Dipolihidroxiestearato de PEG 30. Otro emulsor similar, preferido para su uso con la invencion es ATLOX(r) 4912. Tanto Arlacel P135 como ATLOX(r)4912 son copolimeros de bloque (A-B-A) de glicol de polietileno y acido hidroxiestearico con un peso molecular de aproximadamente 5000 comercialmente disponibles por ICI. Se ha descubierto que con el uso de estos emulsores pueden obtenerse emulsores basados en emulsiones de ag./ac. que son estables y que tienen una viscosidad baja que pueden basarse en aceites metabolizables. Dichos adyuvantes tienen una excelente actividad adyuvante, y son bien toleradas.
MXPA03007766A 2001-02-28 2002-02-26 Emulsiones inyectables de agua en aceite. MXPA03007766A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01200745 2001-02-28
PCT/EP2002/002145 WO2002067899A1 (en) 2001-02-28 2002-02-26 Injectable water-in-oil emulsions

Publications (1)

Publication Number Publication Date
MXPA03007766A true MXPA03007766A (es) 2004-03-16

Family

ID=8179948

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03007766A MXPA03007766A (es) 2001-02-28 2002-02-26 Emulsiones inyectables de agua en aceite.

Country Status (13)

Country Link
US (1) US8496939B2 (es)
EP (1) EP1367997B1 (es)
JP (1) JP4057423B2 (es)
AT (1) ATE438382T1 (es)
AU (1) AU2002253085B2 (es)
BR (1) BR0207698A (es)
CA (1) CA2438692C (es)
DE (1) DE60233206D1 (es)
DK (1) DK1367997T3 (es)
ES (1) ES2331058T3 (es)
MX (1) MXPA03007766A (es)
WO (1) WO2002067899A1 (es)
ZA (1) ZA200306204B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2822834B1 (fr) * 2001-04-02 2005-02-25 Flamel Tech Sa Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
FR2840614B1 (fr) * 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) * 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2860717B1 (fr) * 2003-10-13 2006-02-03 Ethypharm Sa Compositions de particules lipidiques solides monodisperses
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
US7485451B2 (en) * 2004-11-18 2009-02-03 Regents Of The University Of California Storage stable compositions of biological materials
FR2878746B1 (fr) * 2004-12-02 2007-02-23 Vetoquinol Sa Sa Nouvelle composition pharmaceutique utilisable dans le domaine des vaccins
FR2903602B1 (fr) * 2006-07-12 2012-10-26 Seppic Sa Formulation injectable a liberation prolongee de principes actifs, procede pour sa preparation
FR2910318B1 (fr) * 2006-12-20 2009-07-03 Flamel Technologies Sa Dispersion de polyaminoacides dans une phase lipidique continue.
US8821889B2 (en) 2008-08-29 2014-09-02 Boehringer Ingelheim Vetmedica, Inc. West Nile Virus vaccine
EP2361286A4 (en) 2008-12-22 2012-05-23 Henkel Ag & Co Kgaa WATER-BASED CLEANING AGENT FOR CLEANING COLORS ON SOLVENT BASIS
MX350718B (es) 2011-03-14 2017-09-14 Boehringer Ingelheim Vetmedica Inc Vacuna de rinitis equina.
CN103501602B (zh) * 2011-06-10 2016-08-17 胡茨曼澳大利亚股份有限公司 用于农业油基于配制剂的结构化剂和乳化剂
US9102900B2 (en) 2012-05-21 2015-08-11 Basf Se Inverse dispersion comprising a cationic polymer and a stabilizing agent
KR101975179B1 (ko) * 2012-05-21 2019-05-07 바스프 에스이 양이온성 중합체 및 안정화제를 포함하는 역 분산액
EP2666789A1 (en) 2012-05-21 2013-11-27 Basf Se Inverse dispersion comprising an anionic or a nonionic polymer and a stabilizing agent
EP3172305B1 (en) 2014-07-23 2019-04-03 The Procter and Gamble Company Fabric and home care treatment compositions
EP3172300B1 (en) 2014-07-23 2018-12-26 The Procter and Gamble Company Fabric and home care treatment composition
WO2016014743A1 (en) 2014-07-23 2016-01-28 The Procter & Gamble Company Fabric and home care treatment compositions
CA2952985C (en) 2014-07-23 2020-04-28 The Procter & Gamble Company Fabric and home care treatment compositions
WO2016014802A1 (en) 2014-07-23 2016-01-28 The Procter & Gamble Company Fabric and home care treatment compositions
EP3172299B1 (en) 2014-07-23 2019-09-25 The Procter and Gamble Company Fabric and home care treatment compositions
CA2952990C (en) 2014-07-23 2020-04-28 The Procter & Gamble Company Treatment compositions
WO2016073689A1 (en) 2014-11-06 2016-05-12 The Procter & Gamble Company Pre-strained laminates and methods for making the same
GB201506948D0 (en) * 2015-04-23 2015-06-10 Croda Int Plc Emulsions for injectable formulations
US11261402B2 (en) 2016-01-25 2022-03-01 The Procter & Gamble Company Treatment compositions
CA3011431C (en) 2016-01-25 2021-06-01 The Procter & Gamble Company Fabric treatment compositions, their manufacture and use
US20180229216A1 (en) 2017-02-16 2018-08-16 The Procter & Gamble Company Absorbent articles with substrates having repeating patterns of apertures comprising a plurality of repeat units
US12127925B2 (en) 2018-04-17 2024-10-29 The Procter & Gamble Company Webs for absorbent articles and methods of making the same
EP3866843A1 (en) 2018-10-16 2021-08-25 Intervet International B.V. Emulsion vaccine for fish
US12246090B2 (en) 2018-10-16 2025-03-11 Intervet Inc. Stable emulsions of bacterial antigens

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000424B1 (en) * 1977-07-12 1984-02-01 Imperial Chemical Industries Plc Linear or branched ester-ether block copolymers and their use as surfactants either alone or in blends with conventional surfactants
US4806350A (en) * 1986-04-18 1989-02-21 Norden Laboratories, Inc. Vaccine formulation
JP2549118B2 (ja) * 1987-05-30 1996-10-30 三省製薬株式会社 乳化組成物
HU212924B (en) * 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
DE3939492A1 (de) * 1989-11-29 1991-06-06 Mack Chem Pharm Pharmazeutische zubereitungen
US5622649A (en) * 1991-06-27 1997-04-22 Emory University Multiple emulsions and methods of preparation
FR2702373B1 (fr) * 1993-03-08 1996-06-07 Rhone Merieux Emulsions vaccinales fluides eau-dans-l'huile contenant une huile métabolisable.
FR2706766B1 (fr) * 1993-06-21 1995-08-18 Oreal Compositions cosmetiques filtrantes contenant un agent hydrophile comportant au moins un radical acide
US5646212A (en) * 1994-09-02 1997-07-08 Ici Americas Inc. Polyalkylene glycol anhydroxy carboxylic acid dispersant
FR2768337B1 (fr) * 1997-09-16 1999-10-15 Oreal Emulsions triples du type e/h/e contenant un systeme photoprotecteur capable de filtrer les rayons uv; leurs utilisations en cosmetique
US5935589A (en) * 1997-10-17 1999-08-10 Chesebrough-Pond's Usa Co. Stable cosmetic compositions with different pH emulsions
DE19749618A1 (de) * 1997-11-10 1999-05-12 Basf Ag Verwendung von W/O-Emulsionen als Verdicker in kosmetischen und pharmazeutischen Zubereitungen
US6174846B1 (en) * 1997-12-18 2001-01-16 Lever Brothers Company, A Division Of Conopco, Inc. Liquid composition with enhanced low temperature stability
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
EP1137396B1 (en) 1998-12-05 2004-09-29 Imperial Chemical Industries PLC Emulsification systems and emulsions
KR100435921B1 (ko) * 2000-12-29 2004-06-12 주식회사 태평양 동수역학적 이중 안정화에 의한 안정한 수-유-수 다중에멀젼 시스템 및 이의 제조방법

Also Published As

Publication number Publication date
DK1367997T3 (da) 2009-11-30
ES2331058T3 (es) 2009-12-21
EP1367997B1 (en) 2009-08-05
ZA200306204B (en) 2004-09-09
DE60233206D1 (de) 2009-09-17
US20040071716A1 (en) 2004-04-15
BR0207698A (pt) 2004-04-20
CA2438692A1 (en) 2002-09-06
JP4057423B2 (ja) 2008-03-05
WO2002067899A1 (en) 2002-09-06
EP1367997A1 (en) 2003-12-10
US8496939B2 (en) 2013-07-30
AU2002253085B2 (en) 2006-03-09
ATE438382T1 (de) 2009-08-15
JP2004523551A (ja) 2004-08-05
CA2438692C (en) 2010-04-27

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