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MXPA03006001A - Derivados de fosfonato de nucleosido aciclico novedoso, sales de estos y proceso para la preparacion de los mismos. - Google Patents

Derivados de fosfonato de nucleosido aciclico novedoso, sales de estos y proceso para la preparacion de los mismos.

Info

Publication number
MXPA03006001A
MXPA03006001A MXPA03006001A MXPA03006001A MXPA03006001A MX PA03006001 A MXPA03006001 A MX PA03006001A MX PA03006001 A MXPA03006001 A MX PA03006001A MX PA03006001 A MXPA03006001 A MX PA03006001A MX PA03006001 A MXPA03006001 A MX PA03006001A
Authority
MX
Mexico
Prior art keywords
salts
preparation
same
acyclic nucleoside
phosphonate derivatives
Prior art date
Application number
MXPA03006001A
Other languages
English (en)
Inventor
Choi Jong-Ryoo
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of MXPA03006001A publication Critical patent/MXPA03006001A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MXPA03006001A 2001-01-19 2002-01-18 Derivados de fosfonato de nucleosido aciclico novedoso, sales de estos y proceso para la preparacion de los mismos. MXPA03006001A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20010003087 2001-01-19
PCT/KR2002/000086 WO2002057288A1 (en) 2001-01-19 2002-01-18 Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same

Publications (1)

Publication Number Publication Date
MXPA03006001A true MXPA03006001A (es) 2003-09-10

Family

ID=36241797

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03006001A MXPA03006001A (es) 2001-01-19 2002-01-18 Derivados de fosfonato de nucleosido aciclico novedoso, sales de estos y proceso para la preparacion de los mismos.

Country Status (22)

Country Link
US (3) US7157448B2 (es)
EP (1) EP1358198B1 (es)
JP (1) JP3959348B2 (es)
KR (1) KR100441638B1 (es)
CN (1) CN100347185C (es)
AR (1) AR035933A1 (es)
AT (1) ATE478887T1 (es)
AU (1) AU2002230230B2 (es)
BR (1) BR0206165A (es)
CA (1) CA2433591C (es)
DE (1) DE60237429D1 (es)
DK (1) DK1358198T3 (es)
EG (1) EG24382A (es)
ES (1) ES2350197T3 (es)
MX (1) MXPA03006001A (es)
MY (1) MY141789A (es)
NZ (1) NZ526632A (es)
PL (1) PL212730B1 (es)
PT (1) PT1358198E (es)
RU (1) RU2266294C2 (es)
WO (1) WO2002057288A1 (es)
ZA (1) ZA200304181B (es)

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JP2007523180A (ja) * 2004-02-17 2007-08-16 エルジー・ライフ・サイエンシーズ・リミテッド Ｈｉｖ感染治療に有用なヌクレオシドホスホネート誘導体
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US8434912B2 (en) * 2006-02-27 2013-05-07 Illumination Management Solutions, Inc. LED device for wide beam generation
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TWI384986B (zh) * 2007-01-17 2013-02-11 Lg Life Sciences Ltd 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物
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CN102286026B (zh) * 2010-06-18 2014-07-02 中国人民解放军军事医学科学院毒物药物研究所 无环核苷酸类似物的盐及其晶型和药物组合物
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CN106432330B (zh) * 2015-08-11 2019-02-01 天津科伦药物研究有限公司 Lb80380药物的中间体化合物及其制备方法和用途
EP3350191B9 (en) 2015-09-15 2021-12-22 The Regents of the University of California Nucleotide analogs
CN106977548A (zh) * 2016-01-19 2017-07-25 四川海思科制药有限公司 倍司福韦复合物及其制备方法和用途
CN107849074A (zh) * 2016-01-19 2018-03-27 四川海思科制药有限公司 一种核苷类似物的烷氧烷基酯前药及其应用
KR102623581B1 (ko) 2016-07-18 2024-01-11 일동제약(주) 항바이러스성 약물의 오로트산염, 이의 제조 방법 및 상기 염을 포함하는 약제학적 조성물
CN108276443A (zh) * 2017-01-06 2018-07-13 米文君 一种新的化合物及其用途
KR102096144B1 (ko) * 2017-07-03 2020-04-01 주식회사 엘지화학 포스포네이트 뉴클레오사이드계 b형 간염 치료제 합성용 중간체 화합물의 연속식 제조방법
CN108997429B (zh) * 2018-07-27 2020-10-30 广州粤美医药科技有限公司 一种制备贝西福韦的方法
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Also Published As

Publication number Publication date
EP1358198B1 (en) 2010-08-25
ES2350197T3 (es) 2011-01-20
EP1358198A1 (en) 2003-11-05
DE60237429D1 (de) 2010-10-07
DK1358198T3 (da) 2010-10-04
PT1358198E (pt) 2010-10-01
RU2003125372A (ru) 2005-01-20
US7605147B2 (en) 2009-10-20
US20100004440A1 (en) 2010-01-07
AU2002230230B2 (en) 2005-05-26
MY141789A (en) 2010-06-30
NZ526632A (en) 2005-10-28
PL212730B1 (pl) 2012-11-30
JP3959348B2 (ja) 2007-08-15
HK1062017A1 (en) 2004-10-15
JP2004518675A (ja) 2004-06-24
CA2433591C (en) 2009-07-28
ATE478887T1 (de) 2010-09-15
CA2433591A1 (en) 2002-07-25
CN1487949A (zh) 2004-04-07
EP1358198A4 (en) 2008-03-05
US7157448B2 (en) 2007-01-02
RU2266294C2 (ru) 2005-12-20
AR035933A1 (es) 2004-07-28
ZA200304181B (en) 2004-10-06
US7723319B2 (en) 2010-05-25
KR100441638B1 (ko) 2004-07-23
CN100347185C (zh) 2007-11-07
BR0206165A (pt) 2004-02-03
US20060293284A1 (en) 2006-12-28
WO2002057288A1 (en) 2002-07-25
PL373670A1 (en) 2005-09-05
EG24382A (en) 2009-04-05
KR20020062216A (ko) 2002-07-25
US20040063668A1 (en) 2004-04-01

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