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MXPA02008637A - Elemento de respuesta a factor de celulas t. - Google Patents

Elemento de respuesta a factor de celulas t.

Info

Publication number
MXPA02008637A
MXPA02008637A MXPA02008637A MXPA02008637A MXPA02008637A MX PA02008637 A MXPA02008637 A MX PA02008637A MX PA02008637 A MXPA02008637 A MX PA02008637A MX PA02008637 A MXPA02008637 A MX PA02008637A MX PA02008637 A MXPA02008637 A MX PA02008637A
Authority
MX
Mexico
Prior art keywords
constructs
tumour
responsive element
prodrug
selective
Prior art date
Application number
MXPA02008637A
Other languages
English (en)
Inventor
Christopher John Wrighton
Original Assignee
Ml Lab Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0005099A external-priority patent/GB0005099D0/en
Application filed by Ml Lab Plc filed Critical Ml Lab Plc
Publication of MXPA02008637A publication Critical patent/MXPA02008637A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se describen elementos y construcciones de ADN utiles para obtener expresion de gen selectivo de tumor en tumores que tienen una via de ??-catenina/APC mutada; en particular, se describe el uso de estas construcciones para expresar genes que codifican proteinas terapeuticas en celulas de cancer colorrectal; las construcciones comprenden repeticiones multiples de un elemento de union a TCF operablemente enlazado a un promotor; por medio de dicha construccion, se puede lograr la expresion especifica de celulas tumorales de una enzima convertidota de profarmaco tal como nitmrreductasa; acoplada con la administracion sistemica de un profarmaco adecuado, tal como CB1954, se puede lograr la aniquilacion de dichas celulas tumorales.
MXPA02008637A 2000-03-02 2001-03-01 Elemento de respuesta a factor de celulas t. MXPA02008637A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0005099A GB0005099D0 (en) 2000-03-02 2000-03-02 TCF responsive elwment
US18746500P 2000-03-06 2000-03-06
PCT/GB2001/000856 WO2001064739A1 (en) 2000-03-02 2001-03-01 Tcf responsive element

Publications (1)

Publication Number Publication Date
MXPA02008637A true MXPA02008637A (es) 2004-09-06

Family

ID=26243787

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02008637A MXPA02008637A (es) 2000-03-02 2001-03-01 Elemento de respuesta a factor de celulas t.

Country Status (10)

Country Link
US (2) US6608037B2 (es)
EP (1) EP1268536A1 (es)
JP (1) JP2004500097A (es)
CN (1) CN1418224A (es)
AU (1) AU783128B2 (es)
CA (1) CA2401533A1 (es)
HK (1) HK1053845A1 (es)
IL (1) IL151500A0 (es)
MX (1) MXPA02008637A (es)
WO (1) WO2001064739A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2401533A1 (en) * 2000-03-02 2001-09-07 M.L. Laboratories Plc Tcf responsive element
AU2002345658A1 (en) * 2001-06-13 2002-12-23 Eastern Virginia Medical School Methods for targeted expression of therapeutic nucleic acid
NZ531413A (en) * 2001-08-21 2006-01-27 Innovata Plc Improved nitroreductase enzymes
GB0223696D0 (en) * 2002-10-14 2002-11-20 Ml Lab Plc Improved immunotherapy
WO2004070041A1 (en) * 2003-02-06 2004-08-19 Ml Laboratories Plc Vectors for expression of toxins
CA2556790A1 (en) * 2004-03-06 2005-09-15 Innovata Plc Enzyme-prodrug therapy for prosthetic joint repair
GB0517957D0 (en) 2005-09-03 2005-10-12 Morvus Technology Ltd Method of combating infection
GB0526552D0 (en) 2005-12-29 2006-02-08 Morvus Technology Ltd New use
GB2442202A (en) 2006-09-30 2008-04-02 Morvus Technology Ltd Vermin poison
JP2010540534A (ja) 2007-09-28 2010-12-24 イントレキソン コーポレーション 生体治療分子の発現のための治療遺伝子スイッチ構築物およびバイオリアクター、ならびにその使用
WO2011125055A2 (en) * 2010-04-09 2011-10-13 Consorcio De Tecnologia E Innovacion En Salud S.A. Synthetic constructs for polynucleotide and protein expression
EP2593796A4 (en) 2010-07-16 2016-07-27 Auckland Uniservices Ltd BACTERIAL NITROREDUCTASE ENZYMES AND METHOD THEREFOR

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166320A (en) 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
ATE126442T1 (de) 1990-05-18 1995-09-15 Boehringer Ingelheim Int Neue protein-polykation-konjugate.
AU7906691A (en) 1990-05-23 1991-12-10 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Adeno-associated virus (aav)-based eucaryotic vectors
ATE349534T1 (de) * 1991-10-23 2007-01-15 Cancer Rec Tech Ltd Bakterielle nitroreduktase zur reduzierung von cb 1954 und analogen davon in eine zytotoxische form
CA2131620A1 (en) 1992-03-20 1993-09-30 Louis C. Smith A dna transporter system and method of use
WO1995002698A1 (en) 1993-07-12 1995-01-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
FR2719316B1 (fr) 1994-04-28 1996-05-31 Idm Nouveaux complexes d'acide nucléique et de polymère, leur procédé de préparation et leur utilisation pour la transfection de cellules.
WO1996041606A2 (en) 1995-06-08 1996-12-27 Therexsys Limited Improved pharmaceutical compositions for gene therapy
ES2157084T3 (es) 1996-08-16 2001-08-01 Medical Res Council Vectores de expresion episomicos autorreplicantes que confieren expresion genica histoespecifica.
EP1007549B1 (en) 1997-02-12 2006-12-27 Innovata Plc Compositions and methods for highly efficient transfection
US5851775A (en) * 1997-03-20 1998-12-22 Johns Hopkins University β-catenin, Tcf-4, and APC interact to prevent cancer
EP0939122A1 (en) * 1998-02-27 1999-09-01 Universiteit Utrecht Mouse TCF-3 and TCF-4 and tumorigenesis related to WNT/Wingless signalling
AU6010699A (en) * 1998-09-25 2000-04-17 Universiteit Utrecht Apc-2
GB9906815D0 (en) 1999-03-24 1999-05-19 Isrec Anti-neoplastic viral agents
CA2401533A1 (en) * 2000-03-02 2001-09-07 M.L. Laboratories Plc Tcf responsive element

Also Published As

Publication number Publication date
HK1053845A1 (zh) 2003-11-07
US6608037B2 (en) 2003-08-19
US20040048293A1 (en) 2004-03-11
IL151500A0 (en) 2003-04-10
EP1268536A1 (en) 2003-01-02
US7179646B2 (en) 2007-02-20
JP2004500097A (ja) 2004-01-08
CA2401533A1 (en) 2001-09-07
US20020165173A1 (en) 2002-11-07
CN1418224A (zh) 2003-05-14
WO2001064739A1 (en) 2001-09-07
AU3755101A (en) 2001-09-12
AU783128B2 (en) 2005-09-29

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