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MX9805088A - Derivados de octahidro-pirrolo[1,2-a]-pirazina 2,7-sustituidos. - Google Patents

Derivados de octahidro-pirrolo[1,2-a]-pirazina 2,7-sustituidos.

Info

Publication number
MX9805088A
MX9805088A MX9805088A MX9805088A MX9805088A MX 9805088 A MX9805088 A MX 9805088A MX 9805088 A MX9805088 A MX 9805088A MX 9805088 A MX9805088 A MX 9805088A MX 9805088 A MX9805088 A MX 9805088A
Authority
MX
Mexico
Prior art keywords
pyrrolo
pyrazine derivatives
dopamine
substituted octahydro
phenyl
Prior art date
Application number
MX9805088A
Other languages
English (en)
Inventor
Mark A Sanner
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX9805088A publication Critical patent/MX9805088A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Toxicology (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Esta invencion se refiere a compuestos de la formula (Ver Formula) en la que, R1, R2 y R3, X m y n se definen como se ha especificado en la memoria, a sus sales farmacéuticamente aceptables y a las composiciones farmacéuticas que contienen tales compuestos o sus sales.
MX9805088A 1995-12-21 1998-06-22 Derivados de octahidro-pirrolo[1,2-a]-pirazina 2,7-sustituidos. MX9805088A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US898895P 1995-12-21 1995-12-21

Publications (1)

Publication Number Publication Date
MX9805088A true MX9805088A (es) 1998-10-31

Family

ID=21734893

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9805088A MX9805088A (es) 1995-12-21 1998-06-22 Derivados de octahidro-pirrolo[1,2-a]-pirazina 2,7-sustituidos.

Country Status (33)

Country Link
US (1) US5714487A (es)
EP (1) EP0874849B1 (es)
JP (1) JP3204456B2 (es)
KR (1) KR100286786B1 (es)
CN (1) CN1061350C (es)
AR (1) AR005102A1 (es)
AT (1) ATE205846T1 (es)
AU (1) AU704578B2 (es)
BR (1) BR9612246A (es)
CA (1) CA2240594C (es)
CO (1) CO4480107A1 (es)
CZ (1) CZ192998A3 (es)
DE (1) DE69615404T2 (es)
DK (1) DK0874849T3 (es)
ES (1) ES2161377T3 (es)
GR (1) GR3037060T3 (es)
GT (1) GT199600101A (es)
HU (1) HUP9900611A3 (es)
IL (1) IL124453A0 (es)
MA (1) MA26413A1 (es)
MX (1) MX9805088A (es)
NO (1) NO309936B1 (es)
NZ (1) NZ320537A (es)
PE (1) PE25998A1 (es)
PL (1) PL327539A1 (es)
PT (1) PT874849E (es)
RU (1) RU2162470C2 (es)
SI (1) SI0874849T1 (es)
TN (1) TNSN96164A1 (es)
TR (1) TR199801161T2 (es)
TW (1) TW479058B (es)
WO (1) WO1997023482A1 (es)
ZA (1) ZA9610781B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0982030A3 (en) 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands
IL144670A0 (en) * 1999-02-05 2002-05-23 Upjohn Co Process to prepare (5r) - (methylamino) -5,6-dihydro-4h-imidazo [4,5,1-ij]-quinolin-2 (1h) -one
DE60011858T2 (de) 1999-09-10 2005-08-25 Mitsubishi Jidosha Kogyo K.K. Stufenloses Getriebe
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
ATE247110T1 (de) * 1999-09-14 2003-08-15 Aventis Pharma Inc Benzisoxazolyl-, pyridoisoxazolyl- und benzthienyl-phenoxy derivate als d4 antagonisten
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
RU2322443C2 (ru) * 2001-09-19 2008-04-20 Мерк Патент Гмбх Новое применение замещенных аминометилхроманов
TW200801005A (en) * 2005-08-15 2008-01-01 Astrazeneca Ab Acetylenic piperazines as metabotropic glutamate receptor antagonists
US7728031B2 (en) * 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
US8669255B2 (en) * 2011-09-29 2014-03-11 Abbvie Inc. Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers
WO2020051153A1 (en) 2018-09-04 2020-03-12 Pipeline Therapeutics, Inc. Muscarinic acetylcholine m1 receptor antagonists
US11752149B2 (en) 2019-12-02 2023-09-12 Pipeline Therapeutics, Inc. Muscarinic acetylcholine M1 receptor antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4400511A (en) * 1982-05-07 1983-08-23 American Home Products Corporation 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
US5122515A (en) * 1990-06-19 1992-06-16 Smith Ross C Nutrient composition containing dipeptides and method for administering the same
JP3058945B2 (ja) * 1990-10-26 2000-07-04 三共株式会社 Ｎ−（３，３−ジ置換アクリロイル）ピペラジン誘導体
CA2146018A1 (en) * 1992-10-23 1994-05-11 Paul David Leeson Dopamine receptor subtype ligands
CA2146019A1 (en) * 1992-10-23 1994-05-11 Howard B. Broughton Dopamine receptor subtype ligands
JP3004727B2 (ja) * 1994-08-05 2000-01-31 ファイザー・インコーポレーテッド ドパミン作動性活性を有するベンゾイミダゾール誘導体
SI9520096A (sl) * 1994-09-30 1998-04-30 Pfizer Inc. Derivati 2,7-substituiranega oktahidro-1H-pirido /1,2-a/ pirazina
US5576314A (en) * 1994-12-12 1996-11-19 Allelix Biopharmaceuticals Inc. Bicyclic nonane and decane compounds having dopamine receptor affinity

Also Published As

Publication number Publication date
KR100286786B1 (ko) 2001-04-16
NO982843L (no) 1998-06-19
KR19990076616A (ko) 1999-10-15
HUP9900611A2 (hu) 1999-08-30
NO982843D0 (no) 1998-06-19
WO1997023482A1 (en) 1997-07-03
TNSN96164A1 (fr) 2005-03-15
EP0874849A1 (en) 1998-11-04
DE69615404D1 (de) 2001-10-25
AR005102A1 (es) 1999-04-14
IL124453A0 (en) 1998-12-06
PE25998A1 (es) 1998-05-19
BR9612246A (pt) 1999-07-13
JPH11508920A (ja) 1999-08-03
NO309936B1 (no) 2001-04-23
US5714487A (en) 1998-02-03
JP3204456B2 (ja) 2001-09-04
CO4480107A1 (es) 1997-07-09
PT874849E (pt) 2002-01-30
GT199600101A (es) 1998-06-12
CA2240594C (en) 2001-07-24
CN1061350C (zh) 2001-01-31
SI0874849T1 (es) 2001-12-31
HUP9900611A3 (en) 2000-09-28
CN1205704A (zh) 1999-01-20
ES2161377T3 (es) 2001-12-01
MA26413A1 (fr) 2004-12-20
PL327539A1 (en) 1998-12-21
AU7328096A (en) 1997-07-17
DK0874849T3 (da) 2001-11-19
NZ320537A (en) 1999-03-29
ZA9610781B (en) 1998-06-22
CA2240594A1 (en) 1997-07-03
EP0874849B1 (en) 2001-09-19
DE69615404T2 (de) 2002-06-06
GR3037060T3 (en) 2002-01-31
ATE205846T1 (de) 2001-10-15
AU704578B2 (en) 1999-04-29
TR199801161T2 (xx) 1998-10-21
RU2162470C2 (ru) 2001-01-27
CZ192998A3 (cs) 1999-05-12
TW479058B (en) 2002-03-11

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