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MX9800718A - Derivados de 2-(4-substituidos)-bencilamino-2-metil- propanamida. - Google Patents

Derivados de 2-(4-substituidos)-bencilamino-2-metil- propanamida.

Info

Publication number
MX9800718A
MX9800718A MX9800718A MX9800718A MX9800718A MX 9800718 A MX9800718 A MX 9800718A MX 9800718 A MX9800718 A MX 9800718A MX 9800718 A MX9800718 A MX 9800718A MX 9800718 A MX9800718 A MX 9800718A
Authority
MX
Mexico
Prior art keywords
benzylamino
substituted
methyl
alkyl
propanamide derivatives
Prior art date
Application number
MX9800718A
Other languages
English (en)
Other versions
MXPA98000718A (es
Inventor
Paolo Pevarello
Raffaella Amici
Mario Varasi
Alberto Bonsignori
Patricia Salvati
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10778352&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9800718(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of MXPA98000718A publication Critical patent/MXPA98000718A/es
Publication of MX9800718A publication Critical patent/MX9800718A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/30—Sulfides having the sulfur atom of at least one thio group bound to two carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
    • C07C323/35—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
    • C07C323/36—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to an acyclic carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen nuevos compuestos de 2-(4-substituidos)-bencilamino-2-metil-propanamida s, que tienen actividad en el sistema nervioso central, de formula general (I) en donde: n es cero, 1, 2 o 3; X es -O-, -S-, -CH2- o -NH-; cada una de R y R1 es independientemente hidrogeno, alquilo C1-C6, halogeno, hidroxi, alcoxi C1-C4 o trifluometilo; cada una de R2, R3 y R4 es independientemente hidrogeno, o alquilo C1-C6 o cicloalquilo C3-C7; y las sales farmacéuticamente aceptables de los mismos.
MX9800718A 1995-07-27 1996-07-05 Derivados de 2-(4-substituidos)-bencilamino-2-metil- propanamida. MX9800718A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9515412.6A GB9515412D0 (en) 1995-07-27 1995-07-27 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
GB9515412.6 1995-07-27
PCT/EP1996/002961 WO1997005102A1 (en) 1995-07-27 1996-07-05 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives

Publications (2)

Publication Number Publication Date
MXPA98000718A MXPA98000718A (es) 1998-04-01
MX9800718A true MX9800718A (es) 1998-04-30

Family

ID=10778352

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9800718A MX9800718A (es) 1995-07-27 1996-07-05 Derivados de 2-(4-substituidos)-bencilamino-2-metil- propanamida.

Country Status (27)

Country Link
US (1) US5945454A (es)
EP (1) EP0842143B3 (es)
JP (1) JP4040089B2 (es)
KR (1) KR100412747B1 (es)
CN (1) CN1085659C (es)
AR (1) AR003469A1 (es)
AT (1) ATE202078T1 (es)
AU (1) AU711309B2 (es)
BR (1) BR9609849B1 (es)
CA (1) CA2226894C (es)
DE (2) DE69613377D1 (es)
DK (1) DK0842143T5 (es)
EA (1) EA001322B1 (es)
ES (1) ES2159749T7 (es)
GB (1) GB9515412D0 (es)
GR (1) GR3036559T3 (es)
HU (1) HU227806B1 (es)
IL (1) IL122705A (es)
MX (1) MX9800718A (es)
NO (1) NO324273B1 (es)
NZ (1) NZ313185A (es)
PL (1) PL184302B1 (es)
PT (1) PT842143E (es)
SI (1) SI0842143T1 (es)
UA (1) UA44331C2 (es)
WO (1) WO1997005102A1 (es)
ZA (1) ZA965998B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
EP2201945B1 (en) * 1997-11-21 2013-03-06 Purdue Neuroscience Company Use of substituted 2-aminoacetamides for treating or ameliorating anxiety
GB9727523D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
DK1169060T3 (da) 1999-04-09 2006-01-16 Euro Celtique Sa Natriumkanalblokkerpræparater og anvendelse deraf
IL151952A0 (en) 2000-03-31 2003-04-10 Euro Celtique Sa Aminopyridine derivatives and pharmaceutical compositions containing the same
ATE317280T1 (de) * 2001-09-03 2006-02-15 Newron Pharm Spa Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung
US6667327B2 (en) 2002-02-04 2003-12-23 Hoffmann-La Roche Inc. Pyridine amido derivatives
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
AR044007A1 (es) * 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1524267A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Substituted benzylaminoalkylene heterocycles
EP1680127B1 (en) 2003-10-23 2008-10-15 F. Hoffmann-La Roche Ag Benzazepine derivatives as mao-b inhibitors
EP1557166A1 (en) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
KR101277520B1 (ko) * 2004-09-10 2013-06-21 뉴론 파마슈티칼즈 에스. 피. 에이. （할로벤질옥시）벤질아미노－프로판아미드를 포함하는 선택적 나트륨 및／또는 칼슘 채널 조절제로서 유용한 약제학적 조성물
US20070111981A1 (en) * 2005-10-26 2007-05-17 Roth Gerald J New (hetero)aryl compounds with MCH antagonistic activity and medicaments comprising these compounds
NZ567540A (en) 2005-12-22 2010-07-30 Newron Pharm Spa 2-Phenylethylamino derivatives as calcium and/or sodium channel modulators
EP1870097A1 (en) * 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
US20110160308A1 (en) * 2006-07-28 2011-06-30 Alcon Research, Ltd. Use of Monoamine Oxidase Inhibitors to Treat Outer Retina Disorders
AU2008261325B2 (en) 2007-06-15 2012-12-06 Newron Pharmaceuticals S.P.A. Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators
KR101851118B1 (ko) * 2010-04-27 2018-04-23 뉴론 파마슈티칼즈 에스. 피. 에이. 랄핀아미드 메탄설포네이트 염들 또는 이들의 ｒ―에난티오머들의 제조 방법
US10464896B2 (en) 2015-06-11 2019-11-05 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
GB9306886D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
GB9306899D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation

Also Published As

Publication number Publication date
AU6418796A (en) 1997-02-26
CA2226894C (en) 2009-03-31
DE69613377T4 (de) 2009-08-13
BR9609849B1 (pt) 2010-05-18
JP2000500732A (ja) 2000-01-25
BR9609849A (pt) 1999-03-16
US5945454A (en) 1999-08-31
EP0842143B3 (en) 2009-02-18
KR100412747B1 (ko) 2004-04-28
AU711309B2 (en) 1999-10-07
PL324639A1 (en) 1998-06-08
EA199800170A1 (ru) 1998-08-27
EP0842143B1 (en) 2001-06-13
AU711309C (en) 1997-02-26
NO980290L (no) 1998-01-22
AR003469A1 (es) 1998-08-05
NO324273B1 (no) 2007-09-17
DK0842143T3 (da) 2001-07-23
IL122705A0 (en) 1998-08-16
HU227806B1 (en) 2012-03-28
NZ313185A (en) 2000-05-26
UA44331C2 (uk) 2002-02-15
HUP9900351A2 (hu) 1999-06-28
PT842143E (pt) 2001-10-30
SI0842143T1 (es) 2001-08-31
ZA965998B (en) 1997-01-31
GB9515412D0 (en) 1995-09-27
PL184302B1 (pl) 2002-09-30
EP0842143A1 (en) 1998-05-20
HUP9900351A3 (en) 1999-11-29
GR3036559T3 (en) 2001-12-31
DE69613377D1 (de) 2001-07-19
IL122705A (en) 2001-01-28
ATE202078T1 (de) 2001-06-15
CA2226894A1 (en) 1997-02-13
NO980290D0 (no) 1998-01-22
WO1997005102A1 (en) 1997-02-13
CN1085659C (zh) 2002-05-29
DE69613377T2 (de) 2001-09-20
JP4040089B2 (ja) 2008-01-30
KR19990035843A (ko) 1999-05-25
ES2159749T7 (es) 2009-06-18
CN1192199A (zh) 1998-09-02
EA001322B1 (ru) 2001-02-26
ES2159749T3 (es) 2001-10-16
DK0842143T5 (da) 2009-06-02

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