MX9604020A - Arilalquildiazinonas. - Google Patents
Arilalquildiazinonas.Info
- Publication number
- MX9604020A MX9604020A MX9604020A MX9604020A MX9604020A MX 9604020 A MX9604020 A MX 9604020A MX 9604020 A MX9604020 A MX 9604020A MX 9604020 A MX9604020 A MX 9604020A MX 9604020 A MX9604020 A MX 9604020A
- Authority
- MX
- Mexico
- Prior art keywords
- arylalkyldiazinones
- present
- compounds
- refers
- immunodeficiencies
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010061598 Immunodeficiency Diseases 0.000 abstract 1
- 208000029462 Immunodeficiency disease Diseases 0.000 abstract 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
- C07D273/04—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Photoreceptors In Electrophotography (AREA)
- Polymerization Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
Abstract
El invento se refiere a los derivados de la arilalquildiazinona, de formula I: en la que R1, R2, R3, R4, B, Q, y X tienen los significados indicados en la reivindicacion 1, y a sus sales aceptables desde el punto de vista fisiologico. También se refiere a un procedimiento para preparar dichos compuestos, a preparaciones farmacéuticas que los contienen y al empleo de los mismos para el tratamiento de procesos inflamatorios tales como las alergias, el asma y las autoinmunodeficiencias. Los nuevos compuestos presentan una accion inhibidora de la fosfodiesterasa IV.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19533975A DE19533975A1 (de) | 1995-09-14 | 1995-09-14 | Arylalkyl-diazinone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9604020A true MX9604020A (es) | 1997-03-29 |
Family
ID=7772083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9604020A MX9604020A (es) | 1995-09-14 | 1996-09-11 | Arilalquildiazinonas. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5859008A (es) |
| EP (1) | EP0763534B1 (es) |
| JP (1) | JP4149532B2 (es) |
| KR (1) | KR970015578A (es) |
| CN (1) | CN1110495C (es) |
| AT (1) | ATE233258T1 (es) |
| AU (1) | AU716113B2 (es) |
| BR (1) | BR9603736A (es) |
| CA (1) | CA2185397C (es) |
| CZ (1) | CZ286567B6 (es) |
| DE (2) | DE19533975A1 (es) |
| DK (1) | DK0763534T3 (es) |
| ES (1) | ES2192213T3 (es) |
| HU (1) | HUP9602511A3 (es) |
| MX (1) | MX9604020A (es) |
| NO (1) | NO309679B1 (es) |
| PL (1) | PL185961B1 (es) |
| PT (1) | PT763534E (es) |
| RU (1) | RU2167159C2 (es) |
| SI (1) | SI0763534T1 (es) |
| SK (1) | SK281474B6 (es) |
| TW (1) | TW363063B (es) |
| UA (1) | UA48946C2 (es) |
| ZA (1) | ZA967766B (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19502699A1 (de) * | 1995-01-28 | 1996-08-01 | Merck Patent Gmbh | Arylalkyl-thiadiazinone |
| DE69821530T2 (de) * | 1997-12-15 | 2004-12-23 | Altana Pharma Ag | Dihydrobenzifurane |
| SI1070056T1 (en) * | 1998-03-14 | 2004-12-31 | Altana Pharma Ag | Phthalazinone pde iii/iv inhibitors |
| HU229439B1 (hu) | 1999-08-21 | 2013-12-30 | Takeda Gmbh | Roflumilast és salmeterol szinergetikus kombinációja |
| US6756371B1 (en) | 1999-10-25 | 2004-06-29 | Altana Pharma Ag | Phthalazinone derivatives as PDE4 inhibitors |
| CA2388119A1 (en) | 1999-10-25 | 2001-05-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Tetrahydrothiopy ranphthalazinone derivatives as pde4 inhibitors |
| BR0111440A (pt) * | 2000-06-05 | 2003-06-03 | Altana Pharma Ag | Compostos eficazes como agonistas do (beta)2-adrenorreceptor bem como inibidores de pde4 |
| DE10064997A1 (de) * | 2000-12-23 | 2002-06-27 | Merck Patent Gmbh | Benzoylpyridazine |
| JP2004521928A (ja) * | 2001-02-12 | 2004-07-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ４型ホスホジエステラーゼ阻害剤の心筋疾患における使用 |
| HRP20030636B1 (en) | 2001-02-15 | 2012-05-31 | Nycomed Gmbh | Phthalayinone-piperidino-derivatives as pde4 inhibitors |
| PL363544A1 (en) | 2001-04-25 | 2004-11-29 | Altana Pharma Ag | Piperazino-derivatives and their use as pde4 inhibitor |
| EA200301100A1 (ru) | 2001-04-25 | 2004-06-24 | Алтана Фарма Аг | Новые фталазиноны |
| CZ2004213A3 (cs) * | 2001-07-18 | 2004-06-16 | Merck Patent Gmbh | Název neuveden |
| DE10150517A1 (de) * | 2001-10-12 | 2003-04-17 | Merck Patent Gmbh | Verwendung von Phosphodiesterase IV-Inhibitoren |
| RU2203892C1 (ru) * | 2001-10-12 | 2003-05-10 | Белушкина Наталья Николаевна | 2,2,6,6-тетракис(трифторметил)-4-этиламино-5,6-дигидро-1,3,5-оксадиазин ("синтазин"), способ его получения и фармацевтическая композиция на их основе |
| CZ2004516A3 (cs) * | 2001-10-31 | 2004-08-18 | Merckápatentágmbh | Inhibitor fosfodiesterázy typu @Ź jeho kombinace s jinými drogami a jeho použití |
| ES2195785B1 (es) * | 2002-05-16 | 2005-03-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| DE10227269A1 (de) * | 2002-06-19 | 2004-01-08 | Merck Patent Gmbh | Thiazolderivate |
| JP2005538138A (ja) * | 2002-08-10 | 2005-12-15 | アルタナ ファルマ アクチエンゲゼルシャフト | Ｐｄｅ４インヒビターとしてのピリダジノン誘導体 |
| WO2004018457A1 (en) | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Pyrrolidinedione substituted piperidine-phthalazones as pde4 inhibitors |
| ES2211344B1 (es) * | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| WO2004087211A2 (en) | 2003-04-01 | 2004-10-14 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility |
| EP1716133B1 (en) | 2004-02-04 | 2008-03-26 | Nycomed GmbH | 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors |
| WO2005075437A1 (en) * | 2004-02-04 | 2005-08-18 | Altana Pharma Ag | Pyridazinone derivatives and their use as pde4 inhibitors |
| ES2251866B1 (es) * | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| ES2251867B1 (es) * | 2004-06-21 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| AU2006282896A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| JP2009513672A (ja) | 2005-10-31 | 2009-04-02 | ブレインセルス，インコーポレイティド | 神経発生のｇａｂａ受容体媒介調節 |
| DE102005055355A1 (de) * | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | 3,6-Dihydro-2-oxo-6H-[1,3,4]thiadiazinderivate |
| DE102005055354A1 (de) * | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
| US7998971B2 (en) | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| ES2320954B1 (es) * | 2007-03-02 | 2010-03-16 | Laboratorio Almirall S.A. | Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona. |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| US11395820B2 (en) | 2016-03-16 | 2022-07-26 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Small molecules against cereblon to enhance effector t cell function |
| US11730726B2 (en) | 2018-07-11 | 2023-08-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Dimeric immuno-modulatory compounds against cereblon-based mechanisms |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788476A (fr) * | 1971-09-08 | 1973-03-06 | Sandoz Sa | Nouveaux derives de la pyridazinone, leur preparation et leur application comme medicaments |
| DE3505609A1 (de) * | 1985-02-19 | 1986-08-21 | Merck Patent Gmbh, 6100 Darmstadt | Benzimidazolyl-pyridazinone |
| AU614965B2 (en) * | 1987-06-06 | 1991-09-19 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Thiadiazinones |
| DE3734083A1 (de) * | 1987-10-08 | 1989-04-20 | Heumann Pharma Gmbh & Co | Benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB8816944D0 (en) * | 1988-07-15 | 1988-08-17 | Sobio Lab | Compounds |
| US5247076A (en) * | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
| DE4134893A1 (de) * | 1991-10-23 | 1993-04-29 | Merck Patent Gmbh | Thiadiazinone |
| US5326766A (en) * | 1992-08-19 | 1994-07-05 | Dreikorn Barry A | 4-(2-(4-(2-pyridinyloxy)phenyl)ethoxy)quinazoline and analogues thereof |
| DE4310699A1 (de) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Thiadiazinone |
| IL110040A (en) * | 1993-06-29 | 2000-07-16 | Nissan Chemical Ind Ltd | Pyridazinone derivatives their preparation and pharmaceutical compositions comprising them |
| DE4330915C1 (de) * | 1993-09-11 | 1994-09-08 | Steinel Bernhard Werkzeugmasch | Palettenwechsler für Werkzeugmaschinen |
| DE19500558A1 (de) * | 1995-01-11 | 1996-07-18 | Merck Patent Gmbh | 3-Alkoxycarbonyl-thiadiazinone |
| DE19502699A1 (de) * | 1995-01-28 | 1996-08-01 | Merck Patent Gmbh | Arylalkyl-thiadiazinone |
| DE19514568A1 (de) * | 1995-04-20 | 1996-10-24 | Merck Patent Gmbh | Arylalkyl-pyridazinone |
-
1995
- 1995-09-14 DE DE19533975A patent/DE19533975A1/de not_active Withdrawn
-
1996
- 1996-08-05 TW TW085109458A patent/TW363063B/zh active
- 1996-08-26 SK SK1100-96A patent/SK281474B6/sk unknown
- 1996-09-05 EP EP96114211A patent/EP0763534B1/de not_active Expired - Lifetime
- 1996-09-05 AT AT96114211T patent/ATE233258T1/de not_active IP Right Cessation
- 1996-09-05 SI SI9630598T patent/SI0763534T1/xx unknown
- 1996-09-05 PT PT96114211T patent/PT763534E/pt unknown
- 1996-09-05 DK DK96114211T patent/DK0763534T3/da active
- 1996-09-05 ES ES96114211T patent/ES2192213T3/es not_active Expired - Lifetime
- 1996-09-05 DE DE59610164T patent/DE59610164D1/de not_active Expired - Lifetime
- 1996-09-09 CZ CZ19962630A patent/CZ286567B6/cs not_active IP Right Cessation
- 1996-09-09 AU AU65517/96A patent/AU716113B2/en not_active Ceased
- 1996-09-11 MX MX9604020A patent/MX9604020A/es not_active IP Right Cessation
- 1996-09-11 RU RU96118917/04A patent/RU2167159C2/ru not_active IP Right Cessation
- 1996-09-12 CN CN96112589A patent/CN1110495C/zh not_active Expired - Fee Related
- 1996-09-12 BR BR9603736A patent/BR9603736A/pt not_active Application Discontinuation
- 1996-09-12 CA CA002185397A patent/CA2185397C/en not_active Expired - Fee Related
- 1996-09-13 PL PL96316070A patent/PL185961B1/pl unknown
- 1996-09-13 US US08/714,796 patent/US5859008A/en not_active Expired - Lifetime
- 1996-09-13 NO NO963852A patent/NO309679B1/no not_active IP Right Cessation
- 1996-09-13 JP JP26372796A patent/JP4149532B2/ja not_active Expired - Fee Related
- 1996-09-13 ZA ZA967766A patent/ZA967766B/xx unknown
- 1996-09-13 HU HU9602511A patent/HUP9602511A3/hu unknown
- 1996-09-13 UA UA96093557A patent/UA48946C2/uk unknown
- 1996-09-13 KR KR1019960039769A patent/KR970015578A/ko active Granted
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX9604020A (es) | Arilalquildiazinonas. | |
| MXPA02007942A (es) | Derivados de pirrolopirimidinona, procesos de preparacion y uso. | |
| MX9800867A (es) | Halogenobencimidazoles y su empleo como microbicidas. | |
| IL117848A0 (en) | Novel compounds a process for their production and pharmacetical compositions containing same | |
| AP2002002637A0 (en) | Novel piperazine | |
| AP9701041A0 (en) | Pyridylpyrrole compounds. | |
| CA2425560A1 (en) | Anticholinergics, processes for preparing them and their use as pharmaceutical compositions | |
| GEP20032896B (en) | 4-Aminothiazole Derivatives, Containing Them Pharmaceutical Compositions Inhibiting Cyclin-Dependent Kinases and Methods for Treatment | |
| MY106280A (en) | Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use. | |
| MY127718A (en) | Dolastatin 10 derivatives. | |
| IL112622A (en) | Iminoalkylamino or aminoalkylideneamino camptothecin derivatives, process for their preparation and pharmaceutical compositions containing them | |
| IL106128A0 (en) | Vitamin d derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same | |
| GR3023936T3 (en) | Heterocyclic alkylamides, process for their preparation and pharmaceutical compositions containing them | |
| MX9804226A (es) | Derivados novedosos de 2,3,5-trimetil-4-hidroxianilida, su preparacion y su aplicacion de terapeutica. | |
| CA2019404A1 (en) | 11 beta-aryl-4-estrenes, process for their production as well as their use as pharmaceutical agents | |
| MX9708696A (es) | Cefalosporinas antibacterianas. | |
| AP2001002191A0 (en) | 3,3- Biarylpiperine and 2,2-biarylmorpholine derivatives. | |
| HRP940458B1 (en) | New bis-naphtalimides for the treatment of canser | |
| MY132057A (en) | Quinoxalinones, a process for their preparation and their use | |
| MY120550A (en) | Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, processes for preparing them and their use as pharmaceutical compositions. | |
| UA42731C2 (uk) | Арилалкілтіадіазинони, спосіб їх отримання, фармацевтична композиція, спосіб її отримання, спосіб лікування | |
| TW252979B (es) | ||
| IL115184A0 (en) | Anthracycline derivatives their preparation and use | |
| EP0186023A3 (en) | Biliary acid derivatives, process for their preparation and pharmaceutical compositions containing them | |
| MXPA02004441A (es) | Derivados de isoxazol como inhibidores de la fosfodiesterasa. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |