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MX9601994A - Profarmacos de derivados de paclitaxel. - Google Patents

Profarmacos de derivados de paclitaxel.

Info

Publication number
MX9601994A
MX9601994A MX9601994A MX9601994A MX9601994A MX 9601994 A MX9601994 A MX 9601994A MX 9601994 A MX9601994 A MX 9601994A MX 9601994 A MX9601994 A MX 9601994A MX 9601994 A MX9601994 A MX 9601994A
Authority
MX
Mexico
Prior art keywords
prodrugs
paclitaxel derivatives
derivatives
paclitaxel
present
Prior art date
Application number
MX9601994A
Other languages
English (en)
Other versions
MXPA96001994A (es
Inventor
Paul M Scola
John F Kadow
Dolatrai M Vyas
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MXPA96001994A publication Critical patent/MXPA96001994A/es
Publication of MX9601994A publication Critical patent/MX9601994A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invencion se refiere a los nuevos derivados del paclitaxel, a su uso como agentes antitumorales, y a las formulaciones farmacéuticas que los contienen.
MX9601994A 1995-06-06 1996-05-27 Profarmacos de derivados de paclitaxel. MX9601994A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46924795A 1995-06-06 1995-06-06
US08/469,247 1995-06-06

Publications (2)

Publication Number Publication Date
MXPA96001994A MXPA96001994A (es) 1997-08-01
MX9601994A true MX9601994A (es) 1997-08-30

Family

ID=23863053

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9601994A MX9601994A (es) 1995-06-06 1996-05-27 Profarmacos de derivados de paclitaxel.

Country Status (23)

Country Link
EP (1) EP0747385B1 (es)
JP (1) JPH08337589A (es)
KR (1) KR100375956B1 (es)
CN (1) CN1066151C (es)
AR (1) AR002756A1 (es)
AT (1) ATE222259T1 (es)
AU (1) AU695959B2 (es)
CA (1) CA2176191A1 (es)
CZ (1) CZ291516B6 (es)
DE (1) DE69622933T2 (es)
DK (1) DK0747385T3 (es)
ES (1) ES2181824T3 (es)
HU (1) HUP9601524A3 (es)
IL (1) IL118526A (es)
MX (1) MX9601994A (es)
NO (1) NO315233B1 (es)
NZ (1) NZ286723A (es)
PL (1) PL187883B1 (es)
PT (1) PT747385E (es)
RU (1) RU2162082C2 (es)
SG (1) SG72692A1 (es)
TW (1) TW354293B (es)
ZA (1) ZA964261B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395770B1 (en) * 1995-10-26 2002-05-28 Baker Norton Pharmaceuticals, Inc. Method and compositions for administering taxanes orally to human patients
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
PL337064A1 (en) * 1997-05-27 2000-07-31 Baker Norton Pharma Method of and compositions for orally administering taxanes to human beings
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
EP2289521A3 (en) * 1999-02-18 2011-10-05 Arizona Board Of Regents Compositions and methods for use in tergeting vascular destruction
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
AR030188A1 (es) 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
GEP20043226B (en) 2000-02-02 2004-04-26 Florida State Univ Research Foundation Us C7 Carbonate Substituted Taxanes as Antitumor Agents, Pharmaceutical Compositions Containing the Same and Use Thereof as Agents to Inhibit Tumor Growth
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
US7063977B2 (en) 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
KR20030049023A (ko) * 2001-12-13 2003-06-25 주식회사 코오롱 방사선 감작제용 파클리탁셀 유도체
CN101367834B (zh) * 2001-12-21 2012-04-18 卫才公司 用于制备醇和酚的水溶性膦酰氧基甲基衍生物的方法
PA8625301A1 (es) 2004-03-05 2006-06-02 Univ Florida State Res Found Taxanos con sustituyente lactiloxilo en el c7
EP3345632A1 (en) * 2005-02-18 2018-07-11 Abraxis BioScience, LLC Drugs with improved hydrophobicity for incorporation in medical devices
ITMI20050614A1 (it) * 2005-04-12 2006-10-13 Indena Spa Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
RU2420239C1 (ru) * 2009-10-21 2011-06-10 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Федерального агентства по высокотехнологичной медицинской помощи" Способ лечения злокачественных забрюшинных опухолей у детей и подростков
US20160024084A1 (en) 2013-03-15 2016-01-28 Concert Pharmaceuticals, Inc. Deuterated palbociclib
WO2015009889A1 (en) 2013-07-18 2015-01-22 Concert Pharmaceuticals, Inc. Deuterated intedanib derivatives and their use for the treatment of proliferative disorders
SG10202112588PA (en) * 2015-11-19 2021-12-30 Biohaven Pharm Holding Co Ltd Amine prodrugs of pharmaceutical compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
NO310238B1 (no) * 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives

Also Published As

Publication number Publication date
RU2162082C2 (ru) 2001-01-20
CN1144805A (zh) 1997-03-12
HUP9601524A3 (en) 2000-03-28
CA2176191A1 (en) 1996-12-07
NZ286723A (en) 1998-03-25
EP0747385A1 (en) 1996-12-11
HU9601524D0 (en) 1996-07-29
KR100375956B1 (ko) 2003-04-21
AU5471896A (en) 1996-12-19
AR002756A1 (es) 1998-04-29
PL314637A1 (en) 1996-12-09
IL118526A0 (en) 1996-10-16
NO315233B1 (no) 2003-08-04
ZA964261B (en) 1997-11-27
DE69622933D1 (de) 2002-09-19
CZ291516B6 (cs) 2003-03-12
EP0747385B1 (en) 2002-08-14
ATE222259T1 (de) 2002-08-15
JPH08337589A (ja) 1996-12-24
NO962231L (no) 1996-12-09
DK0747385T3 (da) 2002-12-16
PT747385E (pt) 2002-11-29
TW354293B (en) 1999-03-11
HUP9601524A2 (en) 1997-05-28
ES2181824T3 (es) 2003-03-01
DE69622933T2 (de) 2003-04-24
KR970000222A (ko) 1997-01-21
PL187883B1 (pl) 2004-10-29
NO962231D0 (no) 1996-05-31
CZ156396A3 (en) 1996-12-11
SG72692A1 (en) 2000-05-23
AU695959B2 (en) 1998-08-27
IL118526A (en) 2001-05-20
CN1066151C (zh) 2001-05-23

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees