MX9405110A - Nuevos derivados de (1-heteroazolil-1-heterociclil)alcano y su uso comoagentes neuroprotectores. - Google Patents
Nuevos derivados de (1-heteroazolil-1-heterociclil)alcano y su uso comoagentes neuroprotectores.Info
- Publication number
- MX9405110A MX9405110A MX9405110A MX9405110A MX9405110A MX 9405110 A MX9405110 A MX 9405110A MX 9405110 A MX9405110 A MX 9405110A MX 9405110 A MX9405110 A MX 9405110A MX 9405110 A MX9405110 A MX 9405110A
- Authority
- MX
- Mexico
- Prior art keywords
- lower alkyl
- ring
- arylalkyl
- compounds
- independently
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se relaciona con compuestos heterocíclicos novedososque tienen la fórmula general (I) en la que: X es O, S, Se o NR2; Y1, Y2,Y3, Y4 son independientemente N o CR2; Z es O, S, Se, NR2 o C = N; R1 esuno o más grupos seleccionados de H, alquilo inferior, acilo inferior,halógeno, alcoxi inferior o CF3, o R1 y el anillo juntos representan unanillo benzo fusionado opcionalmente sustituido de manera adicional; R2 esH, alquilo inferior, alcoxi inferior-alquilo inferior, hidroxialquiloinferior, aciloxi inferior-alquilo inferior, arilalquilo inferior o CF3, ycuando más de uno de los grupos R2 está presente, estos se puedenseleccionar independientemente; y A es en el que W es O, S, NH o N-alquiloinferior, R3 es H, alquilo inferior o acilo inferior, R4 es alquiloinferior, arilalquilo inferior, ciclopropilo o perfluoroalquilo inferior,o R3 y R4 juntos forman un anillo en el que n es 2, 3 ó 4, R5 y R6 sonindependientemente H, alquilo inferior o arilalquilo inferior; con lacondición de que por lo menos uno de X, Y1, Y2, Y3, o Y4 es nitrógeno enel que el anillo no es 1-metil-2-imidazolilo; los isómeros geométricos yópticos y racematos de los mismos en los que tales isómeros existan, asícomo las sales de adición de ácido farmacéuticamente aceptables de losmismos y solvatos de los mismos; que tienen actividad terapéutica,procesos intermediarios para su preparación, formulaciones farmacéuticasque contienen tales compuestos y el uso medicinal de tales compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE19939302332A SE9302332D0 (sv) | 1993-07-06 | 1993-07-06 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9405110A true MX9405110A (es) | 1995-01-31 |
Family
ID=20390539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9405110A MX9405110A (es) | 1993-07-06 | 1994-07-05 | Nuevos derivados de (1-heteroazolil-1-heterociclil)alcano y su uso comoagentes neuroprotectores. |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US5731335A (es) |
| EP (1) | EP0707584A1 (es) |
| JP (1) | JPH08512312A (es) |
| CN (1) | CN1126994A (es) |
| AU (1) | AU691506B2 (es) |
| BR (1) | BR9406923A (es) |
| CA (1) | CA2164856A1 (es) |
| CZ (1) | CZ5396A3 (es) |
| EE (1) | EE03193B1 (es) |
| EG (1) | EG20569A (es) |
| FI (1) | FI960076A0 (es) |
| HU (1) | HUT75097A (es) |
| IL (1) | IL110157A (es) |
| IS (1) | IS4182A (es) |
| MX (1) | MX9405110A (es) |
| NO (1) | NO305955B1 (es) |
| NZ (1) | NZ268689A (es) |
| PL (1) | PL176471B1 (es) |
| RU (1) | RU2124011C1 (es) |
| SE (1) | SE9302332D0 (es) |
| SG (1) | SG64891A1 (es) |
| SK (1) | SK159895A3 (es) |
| WO (1) | WO1995001979A1 (es) |
| ZA (1) | ZA944569B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| DE19645313A1 (de) | 1996-11-04 | 1998-05-07 | Basf Ag | Substituierte 3-Benzylpyrazole |
| WO1999025346A1 (en) | 1997-11-19 | 1999-05-27 | Takeda Chemical Industries, Ltd. | Novel apoptosis inhibitors |
| GB9726569D0 (en) * | 1997-12-16 | 1998-02-11 | Univ Southampton | Neuroprotective agents |
| AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
| NZ520875A (en) * | 2000-03-24 | 2005-04-29 | Euro Celtique S | Aryl substituted pyrazoles, triazoles and tetrazoles as sodium channel blocker |
| US8802861B2 (en) | 2004-01-12 | 2014-08-12 | Merck Serono Sa | Thiazole derivatives and use thereof |
| MX2007002929A (es) * | 2004-09-10 | 2007-08-16 | Syngenta Ltd | Isoxazoles sustituidos como funguicidas. |
| US7888376B2 (en) * | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| EP2162450B1 (en) * | 2007-05-23 | 2015-02-25 | Allergan, Inc. | ((bicylicheteroaryl) imidazolyl) methylheteroaryl compounds as adrenergic receptor agonists |
| WO2009123164A1 (ja) * | 2008-04-02 | 2009-10-08 | 塩野義製薬株式会社 | 血管内皮リパーゼ阻害活性を有するヘテロ環誘導体 |
| BR112013001237A2 (pt) * | 2010-07-19 | 2016-05-17 | Syngenta Participations Ag | compostos de isoxazola, isoatiazola, furano e tiofeno como microbicidas |
| EP2447261A1 (en) * | 2010-10-29 | 2012-05-02 | Basf Se | Pyrrole, furane and thiophene derivatives and their use as fungicides |
| EP2751117A4 (en) * | 2011-08-30 | 2015-06-24 | Innocrin Pharmaceuticals Inc | METALLOENZYMHEMMERVERBINDUNGEN |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4367090A (en) * | 1981-07-17 | 1983-01-04 | Rhone-Poulenc Agrochimie | Herbicidal N-(5,5-dimethyloxazolideneyl-2,4-dione) 5-(substituted phenoxy-2-substituted benzamides |
| JPS58148882A (ja) * | 1982-02-26 | 1983-09-05 | Tanabe Seiyaku Co Ltd | フリルオキサゾリル酢酸誘導体及びその製法 |
| JPS58150576A (ja) * | 1982-03-03 | 1983-09-07 | Sumitomo Chem Co Ltd | 新規な１，２，４−オキサジアゾ−ル誘導体 |
| JPH01249760A (ja) * | 1988-03-29 | 1989-10-05 | Yamaha Corp | ホトクロミック化合物 |
| SU1657505A1 (ru) * | 1989-07-17 | 1991-06-23 | Казанский научно-исследовательский технологический и проектный институт химико-фотографической промышленности Производственного объединения "Тасма" | Производные 1-(морфолинокарбонил)-или 1-(морфолинокарбонилокси)-пиридиний хлорида в качестве дубителей дл желатинсодержащих слоев галогенсеребр ных фотографических материалов |
| US5086064A (en) * | 1990-03-27 | 1992-02-04 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl thiazolyl, oxazolyl, and imidazolyl methanones and related compounds as antiinflammatory agents |
| US5068237A (en) * | 1990-05-21 | 1991-11-26 | Warner-Lambert Company | Substituted furans and derivatives thereof acting at muscarinic receptors |
| EP0619814A1 (en) * | 1991-12-31 | 1994-10-19 | Fujisawa Pharmaceutical Co., Ltd. | Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity |
-
1993
- 1993-07-06 SE SE19939302332A patent/SE9302332D0/xx unknown
-
1994
- 1994-06-23 IS IS4182A patent/IS4182A/is unknown
- 1994-06-24 ZA ZA944569A patent/ZA944569B/xx unknown
- 1994-06-29 IL IL11015794A patent/IL110157A/xx not_active IP Right Cessation
- 1994-07-05 HU HU9503744A patent/HUT75097A/hu unknown
- 1994-07-05 CN CN94192713A patent/CN1126994A/zh active Pending
- 1994-07-05 NZ NZ268689A patent/NZ268689A/en unknown
- 1994-07-05 AU AU71977/94A patent/AU691506B2/en not_active Ceased
- 1994-07-05 FI FI960076A patent/FI960076A0/fi unknown
- 1994-07-05 JP JP7503998A patent/JPH08512312A/ja active Pending
- 1994-07-05 BR BR9406923A patent/BR9406923A/pt not_active Application Discontinuation
- 1994-07-05 EP EP94921147A patent/EP0707584A1/en not_active Withdrawn
- 1994-07-05 SK SK1598-95A patent/SK159895A3/sk unknown
- 1994-07-05 SG SG1996005493A patent/SG64891A1/en unknown
- 1994-07-05 US US08/379,506 patent/US5731335A/en not_active Expired - Fee Related
- 1994-07-05 CZ CZ9653A patent/CZ5396A3/cs unknown
- 1994-07-05 WO PCT/SE1994/000663 patent/WO1995001979A1/en not_active Ceased
- 1994-07-05 RU RU96103659A patent/RU2124011C1/ru active
- 1994-07-05 CA CA002164856A patent/CA2164856A1/en not_active Abandoned
- 1994-07-05 PL PL94312417A patent/PL176471B1/pl unknown
- 1994-07-05 MX MX9405110A patent/MX9405110A/es not_active IP Right Cessation
- 1994-07-06 EG EG40594A patent/EG20569A/xx active
- 1994-11-23 EE EE9400387A patent/EE03193B1/xx unknown
-
1995
- 1995-06-02 US US08/459,847 patent/US5607956A/en not_active Expired - Fee Related
-
1996
- 1996-01-04 NO NO960028A patent/NO305955B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL110157A (en) | 2000-01-31 |
| CA2164856A1 (en) | 1995-01-19 |
| EG20569A (en) | 1999-08-30 |
| IL110157A0 (en) | 1994-10-07 |
| EE03193B1 (et) | 1999-06-15 |
| AU7197794A (en) | 1995-02-06 |
| US5607956A (en) | 1997-03-04 |
| FI960076L (fi) | 1996-01-08 |
| NO960028L (no) | 1996-02-27 |
| NZ268689A (en) | 1997-11-24 |
| WO1995001979A1 (en) | 1995-01-19 |
| SE9302332D0 (sv) | 1993-07-06 |
| RU2124011C1 (ru) | 1998-12-27 |
| IS4182A (is) | 1995-01-07 |
| CZ5396A3 (en) | 1996-06-12 |
| NO305955B1 (no) | 1999-08-23 |
| EP0707584A1 (en) | 1996-04-24 |
| ZA944569B (en) | 1995-02-15 |
| NO960028D0 (no) | 1996-01-04 |
| PL176471B1 (pl) | 1999-06-30 |
| AU691506B2 (en) | 1998-05-21 |
| CN1126994A (zh) | 1996-07-17 |
| PL312417A1 (en) | 1996-04-15 |
| JPH08512312A (ja) | 1996-12-24 |
| US5731335A (en) | 1998-03-24 |
| FI960076A7 (fi) | 1996-01-08 |
| SG64891A1 (en) | 1999-05-25 |
| BR9406923A (pt) | 1996-07-30 |
| HUT75097A (en) | 1997-04-28 |
| FI960076A0 (fi) | 1996-01-08 |
| HU9503744D0 (en) | 1996-02-28 |
| SK159895A3 (en) | 1996-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |