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MX9304503A - ANTI-INFLAMMATORY COMPOUNDS. - Google Patents

ANTI-INFLAMMATORY COMPOUNDS.

Info

Publication number
MX9304503A
MX9304503A MX9304503A MX9304503A MX9304503A MX 9304503 A MX9304503 A MX 9304503A MX 9304503 A MX9304503 A MX 9304503A MX 9304503 A MX9304503 A MX 9304503A MX 9304503 A MX9304503 A MX 9304503A
Authority
MX
Mexico
Prior art keywords
present
relates
inflammatory compounds
lipoxygenase
cyclooxygenase
Prior art date
Application number
MX9304503A
Other languages
Spanish (es)
Inventor
Simon Teanby Hodgson
David Evan Davies
Steven Smith
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MX9304503A publication Critical patent/MX9304503A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Communicable Diseases (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a derivados de ácido hidroxámico novedosos de la Fórmula (I), y a su uso en terapia médica, particularmente en el tratamiento de una condición clínica, para la cual se indica un inhibidor de la trayectoria metabólica de ácido araquidónico mediado por lipoxigenasa ó ciclooxigenasa. La presente invención también se refiere a formulaciones farmacéuticas y a procedimientos para la preparación de los compuestos de conformidad con la presente invención.The present invention relates to novel hydroxamic acid derivatives of Formula (I), and to their use in medical therapy, particularly in the treatment of a clinical condition, for which an inhibitor of the metabolic pathway of arachidonic acid mediated by lipoxygenase or cyclooxygenase. The present invention also relates to pharmaceutical formulations and procedures for the preparation of the compounds according to the present invention.

MX9304503A 1992-07-27 1993-07-26 ANTI-INFLAMMATORY COMPOUNDS. MX9304503A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929215921A GB9215921D0 (en) 1992-07-27 1992-07-27 Anti-inflammatory compounds

Publications (1)

Publication Number Publication Date
MX9304503A true MX9304503A (en) 1994-04-29

Family

ID=10719360

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304503A MX9304503A (en) 1992-07-27 1993-07-26 ANTI-INFLAMMATORY COMPOUNDS.

Country Status (10)

Country Link
EP (1) EP0652864A1 (en)
JP (1) JPH07509462A (en)
AU (1) AU672810B2 (en)
CA (1) CA2141214A1 (en)
GB (1) GB9215921D0 (en)
IL (1) IL106472A0 (en)
MX (1) MX9304503A (en)
TW (1) TW246670B (en)
WO (1) WO1994002448A1 (en)
ZA (1) ZA935378B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0730588B1 (en) * 1993-11-26 1997-07-02 Pfizer Inc. Isoxazoline compounds as antiinflammatory agents
MX9603943A (en) * 1994-03-09 1997-04-30 Pfizer ISOXAZOLINE COMPOUNDS AS 5-LIPOOXIGENASE INHIBITORS.
JP3322885B2 (en) * 1995-02-02 2002-09-09 日研化学株式会社 N-hydroxyurea derivative
ES2169351T3 (en) 1996-02-13 2002-07-01 Searle & Co COMBINATIONS THAT HAVE IMMUNOSUPPRESSOR EFFECTS, CONTAINING CYCLOXYGENASA-2 AND 5-LIPOXYGENASE INHIBITORS.
WO1997029774A1 (en) 1996-02-13 1997-08-21 G.D. Searle & Co. Combinations, having immunosuppressive effects, containing a cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
JP2000505445A (en) 1996-02-13 2000-05-09 ジー．ディー．サール アンド カンパニー Immunosuppressive effect of administration of cyclooxygenase-2 inhibitor and leukotriene B <4> receptor antagonist
NZ333441A (en) * 1996-06-25 1999-05-28 Cephalon Inc Use of k-252a derivatives for the treatment of peripheral or central nerve disorders, and cytokine overproduction
DE69809924T2 (en) * 1997-07-31 2003-08-21 Abbott Laboratories, Abbott Park N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF METALLOPROTEINASES
US6294573B1 (en) 1997-08-06 2001-09-25 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
US6235786B1 (en) 1997-08-06 2001-05-22 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
US6288261B1 (en) 1998-12-18 2001-09-11 Abbott Laboratories Inhibitors of matrix metalloproteinases
WO2000044712A1 (en) * 1999-01-27 2000-08-03 Abbott Laboratories N-hydroxyformamide derivatives as inhibitors of matrix metalloproteinases
SE0103325D0 (en) 2001-10-04 2001-10-04 Astrazeneca Ab Novel compounds
TW200946105A (en) 2008-02-07 2009-11-16 Kyorin Seiyaku Kk Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK117986A (en) * 1985-03-16 1986-09-17 Wellcome Found ARYLET DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE
PL154186B1 (en) * 1987-07-15 1991-07-31 Wellcome Found Method for manufacturing arylic derivatives of the hydroxamic acid
ATE144247T1 (en) * 1990-07-25 1996-11-15 Abbott Lab ACETYLENE DERIVATIVES WITH LIPOXYGENASE INHIBITING ACTION
JPH06256285A (en) * 1990-12-11 1994-09-13 Pfizer Pharmaceut Co Ltd Hydroxamic acid derivative and its use

Also Published As

Publication number Publication date
CA2141214A1 (en) 1994-02-03
AU672810B2 (en) 1996-10-17
AU4717093A (en) 1994-02-14
JPH07509462A (en) 1995-10-19
TW246670B (en) 1995-05-01
ZA935378B (en) 1995-01-26
WO1994002448A1 (en) 1994-02-03
IL106472A0 (en) 1993-11-15
EP0652864A1 (en) 1995-05-17
GB9215921D0 (en) 1992-09-09

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