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MX9301668A - Monohidratos cristalinos de– clorhidrato de endo-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-benc imidazol-1-carboxamida y del clorhidrato de endo-3-etil-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo- 1h-bencimidazol-1-car. - Google Patents

Monohidratos cristalinos de– clorhidrato de endo-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-benc imidazol-1-carboxamida y del clorhidrato de endo-3-etil-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo- 1h-bencimidazol-1-car.

Info

Publication number
MX9301668A
MX9301668A MX9301668A MX9301668A MX9301668A MX 9301668 A MX9301668 A MX 9301668A MX 9301668 A MX9301668 A MX 9301668A MX 9301668 A MX9301668 A MX 9301668A MX 9301668 A MX9301668 A MX 9301668A
Authority
MX
Mexico
Prior art keywords
benzimidazol
dihydro
oct
oxo
methyl
Prior art date
Application number
MX9301668A
Other languages
English (en)
Inventor
Enzo Cereda
Enrica Dubini
Antoine Ezhaya
Grazia Maffione
Marco Turconi
Original Assignee
Boehringer Ingelheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI920720A external-priority patent/IT1254562B/it
Priority claimed from ITMI920723A external-priority patent/IT1254565B/it
Application filed by Boehringer Ingelheim Italia filed Critical Boehringer Ingelheim Italia
Publication of MX9301668A publication Critical patent/MX9301668A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a los monohidratos cristalinos y farmacológicamente activos del clorhidrato o hidrocloruro de endo-2,3-dihidro-N-(8-metil-8-azabiciclo(3.2.1)oct -3-il)-2-oxo-1H-bencimidazol-1-carboxamida y del clorhidrato o hidrocloruro de endo-3-etil-2,3-dihidro-N-(8-metil-8-azabiciclo(3. 2.1)-oct-3-il)-2-oxo-1H-bencimidazol-1-carboxamida , a los procedimientos para su preparación y a las composiciones farmacéuticas que los contienen.
MX9301668A 1992-03-26 1993-03-25 Monohidratos cristalinos de– clorhidrato de endo-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-benc imidazol-1-carboxamida y del clorhidrato de endo-3-etil-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo- 1h-bencimidazol-1-car. MX9301668A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI920720A IT1254562B (it) 1992-03-26 1992-03-26 Forma cristallina dell'endo-3-etil-2,3-diidro-n-(8-metil-8-azabiciclo (3.2.1) ott-3-il)- 2-oxo-1h-benzimidazolo-1-carbossamide cloridrato
ITMI920723A IT1254565B (it) 1992-03-26 1992-03-26 Forma cristallina dell'endo-2,3-diidro-n-(8 metil-8-azabiciclo-(3.2.1) ott-3-il)-2-oxo-1h-benzimidazolo-1-carbossamide cloridrato

Publications (1)

Publication Number Publication Date
MX9301668A true MX9301668A (es) 1993-09-01

Family

ID=26330860

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301668A MX9301668A (es) 1992-03-26 1993-03-25 Monohidratos cristalinos de– clorhidrato de endo-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-benc imidazol-1-carboxamida y del clorhidrato de endo-3-etil-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo- 1h-bencimidazol-1-car.

Country Status (27)

Country Link
US (1) US5468758A (es)
EP (1) EP0567767B1 (es)
JP (1) JP3279707B2 (es)
AT (1) ATE169016T1 (es)
AU (1) AU654082B2 (es)
BR (1) BR1100564A (es)
CA (1) CA2092510C (es)
CZ (1) CZ286590B6 (es)
DE (1) DE69319955T2 (es)
DK (1) DK0567767T3 (es)
ES (1) ES2118846T3 (es)
FI (1) FI113472B (es)
HR (1) HRP930479B1 (es)
HU (2) HU211075B (es)
IL (1) IL105143A (es)
MX (1) MX9301668A (es)
NO (1) NO300975B1 (es)
NZ (1) NZ247234A (es)
PH (1) PH30413A (es)
PL (1) PL172890B1 (es)
RU (1) RU2125054C1 (es)
SG (1) SG43225A1 (es)
SI (1) SI9300150B (es)
SK (1) SK280555B6 (es)
TW (1) TW385310B (es)
UA (1) UA37179C2 (es)
UY (2) UY25939A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1282015B1 (en) 1996-01-17 2005-05-11 Ricoh Company, Ltd. Fixing apparatus for an image forming apparatus
JPH1039679A (ja) * 1996-05-24 1998-02-13 Ricoh Co Ltd 定着装置
PE20001420A1 (es) 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
US8697722B2 (en) * 2007-11-02 2014-04-15 Sri International Nicotinic acetylcholine receptor modulators
JP5840143B2 (ja) 2010-01-11 2016-01-06 アストライア セラピューティクス， エルエルシーＡｓｔｒａｅａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｌｌｃ ニコチン性アセチルコリン受容体モジュレーター

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136189A (en) * 1975-09-16 1979-01-23 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 2-(5-nitro-furfurylidene)-amino-benzimidoles and fungicidal compositions containing the same
US5223511A (en) * 1987-09-23 1993-06-29 Boehringer Ingelheim Italia S.P.A. Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists
IT1231413B (it) * 1987-09-23 1991-12-04 Angeli Inst Spa Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
GB9121835D0 (en) * 1991-10-15 1991-11-27 Smithkline Beecham Plc Pharmaceuticals
EP0554794B1 (en) * 1992-02-04 1998-07-29 Eisai Co., Ltd. Aminobenzoic acid derivatives

Also Published As

Publication number Publication date
JP3279707B2 (ja) 2002-04-30
PL172890B1 (pl) 1997-12-31
CZ44393A3 (en) 1994-01-19
SG43225A1 (en) 1997-10-17
US5468758A (en) 1995-11-21
RU2125054C1 (ru) 1999-01-20
BR1100564A (pt) 2000-06-27
EP0567767A1 (en) 1993-11-03
TW385310B (en) 2000-03-21
NO300975B1 (no) 1997-08-25
HU9300868D0 (en) 1993-06-28
DK0567767T3 (da) 1999-02-01
AU3541393A (en) 1993-09-30
CA2092510C (en) 2004-02-03
HRP930479A2 (en) 1995-02-28
HUT63846A (en) 1993-10-28
SK22693A3 (en) 1993-11-10
JPH0673053A (ja) 1994-03-15
SI9300150A (en) 1993-09-30
IL105143A (en) 1996-10-16
NO931112D0 (no) 1993-03-25
EP0567767B1 (en) 1998-07-29
FI931329A0 (fi) 1993-03-25
HU211075B (en) 1995-10-30
DE69319955D1 (de) 1998-09-03
NZ247234A (en) 1995-12-21
SK280555B6 (sk) 2000-03-13
DE69319955T2 (de) 1999-04-15
UA37179C2 (uk) 2001-05-15
HU211131A9 (en) 1995-10-30
AU654082B2 (en) 1994-10-20
HRP930479B1 (en) 1999-10-31
ATE169016T1 (de) 1998-08-15
FI113472B (fi) 2004-04-30
CZ286590B6 (cs) 2000-05-17
UY25938A1 (es) 2000-09-29
UY25939A1 (es) 2001-08-27
NO931112L (no) 1993-09-27
PL298263A1 (en) 1994-01-10
SI9300150B (sl) 1998-06-30
CA2092510A1 (en) 1993-09-27
FI931329L (fi) 1993-09-27
HK1010719A1 (en) 1999-06-25
PH30413A (en) 1997-05-09
ES2118846T3 (es) 1998-10-01

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Legal Events

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MM Annulment or lapse due to non-payment of fees