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MX394835B - Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol. - Google Patents

Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol.

Info

Publication number
MX394835B
MX394835B MX2019013979A MX2019013979A MX394835B MX 394835 B MX394835 B MX 394835B MX 2019013979 A MX2019013979 A MX 2019013979A MX 2019013979 A MX2019013979 A MX 2019013979A MX 394835 B MX394835 B MX 394835B
Authority
MX
Mexico
Prior art keywords
preparation
methods
heterocyclic compounds
benzodioxole
benzodioxole heterocyclic
Prior art date
Application number
MX2019013979A
Other languages
English (en)
Other versions
MX2019013979A (es
Inventor
Allan Carsten Dahl
Bjørn Metzler
Esben Paul Krogh Olsen
Johan Eriksson Bajtner
Original Assignee
Union Therapeutics As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Therapeutics As filed Critical Union Therapeutics As
Publication of MX2019013979A publication Critical patent/MX2019013979A/es
Publication of MX394835B publication Critical patent/MX394835B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J21/00—Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
    • B01J21/16—Clays or other mineral silicates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se relaciona con métodos nuevos para la preparación de compuestos heterocíclicos de 1,3-benzodioxol de la fórmula (I). Los compuestos son útiles como inhibidores de PDE4. (I).
MX2019013979A 2017-06-20 2018-06-19 Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol. MX394835B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17176767 2017-06-20
PCT/EP2018/066229 WO2018234299A1 (en) 2017-06-20 2018-06-19 Methods for the preparation of 1,3-benzodioxole heterocyclic compounds

Publications (2)

Publication Number Publication Date
MX2019013979A MX2019013979A (es) 2020-07-13
MX394835B true MX394835B (es) 2025-03-24

Family

ID=59091413

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019013979A MX394835B (es) 2017-06-20 2018-06-19 Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol.

Country Status (14)

Country Link
US (2) US11220514B2 (es)
EP (1) EP3642210B1 (es)
JP (2) JP2020524131A (es)
KR (1) KR102676384B1 (es)
CN (2) CN118344381A (es)
AU (1) AU2018286964B2 (es)
BR (1) BR112019025028A2 (es)
CA (1) CA3064033A1 (es)
DK (1) DK3642210T3 (es)
ES (1) ES2998512T3 (es)
IL (1) IL271399B (es)
MX (1) MX394835B (es)
TW (1) TWI774791B (es)
WO (1) WO2018234299A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3007432A1 (en) 2015-12-18 2017-06-22 Leo Pharma A/S Methods for the preparation of 1,3-benzodioxole heterocyclic compounds
IL271399B (en) 2017-06-20 2022-07-01 Leo Pharma As Methods for the preparation of 1,3-benzodioxole heterocyclic compounds
US11384096B2 (en) 2017-12-15 2022-07-12 UNION therapeutics A/S Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors
LT3911304T (lt) 2019-01-15 2023-11-10 UNION therapeutics A/S Modifikuoto atpalaidavimo tablečių vaisto formos, kurių sudėtyje yra fosfodiesterazės inhibitorių
WO2022200339A1 (en) 2021-03-22 2022-09-29 UNION therapeutics A/S Treatment of hidradenitis suppurativa with orismilast
CN114105865A (zh) * 2021-12-07 2022-03-01 江苏宝众宝达药业股份有限公司 一种3,4,5-三氯吡啶的合成工艺
GB202205715D0 (en) 2022-04-19 2022-06-01 Union Therapeutics As Treatment of neutrophilic dermatoses
GB202306662D0 (en) 2023-05-05 2023-06-21 Union Therapeutics As Dosage regimen
GB202306663D0 (en) 2023-05-05 2023-06-21 Union Therapeutics As Combination therapy

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03148337A (ja) 1989-10-31 1991-06-25 Aisin Seiki Co Ltd ２輪／４輪駆動制御装置
AU705690B2 (en) 1995-05-19 1999-05-27 Kyowa Hakko Kogyo Co. Ltd. Oxygen-containing heterocyclic compounds
US6514996B2 (en) 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
US6169086B1 (en) * 1997-01-27 2001-01-02 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
JPH1159216A (ja) 1997-08-26 1999-03-02 Fuji Heavy Ind Ltd ４輪駆動車の動力配分制御装置
FR2799417B1 (fr) 1999-10-08 2009-01-23 Toyota Motor Co Ltd Dispositif de controle de vehicule, notamment pour la repartition des forces de traction avant-arriere
DE10205274A1 (de) 2002-02-08 2003-08-21 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen
US6630813B2 (en) 2002-03-06 2003-10-07 Ford Global Technologies, Llc Method and apparatus for monitoring the state of the battery of a hybrid electric vehicle
AU2003252467A1 (en) 2002-07-03 2004-01-23 Kyowa Hakko Kogyo Co., Ltd. Process for preparation of 1,3-benzodioxole-2-spiro- cycloalkane derivatives
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
JP2006008522A (ja) 2004-06-22 2006-01-12 Sumitomo Chemical Co Ltd ２，３−ジヒドロキシ−４−アルコキシ−アシルベンゼン類の製造方法
ATE496029T1 (de) 2006-07-14 2011-02-15 Chiesi Farma Spa Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren
AU2007336538B2 (en) 2006-12-22 2012-04-05 Leo Pharma A/S Substituted acetophenones useful as PDE4 inhibitors
KR101571654B1 (ko) * 2007-02-28 2015-11-25 레오 파마 에이/에스 신규한 포스포디에스테라제 억제제
SG172206A1 (en) 2008-12-19 2011-07-28 Leo Pharma As Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases
WO2011124525A1 (de) 2010-04-08 2011-10-13 Boehringer Ingelheim International Gmbh Arnzeimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten
NZ603895A (en) 2010-06-24 2014-10-31 Leo Pharma As Novel phosphodiesterase inhibitors
JP2012229192A (ja) 2011-04-13 2012-11-22 Jsr Corp （ポリ）イソシアヌレート化合物の製造方法
ES2583478T3 (es) 2011-12-21 2016-09-21 Leo Pharma A/S [1,2,4] triazolopiridinas y su uso como inhibidores de fosfodiesterasa
WO2014096018A1 (en) 2012-12-19 2014-06-26 Leo Pharma A/S Methods for the preparation of substituted acetophenones
CA2953284A1 (en) 2014-06-23 2015-12-30 Leo Pharma A/S Methods for the preparation of 1,3-benzodioxole heterocyclic compounds
CA3007432A1 (en) * 2015-12-18 2017-06-22 Leo Pharma A/S Methods for the preparation of 1,3-benzodioxole heterocyclic compounds
RU2764273C2 (ru) 2016-12-12 2022-01-17 Юнион Терапьютикс А/С Замещенные пиразолоазепин-8-оны и их применение в качестве ингибиторов фосфодиэстеразы
CN110167944B (zh) 2016-12-12 2024-08-23 联合疗法公司 取代的吡唑并氮杂䓬-4-酮类及其作为磷酸二酯酶抑制剂的用途
JP6850886B2 (ja) 2016-12-12 2021-03-31 レオ ファーマ アクティーゼルスカブ 置換ピラゾロアゼピン−４−オンおよびそれらのホスホジエステラーゼ阻害剤としての使用
IL271399B (en) 2017-06-20 2022-07-01 Leo Pharma As Methods for the preparation of 1,3-benzodioxole heterocyclic compounds
WO2019057806A1 (en) 2017-09-20 2019-03-28 Leo Pharma A/S SUBSTITUTED DIHYDROTHIENOPYRIMIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
US11384096B2 (en) 2017-12-15 2022-07-12 UNION therapeutics A/S Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors
CN111712503B (zh) 2017-12-15 2024-04-09 联合疗法公司 取代的四氢吡喃二氢噻吩并嘧啶类化合物及其作为磷酸二酯酶抑制剂的用途
CN111712502B (zh) 2017-12-15 2023-10-27 联合疗法公司 取代的氮杂环丁烷二氢噻吩并嘧啶类化合物及其作为磷酸二酯酶抑制剂的用途
LT3911304T (lt) 2019-01-15 2023-11-10 UNION therapeutics A/S Modifikuoto atpalaidavimo tablečių vaisto formos, kurių sudėtyje yra fosfodiesterazės inhibitorių
WO2022200339A1 (en) 2021-03-22 2022-09-29 UNION therapeutics A/S Treatment of hidradenitis suppurativa with orismilast

Also Published As

Publication number Publication date
US12084457B2 (en) 2024-09-10
RU2019138518A (ru) 2021-07-20
MX2019013979A (es) 2020-07-13
AU2018286964A1 (en) 2019-12-05
AU2018286964B2 (en) 2022-04-14
DK3642210T3 (da) 2024-12-09
JP2023029877A (ja) 2023-03-07
CN118344381A (zh) 2024-07-16
TWI774791B (zh) 2022-08-21
CN110741005A (zh) 2020-01-31
CA3064033A1 (en) 2018-12-27
CN110741005B (zh) 2024-04-12
JP2020524131A (ja) 2020-08-13
TW201904975A (zh) 2019-02-01
KR20200013784A (ko) 2020-02-07
BR112019025028A2 (pt) 2020-06-16
IL271399A (en) 2020-01-30
KR102676384B1 (ko) 2024-06-20
US20210147440A1 (en) 2021-05-20
US20220162227A1 (en) 2022-05-26
EP3642210B1 (en) 2024-11-13
RU2019138518A3 (es) 2022-04-14
EP3642210A1 (en) 2020-04-29
IL271399B (en) 2022-07-01
US11220514B2 (en) 2022-01-11
WO2018234299A1 (en) 2018-12-27
ES2998512T3 (en) 2025-02-20
JP7549635B2 (ja) 2024-09-11

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