MX377921B - Proceso para la preparacion de (s)-2-((2-((s)-4-(difluorometil)-2-oxooxazolidin-3-il)-5,6-dihidrobenzo[f]imidazo[1,2-d] [1,4]oxazepin-9-il)amino)propanamida - Google Patents
Proceso para la preparacion de (s)-2-((2-((s)-4-(difluorometil)-2-oxooxazolidin-3-il)-5,6-dihidrobenzo[f]imidazo[1,2-d] [1,4]oxazepin-9-il)amino)propanamidaInfo
- Publication number
- MX377921B MX377921B MX2019006958A MX2019006958A MX377921B MX 377921 B MX377921 B MX 377921B MX 2019006958 A MX2019006958 A MX 2019006958A MX 2019006958 A MX2019006958 A MX 2019006958A MX 377921 B MX377921 B MX 377921B
- Authority
- MX
- Mexico
- Prior art keywords
- oxooxazolidin
- oxazepin
- dihydrobenzo
- propanamide
- imidazo
- Prior art date
Links
- SGEUNORSOZVTOL-CABZTGNLSA-N (2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide Chemical compound FC([C@H]1N(C(OC1)=O)C=1N=C2N(CCOC3=C2C=CC(=C3)N[C@H](C(=O)N)C)C=1)F SGEUNORSOZVTOL-CABZTGNLSA-N 0.000 title 1
- KVQCNKSKFIZOKW-UHFFFAOYSA-N O1C(NCC1)=O.O1N=CC=CC2=C1C=CC=C2 Chemical class O1C(NCC1)=O.O1N=CC=CC2=C1C=CC=C2 KVQCNKSKFIZOKW-UHFFFAOYSA-N 0.000 abstract 1
- LNUFLCYMSVYYNW-ZPJMAFJPSA-N [(2r,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[[(3s,5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-4,5-disulfo Chemical compound O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)[C@H]1O[C@H](COS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O LNUFLCYMSVYYNW-ZPJMAFJPSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se describen métodos para fabricar compuestos de benzoxazepina oxazolidinona, así como los intermediarios sintéticos, incluido el compuesto 18, que tiene la estructura; (ver formula)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662434836P | 2016-12-15 | 2016-12-15 | |
| PCT/EP2017/083143 WO2018109204A1 (en) | 2016-12-15 | 2017-12-15 | Process for the preparation of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino) propanamide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019006958A MX2019006958A (es) | 2019-08-01 |
| MX377921B true MX377921B (es) | 2025-03-10 |
Family
ID=61027659
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019006958A MX377921B (es) | 2016-12-15 | 2017-12-15 | Proceso para la preparacion de (s)-2-((2-((s)-4-(difluorometil)-2-oxooxazolidin-3-il)-5,6-dihidrobenzo[f]imidazo[1,2-d] [1,4]oxazepin-9-il)amino)propanamida |
| MX2020010948A MX2020010948A (es) | 2016-12-15 | 2019-06-13 | Proceso para la preparacion de (s)-2-((2-((s)-4-(difluorometil)-2- oxooxazolidin-3-il)-5,6-dihidrobenzo[f]imidazo[1,2-d] [1,4]oxazepin-9-il)amino)propanamida. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020010948A MX2020010948A (es) | 2016-12-15 | 2019-06-13 | Proceso para la preparacion de (s)-2-((2-((s)-4-(difluorometil)-2- oxooxazolidin-3-il)-5,6-dihidrobenzo[f]imidazo[1,2-d] [1,4]oxazepin-9-il)amino)propanamida. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10781219B2 (es) |
| EP (2) | EP3555107B1 (es) |
| JP (1) | JP7004720B2 (es) |
| KR (1) | KR102537048B1 (es) |
| CN (1) | CN110088111B (es) |
| AR (1) | AR110527A1 (es) |
| AU (2) | AU2017378188B2 (es) |
| CA (1) | CA3044500A1 (es) |
| ES (2) | ES2867389T3 (es) |
| HR (2) | HRP20210592T1 (es) |
| HU (1) | HUE062517T2 (es) |
| IL (2) | IL267265B (es) |
| MX (2) | MX377921B (es) |
| PL (2) | PL3851441T3 (es) |
| SG (1) | SG10201913961PA (es) |
| SI (1) | SI3555107T1 (es) |
| TW (1) | TWI770093B (es) |
| WO (1) | WO2018109204A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2764497T3 (es) | 2015-07-02 | 2020-06-03 | Hoffmann La Roche | Compuestos de benzoxazepina oxazolidinona y procedimientos de uso |
| JP6998969B2 (ja) | 2017-04-28 | 2022-02-10 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | （ｓ）－２－（（２－（（ｓ）－４－（ジフルオロメチル）－２－オキソオキサゾリジン－３－イル）－５，６－ジヒドロベンゾ［ｆ］イミダゾ［１，２－ｄ］［１，４］オキサゼピン－９－イル）アミノ）プロパンアミドの多形体及び固体形態と、生産方法 |
| US12208095B2 (en) | 2019-08-26 | 2025-01-28 | Arvinas Operations, Inc. | Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders |
| JP7678808B2 (ja) * | 2019-11-25 | 2025-05-16 | 上▲海▼翰森生物医▲薬▼科技有限公司 | ３種類の縮合環誘導体含有塩又は結晶形態及びその医薬組成物 |
| US20230149910A1 (en) * | 2020-03-03 | 2023-05-18 | Momentive Performance Materials Inc. | Catalyst composition |
| AR125993A1 (es) | 2021-05-28 | 2023-08-30 | Genentech Inc | Proceso para la preparacion de compuestos de benzoxazepin oxazolidinona |
| TW202440096A (zh) | 2023-03-24 | 2024-10-16 | 美商亞文納營運公司 | 雌激素受體降解劑之給藥方案 |
| TW202517655A (zh) * | 2023-07-14 | 2025-05-01 | 瑞士商赫孚孟拉羅股份公司 | 使用［Ｃｕ（μ－ｓａｌｂｅｎ）］錯合物之Ｃ－Ｎ偶合方法 |
| WO2025036856A1 (en) | 2023-08-11 | 2025-02-20 | F. Hoffmann-La Roche Ag | Pharmaceutical formulation comprising a coated tablet |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010299816C1 (en) | 2009-09-28 | 2018-02-01 | F. Hoffmann-La Roche Ag | Benzoxazepin PI3K inhibitor compounds and methods of use |
| EP2688891B1 (en) * | 2011-03-21 | 2017-11-15 | F. Hoffmann-La Roche AG | Benzoxazepin compounds selective for pi3k p110 delta and methods of use |
| MX2015011438A (es) | 2013-03-13 | 2016-02-03 | Hoffmann La Roche | Procedimiento para preparar compuestos benzoxazepina. |
| ES2764497T3 (es) | 2015-07-02 | 2020-06-03 | Hoffmann La Roche | Compuestos de benzoxazepina oxazolidinona y procedimientos de uso |
| JP6998969B2 (ja) | 2017-04-28 | 2022-02-10 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | （ｓ）－２－（（２－（（ｓ）－４－（ジフルオロメチル）－２－オキソオキサゾリジン－３－イル）－５，６－ジヒドロベンゾ［ｆ］イミダゾ［１，２－ｄ］［１，４］オキサゼピン－９－イル）アミノ）プロパンアミドの多形体及び固体形態と、生産方法 |
-
2017
- 2017-12-15 MX MX2019006958A patent/MX377921B/es unknown
- 2017-12-15 EP EP17835634.1A patent/EP3555107B1/en active Active
- 2017-12-15 PL PL20209166.6T patent/PL3851441T3/pl unknown
- 2017-12-15 HR HRP20210592TT patent/HRP20210592T1/hr unknown
- 2017-12-15 WO PCT/EP2017/083143 patent/WO2018109204A1/en not_active Ceased
- 2017-12-15 PL PL17835634T patent/PL3555107T3/pl unknown
- 2017-12-15 SI SI201730711T patent/SI3555107T1/sl unknown
- 2017-12-15 ES ES17835634T patent/ES2867389T3/es active Active
- 2017-12-15 KR KR1020197020323A patent/KR102537048B1/ko active Active
- 2017-12-15 AU AU2017378188A patent/AU2017378188B2/en active Active
- 2017-12-15 AR ARP170103528A patent/AR110527A1/es unknown
- 2017-12-15 ES ES20209166T patent/ES2953833T3/es active Active
- 2017-12-15 SG SG10201913961PA patent/SG10201913961PA/en unknown
- 2017-12-15 HR HRP20230948TT patent/HRP20230948T1/hr unknown
- 2017-12-15 JP JP2019531931A patent/JP7004720B2/ja active Active
- 2017-12-15 CA CA3044500A patent/CA3044500A1/en active Pending
- 2017-12-15 TW TW106144193A patent/TWI770093B/zh active
- 2017-12-15 EP EP20209166.6A patent/EP3851441B1/en active Active
- 2017-12-15 HU HUE20209166A patent/HUE062517T2/hu unknown
- 2017-12-15 CN CN201780078083.8A patent/CN110088111B/zh active Active
-
2019
- 2019-06-12 IL IL267265A patent/IL267265B/en active IP Right Grant
- 2019-06-13 MX MX2020010948A patent/MX2020010948A/es unknown
- 2019-06-14 US US16/441,765 patent/US10781219B2/en active Active
-
2021
- 2021-02-17 AU AU2021201046A patent/AU2021201046A1/en not_active Abandoned
- 2021-02-24 IL IL281087A patent/IL281087A/en unknown
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