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MX360092B - Terapia de combinación con un agente antihialuronano y un taxano orientado a tumor. - Google Patents

Terapia de combinación con un agente antihialuronano y un taxano orientado a tumor.

Info

Publication number
MX360092B
MX360092B MX2014011965A MX2014011965A MX360092B MX 360092 B MX360092 B MX 360092B MX 2014011965 A MX2014011965 A MX 2014011965A MX 2014011965 A MX2014011965 A MX 2014011965A MX 360092 B MX360092 B MX 360092B
Authority
MX
Mexico
Prior art keywords
combination therapy
tumor
targeted taxane
hyaluronan agent
hyaluronan
Prior art date
Application number
MX2014011965A
Other languages
English (en)
Other versions
MX2014011965A (es
Inventor
C Maneval Daniel
Shepard H Michael
B Thompson Curtis
Original Assignee
Halozyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Halozyme Inc filed Critical Halozyme Inc
Publication of MX2014011965A publication Critical patent/MX2014011965A/es
Publication of MX360092B publication Critical patent/MX360092B/es

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C12N9/003—Dihydrofolate reductase [DHFR] (1.5.1.3)
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    • C12N9/14—Hydrolases (3)
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    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
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    • C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase

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Abstract

La presente invención se refiere a una combinación de composiciones para usarse en el tratamiento de cáncer pancreático, en donde la combinación comprende: una primera composición que comprende una hialuronidasa conjugada con un polímero: y una segunda composición que comprende un taxano orientado a un tumor, en donde el taxano orientado a un tumor comprende nab-paclitaxel o nab-docetaxel.
MX2014011965A 2012-04-04 2013-03-15 Terapia de combinación con un agente antihialuronano y un taxano orientado a tumor. MX360092B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261686429P 2012-04-04 2012-04-04
US201261714719P 2012-10-16 2012-10-16
PCT/US2013/032684 WO2013151774A1 (en) 2012-04-04 2013-03-15 Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane

Publications (2)

Publication Number Publication Date
MX2014011965A MX2014011965A (es) 2015-04-08
MX360092B true MX360092B (es) 2018-10-19

Family

ID=48050937

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014011965A MX360092B (es) 2012-04-04 2013-03-15 Terapia de combinación con un agente antihialuronano y un taxano orientado a tumor.
MX2022013713A MX2022013713A (es) 2012-04-04 2014-10-03 Combinaciones anticancer de un agente antihialuronato y un taxano orientado a tumor.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022013713A MX2022013713A (es) 2012-04-04 2014-10-03 Combinaciones anticancer de un agente antihialuronato y un taxano orientado a tumor.

Country Status (27)

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US (3) US9913822B2 (es)
EP (1) EP2833905B1 (es)
JP (4) JP6042527B2 (es)
KR (2) KR101626703B1 (es)
CN (2) CN108686203A (es)
AU (1) AU2013243873B2 (es)
BR (1) BR112014024848A2 (es)
CA (3) CA3152081A1 (es)
CY (1) CY1120523T1 (es)
DK (1) DK2833905T3 (es)
EA (1) EA031986B1 (es)
ES (1) ES2673093T3 (es)
HR (1) HRP20181187T1 (es)
HU (1) HUE038744T2 (es)
IL (2) IL234703B (es)
LT (1) LT2833905T (es)
MX (2) MX360092B (es)
NZ (1) NZ700073A (es)
PL (1) PL2833905T3 (es)
PT (1) PT2833905T (es)
RS (1) RS57449B1 (es)
SG (1) SG11201406340QA (es)
SI (1) SI2833905T1 (es)
SM (1) SMT201800366T1 (es)
TR (1) TR201809231T4 (es)
WO (1) WO2013151774A1 (es)
ZA (1) ZA201406969B (es)

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CN102943067B (zh) 2003-03-05 2016-06-22 海洋酶公司 可溶性透明质酸酶糖蛋白(sHASEGP)、制备它们的方法、它们的用途和包含它们的药物组合物
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
SG187427A1 (en) 2008-04-14 2013-02-28 Halozyme Inc Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
MX2011004019A (es) 2008-10-15 2011-06-24 Angiochem Inc Conjugados de etoposido y doxorubicina para entrega de farmacos.
RU2011118056A (ru) 2008-10-15 2012-11-27 Ангиокем Инк. Конъюгаты агонистов glp-1 и их применение
CN102307904A (zh) 2008-12-05 2012-01-04 安吉奥开米公司 神经降压素或神经降压素类似物的缀合物及其用途
DK3037529T3 (da) * 2008-12-09 2019-05-20 Halozyme Inc Udvidede opløselige ph20-polypeptider og anvendelse deraf
CN102300987A (zh) 2008-12-17 2011-12-28 安吉奥开米公司 膜型-1基质金属蛋白抑制剂及其用途
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