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MX353727B - Tratamiento de sinucleinopatias. - Google Patents

Tratamiento de sinucleinopatias.

Info

Publication number
MX353727B
MX353727B MX2009012307A MX2009012307A MX353727B MX 353727 B MX353727 B MX 353727B MX 2009012307 A MX2009012307 A MX 2009012307A MX 2009012307 A MX2009012307 A MX 2009012307A MX 353727 B MX353727 B MX 353727B
Authority
MX
Mexico
Prior art keywords
synucleinopathies
treatment
subjects
well
relates generally
Prior art date
Application number
MX2009012307A
Other languages
English (en)
Other versions
MX2009012307A (es
Inventor
Schloss-Macher Michael
Cullen Valerie
Shihabuddin Lamya
H Cheng Seng
Original Assignee
The Brigham And Womens Hospital Inc Star
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40122277&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX353727(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Brigham And Womens Hospital Inc Star filed Critical The Brigham And Womens Hospital Inc Star
Publication of MX2009012307A publication Critical patent/MX2009012307A/es
Publication of MX353727B publication Critical patent/MX353727B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
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    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22041—Cathepsin F (3.4.22.41)
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    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23005—Cathepsin D (3.4.23.5)

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

La presente invención se refiere de manera general a tratar sinucleinopatías en sujetos que no son diagnosticados clínicamente con una enfermedad de almacenamiento lisosomal, así como asociada con método para hacer medicamente y método de clasificación.
MX2009012307A 2007-05-16 2008-05-16 Tratamiento de sinucleinopatias. MX353727B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93046207P 2007-05-16 2007-05-16
US92955407P 2007-07-03 2007-07-03
PCT/US2008/064017 WO2008144591A2 (en) 2007-05-16 2008-05-16 Treatment of synucleinopathies

Publications (2)

Publication Number Publication Date
MX2009012307A MX2009012307A (es) 2010-02-10
MX353727B true MX353727B (es) 2017-12-18

Family

ID=40122277

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012307A MX353727B (es) 2007-05-16 2008-05-16 Tratamiento de sinucleinopatias.

Country Status (17)

Country Link
US (4) US8454954B2 (es)
EP (2) EP3000320B1 (es)
JP (4) JP5291093B2 (es)
CN (2) CN101754682B (es)
AU (1) AU2008254774B2 (es)
BR (1) BRPI0811265A2 (es)
CA (1) CA2684946C (es)
CY (1) CY1117312T1 (es)
DK (1) DK2154969T3 (es)
ES (1) ES2559859T3 (es)
HR (1) HRP20151409T1 (es)
HU (1) HUE027278T2 (es)
MX (1) MX353727B (es)
PL (1) PL2154969T3 (es)
PT (1) PT2154969E (es)
SI (1) SI2154969T1 (es)
WO (1) WO2008144591A2 (es)

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JP2017075181A (ja) 2017-04-20
JP2013241411A (ja) 2013-12-05
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US20130177549A1 (en) 2013-07-11
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