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MX352812B - Fabricacion de acido 2- (5-bromo-4- (4-ciclopropilnaftalen-1-il) -4h-1,2,4-triazol-3-iltio) acetico. - Google Patents

Fabricacion de acido 2- (5-bromo-4- (4-ciclopropilnaftalen-1-il) -4h-1,2,4-triazol-3-iltio) acetico.

Info

Publication number
MX352812B
MX352812B MX2015000082A MX2015000082A MX352812B MX 352812 B MX352812 B MX 352812B MX 2015000082 A MX2015000082 A MX 2015000082A MX 2015000082 A MX2015000082 A MX 2015000082A MX 352812 B MX352812 B MX 352812B
Authority
MX
Mexico
Prior art keywords
cyclopropylnaphthalen
ylthio
triazol
bromo
manufacture
Prior art date
Application number
MX2015000082A
Other languages
English (en)
Other versions
MX2015000082A (es
Inventor
Gunic Esmir
Galvin Gabriel
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of MX2015000082A publication Critical patent/MX2015000082A/es
Publication of MX352812B publication Critical patent/MX352812B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)

Abstract

En el presente documento, se describen ciertos procesos de síntesis de compuestos de Fórmula (I): (ver Fórmula).
MX2015000082A 2012-07-03 2013-07-02 Fabricacion de acido 2- (5-bromo-4- (4-ciclopropilnaftalen-1-il) -4h-1,2,4-triazol-3-iltio) acetico. MX352812B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261667922P 2012-07-03 2012-07-03
PCT/US2013/049135 WO2014008295A1 (en) 2012-07-03 2013-07-02 Manufacture of 2- (5- bromo-4 (-cyclopropylnaphthalen-1-yl) -4h-1,2,4-triazol-3-ylthio) acetic acid

Publications (2)

Publication Number Publication Date
MX2015000082A MX2015000082A (es) 2015-09-04
MX352812B true MX352812B (es) 2017-12-08

Family

ID=49882471

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015000082A MX352812B (es) 2012-07-03 2013-07-02 Fabricacion de acido 2- (5-bromo-4- (4-ciclopropilnaftalen-1-il) -4h-1,2,4-triazol-3-iltio) acetico.

Country Status (25)

Country Link
US (2) US9296709B2 (es)
EP (1) EP2870142B1 (es)
JP (1) JP6124226B2 (es)
KR (1) KR20150028992A (es)
CN (1) CN104736522B (es)
AR (1) AR091651A1 (es)
AU (1) AU2013286739B2 (es)
BR (1) BR112015000160A2 (es)
CA (1) CA2878027A1 (es)
CO (1) CO7170165A2 (es)
ES (1) ES2609595T3 (es)
HU (1) HUE031416T2 (es)
IL (1) IL236413A (es)
MX (1) MX352812B (es)
MY (1) MY174629A (es)
NZ (1) NZ631044A (es)
PL (1) PL2870142T3 (es)
PT (1) PT2870142T (es)
RU (1) RU2666549C2 (es)
SA (2) SA115360678B1 (es)
SG (1) SG11201408800VA (es)
SI (1) SI2870142T1 (es)
TW (2) TWI634110B (es)
WO (1) WO2014008295A1 (es)
ZA (1) ZA201409489B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR091651A1 (es) 2012-07-03 2015-02-18 Ardea Biosciences Inc Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico
WO2014198241A1 (en) * 2013-06-14 2014-12-18 Sunshine Lake Pharma Co., Ltd. Thio-1,2,4-triazole derivatives and method for preparing the same
CN103524440B (zh) * 2013-10-15 2015-09-09 苏州鹏旭医药科技有限公司 痛风治疗药Lesinurad的制备方法及Lesinurad中间体
US10351536B2 (en) * 2013-11-22 2019-07-16 Crystal Pharmatech Co., Ltd. Crystalline forms of lesinurad and its sodium salt
ES2956953T3 (es) * 2014-06-06 2024-01-05 Scripps Research Inst Compuestos de fluoruro de azufre (VI) y su uso en reacción click
CN105294585B (zh) * 2014-07-02 2019-02-12 成都海创药业有限公司 一种治疗痛风的化合物
CN105315218A (zh) * 2014-07-17 2016-02-10 天津药物研究院 一种制备lesinurad中间体1-萘基三唑硫酮的方法
CN104341361B (zh) * 2014-10-27 2017-01-11 张远强 一种腈基取代三氮唑亚磺酰丙二酸类化合物、其制备方法及用途
CN104326999B (zh) * 2014-10-27 2017-01-18 张远强 烷氧基取代的三氮唑亚磺酰丙二酸类化合物、其制备方法及用途
CN104311498B (zh) * 2014-10-27 2016-04-06 张远强 烷氧基取代的三氮唑磺酰丙二酸类化合物、其制备方法及用途
CN105820130B (zh) * 2015-01-08 2018-06-22 天津药物研究院有限公司 三氮唑正丙酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途
CN105985296B (zh) * 2015-02-13 2018-10-16 天津药物研究院有限公司 一种可以工业化的lesinurad中间体1-萘基三唑硫酮的精制工艺
CN109053608A (zh) * 2015-02-17 2018-12-21 华润赛科药业有限责任公司 一种旋光纯的硫代乙酸类化合物、其药物组合物和用途
CN104788318A (zh) * 2015-03-23 2015-07-22 爱斯特（成都）生物制药有限公司 一种4-硝基-环丙基萘的制备方法
CN105622531A (zh) * 2015-04-03 2016-06-01 南京明德新药研发股份有限公司 轴手性异构体及其制备方法和制药用途
CN104817509B (zh) * 2015-04-13 2019-05-17 安徽省逸欣铭医药科技有限公司 Lesinurad类似物及其制备方法和医药用途
CN106187926B (zh) * 2015-04-30 2018-11-27 天津药物研究院有限公司 含二芳基甲烷结构的羧酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途
EP3112334A1 (en) 2015-06-29 2017-01-04 DPx Fine Chemicals Austria GmbH & CoKG Process for manufacturing 1-cyclopropyl-naphthalenes
CN104987311A (zh) * 2015-06-30 2015-10-21 安徽万邦医药科技有限公司 一种[4-(4-环丙基萘-1-基)-5-硝基- 4h-[1,2,4]三唑-3-基硫烷基]-乙酸乙酯的制备方法及其中间体(5-硝基-4h-[1,2,4]三唑-3-基硫基)-乙酸乙酯
CN105017168A (zh) * 2015-07-01 2015-11-04 安徽万邦医药科技有限公司 一种[5-溴-4-(4-环丙基萘-1-基)-4h-[1,2,4]三唑-3-基硫烷基]-乙酸甲酯的新制备方法
WO2017036884A1 (en) 2015-08-28 2017-03-09 Sandoz Ag A lesinurad, free form / lesinurad ethyl ester co-crystal
CN105175348A (zh) * 2015-10-16 2015-12-23 北京康立生医药技术开发有限公司 一种乐司尼达的制备方法
CN105399694B (zh) * 2015-12-11 2017-09-15 浙江京新药业股份有限公司 药物Lesinurad轴手性对映体
WO2017147270A1 (en) * 2016-02-24 2017-08-31 Ardea Biosciences, Inc. Atropisomers of triazole derivative
CN105906576B (zh) * 2016-06-12 2018-04-17 成都百裕制药股份有限公司 一种来司诺雷中间体的制备方法
CN106083680B (zh) * 2016-06-21 2018-11-02 山东川成医药股份有限公司 一种4-环丙基-1-萘基异硫氰酸酯的制备方法
CN106187927B (zh) * 2016-07-26 2020-02-04 山东川成医药股份有限公司 一种Lesinurad中间体的制备方法
CN106220577A (zh) * 2016-07-26 2016-12-14 苏州明锐医药科技有限公司 利新洛德的制备方法
EP3281941B1 (en) 2016-08-11 2019-07-24 Zentiva K.S. Process for preparing 2-(5-bromo-4-(1-cyclopropylnaphthalen-4-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid
CN106632108A (zh) * 2016-12-14 2017-05-10 湖南欧亚生物有限公司 一种来司诺雷的制备方法
EP3372592A1 (en) 2017-03-07 2018-09-12 Zentiva, k.s. Solid forms of lesinurad amine salts
US10351537B2 (en) 2017-03-10 2019-07-16 Apotex Inc. Processes for the preparation of lesinurad and intermediates thereof
EP3315494A1 (en) 2017-04-19 2018-05-02 Química Sintética, S.A. Amorphous form of lesinurad and processes for its preparation
CN108947919B (zh) 2017-05-17 2023-05-02 上海奥博生物医药股份有限公司 一种抗痛风药Lesinurad的新型制备方法及其关键中间体
CN109206323A (zh) * 2017-07-07 2019-01-15 上海现代制药股份有限公司 一种萘胺药物中间体的制备方法
CN107739344A (zh) * 2017-10-10 2018-02-27 浙江新东港药业股份有限公司 制备Lesinurd的方法及其中间体
EP3498697A1 (en) 2017-12-12 2019-06-19 Química Sintética, S.A. Novel salts and polymorphs of lesinurad
CN109970667A (zh) * 2017-12-27 2019-07-05 徐州万邦金桥制药有限公司 一种雷西纳德的精制方法
CN108047148A (zh) * 2017-12-28 2018-05-18 北京沃邦医药科技有限公司 一种雷西纳德杂质的制备方法
CN110878045A (zh) * 2018-09-05 2020-03-13 江西同和药业股份有限公司 一种化合物及其制备方法和应用
CN111116500B (zh) * 2019-12-30 2021-06-08 北京鑫开元医药科技有限公司海南分公司 一种雷西纳德关键中间体的纯化方法
CN111116501B (zh) * 2019-12-30 2021-03-12 北京鑫开元医药科技有限公司海南分公司 一种有效降低杂质含量的雷西纳德中间体的合成方法
CN115697976B (zh) * 2020-06-11 2025-10-10 江苏康缘药业股份有限公司 一种氯代化合物的制备方法
CN112778223A (zh) * 2021-01-25 2021-05-11 海南鑫开源医药科技有限公司 一种雷西纳德氧化杂质的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060135556A1 (en) 2002-08-23 2006-06-22 Jean-Luc Girardet Non-nucleoside reverse transcriptase inhibitors
ATE528001T1 (de) 2004-08-25 2011-10-15 Ardea Biosciences Inc S-triazolyl-alpha-mercaptoacetanilide als inhibitoren von hiv-umkehrtranskriptase
WO2007050087A1 (en) 2004-08-25 2007-05-03 Ardea Biosciences, Inc. N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS
CN103058944B (zh) 2007-11-27 2015-08-05 亚德生化公司 调节血液尿酸水平的化合物
KR101294872B1 (ko) * 2008-09-04 2013-08-08 아디아 바이오사이언스즈 인크. 요산 수치를 조절하기 위한 화합물, 조성물 및 이들의 사용 방법
US8242154B2 (en) 2008-09-04 2012-08-14 Ardea Biosciences, Inc. Compounds, compositions and methods of using same for modulating uric acid levels
US8173690B2 (en) * 2008-09-04 2012-05-08 Ardea Biosciences, Inc. Compounds, compositions and methods of using same for modulating uric acid levels
PH12012501391A1 (en) * 2010-01-08 2012-10-29 Ardea Biosciences Inc Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetate, and uses thereof
CA2794798C (en) 2010-03-30 2017-05-30 Ardea Biosciences, Inc. Treatment of gout
RS57275B1 (sr) 2010-06-15 2018-08-31 Ardea Biosciences Inc Tretman gihta i hiperurikemije
CA2813555C (en) 2010-10-15 2014-11-25 Ardea Biosciences, Inc. Methods for treating hyperuricemia and related diseases
EP2658846B1 (en) 2010-12-30 2016-12-14 Ardea Biosciences, Inc. Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid and uses thereof
AR091651A1 (es) 2012-07-03 2015-02-18 Ardea Biosciences Inc Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico

Also Published As

Publication number Publication date
EP2870142A4 (en) 2016-01-06
CA2878027A1 (en) 2014-01-09
US20160214947A1 (en) 2016-07-28
US20150252010A1 (en) 2015-09-10
TW201604186A (zh) 2016-02-01
TW201406734A (zh) 2014-02-16
WO2014008295A1 (en) 2014-01-09
SA115360678B1 (ar) 2016-09-08
KR20150028992A (ko) 2015-03-17
WO2014008295A8 (en) 2015-01-08
BR112015000160A2 (pt) 2017-06-27
US9296709B2 (en) 2016-03-29
TWI621615B (zh) 2018-04-21
RU2015102723A (ru) 2016-08-20
EP2870142A1 (en) 2015-05-13
RU2666549C2 (ru) 2018-09-18
SG11201408800VA (en) 2015-01-29
JP2015525749A (ja) 2015-09-07
PL2870142T3 (pl) 2017-04-28
AR091651A1 (es) 2015-02-18
HK1206359A1 (en) 2016-01-08
NZ631044A (en) 2015-12-24
IL236413A0 (en) 2015-02-26
TWI634110B (zh) 2018-09-01
CN104736522A (zh) 2015-06-24
CO7170165A2 (es) 2015-01-28
MY174629A (en) 2020-05-03
EP2870142B1 (en) 2016-10-19
SA113340696B1 (ar) 2016-03-06
ES2609595T3 (es) 2017-04-21
HUE031416T2 (en) 2017-07-28
JP6124226B2 (ja) 2017-05-10
IL236413A (en) 2016-11-30
SI2870142T1 (sl) 2017-02-28
AU2013286739B2 (en) 2017-02-23
MX2015000082A (es) 2015-09-04
CN104736522B (zh) 2018-10-09
PT2870142T (pt) 2016-12-27
AU2013286739A1 (en) 2015-01-22
ZA201409489B (en) 2019-01-30

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