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MX2024011378A - Compuestos de urea triciclica como inhibidores de la variante v617f de la cinasa de janus 2 (jak2). - Google Patents

Compuestos de urea triciclica como inhibidores de la variante v617f de la cinasa de janus 2 (jak2).

Info

Publication number
MX2024011378A
MX2024011378A MX2024011378A MX2024011378A MX2024011378A MX 2024011378 A MX2024011378 A MX 2024011378A MX 2024011378 A MX2024011378 A MX 2024011378A MX 2024011378 A MX2024011378 A MX 2024011378A MX 2024011378 A MX2024011378 A MX 2024011378A
Authority
MX
Mexico
Prior art keywords
jak2
urea compounds
inhibitors
tricyclic urea
tricyclic
Prior art date
Application number
MX2024011378A
Other languages
English (en)
Inventor
Eddy W Yue
Ke Zhang
Chunhong He
Yanran Ai
Cooper Taylor
Zhitong Zheng
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MX2024011378A publication Critical patent/MX2024011378A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente solicitud proporciona compuestos de urea tricíclica que modulan la actividad de la variante V617F de JAK2, que son útiles en el tratamiento de varias enfermedades, incluido el cáncer.
MX2024011378A 2022-03-17 2023-03-16 Compuestos de urea triciclica como inhibidores de la variante v617f de la cinasa de janus 2 (jak2). MX2024011378A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263320909P 2022-03-17 2022-03-17
US202263396826P 2022-08-10 2022-08-10
PCT/US2023/064593 WO2023178285A1 (en) 2022-03-17 2023-03-16 Tricyclic urea compounds as jak2 v617f inhibitors

Publications (1)

Publication Number Publication Date
MX2024011378A true MX2024011378A (es) 2024-09-23

Family

ID=85979784

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2024011378A MX2024011378A (es) 2022-03-17 2023-03-16 Compuestos de urea triciclica como inhibidores de la variante v617f de la cinasa de janus 2 (jak2).

Country Status (17)

Country Link
US (2) US12084430B2 (es)
EP (1) EP4493558A1 (es)
JP (1) JP2025509672A (es)
KR (1) KR20240163688A (es)
CN (1) CN119173514A (es)
AU (1) AU2023235313A1 (es)
CA (1) CA3254582A1 (es)
CL (1) CL2024002772A1 (es)
CO (1) CO2024014060A2 (es)
CR (1) CR20240447A (es)
DO (1) DOP2024000183A (es)
GE (1) GEAP202416612A (es)
IL (1) IL315647A (es)
MX (1) MX2024011378A (es)
PE (1) PE20251706A1 (es)
TW (1) TW202337453A (es)
WO (1) WO2023178285A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS66978B1 (sr) 2020-07-02 2025-07-31 Incyte Corp Triciklična jedinjenja uree kao inhibitori jak2 v617f
KR20240163688A (ko) 2022-03-17 2024-11-19 인사이트 코포레이션 Jak2 v617f 억제제로서의 삼환계 우레아 화합물
WO2025111464A1 (en) * 2023-11-22 2025-05-30 Raythera, Inc. Jak2 v617f inhibitors and methods of use thereof

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KR20240163688A (ko) 2022-03-17 2024-11-19 인사이트 코포레이션 Jak2 v617f 억제제로서의 삼환계 우레아 화합물

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