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MX2024005968A - PEPTIDE THAT HAS AFFINITY FOR THE HUMAN TRANSFERRIN RECEPTOR. - Google Patents

PEPTIDE THAT HAS AFFINITY FOR THE HUMAN TRANSFERRIN RECEPTOR.

Info

Publication number
MX2024005968A
MX2024005968A MX2024005968A MX2024005968A MX2024005968A MX 2024005968 A MX2024005968 A MX 2024005968A MX 2024005968 A MX2024005968 A MX 2024005968A MX 2024005968 A MX2024005968 A MX 2024005968A MX 2024005968 A MX2024005968 A MX 2024005968A
Authority
MX
Mexico
Prior art keywords
peptide
affinity
transferrin receptor
human transferrin
amino acid
Prior art date
Application number
MX2024005968A
Other languages
Spanish (es)
Inventor
Kenichi Takahashi
Takashi Onouchi
Original Assignee
Japan Chem Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Chem Res filed Critical Japan Chem Res
Publication of MX2024005968A publication Critical patent/MX2024005968A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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Abstract

La presente invención se refiere, en una modalidad de la misma, a un péptido que tiene afinidad por el receptor de transferrina humano, el cual se puede utilizar para unirse a cualquiera de los compuestos (una proteína, un ácido nucleico, un compuesto de bajo peso molecular, y similares) que deben ser provocados para funcionar en el sistema nervioso central (SNC), con el fin de permitir que el compuesto atraviese la barrera hematoencefálica, y el uso del péptido. El péptido es, por ejemplo, un péptido que tiene la secuencia de aminoácidos seleccionada del grupo que consiste en secuencias de aminoácidos establecidas en SEQ ID NOS: 3 a 7 y 55, o un mutante de la misma.The present invention relates, in one embodiment thereof, to a peptide having affinity for the human transferrin receptor, which can be used to bind to any of the compounds (a protein, a nucleic acid, a low molecular weight compound, and the like) that are to be caused to function in the central nervous system (CNS), in order to allow the compound to cross the blood-brain barrier, and the use of the peptide. The peptide is, for example, a peptide having the amino acid sequence selected from the group consisting of amino acid sequences set forth in SEQ ID NOS: 3 to 7 and 55, or a mutant thereof.

MX2024005968A 2021-11-19 2022-11-18 PEPTIDE THAT HAS AFFINITY FOR THE HUMAN TRANSFERRIN RECEPTOR. MX2024005968A (en)

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WO2024080304A1 (en) * 2022-10-11 2024-04-18 Ｊｃｒファーマ株式会社 Fusion protein of serum albumin and physiologically active protein
AR131798A1 (en) * 2023-02-07 2025-04-30 Japan Chem Res HUMAN TRANSFERRIN RECEPTOR AFFINITY PEPTIDE
WO2025120571A1 (en) * 2023-12-05 2025-06-12 Janssen Biotech, Inc. Compositions and methods to discover targeted oligonucleotide conjugates

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ATE405679T1 (en) 1993-10-19 2008-09-15 Scripps Research Inst SYNTHETIC HUMAN NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST HIV
AUPN523995A0 (en) 1995-09-05 1995-09-28 Crc For Biopharmaceutical Research Pty Ltd Method for producing phage display vectors
US8142781B2 (en) 2005-10-07 2012-03-27 Armagen Technologies, Inc. Fusion proteins for blood-brain barrier delivery
WO2008022349A2 (en) 2006-08-18 2008-02-21 Armagen Technologies, Inc. Agents for blood-brain barrier delivery
EP2997976A1 (en) 2007-07-27 2016-03-23 Armagen Technologies, Inc. Methods and compositions for increasing alpha-l-iduronidase activity in the cns
HRP20190690T1 (en) 2009-10-09 2019-06-28 Armagen, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the cns
EP2639303B1 (en) 2010-11-08 2017-06-07 JCR Pharmaceuticals CO., LTD. Novel expression vector
CA2967830A1 (en) * 2014-11-14 2016-05-19 Ossianix, Inc. Tfr selective binding compounds and related methods
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MX2018000305A (en) 2015-06-24 2018-03-14 Japan Chem Res Anti-human transferrin receptor antibody permeating blood-brain barrier.
CA3052936A1 (en) 2016-12-26 2018-07-05 Jcr Pharmaceuticals Co., Ltd. Fusion protein of bdnf and anti-transferrin receptor antibody
EA201991577A1 (en) * 2016-12-26 2019-12-30 Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД. NEW ANTIBODIES AGAINST THE HUMAN TRANSFERRIN RECEPTOR, ABLE TO BREAK THE HEMATOENCEPHALIC BARRIER
EP3908608A1 (en) * 2019-01-09 2021-11-17 Vect-Horus Transferrin receptor-binding molecules, conjugates thereof and their uses
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