[go: up one dir, main page]

MX2023002439A - Immunogenic compositions and uses thereof. - Google Patents

Immunogenic compositions and uses thereof.

Info

Publication number
MX2023002439A
MX2023002439A MX2023002439A MX2023002439A MX2023002439A MX 2023002439 A MX2023002439 A MX 2023002439A MX 2023002439 A MX2023002439 A MX 2023002439A MX 2023002439 A MX2023002439 A MX 2023002439A MX 2023002439 A MX2023002439 A MX 2023002439A
Authority
MX
Mexico
Prior art keywords
immunogenic compositions
immunogenic polypeptides
encoding
pharmaceutical preparations
provides compositions
Prior art date
Application number
MX2023002439A
Other languages
Spanish (es)
Inventor
Avak Kahvejian
Nicholas Mccartney Plugis
Erica Gabrielle Weinstein
Boer Alexandra Sophie De
ECHELARD Yann Paul Guy Régis
Jennifer A Nelson
Original Assignee
Flagship Pioneering Innovations Vi Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flagship Pioneering Innovations Vi Llc filed Critical Flagship Pioneering Innovations Vi Llc
Publication of MX2023002439A publication Critical patent/MX2023002439A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C12N2840/206—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

This disclosure provides compositions, pharmaceutical preparations, and uses of polyribonucleotides encoding one or more immunogenic polypeptides. In particular, this disclosure features circular polyribonucleotide encoding one or more immunogenic polypeptides.
MX2023002439A 2020-09-03 2021-09-03 Immunogenic compositions and uses thereof. MX2023002439A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063074428P 2020-09-03 2020-09-03
US202063125769P 2020-12-15 2020-12-15
US202163191020P 2021-05-20 2021-05-20
PCT/US2021/049077 WO2022051629A1 (en) 2020-09-03 2021-09-03 Immunogenic compositions and uses thereof

Publications (1)

Publication Number Publication Date
MX2023002439A true MX2023002439A (en) 2023-05-09

Family

ID=77951867

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023002439A MX2023002439A (en) 2020-09-03 2021-09-03 Immunogenic compositions and uses thereof.

Country Status (9)

Country Link
EP (1) EP4208196A1 (en)
JP (1) JP2023542492A (en)
CN (1) CN116157148A (en)
AU (1) AU2021336976A1 (en)
CA (1) CA3193746A1 (en)
IL (1) IL300947A (en)
MX (1) MX2023002439A (en)
TW (1) TW202218669A (en)
WO (1) WO2022051629A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202330916A (en) 2021-09-17 2023-08-01 美商旗艦先鋒創新有限責任公司 Compositions and methods for producing circular polyribonucleotides
JP2025509106A (en) * 2022-03-21 2025-04-11 バイオ アドヴェンチャー カンパニー リミテッド Internal ribosome entry sites (IRES), plasmid vectors and circular mRNA for enhancing protein expression
JP2025520111A (en) * 2022-06-01 2025-07-01 フラッグ バイオ， インコーポレイテッド RNA adjuvants, methods and uses thereof
US20250161406A1 (en) * 2022-06-07 2025-05-22 University Of South Florida Preventing alu sines-mediated pathologies

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US99823A (en) 1870-02-15 Improved indigo soap
AU649066B2 (en) 1990-07-25 1994-05-12 Syngene, Inc. Circular extension for generating multiple nucleic acid complements
US5426180A (en) 1991-03-27 1995-06-20 Research Corporation Technologies, Inc. Methods of making single-stranded circular oligonucleotides
EP0623171A4 (en) 1992-01-13 1997-02-12 Univ Duke Enzymatic rna molecules.
US5773244A (en) 1993-05-19 1998-06-30 Regents Of The University Of California Methods of making circular RNA
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5766903A (en) 1995-08-23 1998-06-16 University Technology Corporation Circular RNA and uses thereof
US5849727A (en) 1996-06-28 1998-12-15 Board Of Regents Of The University Of Nebraska Compositions and methods for altering the biodistribution of biological agents
CA2289702C (en) 1997-05-14 2008-02-19 Inex Pharmaceuticals Corp. High efficiency encapsulation of charged therapeutic agents in lipid vesicles
US6429301B1 (en) 1998-04-17 2002-08-06 Whitehead Institute For Biomedical Research Use of a ribozyme to join nucleic acids and peptides
US6693086B1 (en) 1998-06-25 2004-02-17 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
US6210931B1 (en) 1998-11-30 2001-04-03 The United States Of America As Represented By The Secretary Of Agriculture Ribozyme-mediated synthesis of circular RNA
US20030077829A1 (en) 2001-04-30 2003-04-24 Protiva Biotherapeutics Inc.. Lipid-based formulations
IL161100A0 (en) 2001-09-28 2004-08-31 Max Planck Gesellschaft Identification of novel genes coding for small temporal rnas
EP1648914A4 (en) 2003-07-31 2009-12-16 Regulus Therapeutics Inc OLIGOMER COMPOUNDS AND COMPOSITIONS FOR USE IN THE MODULATION OF SMALL NON-CODING RNAS
AU2004272646B2 (en) 2003-09-15 2011-11-24 Arbutus Biopharma Corporation Polyethyleneglycol-modified lipid compounds and uses thereof
JP4380411B2 (en) 2004-04-30 2009-12-09 澁谷工業株式会社 Sterilization method
DK1830888T3 (en) 2004-12-27 2015-10-19 Silence Therapeutics Gmbh LIPID COMPLEX COATED WITH PEG AND APPLICATION THEREOF
US7404969B2 (en) 2005-02-14 2008-07-29 Sirna Therapeutics, Inc. Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
AU2006325030B2 (en) 2005-12-16 2012-07-26 Cellectis Cell penetrating peptide conjugates for delivering nucleic acids into cells
KR100859972B1 (en) 2006-02-20 2008-09-25 이화여자대학교 산학협력단 Cell membrane-penetrating peptide
WO2008008230A2 (en) 2006-07-10 2008-01-17 Memsic, Inc. A system for sensing yaw rate using a magnetic field sensor and portable electronic devices using the same
JP5296328B2 (en) 2007-05-09 2013-09-25 独立行政法人理化学研究所 Single-stranded circular RNA and method for producing the same
CA2709875C (en) 2008-01-02 2019-07-16 Tekmira Pharmaceuticals Corporation Improved compositions and methods for the delivery of nucleic acids
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
WO2009132131A1 (en) 2008-04-22 2009-10-29 Alnylam Pharmaceuticals, Inc. Amino lipid based improved lipid formulation
WO2010037408A1 (en) * 2008-09-30 2010-04-08 Curevac Gmbh Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
PL2350043T3 (en) 2008-10-09 2014-09-30 Tekmira Pharmaceuticals Corp Improved amino lipids and methods for the delivery of nucleic acids
WO2010048228A2 (en) 2008-10-20 2010-04-29 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of transthyretin
WO2010053572A2 (en) 2008-11-07 2010-05-14 Massachusetts Institute Of Technology Aminoalcohol lipidoids and uses thereof
WO2010054384A1 (en) 2008-11-10 2010-05-14 Alnylam Pharmaceuticals, Inc. Lipids and compositions for the delivery of therapeutics
WO2010054406A1 (en) 2008-11-10 2010-05-14 Alnylam Pharmaceuticals, Inc. Novel lipids and compositions for the delivery of therapeutics
WO2010084371A1 (en) 2009-01-26 2010-07-29 Mitoprod Novel circular interfering rna molecules
KR102066189B1 (en) 2009-06-10 2020-01-14 알닐람 파마슈티칼스 인코포레이티드 Improved lipid formulation
US8569256B2 (en) 2009-07-01 2013-10-29 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
JP5766188B2 (en) 2009-07-01 2015-08-19 プロチバ バイオセラピューティクス インコーポレイティッド Lipid formulations for delivering therapeutic agents to solid tumors
ES2579936T3 (en) 2009-08-20 2016-08-17 Sirna Therapeutics, Inc. New cationic lipids with various head groups for oligonucleotide delivery
WO2011066651A1 (en) 2009-12-01 2011-06-09 Protiva Biotherapeutics, Inc. Snalp formulations containing antioxidants
EP2525781A1 (en) 2010-01-22 2012-11-28 Schering Corporation Novel cationic lipids for oligonucleotide delivery
WO2011097480A1 (en) 2010-02-05 2011-08-11 University Of Louisville Research Foundation, Inc. Exosomal compositions and methods for the treatment of disease
JP2013527856A (en) 2010-05-12 2013-07-04 プロチバ バイオセラピューティクス インコーポレイティッド Cationic lipids and methods of use
WO2011141704A1 (en) 2010-05-12 2011-11-17 Protiva Biotherapeutics, Inc Novel cyclic cationic lipids and methods of use
SG186085A1 (en) 2010-06-03 2013-01-30 Alnylam Pharmaceuticals Inc Biodegradable lipids for the delivery of active agents
EP2575767B1 (en) 2010-06-04 2017-01-04 Sirna Therapeutics, Inc. Novel low molecular weight cationic lipids for oligonucleotide delivery
RU2556800C2 (en) 2010-06-14 2015-07-20 Ф.Хоффманн-Ля Рош Аг Cell-penetrating peptides and thereof application
US9006417B2 (en) 2010-06-30 2015-04-14 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
WO2012016184A2 (en) 2010-07-30 2012-02-02 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
DK4226941T3 (en) 2010-08-31 2024-12-02 Glaxosmithkline Biologicals Sa PEGYLATED LIPOSOMES FOR DELIVERY OF IMMUNOGEN-ENCODING RNA
CN103384515B (en) 2010-08-31 2017-02-15 诺华有限公司 Lipids suitable for liposomal delivery of protein-coding RNA
WO2012040184A2 (en) 2010-09-20 2012-03-29 Merck Sharp & Dohme Corp. Novel low molecular weight cationic lipids for oligonucleotide delivery
EP2621480B1 (en) 2010-09-30 2018-08-15 Sirna Therapeutics, Inc. Low molecular weight cationic lipids for oligonucleotide delivery
US9029590B2 (en) 2010-10-21 2015-05-12 Sirna Therapeutics, Inc. Low molecular weight cationic lipids for oligonucleotide delivery
US9617461B2 (en) 2010-12-06 2017-04-11 Schlumberger Technology Corporation Compositions and methods for well completions
US9999673B2 (en) 2011-01-11 2018-06-19 Alnylam Pharmaceuticals, Inc. PEGylated lipids and their use for drug delivery
CN103764121A (en) 2011-07-06 2014-04-30 诺华股份有限公司 Liposomes having useful N:P ratio for delivery of RNA molecules
WO2013016058A1 (en) 2011-07-22 2013-01-31 Merck Sharp & Dohme Corp. Novel bis-nitrogen containing cationic lipids for oligonucleotide delivery
WO2013049328A1 (en) 2011-09-27 2013-04-04 Alnylam Pharmaceuticals, Inc. Di-aliphatic substituted pegylated lipids
PE20181541A1 (en) 2011-10-27 2018-09-26 Massachusetts Inst Technology DERIVATIVES OF AMINO ACIDS FUNCTIONALIZED IN THE N TERMINAL, CAPABLE OF FORMING DRUG ENCAPSULATING MICROSPHERES
WO2013070324A1 (en) 2011-11-07 2013-05-16 University Of Louisville Research Foundation, Inc. Edible plant-derived microvesicle compositions for diagnosis and treatment of disease
EP2781507B1 (en) 2011-11-18 2017-03-22 Nof Corporation Cationic lipid having improved intracellular kinetics
HK1200089A1 (en) 2011-12-07 2015-07-31 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
WO2013086373A1 (en) 2011-12-07 2013-06-13 Alnylam Pharmaceuticals, Inc. Lipids for the delivery of active agents
CA2856737C (en) 2011-12-07 2023-09-26 Alnylam Pharmaceuticals, Inc. Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents
US9839616B2 (en) 2011-12-12 2017-12-12 Kyowa Hakko Kirin Co., Ltd. Lipid nano particles comprising cationic lipid for drug delivery system
WO2013116126A1 (en) 2012-02-01 2013-08-08 Merck Sharp & Dohme Corp. Novel low molecular weight, biodegradable cationic lipids for oligonucleotide delivery
PT2817287T (en) 2012-02-24 2018-12-28 Arbutus Biopharma Corp Trialkyl cationic lipids and methods of use thereof
WO2013148541A1 (en) 2012-03-27 2013-10-03 Merck Sharp & Dohme Corp. DIETHER BASED BIODEGRADABLE CATIONIC LIPIDS FOR siRNA DELIVERY
EA201891018A1 (en) 2013-03-08 2018-09-28 Новартис Аг LIPIDS AND LIPID COMPOSITIONS FOR DELIVERY OF ACTIVE AGENTS
CN105555757A (en) 2013-07-23 2016-05-04 普洛体维生物治疗公司 Compositions and methods for delivering messenger RNA
CN112656954A (en) 2013-10-22 2021-04-16 夏尔人类遗传性治疗公司 Lipid formulations for delivery of messenger RNA
CN110003066B (en) 2013-11-18 2021-09-03 阿克丘勒斯治疗公司 Ionizable cationic lipids for RNA delivery
US9365610B2 (en) 2013-11-18 2016-06-14 Arcturus Therapeutics, Inc. Asymmetric ionizable cationic lipid for RNA delivery
EP3071515A2 (en) 2013-11-18 2016-09-28 Rubius Therapeutics, Inc. Synthetic membrane-receiver complexes
EP3083556B1 (en) 2013-12-19 2019-12-25 Novartis AG Lipids and lipid compositions for the delivery of active agents
EP3083579B1 (en) 2013-12-19 2022-01-26 Novartis AG Lipids and lipid compositions for the delivery of active agents
RU2736495C2 (en) 2014-04-01 2020-11-17 Рубиус Терапьютикс, Инк. Method and compositions for immunomodulation
IL298516B2 (en) 2014-06-25 2025-03-01 Acuitas Therapeutics Inc Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
WO2016036735A1 (en) 2014-09-05 2016-03-10 The Johns Hopkins University Liposome-based mucus-penetrating particles for mucosal delivery
US20180135012A1 (en) 2015-05-13 2018-05-17 Rubius Therapeutics, Inc. Membrane-receiver complex therapeutics
LT3310764T (en) 2015-06-19 2023-06-12 Massachusetts Institute Of Technology Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell
SI3313829T1 (en) 2015-06-29 2024-09-30 Acuitas Therapeutics Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
EP3316862A4 (en) 2015-07-02 2019-02-06 University of Louisville Research Foundation, Inc. COMPOSITIONS OF MICROVESICLES DERIVED FROM A PLANT FOR THE ADMINISTRATION OF ARNMI AND CANCER TREATMENT METHODS
CA2998810A1 (en) 2015-09-17 2017-03-23 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
RS63986B1 (en) 2015-10-28 2023-03-31 Acuitas Therapeutics Inc Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
ES2924407T3 (en) 2015-12-10 2022-10-06 Modernatx Inc Compositions and methods for the delivery of therapeutic agents
EP3397613A1 (en) 2015-12-30 2018-11-07 Acuitas Therapeutics Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
RS62939B1 (en) 2016-01-11 2022-03-31 Rubius Therapeutics Inc Compositions and methods related to multimodal therapeutic cell systems for cancer indications
JP7245651B2 (en) 2016-03-30 2023-03-24 インテリア セラピューティクス，インコーポレイテッド Lipid Nanoparticle Formulations for CRISPR/CAS Components
WO2018009838A1 (en) 2016-07-07 2018-01-11 Rubius Therapeutics, Inc. Compositions and methods related to therapeutic cell systems expressing exogenous rna
EP3532103B1 (en) 2016-10-26 2025-12-03 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
US20180153989A1 (en) 2016-12-02 2018-06-07 Rubius Therapeutics, Inc. Compositions and methods related to cell systems for penetrating solid tumors
CA3045131A1 (en) 2016-12-14 2018-06-21 Ligandal, Inc. Methods and compositions for nucleic acid and protein payload delivery
BR112019016951A2 (en) 2017-02-17 2020-05-26 Rubius Therapeutics, Inc. FUNCTIONED ERYTHROID CELLS
DK3622079T3 (en) 2017-05-08 2025-11-17 Flagship Pioneering Innovations V Inc COMPOSITIONS FOR FACILITATING MEMBRANE FUSION AND USES THEREOF
US20210059953A1 (en) 2017-09-08 2021-03-04 Generation Bio Co. Lipid nanoparticle formulations of non-viral, capsid-free dna vectors
AR113031A1 (en) 2017-09-29 2020-01-15 Intellia Therapeutics Inc LIPID NANOPARTICLE COMPOSITIONS (LNP) INCLUDING RNA
EA202090873A1 (en) 2017-09-29 2020-08-17 Интеллиа Терапьютикс, Инк. POLYNUCLEOTIDES, COMPOSITIONS AND METHODS FOR EDITING THE GENOME
BR112020011670A2 (en) * 2017-12-15 2020-11-17 Flagship Pioneering Innovations Vi, Llc. compositions comprising circular polyribonucleotides and their uses
US10736957B2 (en) * 2017-12-19 2020-08-11 President And Fellows Of Harvard College Enhanced immunogenicity of mRNA with co-encoded adjuvant sequences
EP3790964A4 (en) 2018-05-11 2022-06-08 Beam Therapeutics, Inc. METHODS OF SUPPRESSING PATHOGENIC MUTATIONS USING BASIC PROGRAMMABLE EDITOR SYSTEMS
AR116016A1 (en) 2018-08-24 2021-03-25 Flagship Pioneering Innovations Vi Llc METHODS FOR MANUFACTURING VEGETABLE MESSENGER PACKAGES
WO2020061457A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
WO2020081938A1 (en) 2018-10-18 2020-04-23 Acuitas Therapeutics, Inc. Lipids for lipid nanoparticle delivery of active agents
US20200157157A1 (en) 2018-11-21 2020-05-21 Translate Bio, Inc. TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR
CA3137956A1 (en) 2019-04-25 2020-10-29 Intellia Therapeutics, Inc. Ionizable amine lipids and lipid nanoparticles
MX2022006854A (en) 2019-12-04 2022-11-30 Orna Therapeutics Inc COMPOSITIONS AND METHODS OF CIRCULAR RNA.

Also Published As

Publication number Publication date
WO2022051629A9 (en) 2022-05-12
CN116157148A (en) 2023-05-23
WO2022051629A1 (en) 2022-03-10
AU2021336976A1 (en) 2023-03-23
EP4208196A1 (en) 2023-07-12
TW202218669A (en) 2022-05-16
CA3193746A1 (en) 2022-03-10
IL300947A (en) 2023-04-01
JP2023542492A (en) 2023-10-10

Similar Documents

Publication Publication Date Title
MX2022014607A (en) Immunogenic compositions and uses thereof.
MX2023002439A (en) Immunogenic compositions and uses thereof.
PH12023500004A1 (en) Conjugated hepcidin mimetics
PH12023550161A1 (en) Pharmaceutical composition and use thereof
EP4501952A3 (en) Conjugated hepcidin mimetics
WO2020198403A3 (en) Compositions comprising modified circular polyribonucleotides and uses thereof
PH12022550988A1 (en) Ras inhibitors
PH12022550973A1 (en) Ras inhibitors
PH12020500241A1 (en) Cytokine conjugates for the treatment of autoimmune diseases
MX2025003235A (en) Compositions and methods for membrane protein delivery
MX2019009839A (en) Functionalized erythroid cells.
CL2019002134A1 (en) Immunomodulatory mRNA therapeutic compositions encoding oncogenic mutation activation peptides.
MX2025003080A (en) Il-15 conjugates and uses thereof
PH12022550510A1 (en) Conjugated hepcidin mimetics
MX2025001906A (en) Anti-ror antibody constructs
MX2022014161A (en) Sars-cov-2 vaccines.
WO2019084343A8 (en) Peptide compositions and methods of use thereof
MX2023009527A (en) Irak4 degraders and uses thereof.
EP3957723A3 (en) Engineered ligase variants
MX2024007966A (en) Novel anti-tslp antibodies.
MX2021011320A (en) Combination therapy with omomyc and an antibody binding pd-1 or ctla-4 for the treatment of cancer.
MX2022007981A (en) Polyether derivatives, uses, and methods of making the same.
ZA202310057B (en) Anti-c-met antibody drug conjugates
MX2023008423A (en) Novel anti-gremlin1 antibodies.
MX2023011400A (en) Immunogenic compositions.