MX2023000045A - Nuevos procesos e intermediarios para la preparacion de estimulantes de guanilato ciclasa soluble. - Google Patents
Nuevos procesos e intermediarios para la preparacion de estimulantes de guanilato ciclasa soluble.Info
- Publication number
- MX2023000045A MX2023000045A MX2023000045A MX2023000045A MX2023000045A MX 2023000045 A MX2023000045 A MX 2023000045A MX 2023000045 A MX2023000045 A MX 2023000045A MX 2023000045 A MX2023000045 A MX 2023000045A MX 2023000045 A MX2023000045 A MX 2023000045A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- intermediaries
- guanylate cyclase
- soluble guanylate
- new processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procesos nuevos para la preparación de compuestos de Fórmula I. Algunos de estos compuestos son de utilidad como estimulantes de la guanilato ciclasa soluble (sGC). Otros son intermediarios para usar en la preparación de los estimulantes. Estos procesos son adecuados para preparaciones a gran escala y producen 3-(2-pirimidinil)pirazoles de la Fórmula I estables, de gran pureza y rendimientos elevados. La invención ofrece la ventaja adicional de comprender condiciones de reacción sencillas, adecuadas para aumentar la escala en una producción a gran escala. También se proveen nuevos intermediarios para usar en la preparación de los compuestos. (ver Fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862615678P | 2018-01-10 | 2018-01-10 | |
| PCT/CN2018/076982 WO2019161534A1 (en) | 2018-02-22 | 2018-02-22 | Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023000045A true MX2023000045A (es) | 2023-02-01 |
Family
ID=65279655
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020007364A MX2020007364A (es) | 2018-01-10 | 2019-01-10 | Nuevos procesos e intermediarios para la preparación de estimulantes de guanilato ciclasa soluble. |
| MX2023000044A MX2023000044A (es) | 2018-01-10 | 2020-07-13 | Nuevos procesos e intermediarios para la preparacion de estimulantes de guanilato ciclasa soluble. |
| MX2023000045A MX2023000045A (es) | 2018-01-10 | 2020-07-13 | Nuevos procesos e intermediarios para la preparacion de estimulantes de guanilato ciclasa soluble. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020007364A MX2020007364A (es) | 2018-01-10 | 2019-01-10 | Nuevos procesos e intermediarios para la preparación de estimulantes de guanilato ciclasa soluble. |
| MX2023000044A MX2023000044A (es) | 2018-01-10 | 2020-07-13 | Nuevos procesos e intermediarios para la preparacion de estimulantes de guanilato ciclasa soluble. |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US11274096B2 (es) |
| EP (3) | EP4570797A3 (es) |
| JP (2) | JP7357621B2 (es) |
| KR (3) | KR102739727B1 (es) |
| CN (3) | CN118184645A (es) |
| AU (3) | AU2019206560B2 (es) |
| BR (1) | BR112020013985A2 (es) |
| CA (1) | CA3087943A1 (es) |
| CL (3) | CL2020001814A1 (es) |
| ES (1) | ES2963447T3 (es) |
| IL (3) | IL314714A (es) |
| JO (1) | JOP20200165A1 (es) |
| MA (2) | MA51565A (es) |
| MX (3) | MX2020007364A (es) |
| SG (1) | SG11202006311SA (es) |
| TW (2) | TWI888947B (es) |
| WO (1) | WO2019140095A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201990237A1 (ru) | 2016-07-07 | 2019-08-30 | Сайклерион Терапьютикс, Инк. | Новые способы получения стимуляторов растворимой гуанилатциклазы |
| KR102739727B1 (ko) | 2018-01-10 | 2024-12-05 | 사이클리온 테라퓨틱스, 인크. | 가용성 구아닐레이트 시클라제 자극제의 제조를 위한 신규 방법 및 중간체 |
| WO2024131850A1 (zh) * | 2022-12-21 | 2024-06-27 | 广东东阳光药业股份有限公司 | 氟取代的吲唑化合物的晶型及其用途 |
| WO2024131860A1 (zh) * | 2022-12-21 | 2024-06-27 | 广东东阳光药业股份有限公司 | 氟取代的吲唑化合物的晶型及其用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103313976B (zh) * | 2010-06-30 | 2016-11-23 | 铁木医药有限公司 | sGC刺激物 |
| EP2970243B1 (en) * | 2013-03-15 | 2019-11-27 | Cyclerion Therapeutics, Inc. | Sgc stimulators |
| US20160324856A1 (en) * | 2014-01-13 | 2016-11-10 | Ironwood Pharmaceuticals, Inc. | Use of sgc stimulators for the treatment of neuromuscular disorders |
| WO2016044447A1 (en) * | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | Pyrazole derivatives as sgc stimulators |
| US10047095B2 (en) * | 2014-09-17 | 2018-08-14 | Ironwood Pharmaceuticals, Inc. | sGC stimulators |
| EA201891315A1 (ru) | 2015-11-30 | 2018-12-28 | Айронвуд Фармасьютикалз, Инк. | Твердые дисперсии, содержащие стимулятор sgc |
| AU2017292811B2 (en) | 2016-07-07 | 2021-10-21 | Cyclerion Therapeutics, Inc. | Novel processes for preparation of soluble guanylate cyclase stimulators |
| EA201990237A1 (ru) | 2016-07-07 | 2019-08-30 | Сайклерион Терапьютикс, Инк. | Новые способы получения стимуляторов растворимой гуанилатциклазы |
| KR102739727B1 (ko) | 2018-01-10 | 2024-12-05 | 사이클리온 테라퓨틱스, 인크. | 가용성 구아닐레이트 시클라제 자극제의 제조를 위한 신규 방법 및 중간체 |
-
2019
- 2019-01-10 KR KR1020207022640A patent/KR102739727B1/ko active Active
- 2019-01-10 JO JOP/2020/0165A patent/JOP20200165A1/ar unknown
- 2019-01-10 MX MX2020007364A patent/MX2020007364A/es unknown
- 2019-01-10 CN CN202410363182.2A patent/CN118184645A/zh active Pending
- 2019-01-10 ES ES19703440T patent/ES2963447T3/es active Active
- 2019-01-10 CN CN201980017700.2A patent/CN111902410B/zh active Active
- 2019-01-10 MA MA051565A patent/MA51565A/fr unknown
- 2019-01-10 KR KR1020247039985A patent/KR20250002720A/ko active Pending
- 2019-01-10 CN CN202410363184.1A patent/CN118221665A/zh active Pending
- 2019-01-10 IL IL314714A patent/IL314714A/en unknown
- 2019-01-10 WO PCT/US2019/013060 patent/WO2019140095A1/en not_active Ceased
- 2019-01-10 EP EP25174051.0A patent/EP4570797A3/en active Pending
- 2019-01-10 JP JP2020538535A patent/JP7357621B2/ja active Active
- 2019-01-10 BR BR112020013985-8A patent/BR112020013985A2/pt unknown
- 2019-01-10 EP EP19703440.8A patent/EP3737679B1/en active Active
- 2019-01-10 TW TW112138274A patent/TWI888947B/zh active
- 2019-01-10 IL IL319883A patent/IL319883A/en unknown
- 2019-01-10 KR KR1020257010603A patent/KR20250048609A/ko active Pending
- 2019-01-10 MA MA71753A patent/MA71753A/fr unknown
- 2019-01-10 CA CA3087943A patent/CA3087943A1/en active Pending
- 2019-01-10 TW TW108101044A patent/TWI821237B/zh active
- 2019-01-10 SG SG11202006311SA patent/SG11202006311SA/en unknown
- 2019-01-10 EP EP23187776.2A patent/EP4249469A3/en active Pending
- 2019-01-10 AU AU2019206560A patent/AU2019206560B2/en active Active
- 2019-01-10 IL IL275748A patent/IL275748B2/en unknown
- 2019-01-10 US US16/961,109 patent/US11274096B2/en active Active
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2020
- 2020-07-07 CL CL2020001814A patent/CL2020001814A1/es unknown
- 2020-07-13 MX MX2023000044A patent/MX2023000044A/es unknown
- 2020-07-13 MX MX2023000045A patent/MX2023000045A/es unknown
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2021
- 2021-10-08 US US17/497,352 patent/US11708361B2/en active Active
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2022
- 2022-04-08 CL CL2022000907A patent/CL2022000907A1/es unknown
- 2022-04-08 CL CL2022000904A patent/CL2022000904A1/es unknown
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2023
- 2023-04-28 US US18/140,966 patent/US12030874B2/en active Active
- 2023-09-26 JP JP2023162922A patent/JP7744955B2/ja active Active
- 2023-11-22 AU AU2023270260A patent/AU2023270260A1/en active Pending
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2024
- 2024-05-22 US US18/671,182 patent/US12275724B2/en active Active
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2025
- 2025-03-31 AU AU2025202281A patent/AU2025202281A1/en active Pending
- 2025-04-11 US US19/176,742 patent/US20250361228A1/en active Pending
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