MX2022012920A - Composiciones de resiniferatoxina. - Google Patents
Composiciones de resiniferatoxina.Info
- Publication number
- MX2022012920A MX2022012920A MX2022012920A MX2022012920A MX2022012920A MX 2022012920 A MX2022012920 A MX 2022012920A MX 2022012920 A MX2022012920 A MX 2022012920A MX 2022012920 A MX2022012920 A MX 2022012920A MX 2022012920 A MX2022012920 A MX 2022012920A
- Authority
- MX
- Mexico
- Prior art keywords
- resiniferatoxin
- compositions
- liquid compositions
- aqueous solid
- aqueous
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- IKYCZSUNGFRBJS-UHFFFAOYSA-N Euphorbia factor RL9 = U(1) = Resiniferatoxin Natural products COC1=CC(O)=CC(CC(=O)OCC=2CC3(O)C(=O)C(C)=CC3C34C(C)CC5(OC(O4)(CC=4C=CC=CC=4)OC5C3C=2)C(C)=C)=C1 IKYCZSUNGFRBJS-UHFFFAOYSA-N 0.000 title abstract 4
- DSDNAKHZNJAGHN-UHFFFAOYSA-N resinferatoxin Natural products C1=C(O)C(OC)=CC(CC(=O)OCC=2CC3(O)C(=O)C(C)=CC3C34C(C)CC5(OC(O4)(CC=4C=CC=CC=4)OC5C3C=2)C(C)=C)=C1 DSDNAKHZNJAGHN-UHFFFAOYSA-N 0.000 title abstract 4
- DSDNAKHZNJAGHN-MXTYGGKSSA-N resiniferatoxin Chemical compound C1=C(O)C(OC)=CC(CC(=O)OCC=2C[C@]3(O)C(=O)C(C)=C[C@H]3[C@@]34[C@H](C)C[C@@]5(O[C@@](O4)(CC=4C=CC=CC=4)O[C@@H]5[C@@H]3C=2)C(C)=C)=C1 DSDNAKHZNJAGHN-MXTYGGKSSA-N 0.000 title abstract 4
- 229940073454 resiniferatoxin Drugs 0.000 title abstract 4
- 239000007788 liquid Substances 0.000 abstract 4
- 239000007787 solid Substances 0.000 abstract 4
- 239000003085 diluting agent Substances 0.000 abstract 2
- 208000006820 Arthralgia Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
La invención proporciona composiciones sólidas y líquidas no acuosas que comprenden resiniferatoxina y un tensoactivo. Las composiciones sólidas y líquidas no acuosas se pueden utilizar para preparar composiciones acuosas que se utilizan en el tratamiento del dolor, específicamente dolor articular relacionado con osteoartritis. Además, la invención proporciona kits que contienen las composiciones sólidas y líquidas no acuosas y un diluyente y métodos para preparar las composiciones. Las composiciones sólidas y líquidas no acuosas permiten un almacenamiento y recuperación más prolongados de resiniferatoxina en comparación con resiniferatoxina sola antes de la reconstitución con un diluyente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20169668 | 2020-04-15 | ||
| PCT/EP2021/059562 WO2021209450A1 (en) | 2020-04-15 | 2021-04-13 | Resiniferatoxin compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022012920A true MX2022012920A (es) | 2022-11-16 |
Family
ID=70289711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022012920A MX2022012920A (es) | 2020-04-15 | 2021-04-13 | Composiciones de resiniferatoxina. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20230051321A1 (es) |
| EP (2) | EP4487872A3 (es) |
| JP (1) | JP2023522537A (es) |
| KR (1) | KR20230002560A (es) |
| CN (1) | CN115551480B (es) |
| AU (1) | AU2021256948B2 (es) |
| BR (1) | BR112022020862A2 (es) |
| CA (1) | CA3172784A1 (es) |
| DK (1) | DK4135652T3 (es) |
| ES (1) | ES3004508T3 (es) |
| FI (1) | FI4135652T3 (es) |
| HR (1) | HRP20250055T1 (es) |
| HU (1) | HUE069859T2 (es) |
| IL (1) | IL297063A (es) |
| LT (1) | LT4135652T (es) |
| MX (1) | MX2022012920A (es) |
| PL (1) | PL4135652T3 (es) |
| PT (1) | PT4135652T (es) |
| RS (1) | RS66427B1 (es) |
| SI (1) | SI4135652T1 (es) |
| WO (1) | WO2021209450A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250228815A1 (en) | 2024-01-15 | 2025-07-17 | Gruenenthal Gmbh | Lyophilized resiniferatoxin |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9711962D0 (en) * | 1997-06-10 | 1997-08-06 | Reckitt & Colmann Prod Ltd | Therapeutically active compositions |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US20040048910A1 (en) * | 2002-08-22 | 2004-03-11 | Bove Susan Elizabeth | Method of treating osteoarthritis |
| EP2907503A1 (en) * | 2003-04-10 | 2015-08-19 | Neurogesx, Inc. | Methods and compositions for administration of TRPV1 agonists |
| EP1838301B1 (de) * | 2004-12-28 | 2015-01-28 | Mestex AG | Verwendung von resiniferatoxin (rtx) für die herstellung eines mittels zur behandlung von schmerzen |
| CA2635581C (en) * | 2005-12-28 | 2017-02-28 | Vertex Pharmaceuticals Incorporated | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| AR075180A1 (es) * | 2009-01-29 | 2011-03-16 | Novartis Ag | Formulaciones orales solidas de una pirido-pirimidinona |
| EA201890884A1 (ru) * | 2015-10-06 | 2018-11-30 | Флекс Фарма, Инк. | Способ и композиции для нежелательных и аномальных мышечных сокращений |
| WO2017087803A1 (en) * | 2015-11-20 | 2017-05-26 | Sorrento Therapeutics, Inc. | Methods for pain treatment using resiniferatoxin |
| MX391441B (es) * | 2016-08-02 | 2025-03-21 | Durect Corp | Composiciones que comprenden sulfato de colesterol oxigenado y por lo menos uno de poli-alquilen-glicol, carboxi-metil-celulosa y polioxilglicerido. |
| JP2018024648A (ja) * | 2016-08-05 | 2018-02-15 | 日本化薬株式会社 | ボルテゾミブを含有する医薬製剤の製造方法 |
| US20190321493A1 (en) * | 2016-11-18 | 2019-10-24 | Mayo Foundation For Medical Education And Research | Materials and methods for treating regional pain |
| AU2018327301B2 (en) * | 2017-09-11 | 2024-08-22 | Vivasor, Inc. | Formulation of resiniferatoxin |
| US12029725B2 (en) * | 2019-01-22 | 2024-07-09 | Vivasor, Inc. | Method for treating osteoarthritis pain by administering resiniferatoxin |
-
2021
- 2021-04-13 LT LTEPPCT/EP2021/059562T patent/LT4135652T/lt unknown
- 2021-04-13 AU AU2021256948A patent/AU2021256948B2/en active Active
- 2021-04-13 HR HRP20250055TT patent/HRP20250055T1/hr unknown
- 2021-04-13 SI SI202130263T patent/SI4135652T1/sl unknown
- 2021-04-13 BR BR112022020862A patent/BR112022020862A2/pt unknown
- 2021-04-13 CN CN202180028634.6A patent/CN115551480B/zh active Active
- 2021-04-13 CA CA3172784A patent/CA3172784A1/en active Pending
- 2021-04-13 ES ES21717110T patent/ES3004508T3/es active Active
- 2021-04-13 EP EP24215210.6A patent/EP4487872A3/en active Pending
- 2021-04-13 PL PL21717110.7T patent/PL4135652T3/pl unknown
- 2021-04-13 MX MX2022012920A patent/MX2022012920A/es unknown
- 2021-04-13 HU HUE21717110A patent/HUE069859T2/hu unknown
- 2021-04-13 DK DK21717110.7T patent/DK4135652T3/da active
- 2021-04-13 RS RS20250062A patent/RS66427B1/sr unknown
- 2021-04-13 KR KR1020227038425A patent/KR20230002560A/ko active Pending
- 2021-04-13 EP EP21717110.7A patent/EP4135652B1/en active Active
- 2021-04-13 JP JP2022548441A patent/JP2023522537A/ja active Pending
- 2021-04-13 IL IL297063A patent/IL297063A/en unknown
- 2021-04-13 WO PCT/EP2021/059562 patent/WO2021209450A1/en not_active Ceased
- 2021-04-13 FI FIEP21717110.7T patent/FI4135652T3/fi active
- 2021-04-13 PT PT217171107T patent/PT4135652T/pt unknown
-
2022
- 2022-10-17 US US17/967,507 patent/US20230051321A1/en not_active Abandoned
-
2024
- 2024-07-29 US US18/787,515 patent/US20240382449A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4135652B1 (en) | 2024-12-18 |
| JP2023522537A (ja) | 2023-05-31 |
| US20230051321A1 (en) | 2023-02-16 |
| FI4135652T3 (fi) | 2025-01-21 |
| SI4135652T1 (sl) | 2025-03-31 |
| EP4135652A1 (en) | 2023-02-22 |
| HRP20250055T1 (hr) | 2025-03-28 |
| WO2021209450A1 (en) | 2021-10-21 |
| BR112022020862A2 (pt) | 2022-11-29 |
| KR20230002560A (ko) | 2023-01-05 |
| LT4135652T (lt) | 2025-02-10 |
| CN115551480B (zh) | 2025-11-18 |
| ES3004508T3 (en) | 2025-03-12 |
| CA3172784A1 (en) | 2021-10-21 |
| HUE069859T2 (hu) | 2025-04-28 |
| RS66427B1 (sr) | 2025-02-28 |
| EP4487872A2 (en) | 2025-01-08 |
| CN115551480A (zh) | 2022-12-30 |
| US20240382449A1 (en) | 2024-11-21 |
| EP4487872A3 (en) | 2025-03-26 |
| AU2021256948A1 (en) | 2022-09-01 |
| DK4135652T3 (da) | 2025-01-20 |
| PT4135652T (pt) | 2025-01-16 |
| PL4135652T3 (pl) | 2025-03-10 |
| IL297063A (en) | 2022-12-01 |
| AU2021256948B2 (en) | 2025-06-19 |
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