MX2022007227A - Compuestos para el tratamiento de la enfermedad de alzheimer. - Google Patents
Compuestos para el tratamiento de la enfermedad de alzheimer.Info
- Publication number
- MX2022007227A MX2022007227A MX2022007227A MX2022007227A MX2022007227A MX 2022007227 A MX2022007227 A MX 2022007227A MX 2022007227 A MX2022007227 A MX 2022007227A MX 2022007227 A MX2022007227 A MX 2022007227A MX 2022007227 A MX2022007227 A MX 2022007227A
- Authority
- MX
- Mexico
- Prior art keywords
- hydroxy
- alzheimer
- disease
- treatment
- compounds
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- -1 6-hydroxy-2,5,7,8-tetramethylchroman-2yl Chemical group 0.000 abstract 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 abstract 2
- SEBPXHSZHLFWRL-UHFFFAOYSA-N 3,4-dihydro-2,2,5,7,8-pentamethyl-2h-1-benzopyran-6-ol Chemical compound O1C(C)(C)CCC2=C1C(C)=C(C)C(O)=C2C SEBPXHSZHLFWRL-UHFFFAOYSA-N 0.000 abstract 2
- CKJNUZNMWOVDFN-UHFFFAOYSA-N methanone Chemical compound O=[CH-] CKJNUZNMWOVDFN-UHFFFAOYSA-N 0.000 abstract 2
- 125000000687 hydroquinonyl group Chemical class C1(O)=C(C=C(O)C=C1)* 0.000 abstract 1
- 230000006386 memory function Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La invención se refiere a determinados compuestos de cromanol, quinona o hidroquinona y derivados de estos para el tratamiento de la enfermedad de Alzheimer y/o para mejorar la función de la memoria y/o reducir la carga de placa. Específicamente, la presente invención se refiere a compuestos de cromanol elegidos a partir de (6-hidroxi-2,5,7,8-tetrametilcroman-2il)(piperazin-1-5 il)metanona, clorhidrato de ((S)-6-hidroxi-2,5,7,8-tetrametil-N-(( R)-piperidin-3-il)croman-2-carboxamida y S-(6-hidroxi-2,5,7,8-tetr ametilcro-man-2-il)(4-(2-hidroxietil)piperazin-1-il)metanona y sales farmacéuticamente aceptables de estos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2024431A NL2024431B1 (en) | 2019-12-11 | 2019-12-11 | Compounds for treatment of alzheimer’s disease |
| PCT/NL2020/050782 WO2021118359A1 (en) | 2019-12-11 | 2020-12-11 | Compounds for treatment of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022007227A true MX2022007227A (es) | 2022-09-19 |
Family
ID=69173381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022007227A MX2022007227A (es) | 2019-12-11 | 2020-12-11 | Compuestos para el tratamiento de la enfermedad de alzheimer. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20230052152A1 (es) |
| EP (1) | EP4072550A1 (es) |
| JP (1) | JP7695246B2 (es) |
| KR (1) | KR20220119032A (es) |
| AU (1) | AU2020400823A1 (es) |
| BR (1) | BR112022011344A2 (es) |
| CA (1) | CA3164071A1 (es) |
| CL (1) | CL2022001520A1 (es) |
| GE (1) | GEAP202516676A (es) |
| IL (1) | IL293758A (es) |
| JO (1) | JOP20220140A1 (es) |
| MX (1) | MX2022007227A (es) |
| NL (1) | NL2024431B1 (es) |
| PH (1) | PH12022551418A1 (es) |
| WO (1) | WO2021118359A1 (es) |
| ZA (1) | ZA202206837B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL2010010C2 (en) * | 2012-12-19 | 2014-06-23 | Sulfateq B V | Compounds for protection of cells. |
| NL2031091B1 (en) * | 2022-02-28 | 2023-09-07 | Sulfateq Bv | Chromanol compounds for treatment or prophylaxis of ageing and ageing-associated disorders |
| JP2025537481A (ja) * | 2022-10-18 | 2025-11-18 | イムヌジェネティクス アーゲー | アルツハイマー型認知症に罹患している又はアルツハイマー型認知症を発症する危険性のある対象の特定 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1339404A2 (en) * | 2000-10-31 | 2003-09-03 | Colgate-Palmolive Company | Composition and method |
| HRP20150843T1 (hr) | 2007-05-22 | 2015-09-11 | Otsuka Pharmaceutical Co., Ltd. | Lijek koji sadrži derivat karbostirila i donepezil za lijeäśenje alzheimerove bolesti |
| SI3456707T1 (sl) * | 2007-11-06 | 2020-10-30 | Ptc Therapeutics, Inc. | Derivati 4-(P-kuinonil)-2-hidroksibutanamida za zdravljenje mitohondrijske bolezni |
| ES2622190T5 (es) | 2012-07-12 | 2020-04-23 | Khondrion Ip B V | Derivados de cromanilo para tratar una enfermedad mitocondrial |
| JO3459B1 (ar) | 2012-09-09 | 2020-07-05 | H Lundbeck As | تركيبات صيدلانية لعلاج مرض الزهايمر |
| NL2010010C2 (en) | 2012-12-19 | 2014-06-23 | Sulfateq B V | Compounds for protection of cells. |
| PT2994160T (pt) | 2013-05-06 | 2019-08-07 | Baxalta Inc | Tratamento de sub-populações com doença de alzheimer com imunoglobulina g combinada |
| WO2017060432A1 (en) | 2015-10-08 | 2017-04-13 | Khondrion Ip B.V. | Novel compounds for treating mitochondrial disease |
| US11672787B2 (en) * | 2017-11-22 | 2023-06-13 | Khondrion Ip B.V. | Compounds as mPGES-1 inhibitors |
-
2019
- 2019-12-11 NL NL2024431A patent/NL2024431B1/en active
-
2020
- 2020-12-11 IL IL293758A patent/IL293758A/en unknown
- 2020-12-11 MX MX2022007227A patent/MX2022007227A/es unknown
- 2020-12-11 EP EP20828157.6A patent/EP4072550A1/en active Pending
- 2020-12-11 BR BR112022011344A patent/BR112022011344A2/pt unknown
- 2020-12-11 GE GEAP202516676A patent/GEAP202516676A/en unknown
- 2020-12-11 KR KR1020227020822A patent/KR20220119032A/ko active Pending
- 2020-12-11 PH PH1/2022/551418A patent/PH12022551418A1/en unknown
- 2020-12-11 AU AU2020400823A patent/AU2020400823A1/en active Pending
- 2020-12-11 JP JP2022535567A patent/JP7695246B2/ja active Active
- 2020-12-11 CA CA3164071A patent/CA3164071A1/en active Pending
- 2020-12-11 WO PCT/NL2020/050782 patent/WO2021118359A1/en not_active Ceased
- 2020-12-11 JO JOP/2022/0140A patent/JOP20220140A1/ar unknown
- 2020-12-11 US US17/783,671 patent/US20230052152A1/en active Pending
-
2022
- 2022-06-09 CL CL2022001520A patent/CL2022001520A1/es unknown
- 2022-06-20 ZA ZA2022/06837A patent/ZA202206837B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL293758A (en) | 2022-08-01 |
| NL2024431B1 (en) | 2021-09-07 |
| JP2023506480A (ja) | 2023-02-16 |
| ZA202206837B (en) | 2023-11-29 |
| AU2020400823A1 (en) | 2022-06-23 |
| EP4072550A1 (en) | 2022-10-19 |
| US20230052152A1 (en) | 2023-02-16 |
| BR112022011344A2 (pt) | 2022-08-23 |
| CA3164071A1 (en) | 2021-06-17 |
| WO2021118359A1 (en) | 2021-06-17 |
| GEAP202516676A (en) | 2025-02-10 |
| PH12022551418A1 (en) | 2023-11-20 |
| KR20220119032A (ko) | 2022-08-26 |
| JP7695246B2 (ja) | 2025-06-18 |
| JOP20220140A1 (ar) | 2023-01-30 |
| CL2022001520A1 (es) | 2023-02-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2022001520A1 (es) | Compuestos para el tratamiento de la enfermedad de alzheimer | |
| JOP20220247A1 (ar) | مثبطات كرومينون تفارغية لفوسفوينوسيتيد 3 كيناز (pi3k) لعلاج أمراض مرتبطة بتعديل p13k | |
| UY26782A1 (es) | Derivados del benzotiazol | |
| CY1121330T1 (el) | Συνθεσεις που περιλαμβανουν αζελαστινη και μεθοδοι χρησης αυτων | |
| CR20230517A (es) | Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades | |
| CL2004000174A1 (es) | Compuestos derivados de malonamida n,n'-disustituidos; procedimiento de preparacion; composicion farmaceutica; y uso del compuesto en el tratamiento de la enfermedad de alzheimer. | |
| UY30377A1 (es) | Inhibidores triciclicos fusionados de sulfonamida de gama-secretasa | |
| EA200900152A1 (ru) | Ингибиторы пирролотриазинкиназы | |
| EA200971069A1 (ru) | Метаболиты производных (тио)карбомоилциклогексана | |
| GT200500098A (es) | Nuevos compuestos | |
| GT200500060A (es) | Compuestos de imidazol para el tratamiento de trastornos neurodegenerativos | |
| CL2021002165A1 (es) | Nuevos derivados de compuestos heterociclicos y uso de los mismos | |
| EA200971086A1 (ru) | Фармацевтические композиции и способ лечения шизофрении | |
| NO20082643L (no) | Isokinolinaminopyrazolderivater, deres fremstilling og anvendelse som farmasoytiske midler for behandling av kreft | |
| BRPI0416989A (pt) | derivados aminopirazole como inibidores gsk-3 | |
| CL2021001396A1 (es) | Derivados de panteteína y usos de los mismos | |
| UY30426A1 (es) | Derivados sustituidos del 3-(4-metoxi-fenil)-3h-isoindol-1-ilamina trifluoroacetado, sus sales o solvatos farmaceuticamente aceptables, formulaciones farmacéuticas y aplicaciones. | |
| UA112055C2 (uk) | Солі 4-[2-[[5-метил-1-(2-нафталініл)-1h-піразол-3-іл]оксі]етил]морфоліну | |
| UY30025A1 (es) | Derivados sustituidos de las 2-amino-5,6-dihidro pirimidin-4(3h)-onas y sus sales farmacéuticamente aceptables, composiciones farmacéuticas conteniéndolos y aplicaciones. | |
| DOP2002000422A (es) | Agentes antibacterianos. | |
| GB0112348D0 (en) | Compounds | |
| SV2009002900A (es) | Diarilurea para el tratamiento de hipertension pulmonar | |
| EA200601194A1 (ru) | Новые производные бензофурана, используемые для профилактики или лечения нарушений, связанных с 5-ht-рецептором | |
| NO20092035L (no) | Tiazolylforbindelser anvendbare som kinaseinhibitorer | |
| CL2023000800A1 (es) | Compuestos de cromanol para el tratamiento de la insuficiencia cardíaca |