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MX2022006304A - Composiciones y metodos para inhibir la actividad biologica de biomoleculas solubles. - Google Patents

Composiciones y metodos para inhibir la actividad biologica de biomoleculas solubles.

Info

Publication number
MX2022006304A
MX2022006304A MX2022006304A MX2022006304A MX2022006304A MX 2022006304 A MX2022006304 A MX 2022006304A MX 2022006304 A MX2022006304 A MX 2022006304A MX 2022006304 A MX2022006304 A MX 2022006304A MX 2022006304 A MX2022006304 A MX 2022006304A
Authority
MX
Mexico
Prior art keywords
compositions
biological activity
inhibiting
methods
soluble biomolecules
Prior art date
Application number
MX2022006304A
Other languages
English (en)
Inventor
Louis Hawthorne
Original Assignee
Nanotics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanotics Llc filed Critical Nanotics Llc
Publication of MX2022006304A publication Critical patent/MX2022006304A/es

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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
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    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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Abstract

La descripción provee, entre otras cosas, composiciones que se unen a, e inhiben, la actividad biológica de biomoléculas solubles, así como composiciones farmacéuticas de las mismas. También en este documento se provee una serie de aplicaciones (por ejemplo, aplicaciones terapéuticas) en las cuales las composiciones son útiles.
MX2022006304A 2014-10-03 2017-03-24 Composiciones y metodos para inhibir la actividad biologica de biomoleculas solubles. MX2022006304A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462059628P 2014-10-03 2014-10-03
US201562198519P 2015-07-29 2015-07-29
US201562198541P 2015-07-29 2015-07-29

Publications (1)

Publication Number Publication Date
MX2022006304A true MX2022006304A (es) 2022-06-22

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MX2017003903A MX2017003903A (es) 2014-10-03 2015-10-02 Composiciones y metodos para inhibir la actividad biologica de biomoleculas solubles.
MX2022006304A MX2022006304A (es) 2014-10-03 2017-03-24 Composiciones y metodos para inhibir la actividad biologica de biomoleculas solubles.

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MX2017003903A MX2017003903A (es) 2014-10-03 2015-10-02 Composiciones y metodos para inhibir la actividad biologica de biomoleculas solubles.

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US (6) US9623081B2 (es)
EP (1) EP3215176A4 (es)
JP (4) JP6876608B2 (es)
KR (2) KR102510540B1 (es)
CN (4) CN106999550B (es)
AU (3) AU2015327928A1 (es)
BR (1) BR112017006552A2 (es)
CA (1) CA2962251A1 (es)
EA (1) EA035898B1 (es)
IL (1) IL251232B (es)
MX (2) MX2017003903A (es)
MY (1) MY203626A (es)
SG (1) SG11201702304UA (es)
WO (1) WO2016054522A1 (es)

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Publication number Priority date Publication date Assignee Title
US20170038382A1 (en) * 2014-01-24 2017-02-09 Ntercept, Llc Methods and compositions for immune dis-inhibition
CN106999550B (zh) 2014-10-03 2023-02-28 纳米提克斯有限责任公司 用于抑制可溶生物分子的生物活性的组合物以及方法
MY198240A (en) * 2015-06-30 2023-08-16 Nanotics Llc Compositions and methods related to scavanger particles priority claim
CN116999396A (zh) * 2015-07-29 2023-11-07 纳米提克斯有限责任公司 用于清除可溶性生物分子的模块化组合物及其相关方法
WO2018129188A1 (en) * 2017-01-04 2018-07-12 Nanotics, Llc Methods for assembling scavenging particles
IL299915A (en) 2017-01-04 2023-03-01 Nanotics Llc Methods for assembling cleaning particles
CN109173755B (zh) * 2018-09-19 2020-04-03 苏州大学 超疏水多功能膜及其制备方法与在油水分离中的应用
US20220023343A1 (en) * 2018-11-19 2022-01-27 Board Of Regents, The University Of Texas System Suicide gene

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
KR0185215B1 (ko) 1990-11-30 1999-05-01 요시다 쇼오지 서방성 안구삽입용 약제
DE69330523D1 (de) 1992-08-21 2001-09-06 Vrije Universiteit Brussel Bru Immunoglobuline ohne leichte ketten
US6005079A (en) 1992-08-21 1999-12-21 Vrije Universiteit Brussels Immunoglobulins devoid of light chains
ES2162863T3 (es) 1993-04-29 2002-01-16 Unilever Nv Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae.
US5814272A (en) 1996-02-21 1998-09-29 Millipore Corporation Method for forming dendritic metal particles
US7070590B1 (en) 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US6620382B1 (en) 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
US8197430B1 (en) 1998-05-22 2012-06-12 Biopheresis Technologies, Inc. Method and system to remove cytokine inhibitor in patients
EP2087907B1 (en) 1999-11-10 2014-09-24 Innatus Corporation Method and system to remove cytokine inhibitor in patients
EP1174129A1 (en) 2000-07-17 2002-01-23 Zenner, Hans Peter, Prof. Dr. med. Use of a matrix-metalloprotease inhibitor for the treatment of cancer
JP2002248682A (ja) * 2001-02-26 2002-09-03 Neoex Lab Inc 表皮装着用の型、及び表皮装着方法
DE10144251A1 (de) * 2001-08-31 2003-03-27 Fraunhofer Ges Forschung Vorrichtung für die gerichtete Immobilisierung von Proteinen
DE10144252A1 (de) * 2001-08-31 2003-03-27 Fraunhofer Ges Forschung Nanopartikel mit daran immobilisiertem biologisch aktivem TNF
US7629341B2 (en) 2002-06-12 2009-12-08 Symphony Evolution, Inc. Human ADAM-10 inhibitors
JP2006503865A (ja) 2002-09-30 2006-02-02 アキュスフィア, インコーポレイテッド 吸入のための徐放性の多孔性微粒子
BRPI0316282B8 (pt) 2002-11-15 2021-05-25 Genmab As anticorpo humano isolado monoclonal, composição, imunoconjugado, molécula biespecífica ou multiespecífica, método e conjunto de diagnóstico para detectar a presença de antígeno cd25 ou uma célula que expressa cd25, e, vetor de expressão
US7297298B2 (en) 2002-12-25 2007-11-20 Fujifilm Corporation Nano-particles and process for producing nano-particles
WO2004071641A2 (en) * 2003-02-10 2004-08-26 Pointilliste, Inc. Self-assembling arrays and uses thereof
AU2005240082B2 (en) 2004-04-30 2009-07-23 Innatus Corporation Method and system to remove soluble TNFR1,TNFR2, and IL2 in patients
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
CA2574496C (en) 2004-07-22 2014-04-22 Early Detection, Llc Methods for diagnosis using anti-cytokine receptor antibodies
CN101123990A (zh) 2004-10-01 2008-02-13 Mida科技有限公司 包含抗原和佐剂的纳米颗粒,和免疫原性结构
US20070248680A1 (en) * 2005-02-08 2007-10-25 Board Of Regents, The University Of Texas System Particles for Inactivating Toxins
US20110097277A1 (en) 2005-08-25 2011-04-28 University Of Washington Particles coated with zwitterionic polymers
FR2895289B1 (fr) 2005-12-23 2009-08-21 Centre Nat Rech Scient Synthese de particules dans des structures dendritiques en milieux fluides supercritiques
US20070189944A1 (en) 2006-02-13 2007-08-16 Advanced Materials Technology, Inc. Porous microparticles with solid cores
WO2008021908A2 (en) 2006-08-08 2008-02-21 Board Of Regents Of The University Of Texas Multistage delivery of active agents
US20080075690A1 (en) 2006-09-22 2008-03-27 Mark Douglas Howell Method for enhancing immune responses in mammals
JPWO2008041774A1 (ja) * 2006-10-02 2010-02-04 独立行政法人物質・材料研究機構 骨伝導能を有する徐放性製剤
WO2008127515A1 (en) * 2007-03-01 2008-10-23 Cytologic, Inc. Compositions and method for enhancing immune responses in mammals
WO2009029870A2 (en) 2007-08-31 2009-03-05 Hybrid Silica Technologies, Inc. Peg-coated core-shell silica nanoparticles and methods of manufacture and use
EP2033660A1 (en) * 2007-09-05 2009-03-11 Freie Universität Berlin Functionalized nanoparticles for the inhibition of selectin-mediated cell adhesion
US8586096B2 (en) 2007-10-01 2013-11-19 The Curators Of The University Of Missouri Soy or lentil stabilized gold nanoparticles and method for making same
WO2009061853A2 (en) 2007-11-05 2009-05-14 Massachusetts Institute Of Technology Mutant interleukin-2 (il-2) polypeptides
US20100008978A1 (en) * 2008-05-09 2010-01-14 The Regents Of The University Of California Nanoparticles effective for internalization into cells
US9333163B2 (en) 2008-10-06 2016-05-10 Massachusetts Institute Of Technology Particles with multiple functionalized surface domains
US9399075B2 (en) 2008-12-29 2016-07-26 General Electric Company Nanoparticle contrast agents for diagnostic imaging
US8574549B2 (en) 2008-12-29 2013-11-05 General Electric Company Nanoparticle contrast agents for diagnostic imaging
WO2010084088A2 (en) 2009-01-21 2010-07-29 Basf Se Starch nanoparticles for drug delivery systems
US20120108787A1 (en) * 2009-02-26 2012-05-03 Nubiome, Inc. Immobilization Particles for Removal of Microorganisms and/or Chemicals
US8685538B2 (en) 2009-03-25 2014-04-01 Northeastern University Stable polyelectrolyte coated nanoparticles
NZ807894A (en) 2009-04-29 2025-08-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
WO2011003109A1 (en) 2009-07-02 2011-01-06 Sloan-Kettering Institute For Cancer Research Fluorescent silica-based nanoparticles
WO2011084620A2 (en) 2009-12-16 2011-07-14 Brigham And Women's Hospital, Inc. Particles for multiple agent delivery
US20120141797A1 (en) 2010-04-21 2012-06-07 Brookhaven Science Associates, Llc Zwitterion-Linker Coatings for Nano-objects in Solutions of Multivalent Counterions
WO2011140829A1 (en) 2010-05-14 2011-11-17 The University Of Hong Kong Solid supported gold nanoparticles, methods of use thereof, and methods for making same
CN103201629B (zh) 2010-10-13 2015-08-05 药品诊断学公司 用于包覆纳米粒子的方法
EP2468764A1 (en) 2010-12-24 2012-06-27 Rijksuniversiteit te Groningen TNF family ligand variants
SG10201804552WA (en) * 2011-01-24 2018-07-30 Anterios Inc Nanoparticle compositions, formulations thereof, and uses therefor
KR101642903B1 (ko) 2011-02-09 2016-07-27 한화케미칼 주식회사 친수성 물질이 코팅된 산화철 나노입자의 제조방법 및 이를 이용하는 자기공명영상 조영제
WO2012163544A1 (en) 2011-06-01 2012-12-06 Biopheresis Technologies, Inc. Removal of soluble tumor necrosis factor receptor 2 (stnfr2)
DK2714017T3 (en) 2011-06-02 2018-09-03 Univ California MEMBRANE-WRAPPED NANOPARTICLES AND METHOD OF USE
WO2013011764A1 (ja) 2011-07-15 2013-01-24 国立大学法人 東京大学 シリコンマイクロ粒子及びその合成方法
CN104203092A (zh) 2011-08-26 2014-12-10 维科纳米医药有限公司 病原体和物质陷阱
WO2013029278A1 (en) 2011-09-02 2013-03-07 National Center For Nanoscience And Technology A method for preparing functionalized silicon nanoparticles
WO2013095736A2 (en) 2011-09-27 2013-06-27 The Methodist Hospital Research Institute Gold-in-silicon nanoassembly for thermal therapy and methods of use
US8926994B2 (en) 2011-12-07 2015-01-06 The Methodist Hospital Research Institute Mesoporous silicon particles for the presentation of tumor antigens and adjuvant for anti-cancer immunity
US20130337070A1 (en) 2012-05-25 2013-12-19 University Of Central Florida Research Foundation Inc. Coated Nanoparticle Therapy for Skin Cancer
WO2013179143A2 (en) 2012-06-01 2013-12-05 Biopheresis Technologies, Inc. Sensitization of cancer cells by the removal of soluble tumor necrosis factor receptors
US10842749B2 (en) 2012-06-12 2020-11-24 The Methodist Hospital Research Institute Compositions and methods of treating therapy resistant cancer and uses thereof
US10543278B2 (en) 2012-09-12 2020-01-28 Ramot At Tel-Aviv University Ltd. Immunoparticles and methods of generating and using same
WO2014109842A2 (en) * 2012-11-28 2014-07-17 Cytimmune Sciences, Inc. Nanotechnology based medicine for biodefense
US9309114B2 (en) 2013-01-14 2016-04-12 Xerox Corporation Porous nanoparticles produced by solvent-free emulsification
CN105025928A (zh) 2013-03-15 2015-11-04 普西维达公司 用于递送治疗剂的可生物蚀解的硅基组合物
AU2014232907B2 (en) 2013-03-15 2017-12-21 Cornell University Multimodal silica-based nanoparticles
ITMI20130631A1 (it) * 2013-04-18 2014-10-19 Consiglio Nazionale Ricerche Metodo di realizzazione di una guida d'onda in un substrato tramite laser a femtosecondi
US10316320B2 (en) 2013-04-18 2019-06-11 Bar Ilan University Systems comprising non-immunogenic and nuclease resistant nucleic acid origami devices for molecular computation
US20150112842A1 (en) 2013-10-21 2015-04-23 Insurance Auto Auctions, Inc. Parts exchange method and apparatus
US20170038382A1 (en) 2014-01-24 2017-02-09 Ntercept, Llc Methods and compositions for immune dis-inhibition
CN106999550B (zh) * 2014-10-03 2023-02-28 纳米提克斯有限责任公司 用于抑制可溶生物分子的生物活性的组合物以及方法
MY198240A (en) 2015-06-30 2023-08-16 Nanotics Llc Compositions and methods related to scavanger particles priority claim
CN116999396A (zh) 2015-07-29 2023-11-07 纳米提克斯有限责任公司 用于清除可溶性生物分子的模块化组合物及其相关方法
US20170056327A1 (en) 2015-08-25 2017-03-02 The Methodist Hospital Micro/nano composite drug delivery formulations and uses thereof
WO2017176762A1 (en) 2016-04-06 2017-10-12 Nanotics, Llc Particles comprising subparticles or nucleic acid scaffolds
IL299915A (en) 2017-01-04 2023-03-01 Nanotics Llc Methods for assembling cleaning particles
WO2018129188A1 (en) 2017-01-04 2018-07-12 Nanotics, Llc Methods for assembling scavenging particles

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