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MX2022001083A - Micelas lipídicas anfifílicas peptídicas (palm) para tratamiento de neuropatía periférica inducida por quimioterapia relacionada con el tratamiento del cáncer. - Google Patents

Micelas lipídicas anfifílicas peptídicas (palm) para tratamiento de neuropatía periférica inducida por quimioterapia relacionada con el tratamiento del cáncer.

Info

Publication number
MX2022001083A
MX2022001083A MX2022001083A MX2022001083A MX2022001083A MX 2022001083 A MX2022001083 A MX 2022001083A MX 2022001083 A MX2022001083 A MX 2022001083A MX 2022001083 A MX2022001083 A MX 2022001083A MX 2022001083 A MX2022001083 A MX 2022001083A
Authority
MX
Mexico
Prior art keywords
palm
treatment
peripheral neuropathy
amphiphylic
peptided
Prior art date
Application number
MX2022001083A
Other languages
English (en)
Inventor
Reynold Homan
Original Assignee
Peptinovo Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peptinovo Biopharma Inc filed Critical Peptinovo Biopharma Inc
Publication of MX2022001083A publication Critical patent/MX2022001083A/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Optics & Photonics (AREA)
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  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente descripción proporciona un método para el tratamiento o la prevención de la neuropatía periférica inducida por la quimioterapia (CIPN, por sus siglas en inglés) en un paciente con cáncer tratado con, o que vaya a tratarse con, un agente quimioterapéutico que provoque CIPN; el método comprende: administrar una cantidad terapéuticamente efectiva de una composición que contiene una nanopartícula de micela lipídica anfifílica peptídica (PALM, por sus siglas en inglés) al paciente con cáncer, donde la nanopartícula de PALM comprende una PALM que contiene el agente quimioterapéutico que provoca CIPN, y donde la PALM comprende un péptido, y un componente lipídico que comprende esfingomielina y uno o más fosfolípidos adicionales.
MX2022001083A 2019-08-13 2020-08-11 Micelas lipídicas anfifílicas peptídicas (palm) para tratamiento de neuropatía periférica inducida por quimioterapia relacionada con el tratamiento del cáncer. MX2022001083A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962886282P 2019-08-13 2019-08-13
PCT/US2020/045785 WO2021030359A1 (en) 2019-08-13 2020-08-11 Palm for the treatment of chemotherapy-induced peripheral neuropathy incidental to the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2022001083A true MX2022001083A (es) 2022-05-18

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MX2022001083A MX2022001083A (es) 2019-08-13 2020-08-11 Micelas lipídicas anfifílicas peptídicas (palm) para tratamiento de neuropatía periférica inducida por quimioterapia relacionada con el tratamiento del cáncer.

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US (1) US20240189230A1 (es)
EP (1) EP4013444A4 (es)
JP (1) JP7657775B2 (es)
KR (1) KR20220045203A (es)
CN (1) CN114401736A (es)
AU (1) AU2020329923A1 (es)
CA (1) CA3147790A1 (es)
IL (1) IL290487A (es)
MX (1) MX2022001083A (es)
WO (1) WO2021030359A1 (es)

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Publication number Priority date Publication date Assignee Title
CN116019911B (zh) * 2022-11-11 2023-11-28 海南大学 一种基于功能化二氧化硅并携载诊疗试剂的纳米颗粒及其制备方法与应用

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US20080045559A1 (en) * 2003-10-29 2008-02-21 Sonus Pharmaceuticals, Inc. Tocopherol-modified therapeutic drug compounds
PT2056675T (pt) * 2006-10-12 2019-05-09 Galera Labs Llc Métodos de tratamento da mucosite oral
WO2012092339A2 (en) * 2010-12-28 2012-07-05 The Children's Hospital Of Philadelphia The design of hydrolytically releasable prodrugs for sustained release nanoparticle formulations
NZ616227A (en) * 2011-04-11 2016-01-29 Abb Vie Inc Parp inhibitors for the treatment of cipn
CN104582732A (zh) * 2012-06-15 2015-04-29 布里格姆及妇女医院股份有限公司 治疗癌症的组合物及其制造方法
US20150202186A1 (en) * 2014-01-23 2015-07-23 Sova Pharmaceuticals, Inc. CYSTATHIONINE-(gamma)-LYASE (CSE) INHIBITORS FOR TREATING PAIN
KR20160132496A (ko) * 2014-04-03 2016-11-18 인빅터스 온콜로지 피비티. 엘티디. 초분자 조합 치료제
JP2018528257A (ja) * 2015-07-10 2018-09-27 ペプティノボ・バイオファーマ・リミテッド・ライアビリティ・カンパニーＰｅｐｔｉｎｏｖｏ Ｂｉｏｐｈａｒｍａ， ＬＬＣ 疎水性薬剤の効能を改善するための配合物
SG10201912394VA (en) * 2015-07-15 2020-02-27 Celator Pharmaceuticals Inc Improved nanoparticle delivery systems
JP7090034B2 (ja) * 2016-05-20 2022-06-23 ザ ユニバーシティ オブ シカゴ 化学療法、標的療法、光線力学療法、免疫療法及びそれらの任意の組み合わせのためのナノ粒子

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EP4013444A1 (en) 2022-06-22
CN114401736A (zh) 2022-04-26
WO2021030359A1 (en) 2021-02-18
KR20220045203A (ko) 2022-04-12
JP2022544262A (ja) 2022-10-17
AU2020329923A1 (en) 2022-02-24
US20240189230A1 (en) 2024-06-13
CA3147790A1 (en) 2021-02-18
IL290487A (en) 2022-04-01
JP7657775B2 (ja) 2025-04-07
EP4013444A4 (en) 2023-11-01

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