MX2021005992A - Gaboxadol para reducir el riesgo de suicidio y para alivio rápido de la depresión. - Google Patents
Gaboxadol para reducir el riesgo de suicidio y para alivio rápido de la depresión.Info
- Publication number
- MX2021005992A MX2021005992A MX2021005992A MX2021005992A MX2021005992A MX 2021005992 A MX2021005992 A MX 2021005992A MX 2021005992 A MX2021005992 A MX 2021005992A MX 2021005992 A MX2021005992 A MX 2021005992A MX 2021005992 A MX2021005992 A MX 2021005992A
- Authority
- MX
- Mexico
- Prior art keywords
- depression
- gaboxadol
- suicide
- reducing risk
- rapid relief
- Prior art date
Links
- 206010010144 Completed suicide Diseases 0.000 title abstract 2
- ZXRVKCBLGJOCEE-UHFFFAOYSA-N Gaboxadol Chemical compound C1NCCC2=C1ONC2=O ZXRVKCBLGJOCEE-UHFFFAOYSA-N 0.000 title abstract 2
- 229950004346 gaboxadol Drugs 0.000 title abstract 2
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000024714 major depressive disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000036651 mood Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 238000011285 therapeutic regimen Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Se describen métodos y composiciones para reducir rápidamente el riesgo de suicidio en pacientes que sufren de tendencias suicidas agudas, y para aliviar rápidamente los síntomas del estado de ánimo en la depresión mayor y la depresión resistente al tratamiento, utilizando un nuevo régimen terapéutico que comprende una administración única o intermitente de una dosis elevada de gaboxadol, o una sal farmacéuticamente aceptable del mismo, al sujeto que lo necesite.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862770287P | 2018-11-21 | 2018-11-21 | |
| PCT/US2019/062554 WO2020106927A1 (en) | 2018-11-21 | 2019-11-21 | Gaboxadol for reducing risk of suicide and rapid relief of depression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021005992A true MX2021005992A (es) | 2021-09-14 |
Family
ID=70728606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021005992A MX2021005992A (es) | 2018-11-21 | 2019-11-21 | Gaboxadol para reducir el riesgo de suicidio y para alivio rápido de la depresión. |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US11123332B2 (es) |
| EP (1) | EP3883566A4 (es) |
| JP (1) | JP2022514194A (es) |
| KR (1) | KR20210110585A (es) |
| CN (1) | CN113395962A (es) |
| AU (1) | AU2019384157A1 (es) |
| BR (1) | BR112021009944A2 (es) |
| CA (1) | CA3120856A1 (es) |
| GB (1) | GB2594616A (es) |
| IL (1) | IL283311A (es) |
| MX (1) | MX2021005992A (es) |
| SG (1) | SG11202105358RA (es) |
| WO (1) | WO2020106927A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2887944B1 (en) | 2012-08-21 | 2021-10-06 | Sage Therapeutics, Inc. | Allopregnanolone for treating refractory status epilepticus |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| AU2017229656B2 (en) | 2016-03-08 | 2022-09-29 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| MX2019001669A (es) * | 2016-08-11 | 2019-09-27 | Ovid Therapeutics Inc | Metodos y composiciones para el tratamiento de trastornos epilepticos. |
| US10071083B2 (en) * | 2017-02-03 | 2018-09-11 | Ovid Therapeutics Inc | Use of gaboxadol in the treatment of tinnitus |
| PT3505157T (pt) | 2017-12-29 | 2022-02-18 | Celon Pharma Sa | Composição de cetamina em pó seco para administração pulmonar em depressão resistente ao tratamento |
| CN113395962A (zh) * | 2018-11-21 | 2021-09-14 | Certego治疗公司 | 加波沙朵用于降低自杀风险和快速缓解抑郁症 |
| AU2021275863A1 (en) | 2020-05-20 | 2023-02-02 | Certego Therapeutics Inc. | Ring deuterated gaboxadol and its use for the treatment of psychiatric disorders |
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| US4362731A (en) | 1980-09-01 | 1982-12-07 | Sandoz Ltd. | Myotonolytic use of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridin-3-ol and derivatives thereof |
| US4353910A (en) | 1981-11-27 | 1982-10-12 | Kefalas A/S | Derivatives of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-one, pharmaceutical compositions and methods of treatment |
| DE19525598C2 (de) | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
| AR031473A1 (es) | 2000-11-20 | 2003-09-24 | Lundbeck & Co As H | Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide |
| US20020165217A1 (en) | 2001-05-01 | 2002-11-07 | Pfizer Inc. | Combination treatment for anxiety and depression |
| TW200501951A (en) | 2003-06-25 | 2005-01-16 | Lundbeck & Co As H | Treatment of neuropathic pain, fibromyalgia or rheumatoid arthritis |
| EP2145620A3 (en) | 2003-06-25 | 2010-03-17 | H. Lundbeck A/S | Gaboxadol for treating depression and other affective disorders |
| TW200509918A (en) | 2003-06-25 | 2005-03-16 | Lundbeck & Co As H | Treatment of depression and other affective disorders |
| CL2004001603A1 (es) * | 2003-06-25 | 2005-05-27 | Lundbeck & Co As H | Uso de gabaxadol para preparar un medicamento util para el tratamiento del dolor neuropatico. |
| US20050234093A1 (en) | 2003-06-25 | 2005-10-20 | H. Lundbeck A/S | Treatment of depression and other affective disorders |
| AR045540A1 (es) | 2003-09-05 | 2005-11-02 | Lundbeck & Co As H | Metodo de elaboracion de 4,5,6,7 tetrahidroisoxazol [5,4-c] piridin-3-ol (thip) |
| UY28650A1 (es) * | 2003-12-05 | 2005-02-28 | Forest Laboratories | Memantina para la prevencion o disminucion de la conducta suicida y para el tratamiento de la depresion mayor asociada con esta conducta |
| US20050137222A1 (en) | 2003-12-18 | 2005-06-23 | H. Lundbeck A/S | Treatment of insomnia in human patients |
| GB0402118D0 (en) | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
| MXPA06011325A (es) | 2004-04-02 | 2006-12-15 | Lundbeck & Co As H | Tratamiento de la funcion respiratoria alterada con gaboxadol. |
| ZA200607427B (en) | 2004-04-02 | 2009-02-25 | Lundbeck & Co As H | Treatment of impaired respiratory function with gaboxadol |
| GB0417558D0 (en) | 2004-08-06 | 2004-09-08 | Merck Sharp & Dohme | Novel combination therapy |
| EP1848420A4 (en) | 2005-01-28 | 2008-01-23 | Merck & Co Inc | POLYMORPH SHAPES OF A GABAA AGONIST |
| EP1906953A4 (en) | 2005-04-29 | 2009-05-20 | Lundbeck & Co As H | ACID AND BASE SALT FORMS OF GABOXADOL |
| DE102005020882A1 (de) | 2005-05-04 | 2006-11-09 | Dömling, Alexander, Dr. | Verwendung von Gaboxadol und Derivaten zur Behandlung von Kinase-induzierten Krankheiten |
| FR2889811B1 (fr) | 2005-08-19 | 2009-10-09 | Sanofi Aventis Sa | Association d'un agent hypnotique a duree d'action longue et d'un agent hypnotique a duree d'action courte, composition pharmaceutique la contenant et son application en therapeutique. |
| CN101466364A (zh) * | 2006-03-22 | 2009-06-24 | 纽约大学西奈山医学院 | 鼻内施用氯胺酮治疗抑郁症 |
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| GB0810063D0 (en) | 2008-06-03 | 2008-07-09 | Renovo Ltd | Medicaments and methods for inhibition of scarring |
| CA2732636A1 (en) | 2008-09-01 | 2009-05-07 | H. Lundbeck A/S | Pharmaceutical composition comprising gaboxadol and an inhibitor of pat1 or oat |
| ES2836905T3 (es) * | 2014-03-31 | 2021-06-28 | Univ Maryland | Uso de moduladores negativos de los receptores gaba que contienen subunidades alfa5 como antidepresivos de acción rápida |
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| WO2016176609A1 (en) | 2015-04-30 | 2016-11-03 | Ovid Therapeutics Inc | Methods of treating prader-willi syndrome |
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| AR105378A1 (es) | 2015-07-17 | 2017-09-27 | Ovid Therapeutics Inc | Métodos de tratamiento de trastornos del desarrollo con gaboxadol |
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| CN108135889A (zh) | 2015-08-11 | 2018-06-08 | 奥维德医疗公司 | 用于在危重监护治疗期间使用的镇静方法和肠胃外制剂 |
| US9351968B1 (en) | 2015-09-09 | 2016-05-31 | Ovid Therapeutics Inc | Methods of treating developmental disorders using pipradrol |
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| US10071083B2 (en) | 2017-02-03 | 2018-09-11 | Ovid Therapeutics Inc | Use of gaboxadol in the treatment of tinnitus |
| EP3595669A4 (en) | 2017-03-15 | 2021-03-03 | Ovid Therapeutics Inc. | USE OF TAILOR-MADE RECEPTORS ACTIVATED EXCLUSIVELY BY CUSTOM-MADE MEDICINES IN THE TREATMENT OF EPILEPTIC DISORDERS |
| US20180338959A1 (en) | 2017-05-24 | 2018-11-29 | Ovid Therapeutics Inc. | Treatment of depressive disorders |
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| WO2019055369A1 (en) | 2017-09-12 | 2019-03-21 | Ovid Therapeutics Inc. | USE OF GABOXADOL IN THE TREATMENT OF NARCOLEPSIA |
| CN107595850A (zh) | 2017-10-25 | 2018-01-19 | 桂林浩新科技服务有限公司 | 一种有效提高睡眠质量的药物组合物及其用途 |
| AU2019249277A1 (en) | 2018-04-06 | 2020-10-22 | Ovid Therapeutics Inc. | Use of gaboxadol in the treatment of substance use disorders |
| CN113395962A (zh) * | 2018-11-21 | 2021-09-14 | Certego治疗公司 | 加波沙朵用于降低自杀风险和快速缓解抑郁症 |
-
2019
- 2019-11-21 CN CN201980089656.6A patent/CN113395962A/zh active Pending
- 2019-11-21 GB GB2108720.0A patent/GB2594616A/en not_active Withdrawn
- 2019-11-21 MX MX2021005992A patent/MX2021005992A/es unknown
- 2019-11-21 SG SG11202105358RA patent/SG11202105358RA/en unknown
- 2019-11-21 KR KR1020217019089A patent/KR20210110585A/ko not_active Ceased
- 2019-11-21 AU AU2019384157A patent/AU2019384157A1/en not_active Abandoned
- 2019-11-21 WO PCT/US2019/062554 patent/WO2020106927A1/en not_active Ceased
- 2019-11-21 JP JP2021529111A patent/JP2022514194A/ja active Pending
- 2019-11-21 EP EP19886329.2A patent/EP3883566A4/en not_active Withdrawn
- 2019-11-21 BR BR112021009944-1A patent/BR112021009944A2/pt not_active IP Right Cessation
- 2019-11-21 US US16/691,049 patent/US11123332B2/en not_active Expired - Fee Related
- 2019-11-21 US US17/295,845 patent/US20220008398A1/en not_active Abandoned
- 2019-11-21 CA CA3120856A patent/CA3120856A1/en active Pending
-
2021
- 2021-04-02 US US17/221,178 patent/US20220054461A1/en not_active Abandoned
- 2021-05-20 IL IL283311A patent/IL283311A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11202105358RA (en) | 2021-06-29 |
| BR112021009944A2 (pt) | 2021-08-17 |
| US11123332B2 (en) | 2021-09-21 |
| GB202108720D0 (en) | 2021-08-04 |
| KR20210110585A (ko) | 2021-09-08 |
| AU2019384157A1 (en) | 2021-06-17 |
| US20220008398A1 (en) | 2022-01-13 |
| US20220054461A1 (en) | 2022-02-24 |
| JP2022514194A (ja) | 2022-02-10 |
| WO2020106927A1 (en) | 2020-05-28 |
| CN113395962A (zh) | 2021-09-14 |
| US20200155522A1 (en) | 2020-05-21 |
| CA3120856A1 (en) | 2020-05-28 |
| EP3883566A1 (en) | 2021-09-29 |
| IL283311A (en) | 2021-07-29 |
| GB2594616A (en) | 2021-11-03 |
| EP3883566A4 (en) | 2022-09-07 |
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