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MX2019014321A - Compuestos biciclicos 5,6-fusionados y composiciones para el tratamiento de enfermedades parasitarias. - Google Patents

Compuestos biciclicos 5,6-fusionados y composiciones para el tratamiento de enfermedades parasitarias.

Info

Publication number
MX2019014321A
MX2019014321A MX2019014321A MX2019014321A MX2019014321A MX 2019014321 A MX2019014321 A MX 2019014321A MX 2019014321 A MX2019014321 A MX 2019014321A MX 2019014321 A MX2019014321 A MX 2019014321A MX 2019014321 A MX2019014321 A MX 2019014321A
Authority
MX
Mexico
Prior art keywords
fused
compositions
treatment
parasitic diseases
bicyclic compounds
Prior art date
Application number
MX2019014321A
Other languages
English (en)
Other versions
MX389106B (es
Inventor
Molteni Valentina
m smith Jeffrey
Liu Xiaodong
Liang Fang
Suresh Nagle Advait
Jiricek Jan
K Lerario Isabelle
Ratnikov Maxim
Xie Yongping
Pearly NG Shuyi
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2019014321A publication Critical patent/MX2019014321A/es
Publication of MX389106B publication Critical patent/MX389106B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona un compuesto de la Fórmula (I) o una sal farmacéuticamente aceptable del mismo; (ver Fórmula) un método de preparación de los compuestos de la invención, y sus usos terapéuticos. La presente invención además proporciona una combinación de agentes farmacológicamente activos y una composición farmacéutica.
MX2019014321A 2017-05-31 2018-05-29 Compuestos biciclicos 5,6-fusionados y composiciones para el tratamiento de enfermedades parasitarias. MX389106B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762513211P 2017-05-31 2017-05-31
US201762581919P 2017-11-06 2017-11-06
PCT/IB2018/053818 WO2018220531A1 (en) 2017-05-31 2018-05-29 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases

Publications (2)

Publication Number Publication Date
MX2019014321A true MX2019014321A (es) 2020-02-05
MX389106B MX389106B (es) 2025-03-20

Family

ID=62749123

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019014321A MX389106B (es) 2017-05-31 2018-05-29 Compuestos biciclicos 5,6-fusionados y composiciones para el tratamiento de enfermedades parasitarias.

Country Status (26)

Country Link
US (2) US11384078B2 (es)
EP (1) EP3630771B1 (es)
JP (1) JP7187490B2 (es)
KR (1) KR20200010275A (es)
CN (1) CN110678468B (es)
AR (1) AR111826A1 (es)
AU (1) AU2018276190B2 (es)
BR (1) BR112019024804A2 (es)
CA (1) CA3060990A1 (es)
CL (1) CL2019003467A1 (es)
CO (1) CO2019013254A2 (es)
CR (1) CR20190545A (es)
CU (1) CU24543B1 (es)
DO (1) DOP2019000299A (es)
EC (1) ECSP19084722A (es)
ES (1) ES2927207T3 (es)
IL (1) IL270927B (es)
JO (1) JOP20190278A1 (es)
MA (1) MA50495A (es)
MX (1) MX389106B (es)
PE (1) PE20201148A1 (es)
PH (1) PH12019502652A1 (es)
RU (1) RU2738647C1 (es)
TW (1) TW201902894A (es)
UY (1) UY37745A (es)
WO (1) WO2018220531A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190278A1 (ar) * 2017-05-31 2019-11-28 Novartis Ag مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية
CN115397807B (zh) * 2020-04-17 2024-08-13 帝斯曼知识产权资产管理有限公司 用于制备取代的烯胺化合物的方法
US20230250064A1 (en) * 2020-06-23 2023-08-10 Shanghai Meiyue Biotech Development Co., Ltd. Preparation method for fused pyrazole-type compound

Family Cites Families (15)

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DE10053275A1 (de) * 2000-10-27 2002-05-02 Dresden Arzneimittel Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
CL2004000398A1 (es) 2003-02-27 2005-03-18 Uriach Y Compania S A J Compuestos derivados de pirazolopiridinas, sus sales; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar enfermedades mediadas por quinasas p38, en especial por citocinas, tnf-alfa, il-1, il-6 y/o il-8, tales como enfermedad
US20120220453A1 (en) 2011-02-25 2012-08-30 Dow Agrosciences Llc Pesticidal compostions and processes related thereto
WO2013067302A1 (en) 2011-11-04 2013-05-10 Glaxosmithkline Intellectual Property (No. 2) Limited Method of treatment
WO2013106254A1 (en) 2012-01-11 2013-07-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
ES2655030T3 (es) 2012-11-19 2018-02-16 Novartis Ag Compuestos y composiciones para el tratamiento de enfermedades parasitarias
WO2014151729A1 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
UY35400A (es) * 2013-03-15 2014-10-31 Novartis Ag Compuestos y composiciones para el tratamiento de enfermedades parasitarias
TWI674263B (zh) 2013-12-19 2019-10-11 瑞士商諾華公司 用於治療寄生蟲疾病之化合物及組合物
ES2700352T3 (es) 2014-12-02 2019-02-15 Bayer Cropscience Ag Compuestos bicíclicos como pesticidas
CN112679467B (zh) 2015-03-11 2024-11-01 Fmc公司 杂环取代的二环唑杀有害生物剂
JP2018516265A (ja) 2015-05-29 2018-06-21 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 抗寄生虫剤としてのイミダゾ［１，２−ｂ］［１，２，４］トリアジン誘導体
RU2734877C2 (ru) 2015-08-07 2020-10-23 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Соединения
HRP20201746T1 (hr) 2016-05-03 2020-12-25 Bayer Pharma Aktiengesellschaft Aromatski derivati sulfonamida
JOP20190278A1 (ar) * 2017-05-31 2019-11-28 Novartis Ag مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية

Also Published As

Publication number Publication date
CR20190545A (es) 2020-01-15
EP3630771B1 (en) 2022-06-29
ES2927207T3 (es) 2022-11-03
EP3630771A1 (en) 2020-04-08
IL270927B (en) 2022-01-01
WO2018220531A1 (en) 2018-12-06
JP2020521775A (ja) 2020-07-27
CL2019003467A1 (es) 2020-03-13
UY37745A (es) 2019-01-02
PH12019502652A1 (en) 2020-07-13
IL270927A (en) 2020-01-30
CN110678468A (zh) 2020-01-10
US20200109142A1 (en) 2020-04-09
CO2019013254A2 (es) 2020-01-17
TW201902894A (zh) 2019-01-16
MA50495A (fr) 2021-04-28
JP7187490B2 (ja) 2022-12-12
KR20200010275A (ko) 2020-01-30
JOP20190278A1 (ar) 2019-11-28
MX389106B (es) 2025-03-20
AR111826A1 (es) 2019-08-21
BR112019024804A2 (pt) 2020-06-09
CN110678468B (zh) 2022-07-29
CA3060990A1 (en) 2018-12-06
RU2738647C1 (ru) 2020-12-15
US20220324863A1 (en) 2022-10-13
DOP2019000299A (es) 2019-12-15
CU20190095A7 (es) 2020-10-20
PE20201148A1 (es) 2020-10-26
US11384078B2 (en) 2022-07-12
AU2018276190A1 (en) 2019-11-07
CU24543B1 (es) 2021-08-06
AU2018276190B2 (en) 2020-05-14
ECSP19084722A (es) 2019-12-27

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