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MX2019005420A - Preparacion de acido (r)-3-hidroxibutirico o sus sales mediante fermentacion de una etapa. - Google Patents

Preparacion de acido (r)-3-hidroxibutirico o sus sales mediante fermentacion de una etapa.

Info

Publication number
MX2019005420A
MX2019005420A MX2019005420A MX2019005420A MX2019005420A MX 2019005420 A MX2019005420 A MX 2019005420A MX 2019005420 A MX2019005420 A MX 2019005420A MX 2019005420 A MX2019005420 A MX 2019005420A MX 2019005420 A MX2019005420 A MX 2019005420A
Authority
MX
Mexico
Prior art keywords
hydroxybutyric acid
salts
preparation
step fermentation
fermentation
Prior art date
Application number
MX2019005420A
Other languages
English (en)
Inventor
Liao Kylin
Fan Wenchao
Original Assignee
Nnb Nutrition Usa Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nnb Nutrition Usa Llc filed Critical Nnb Nutrition Usa Llc
Publication of MX2019005420A publication Critical patent/MX2019005420A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/124—Acids containing four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se relaciona a un proceso para preparar ácido (R)-3-hidroxibutírico o una sal del mismo mediante fermentación de una etapa con un microorganismo no patogénico. La fermentación de ácido (R)-3-hidroxibutírico se realizó al suministrar con ciertas fuentes de carbono y nitrógeno. Estos microorganismos incluyen una cepa de Bacteria HR057 de Ácido Glutámico o un tipo de Corynebacterium Glutamicum genéticamente diseñada.
MX2019005420A 2017-04-04 2018-04-03 Preparacion de acido (r)-3-hidroxibutirico o sus sales mediante fermentacion de una etapa. MX2019005420A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762481476P 2017-04-04 2017-04-04
PCT/US2018/025879 WO2018187324A1 (en) 2017-04-04 2018-04-03 Preparation of (r)-3-hydroxybutyric acid or its salts by one-step fermentation

Publications (1)

Publication Number Publication Date
MX2019005420A true MX2019005420A (es) 2019-11-18

Family

ID=63672435

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019005420A MX2019005420A (es) 2017-04-04 2018-04-03 Preparacion de acido (r)-3-hidroxibutirico o sus sales mediante fermentacion de una etapa.

Country Status (9)

Country Link
US (3) US10428357B2 (es)
EP (1) EP3507272A4 (es)
JP (1) JP7156594B2 (es)
KR (1) KR102480436B1 (es)
CN (1) CN110035991B (es)
AU (1) AU2018250146B2 (es)
CA (1) CA3039255C (es)
MX (1) MX2019005420A (es)
WO (1) WO2018187324A1 (es)

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US11103470B2 (en) 2017-11-22 2021-08-31 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US11241403B2 (en) 2016-03-11 2022-02-08 Axcess Global Sciences, Llc Beta-hydroxybutyrate mixed salt compositions and methods of use
US10925843B2 (en) 2018-04-18 2021-02-23 Axcess Global Sciences, Llc Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate
US11806324B2 (en) 2018-04-18 2023-11-07 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies
US12109182B2 (en) 2016-04-19 2024-10-08 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate and related compounds in humans
US11202769B2 (en) 2017-11-22 2021-12-21 Axcess Global Sciences, Llc Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function
US12090129B2 (en) 2017-11-22 2024-09-17 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US12329734B2 (en) 2017-12-19 2025-06-17 Axcess Global Sciences, Llc Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow
US11944598B2 (en) 2017-12-19 2024-04-02 Axcess Global Sciences, Llc Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer
CN110862316A (zh) * 2018-08-27 2020-03-06 浙江华睿生物技术有限公司 一种（r）-3-羟基丁酸的晶型及其应用
CN109369372A (zh) * 2018-11-28 2019-02-22 上海欣海国际贸易有限公司 一种制备3-羟基丁酸盐的方法
US12472200B2 (en) 2019-05-15 2025-11-18 Axcess Global Sciences, Llc Autobiotic compositions and method for promoting healthy gut microbiome
CN111944853A (zh) * 2019-05-17 2020-11-17 南京纽邦生物科技有限公司 一种微生物发酵生产(r)-3-羟基丁酸的方法
US12167993B2 (en) 2019-06-21 2024-12-17 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
US11969430B1 (en) 2023-03-10 2024-04-30 Axcess Global Sciences, Llc Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance
US11950616B2 (en) 2019-06-21 2024-04-09 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
CN111534561A (zh) * 2020-05-19 2020-08-14 南京纽邦生物科技有限公司 一种(r)-3-羟基丁酸的制备方法
AU2021327408A1 (en) * 2020-08-18 2023-04-20 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies
US12186297B2 (en) 2020-08-26 2025-01-07 Axcess Global Sciences, Llc Compositions and methods for increasing lean-to-fat mass ratio
CN115968364A (zh) * 2021-04-16 2023-04-14 南京纽邦生物科技有限公司 低铅和低砷的β-羟基丁酸盐及其生产方法
CN114436807B (zh) * 2022-01-24 2023-12-22 珠海麦得发生物科技股份有限公司 一种(r)-3-羟基丁酸盐的制备方法
CN120919030A (zh) * 2025-10-10 2025-11-11 广东康容实业有限公司 一种抗氧化组合物及其制备方法和应用

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Also Published As

Publication number Publication date
JP2019536478A (ja) 2019-12-19
KR102480436B1 (ko) 2022-12-21
JP7156594B2 (ja) 2022-10-19
US20190376098A1 (en) 2019-12-12
AU2018250146B2 (en) 2020-11-05
WO2018187324A1 (en) 2018-10-11
CN110035991A (zh) 2019-07-19
CN110035991B (zh) 2022-06-17
CA3039255A1 (en) 2018-10-11
US20180282767A1 (en) 2018-10-04
US20220162653A1 (en) 2022-05-26
KR20190137060A (ko) 2019-12-10
EP3507272A1 (en) 2019-07-10
AU2018250146A1 (en) 2019-04-18
EP3507272A4 (en) 2019-07-10
CA3039255C (en) 2022-11-29
US10428357B2 (en) 2019-10-01
US11198890B2 (en) 2021-12-14

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