MX2019003091A - Inhibidores de la interaccion de menina-mll. - Google Patents
Inhibidores de la interaccion de menina-mll.Info
- Publication number
- MX2019003091A MX2019003091A MX2019003091A MX2019003091A MX2019003091A MX 2019003091 A MX2019003091 A MX 2019003091A MX 2019003091 A MX2019003091 A MX 2019003091A MX 2019003091 A MX2019003091 A MX 2019003091A MX 2019003091 A MX2019003091 A MX 2019003091A
- Authority
- MX
- Mexico
- Prior art keywords
- menin
- inhibitors
- mll
- interaction
- mll interaction
- Prior art date
Links
- 230000003993 interaction Effects 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101710169972 Menin Proteins 0.000 abstract 1
- 102100030550 Menin Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662395618P | 2016-09-16 | 2016-09-16 | |
| PCT/US2017/051780 WO2018053267A1 (fr) | 2016-09-16 | 2017-09-15 | Inhibiteurs de l'interaction ménine-mll |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019003091A true MX2019003091A (es) | 2019-07-08 |
Family
ID=59966892
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019003091A MX2019003091A (es) | 2016-09-16 | 2017-09-15 | Inhibidores de la interaccion de menina-mll. |
| MX2022013841A MX2022013841A (es) | 2016-09-16 | 2019-03-15 | Inhibidores de la interaccion de menina-mll. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022013841A MX2022013841A (es) | 2016-09-16 | 2019-03-15 | Inhibidores de la interaccion de menina-mll. |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10899758B2 (fr) |
| EP (2) | EP3512850B1 (fr) |
| JP (3) | JP2019529421A (fr) |
| KR (1) | KR102536029B1 (fr) |
| CN (2) | CN118359610A (fr) |
| AR (1) | AR109658A1 (fr) |
| AU (1) | AU2017326006B2 (fr) |
| CA (1) | CA3036987A1 (fr) |
| DK (1) | DK3512850T3 (fr) |
| ES (1) | ES2948949T3 (fr) |
| FI (1) | FI3512850T3 (fr) |
| IL (2) | IL295972A (fr) |
| MX (2) | MX2019003091A (fr) |
| PL (1) | PL3512850T3 (fr) |
| TW (1) | TWI757340B (fr) |
| WO (1) | WO2018053267A1 (fr) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10246464B2 (en) | 2014-09-09 | 2019-04-02 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| WO2016197027A1 (fr) | 2015-06-04 | 2016-12-08 | Kura Oncology, Inc. | Méthodes et compositions d'inhibition de l'interaction de la ménine avec les protéines mll |
| TWI703150B (zh) | 2015-06-04 | 2020-09-01 | 美商庫拉腫瘤技術股份有限公司 | 用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物 |
| SG11201807834WA (en) | 2016-03-16 | 2018-10-30 | Kura Oncology Inc | Bridged bicyclic inhibitors of menin-mll and methods of use |
| MX388839B (es) | 2016-03-16 | 2025-03-20 | Kura Oncology Inc | Inhibidores sustituidos de menina-mll y metodos de uso |
| ES2899936T3 (es) | 2016-05-02 | 2022-03-15 | The Regents Of The Univ Of Michigan Office Of Technology Transfer | Piperidinas como inhibidores de meninas |
| MX381228B (es) | 2016-06-10 | 2025-03-12 | Vitae Pharmaceuticals Llc | Inhibidores de la interacción de menina-leucemia de linaje mixto. |
| AU2017326485B2 (en) | 2016-09-14 | 2021-04-22 | Janssen Pharmaceutica Nv | Fused bicyclic inhibitors of menin-MLL interaction |
| BR112019004691A2 (pt) | 2016-09-14 | 2019-06-25 | Janssen Pharmaceutica Nv | inibidores bicíclicos em espiro da interação menina-mll |
| US12084462B2 (en) | 2016-09-14 | 2024-09-10 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-MLL interaction |
| ES2948949T3 (es) * | 2016-09-16 | 2023-09-22 | Vitae Pharmaceuticals Llc | Inhibidores de la interacción menina-MLL |
| MX391405B (es) | 2016-12-15 | 2025-03-21 | Janssen Pharmaceutica Nv | Inhibidores de azepano de la interacción menina-mll. |
| EP3601249A4 (fr) | 2017-03-24 | 2020-12-16 | Kura Oncology, Inc. | Méthodes de traitement d'hémopathies malignes et du sarcome d'ewing |
| MX2019011412A (es) | 2017-03-31 | 2020-02-07 | Univ Michigan Regents | Piperidinas como inhibidores de menina covalentes. |
| WO2018226976A1 (fr) | 2017-06-08 | 2018-12-13 | Kura Oncology, Inc. | Procédés et compositions d'inhibition de l'interaction de la ménine avec les protéines mll |
| US11649251B2 (en) | 2017-09-20 | 2023-05-16 | Kura Oncology, Inc. | Substituted inhibitors of menin-MLL and methods of use |
| KR20190043437A (ko) | 2017-10-18 | 2019-04-26 | 씨제이헬스케어 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
| US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
| US11447484B2 (en) * | 2018-01-26 | 2022-09-20 | Shionogi & Co., Ltd. | Cyclic compound having dopamine D3 receptor antagonistic effect |
| JP7239562B2 (ja) | 2018-03-30 | 2023-03-14 | 住友ファーマ株式会社 | 光学活性な架橋型環状２級アミン誘導体 |
| AU2019327006B2 (en) * | 2018-08-27 | 2024-02-15 | Sumitomo Pharma Co., Ltd. | Optically active azabicyclic derivative |
| AU2019340173B2 (en) * | 2018-09-13 | 2024-02-08 | Kissei Pharmaceutical Co., Ltd. | Imidazopyridinone compound |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| KR20210100612A (ko) | 2018-12-06 | 2021-08-17 | 다이이찌 산쿄 가부시키가이샤 | 시클로알칸-1,3-디아민 유도체 |
| WO2021053617A1 (fr) * | 2019-09-20 | 2021-03-25 | Novartis Ag | Inhibiteurs de mll1 et agents anticancéreux |
| WO2021060453A1 (fr) * | 2019-09-27 | 2021-04-01 | 大日本住友製薬株式会社 | Dérivé d'amine secondaire optiquement actif réticulé |
| EP4077312A4 (fr) | 2019-12-19 | 2024-01-17 | Janssen Pharmaceutica NV | Dérivés spiro à chaîne droite substitués |
| WO2021138540A1 (fr) | 2020-01-03 | 2021-07-08 | Berg Llc | Amides polycycliques utilisés en tant que modulateurs d'ube2k pour le traitement du cancer |
| CN111297863B (zh) * | 2020-03-30 | 2021-06-25 | 四川大学华西医院 | menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用 |
| AR122159A1 (es) * | 2020-05-28 | 2022-08-17 | Novartis Ag | Inhibidores de mll1 y agentes antineoplásicos |
| CR20230314A (es) | 2020-12-17 | 2023-08-18 | Astrazeneca Ab | N-(2-(4-cianotiazolidin-3-il)-2-oxoetil)-quinolin-4-carboxamidas |
| JP2024518425A (ja) | 2021-05-08 | 2024-05-01 | ヤンセン ファーマシューティカ エヌ．ベー． | 置換スピロ誘導体 |
| CA3215379A1 (fr) | 2021-05-08 | 2022-11-17 | Olivier Alexis Georges Querolle | Derives spiro substitues |
| IL308476A (en) | 2021-05-14 | 2024-01-01 | Syndax Pharmaceuticals Inc | Inhibitors of the menin-mil interaction |
| IL308862A (en) | 2021-06-01 | 2024-01-01 | Janssen Pharmaceutica Nv | Altered phenyl-1H-pyrrolo[3,2-c]pyridine histories |
| BR112023025436A2 (pt) | 2021-06-03 | 2024-02-27 | Janssen Pharmaceutica Nv | Piridazinas ou 1,2,4-triazinas substituídas por aminas espirocíclicas |
| EP4355747A1 (fr) | 2021-06-17 | 2024-04-24 | JANSSEN Pharmaceutica NV | Sel de bésylate (r)-n-éthyl-5-fluoro-n-isopropyl-2-((5-(2-(6-((2-méthoxyéthyl)(méthyl)amino)-2-m éthylhexan-3-yl)-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl)oxy)benzamide pour le traitement de maladies telles que le cancer |
| CN116903609A (zh) * | 2021-11-05 | 2023-10-20 | 上海优理惠生医药有限公司 | 一种化合物、包含其的药物组合物及其应用 |
| WO2023084320A1 (fr) * | 2021-11-11 | 2023-05-19 | V-Ensure Pharma Technologies Private Limited | Compositions antidiabétiques reconstituables à usage unique |
| WO2023193790A1 (fr) * | 2022-04-08 | 2023-10-12 | Janssen Pharmaceutica Nv | Formes cristallines d'un inhibiteur de l'interaction ménine/mll |
| KR20250109775A (ko) | 2022-11-24 | 2025-07-17 | 오리존 지노믹스 에스.에이. | 암 치료를 위한 lsd1 억제제 및 메닌 억제제의 조합 |
| CN120435473A (zh) * | 2022-11-30 | 2025-08-05 | 詹森药业有限公司 | 取代的1-苯基-3,4-二氢吡啶并[3,4-d]嘧啶-2-酮衍生物 |
| EP4626427A1 (fr) * | 2022-11-30 | 2025-10-08 | Janssen Pharmaceutica NV | Combinaisons comprenant un inhibiteur de ménine-mll et un inhibiteur de bcl-2 |
| CN120322230A (zh) * | 2022-11-30 | 2025-07-15 | 詹森药业有限公司 | 包含多发性内分泌癌蛋白-mll抑制剂和至少一种其他治疗剂的组合 |
| WO2024114662A1 (fr) * | 2022-11-30 | 2024-06-06 | Janssen Pharmaceutica Nv | Composés bicycliques à substitution cyclobutyle |
| AR132185A1 (es) * | 2023-03-24 | 2025-06-04 | Acerta Pharma Bv | COMPUESTOS DE 1-H-PIRROLO[2,3-c]PIRIDINA |
| WO2025067111A1 (fr) * | 2023-09-27 | 2025-04-03 | 苏州必扬医药科技有限公司 | Inhibiteur d'interaction ménine-mll et son procédé de préparation, et application |
| WO2025119184A1 (fr) * | 2023-12-04 | 2025-06-12 | 首药控股(北京)股份有限公司 | Composé polycyclique substitué |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ2001959A3 (cs) * | 1998-09-18 | 2001-12-12 | Basf Aktiengesellschaft | 4-Aminopyrrolopyrimidiny jako inhibitory kinasy |
| CA2605738C (fr) | 2005-04-25 | 2013-10-01 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Nouveaux aza-heterocycles constituant des inhibiteurs de kinases |
| WO2010066629A2 (fr) * | 2008-12-09 | 2010-06-17 | F. Hoffmann-La Roche Ag | Nouvelles azaindoles |
| GB201004311D0 (en) * | 2010-03-15 | 2010-04-28 | Proximagen Ltd | New enzyme inhibitor compounds |
| EP3590938B1 (fr) * | 2010-05-31 | 2023-05-24 | ONO Pharmaceutical Co., Ltd. | Dérivé de purinone comme inhibiteur de la kinase btk |
| US9273056B2 (en) | 2011-10-03 | 2016-03-01 | The University Of North Carolina At Chapel Hill | Pyrrolopyrimidine compounds for the treatment of cancer |
| US8377946B1 (en) * | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| WO2014017659A1 (fr) * | 2012-07-27 | 2014-01-30 | 独立行政法人理化学研究所 | Agent destiné à traiter ou à supprimer une récidive de leucémie myélogène aiguë |
| MX2015006168A (es) | 2012-11-15 | 2015-08-10 | Pharmacyclics Inc | Compuestos de pirrolopirimidina como inhibidores de quinasas. |
| US20160113893A1 (en) * | 2013-06-12 | 2016-04-28 | Proximagen Limited | New therapeutic uses of enzyme inhibitors |
| US20210317140A1 (en) * | 2013-10-18 | 2021-10-14 | Medivation Technologies, Inc. | Heterocyclic Compounds and Methods of Use |
| ES2827523T3 (es) | 2015-03-11 | 2021-05-21 | Riken | Agente terapéutico para la leucemia intratable |
| ES2948949T3 (es) * | 2016-09-16 | 2023-09-22 | Vitae Pharmaceuticals Llc | Inhibidores de la interacción menina-MLL |
-
2017
- 2017-09-15 ES ES17772585T patent/ES2948949T3/es active Active
- 2017-09-15 TW TW106131767A patent/TWI757340B/zh active
- 2017-09-15 EP EP17772585.0A patent/EP3512850B1/fr active Active
- 2017-09-15 EP EP23167055.5A patent/EP4230627A3/fr active Pending
- 2017-09-15 IL IL295972A patent/IL295972A/en unknown
- 2017-09-15 CN CN202410398451.9A patent/CN118359610A/zh active Pending
- 2017-09-15 MX MX2019003091A patent/MX2019003091A/es unknown
- 2017-09-15 WO PCT/US2017/051780 patent/WO2018053267A1/fr not_active Ceased
- 2017-09-15 DK DK17772585.0T patent/DK3512850T3/da active
- 2017-09-15 CA CA3036987A patent/CA3036987A1/fr active Pending
- 2017-09-15 JP JP2019514787A patent/JP2019529421A/ja not_active Withdrawn
- 2017-09-15 PL PL17772585.0T patent/PL3512850T3/pl unknown
- 2017-09-15 FI FIEP17772585.0T patent/FI3512850T3/fi active
- 2017-09-15 US US16/333,852 patent/US10899758B2/en active Active
- 2017-09-15 CN CN201780063763.2A patent/CN110325533A/zh active Pending
- 2017-09-15 AR ARP170102556A patent/AR109658A1/es unknown
- 2017-09-15 KR KR1020197010730A patent/KR102536029B1/ko active Active
- 2017-09-15 AU AU2017326006A patent/AU2017326006B2/en active Active
- 2017-09-15 IL IL265028A patent/IL265028B/en unknown
-
2019
- 2019-03-15 MX MX2022013841A patent/MX2022013841A/es unknown
-
2020
- 2020-08-11 US US16/990,657 patent/US11739085B2/en active Active
-
2022
- 2022-10-06 JP JP2022161777A patent/JP2022189853A/ja active Pending
-
2023
- 2023-05-18 US US18/320,111 patent/US20240124447A1/en active Pending
-
2024
- 2024-11-08 JP JP2024195965A patent/JP2025022910A/ja active Pending
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