MX2019001633A - Proteina derivada de la seda para el tratamiento de la inflamacion. - Google Patents
Proteina derivada de la seda para el tratamiento de la inflamacion.Info
- Publication number
- MX2019001633A MX2019001633A MX2019001633A MX2019001633A MX2019001633A MX 2019001633 A MX2019001633 A MX 2019001633A MX 2019001633 A MX2019001633 A MX 2019001633A MX 2019001633 A MX2019001633 A MX 2019001633A MX 2019001633 A MX2019001633 A MX 2019001633A
- Authority
- MX
- Mexico
- Prior art keywords
- silk
- treatment
- inflammation
- protein derived
- effective amount
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Insects & Arthropods (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
En el presente documento se describen procedimientos para reducir la inflamación mediante la administración de una cantidad eficaz de proteínas obtenidas de la seda (SDP) o una fracción de las mismas a un sujeto que tiene una afección inflamatoria. Los procedimientos incluyen el tratamiento de afecciones inflamatorias y heridas, incluyendo heridas de la córnea, que comprende la administración tópica de una cantidad eficaz de material de SDP como se describe en el presente documento.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374532P | 2016-08-12 | 2016-08-12 | |
| US201662407863P | 2016-10-13 | 2016-10-13 | |
| US201762467697P | 2017-03-06 | 2017-03-06 | |
| PCT/US2017/046659 WO2018031973A1 (en) | 2016-08-12 | 2017-08-12 | Silk-derived protein for treating inflammation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019001633A true MX2019001633A (es) | 2019-09-18 |
Family
ID=61163249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019001633A MX2019001633A (es) | 2016-08-12 | 2017-08-12 | Proteina derivada de la seda para el tratamiento de la inflamacion. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11242367B2 (es) |
| EP (1) | EP3496662A4 (es) |
| JP (1) | JP2019531334A (es) |
| KR (1) | KR102275012B1 (es) |
| CN (1) | CN109862851A (es) |
| AU (1) | AU2017310520A1 (es) |
| CA (1) | CA3033507A1 (es) |
| MX (1) | MX2019001633A (es) |
| NZ (1) | NZ751231A (es) |
| SG (1) | SG11201901137UA (es) |
| WO (1) | WO2018031973A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9394355B2 (en) | 2014-08-20 | 2016-07-19 | Silk Technologies, Ltd. | Fibroin-derived protein composition |
| WO2019094702A1 (en) | 2017-11-10 | 2019-05-16 | Cocoon Biotech Inc. | Ocular applications of silk-based products |
| EP3910096A4 (en) * | 2019-01-09 | 2023-05-24 | Spiber Inc. | MODIFIED FIBROIN |
| WO2020247594A1 (en) | 2019-06-04 | 2020-12-10 | Cocoon Biotech Inc. | Silk-based products, formulations, and methods of use |
| KR102374291B1 (ko) * | 2019-09-10 | 2022-03-14 | 강릉원주대학교산학협력단 | 천연 포졸란을 포함하는 사료 첨가제 조성물 |
| JP7670704B2 (ja) * | 2019-11-15 | 2025-04-30 | シルク テクノロジーズ、リミテッド | 絹由来タンパク質の安定した配合物 |
| IT201900023142A1 (it) * | 2019-12-05 | 2021-06-05 | Sifi Spa | Composizione topica oculare contenente metaboliti della fermentazione di lactobacillus |
| KR102194995B1 (ko) * | 2020-09-16 | 2020-12-28 | 장혜란 | 진단을 위한 개선된 건조체액의 안정화 조성물 및 이의 응용방법 |
| US12161693B2 (en) | 2021-04-14 | 2024-12-10 | Cocoon Biotech Inc. | Methods of making stable silk fibroin formulations |
| JP2024538181A (ja) * | 2021-10-18 | 2024-10-18 | エボルブド バイ ネイチャー, インコーポレイテッド | 絹によって刺激されたコラーゲン及びクローディン-1発現、並びに絹によって刺激された抗炎症効果 |
| CN114685825B (zh) * | 2022-03-22 | 2023-02-28 | 浙江大学 | 一种蚕丝蛋白共晶凝胶的制备方法及其产品和应用 |
| CN117288958B (zh) * | 2023-09-18 | 2025-08-29 | 福州大学附属省立医院 | 一种检测蛋白质的试剂在制备诊断精神分裂症攻击性行为的产品中的应用 |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5931520B2 (ja) | 1979-03-22 | 1984-08-02 | カネボウ株式会社 | 絹フイブロインペプチド水溶液の製造法 |
| IL101850A (en) | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them |
| CA2125060C (en) | 1993-07-02 | 1999-03-30 | Henry P. Dabrowski | Ophthalmic solution for artificial tears |
| JPH0767686A (ja) | 1993-09-06 | 1995-03-14 | Shinano Kenshi Co Ltd | 低分子量の絹フィブロインペプチドの製造方法 |
| US5760004A (en) | 1994-11-21 | 1998-06-02 | Protein Polymer Technologies, Inc. | Chemical modification of repetitive polymers to enhance water solubility |
| JP3449658B2 (ja) | 1994-12-21 | 2003-09-22 | 杏林製薬株式会社 | 安定性に優れた8−アルコキシキノロンカルボン酸水和物並びにその製造方法 |
| US5895645A (en) | 1995-01-31 | 1999-04-20 | Bausch & Lomb Incorporated | Opthalmic solution for artificial tears |
| JPH08295697A (ja) | 1995-04-26 | 1996-11-12 | Kanebo Ltd | 高濃度絹フィブロイン水溶液の製造方法 |
| AU2022599A (en) | 1997-12-31 | 1999-07-19 | Kimberly-Clark Worldwide, Inc. | Method of reducing molecular weights and polydispersity indices of polymers of ethylene oxide |
| FR2774588B1 (fr) | 1998-02-11 | 2000-05-05 | Oreal | Composition cosmetique ou dermatologique contenant au moins une proteine de soie d'arachnides naturelle, recombinante ou un analogue |
| CN1133432C (zh) | 1998-08-21 | 2004-01-07 | 千寿制药株式会社 | 含水液体药物组合物 |
| JP2000143472A (ja) | 1998-11-10 | 2000-05-23 | Hiroshi Akai | 紫外線吸収機能を有する化粧剤 |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| NZ521185A (en) | 2000-07-14 | 2005-02-25 | Allergan Inc | Compositions containing alpha-2-adrenergic agonist components |
| US8858961B2 (en) | 2000-07-14 | 2014-10-14 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| KR20030023700A (ko) | 2000-07-14 | 2003-03-19 | 알러간, 인코포레이티드 | 치료활성 성분을 함유하고 용해도가 증강된 조성물 |
| US20030206897A1 (en) | 2000-09-13 | 2003-11-06 | The Procter & Gamble Company | Cosmetic compositions |
| IT1316885B1 (it) | 2000-10-02 | 2003-05-13 | Consorzio Per Gli Studi Uni | Procedimento per la preparazione di un tessuto non tessuto in fibroinadi seta. |
| CN1277584C (zh) | 2001-10-25 | 2006-10-04 | 康涅狄格大学 | 生物活性物质,制备生物活性物质的方法及其使用方法 |
| WO2003045336A1 (en) | 2001-11-29 | 2003-06-05 | National Institute Of Agrobiological Sciences | Emulsifier and process for producing the same |
| US7351404B2 (en) | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| US7642258B2 (en) | 2002-04-19 | 2010-01-05 | Allergan, Inc. | Combination of brimonidine and timolol for topical ophthalmic use |
| US7030149B2 (en) | 2002-04-19 | 2006-04-18 | Allergan, Inc. | Combination of brimonidine timolol for topical ophthalmic use |
| US7842780B2 (en) | 2003-01-07 | 2010-11-30 | Trustees Of Tufts College | Silk fibroin materials and use thereof |
| US7060260B2 (en) | 2003-02-20 | 2006-06-13 | E.I. Du Pont De Nemours And Company | Water-soluble silk proteins in compositions for skin care, hair care or hair coloring |
| KR20040077553A (ko) * | 2003-02-28 | 2004-09-04 | 독립행정법인농업생물자원연구소 | 견 단백질로부터 세포 생육 펩티드의 추출과 이용 |
| US7115388B2 (en) | 2003-03-14 | 2006-10-03 | National Institute Of Agrobiological Sciences | Production of functional polypeptides originating from silk protein and use thereof |
| US20050196370A1 (en) | 2003-03-18 | 2005-09-08 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
| CA2562415C (en) | 2003-04-10 | 2015-10-27 | Tufts University | Concentrated aqueous silk fibroin solutions free of organic solvents and uses thereof |
| CA2468664C (en) | 2003-06-03 | 2012-03-06 | Allergan, Inc. | Ketorolac tromethamine compositions for treating or preventing ocular pain |
| JP2007501799A (ja) | 2003-08-07 | 2007-02-01 | アラーガン、インコーポレイテッド | 眼内に医薬を送達するための組成物ならびにその調製方法および使用方法 |
| US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| EP1682537B1 (en) | 2003-11-05 | 2012-03-28 | SARcode Bioscience Inc. | Modulators of cellular adhesion |
| US20050202097A1 (en) | 2004-03-12 | 2005-09-15 | Melbj Holdings, Llc, Florida | Lubricant for the ocular surface |
| EP1609801A1 (en) | 2004-06-25 | 2005-12-28 | Technische Universität München | Proteins of natural origin and materials made therefrom |
| US10010574B2 (en) | 2004-07-31 | 2018-07-03 | Brainguard Co., Ltd. | Silk peptide for improving neuroprotective and neurofunctional effects and a method of its preparation |
| US8569367B2 (en) | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
| WO2010102078A1 (en) | 2009-03-04 | 2010-09-10 | Allergan, Inc. | Enhanced bimatoprost ophthalmic solution |
| US7851504B2 (en) | 2005-03-16 | 2010-12-14 | Allergan, Inc. | Enhanced bimatoprost ophthalmic solution |
| EP2444079B1 (en) | 2005-05-17 | 2016-11-30 | SARcode Bioscience Inc. | Compositions and Methods for Treatment of Eye Disorders |
| JP5748392B2 (ja) | 2005-10-05 | 2015-07-15 | コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション | 絹タンパク質 |
| DK3150209T3 (da) | 2006-03-31 | 2019-10-28 | Vistakon Pharmaceuticals Llc | Okulære allergibehandlinger |
| WO2007130364A2 (en) | 2006-05-01 | 2007-11-15 | Riolan Technologies, Inc. | Compositions, methods, and kits for treating dry eye |
| WO2008109138A1 (en) | 2007-03-07 | 2008-09-12 | Grune Guerry L | Spf compositions |
| CN104013598A (zh) | 2007-05-29 | 2014-09-03 | 塔夫茨大学信托人 | 利用超声处理使丝纤蛋白凝胶化的方法 |
| CN101194666A (zh) | 2007-11-28 | 2008-06-11 | 吴江市方霞企业信息咨询有限公司 | 蚕蛹丝素蛋白功能性食品 |
| WO2009088119A1 (en) | 2008-01-07 | 2009-07-16 | Bioleaders Corporation | Composition for preventing or treating dry eye syndrome comprising poly-gamma-glutamic acid |
| US7842714B2 (en) | 2008-03-03 | 2010-11-30 | Allergan, Inc. | Ketorolac tromethamine compositions for treating ocular pain |
| WO2009139817A2 (en) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
| US8569730B2 (en) | 2008-07-08 | 2013-10-29 | Sandisk 3D Llc | Carbon-based interface layer for a memory device and methods of forming the same |
| WO2010141133A2 (en) | 2009-03-04 | 2010-12-09 | Trustees Of Tufts College | Silk fibroin systems for antibiotic delivery |
| US20110014287A1 (en) | 2009-04-20 | 2011-01-20 | Altman Gregory H | Silk Fibroin Hydrogels and Uses Thereof |
| MX358504B (es) | 2009-06-05 | 2018-08-21 | Allergan Inc | Lagrimas artificiales y usos terapeuticos. |
| IN2012DN00445A (es) | 2009-07-14 | 2015-05-15 | Tufts College | |
| WO2011050175A1 (en) | 2009-10-21 | 2011-04-28 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
| WO2011109691A2 (en) | 2010-03-05 | 2011-09-09 | Trustees Of Tufts College | Silk-based ionomeric compositions |
| US8309689B2 (en) | 2010-05-20 | 2012-11-13 | Taipei Medical University | High yield dialysis-free process for producing organosoluble regenerated silk fibroin |
| CA2839719A1 (en) | 2010-06-17 | 2011-12-22 | Tufts University / Trustees Of Tufts College | Silk optical particles and uses thereof |
| US20140193466A1 (en) | 2011-06-07 | 2014-07-10 | Cornell University | Silk compositions and methods of using same |
| CN102860969A (zh) | 2011-07-07 | 2013-01-09 | 刘畅 | 一种大豆眼霜 |
| JP2015508104A (ja) | 2012-02-22 | 2015-03-16 | トラスティーズ オブ タフツ カレッジ | 治療薬の眼への送達のための組成物および方法 |
| US9056063B2 (en) | 2012-03-13 | 2015-06-16 | James E. Hanson | Natural sunscreen composition |
| US20150079012A1 (en) | 2012-04-20 | 2015-03-19 | Trustees Of Tufts College | Silk fibroin-based personal care compositions |
| SI3715345T1 (sl) | 2012-07-25 | 2024-07-31 | Bausch + Lomb Ireland Limited | Priprava zaviralca lfa-1 |
| WO2014127007A1 (en) | 2013-02-12 | 2014-08-21 | Seryx Biomedical, Inc. | Ophthalmic formulation derived from silk protein |
| MX367597B (es) | 2013-03-15 | 2019-08-28 | Patheon Softgels Inc | Cápsulas a base de seda. |
| EP3412682B1 (en) | 2013-03-15 | 2022-08-31 | Trustees Of Tufts College | Low molecular weight silk compositions and stabilizing silk compositions |
| CN103239707A (zh) | 2013-05-22 | 2013-08-14 | 江苏紫石化工科技有限公司 | 治疗近视的滴眼液 |
| EP4509520A3 (en) | 2013-09-30 | 2025-10-22 | Evolved by Nature, Inc. | Silk protein fragment compositions and articles manufactured therefrom |
| AU2014353110B2 (en) | 2013-11-19 | 2018-05-10 | Cornell University | Tissue scaffold materials for tissue regeneration and methods of making |
| US9394355B2 (en) * | 2014-08-20 | 2016-07-19 | Silk Technologies, Ltd. | Fibroin-derived protein composition |
| US10758645B2 (en) * | 2014-12-17 | 2020-09-01 | Tufts University | Injectable, flexible hydroxyapatite-silk foams for osteochondral and dental repair |
| CA3020342A1 (en) * | 2016-04-08 | 2017-11-23 | Cornell University | A method to enhance wound healing using silk-derived protein |
-
2017
- 2017-08-12 CN CN201780062299.5A patent/CN109862851A/zh active Pending
- 2017-08-12 KR KR1020197007002A patent/KR102275012B1/ko active Active
- 2017-08-12 MX MX2019001633A patent/MX2019001633A/es unknown
- 2017-08-12 WO PCT/US2017/046659 patent/WO2018031973A1/en not_active Ceased
- 2017-08-12 EP EP17840394.5A patent/EP3496662A4/en not_active Withdrawn
- 2017-08-12 SG SG11201901137UA patent/SG11201901137UA/en unknown
- 2017-08-12 CA CA3033507A patent/CA3033507A1/en active Pending
- 2017-08-12 JP JP2019529464A patent/JP2019531334A/ja active Pending
- 2017-08-12 US US16/324,844 patent/US11242367B2/en active Active
- 2017-08-12 AU AU2017310520A patent/AU2017310520A1/en not_active Abandoned
- 2017-08-12 NZ NZ751231A patent/NZ751231A/en unknown
-
2022
- 2022-02-07 US US17/666,268 patent/US20220332773A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190042608A (ko) | 2019-04-24 |
| JP2019531334A (ja) | 2019-10-31 |
| EP3496662A1 (en) | 2019-06-19 |
| US11242367B2 (en) | 2022-02-08 |
| NZ751231A (en) | 2025-08-29 |
| SG11201901137UA (en) | 2019-03-28 |
| CN109862851A (zh) | 2019-06-07 |
| CA3033507A1 (en) | 2018-02-15 |
| AU2017310520A1 (en) | 2019-03-21 |
| WO2018031973A1 (en) | 2018-02-15 |
| EP3496662A4 (en) | 2019-10-30 |
| US20190169243A1 (en) | 2019-06-06 |
| KR102275012B1 (ko) | 2021-07-07 |
| US20220332773A1 (en) | 2022-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2019001633A (es) | Proteina derivada de la seda para el tratamiento de la inflamacion. | |
| CL2018001897A1 (es) | Composiciones para modular la expresión de sod-1 (divisional solicitud 201602509) | |
| CL2018001685A1 (es) | Compuestos heterociclicos como inmuno moduladores. | |
| IL268850A (en) | Combinations of a 4-pyrimidinesulfamide derivative with active ingredients for the treatment of endothelin related diseases | |
| EA201890725A1 (ru) | Агонисты фарнезоидного х-рецептора и их применение | |
| EA201990598A1 (ru) | Высококонцентрированные низковязкие препараты ингибирующего masp-2 антитела, наборы и способы | |
| MX2019001481A (es) | Derivado de oxopicolinamida, metodo de preparacion y uso farmaceutico del mismo. | |
| MX2018005315A (es) | Composiciones y metodos para el tratamiento del cancer. | |
| CL2021001395A1 (es) | Compuestos derivados de panteteínas cíclicas; composición farmacéutica que los comprende; y su uso para aumentar las concentraciones de acetil-coa, para el tratamiento de cáncer, enfermedad inflamatoria, enfermedad neurodegenerativa, esclerosis múltiple, entre otras enfermedades. | |
| CR20160222U (es) | Formas solidas de acido { [ -(3- clorofenil) -3- hidroxipiridin -2-carbonil] amino} acetico, composiciones, y usos de las mismas | |
| SV2018005714A (es) | Composiciones y metodos para disminuir la expresion de tau | |
| CR20190394A (es) | Compuestos de inhibidores de autotaxina | |
| CR20150637A (es) | Tratamiento de enfermedades miopaticas y neurodegenerativas por agregación de proteina mediante administración parenteral | |
| CL2019001749A1 (es) | Uso de anticuerpos anti-esclerostina en el tratamiento de osteogenesis imperfecta. | |
| EA202090014A1 (ru) | Гетероароматические соединения в качестве ингибиторов ванина | |
| NI201600070A (es) | Inhibidores tetracíclicos de autotaxina | |
| IL280664A (en) | 2-arylbenzimidazoles as ppargc1a activators for treating neurodegenerative diseases | |
| EA201792571A1 (ru) | Терапевтическое применение l-4-хлорокинуренина | |
| CL2021002483A1 (es) | Compuestos y composiciones como moduladores de la señalización tlr | |
| EA201692402A1 (ru) | Лекарственные формы для местного применения и их использование | |
| EA201892265A1 (ru) | Способы лечения офтальмологических заболеваний | |
| EA202091112A1 (ru) | Сокристаллы, фармацевтические композиции на их основе и способы лечения, предусматривающие их применение | |
| BR112018015367A2 (pt) | carreadores oromucosais de nanofibra para tratamento terapêutico | |
| CO2019009020A2 (es) | Derivados de pirazol como inhibidores de bromodominio. | |
| AR101486A1 (es) | Anticuerpos anti proteína similar a angiopoyetina 4 y métodos de uso |