MX2018014868A - Composiciones y metodos de uso de nintedanib para mejorar el exito de la cirugia del glaucoma. - Google Patents
Composiciones y metodos de uso de nintedanib para mejorar el exito de la cirugia del glaucoma.Info
- Publication number
- MX2018014868A MX2018014868A MX2018014868A MX2018014868A MX2018014868A MX 2018014868 A MX2018014868 A MX 2018014868A MX 2018014868 A MX2018014868 A MX 2018014868A MX 2018014868 A MX2018014868 A MX 2018014868A MX 2018014868 A MX2018014868 A MX 2018014868A
- Authority
- MX
- Mexico
- Prior art keywords
- nintedanib
- compositions
- methods
- glaucoma surgery
- improving
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- XZXHXSATPCNXJR-ZIADKAODSA-N nintedanib Chemical compound O=C1NC2=CC(C(=O)OC)=CC=C2\C1=C(C=1C=CC=CC=1)\NC(C=C1)=CC=C1N(C)C(=O)CN1CCN(C)CC1 XZXHXSATPCNXJR-ZIADKAODSA-N 0.000 title abstract 3
- 229960004378 nintedanib Drugs 0.000 title abstract 3
- 208000010412 Glaucoma Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000001356 surgical procedure Methods 0.000 title abstract 2
- 239000002256 antimetabolite Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se divulgan en el presente documento composiciones y métodos de uso de nintedanib para mejorar la tasa de éxito de la cirugía de filtración del glaucoma. Puede usarse nintedanib solo o en combinación con un fármaco antimetabolito en una formulación ocular tópica o de implante.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662344870P | 2016-06-02 | 2016-06-02 | |
| US201662344878P | 2016-06-02 | 2016-06-02 | |
| PCT/US2017/034792 WO2017210130A1 (en) | 2016-06-02 | 2017-05-26 | Compositions and methods of using nintedanib for improving glaucoma surgery success |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018014868A true MX2018014868A (es) | 2019-09-13 |
Family
ID=60477780
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018014868A MX2018014868A (es) | 2016-06-02 | 2017-05-26 | Composiciones y metodos de uso de nintedanib para mejorar el exito de la cirugia del glaucoma. |
| MX2018014869A MX389460B (es) | 2016-06-02 | 2017-05-26 | Composiciones y metodos de uso en nintedanib para tratar enfermedades oculares con neovascularizacion anormal. |
| MX2022000754A MX2022000754A (es) | 2016-06-02 | 2018-11-30 | Composiciones y metodos de uso de nintedanib para tratar enfermedades oculares con neovascularizacion anormal. |
| MX2024007658A MX2024007658A (es) | 2016-06-02 | 2018-11-30 | Composiciones y metodos de uso de nintedanib para mejorar el exito de la cirugia del glaucoma. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018014869A MX389460B (es) | 2016-06-02 | 2017-05-26 | Composiciones y metodos de uso en nintedanib para tratar enfermedades oculares con neovascularizacion anormal. |
| MX2022000754A MX2022000754A (es) | 2016-06-02 | 2018-11-30 | Composiciones y metodos de uso de nintedanib para tratar enfermedades oculares con neovascularizacion anormal. |
| MX2024007658A MX2024007658A (es) | 2016-06-02 | 2018-11-30 | Composiciones y metodos de uso de nintedanib para mejorar el exito de la cirugia del glaucoma. |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US11246864B2 (es) |
| EP (3) | EP4248971A3 (es) |
| JP (4) | JP7082115B2 (es) |
| KR (6) | KR102657707B1 (es) |
| CN (3) | CN119656170A (es) |
| AU (6) | AU2017274197B2 (es) |
| BR (2) | BR112018074450A2 (es) |
| CA (2) | CA3025325A1 (es) |
| MX (4) | MX2018014868A (es) |
| WO (2) | WO2017210130A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102643821B1 (ko) | 2015-06-06 | 2024-03-07 | 클라우드브레이크 테라퓨틱스, 엘엘씨 | 익상편을 치료하기 위한 조성물 및 방법 |
| MX2018014868A (es) | 2016-06-02 | 2019-09-13 | Cloudbreak Therapeutics Llc | Composiciones y metodos de uso de nintedanib para mejorar el exito de la cirugia del glaucoma. |
| US11278546B2 (en) * | 2016-07-22 | 2022-03-22 | Aiviva Biopharma, Inc. | Multikinase inhibitors and uses in ocular fibrosis |
| WO2020036993A1 (en) * | 2018-08-15 | 2020-02-20 | Aiviva Biopharma, Inc. | Multi-kinase inhibitors of vegf and tgf beta and uses thereof |
| US20190388407A1 (en) | 2017-02-12 | 2019-12-26 | Aiviva Biopharma, Inc. | Multikinase inhibitors of vegf and tfg beta and uses thereof |
| WO2021142298A1 (en) * | 2020-01-08 | 2021-07-15 | Radiance Therapeutics, Inc. | Methods, systems, and compositions for maintaining functioning drainage blebs |
| GB201714392D0 (en) | 2017-09-07 | 2017-10-25 | Marsteller Laurence | Methods and devices for treating glaucoma |
| US12156873B2 (en) | 2018-05-25 | 2024-12-03 | Ads Therapeutics Llc | Composition for treating ocular hyperemia and a method for treating ocular hyperemia with the same |
| CA3110287A1 (en) * | 2018-08-28 | 2020-03-05 | Cloudbreak Therapeutics, Llc | Emulsion formulations of multikinase inhibitors |
| CN115869258A (zh) * | 2018-09-25 | 2023-03-31 | 奥尔德拉医疗公司 | 用于治疗干眼病的调配物 |
| JP2022502160A (ja) | 2018-09-28 | 2022-01-11 | ラディアンス セラピューティクス、インコーポレイテッド | 低侵襲マイクロ強膜切開術に関連した、機能しているドレナージ小疱を維持するための方法、システム、及び組成物 |
| JP7368472B2 (ja) | 2018-11-29 | 2023-10-24 | ラディアンス セラピューティクス、インコーポレイテッド | β線の適用のための眼科用小線源治療システム及びデバイス |
| BR112021026662A2 (pt) * | 2019-09-10 | 2022-04-12 | Cloudbreak Therapeutics Llc | Métodos para aliviar a preocupação associada à pterígio sobre a aparência do olho |
| CN110787127A (zh) * | 2019-12-11 | 2020-02-14 | 龚雁 | 眼用温敏凝胶及其制备方法 |
| DK3884929T3 (da) | 2020-03-25 | 2023-09-25 | Ocular Therapeutix Inc | Øjenimplantat indeholdende en tyrosinkinase-inhibitor |
| TW202216119A (zh) * | 2020-06-30 | 2022-05-01 | 瑞士商歐庫利斯公司 | 眼用活性醫藥成分輸送的固態環糊精複合物製備 |
| KR102769064B1 (ko) * | 2020-12-30 | 2025-02-19 | 한국과학기술연구원 | 닌테다닙을 포함하는 암 치료 효과 증진용 조성물 및 이의 용도 |
| USD1076086S1 (en) | 2021-11-23 | 2025-05-20 | Radiance Therapeutics, Inc. | Opthalmic brachytherapy device |
| USD1076085S1 (en) | 2021-11-23 | 2025-05-20 | Radiance Therapeutics, Inc. | Opthalmic brachytherapy device |
| CN116251186B (zh) * | 2021-12-09 | 2025-04-25 | 成都瑞沐生物医药科技有限公司 | 一种酪氨酸激酶抑制剂眼用制剂及其制备方法和用途 |
| WO2024215649A1 (en) | 2023-04-11 | 2024-10-17 | Ocular Therapeutix, Inc. | Ocular implant comprising axitinib polymorph iv |
| MX2023009955A (es) * | 2023-08-24 | 2025-03-07 | Sophia Holdings S A De C V | Composiciones farmaceuticas oftalmicas que contienen dorzolamida, metodos para su preparacion y uso de las mismas. |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU739271B2 (en) | 1997-02-14 | 2001-10-11 | Kissei Pharmaceutical Co. Ltd. | Agents inhibiting progress of pterygium and postoperative recurrence of the same |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| US7442372B2 (en) * | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
| CA2572223C (en) | 2004-06-25 | 2014-08-12 | The Johns Hopkins University | Angiogenesis inhibitors |
| WO2006020979A2 (en) | 2004-08-13 | 2006-02-23 | Yale University | Factor vii conjugates for selectively treating neovascularization disorders |
| US9993558B2 (en) * | 2004-10-01 | 2018-06-12 | Ramscor, Inc. | Sustained release eye drop formulations |
| US7893040B2 (en) | 2005-07-22 | 2011-02-22 | Oculis Ehf | Cyclodextrin nanotechnology for ophthalmic drug delivery |
| US20080003219A1 (en) | 2005-09-26 | 2008-01-03 | Minu, L.L.C. | Delivery of an ocular agent |
| WO2007038453A2 (en) | 2005-09-26 | 2007-04-05 | Advanced Ocular Systems Limited | Use of an anti-vascular endothelial growth factor (vegf) agent to ameliorate inflammation |
| US8558002B2 (en) | 2006-11-16 | 2013-10-15 | Allergan, Inc. | Sulfoximines as kinase inhibitors |
| CA2682859C (en) | 2007-04-05 | 2013-10-08 | Pfizer Products Inc. | Crystalline forms of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethenyl)indazole for treatment of abnormal cell growth in mammals |
| US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
| RU2351298C1 (ru) | 2007-11-27 | 2009-04-10 | Государственное учреждение "УФИМСКИЙ НАУЧНО-ИССЛЕДОВАТЕЛЬСКИЙ ИНСТИТУТ ГЛАЗНЫХ БОЛЕЗНЕЙ" Академии наук Республики Башкортостан (УфНИИ ГБ АН РБ) | Способ профилактики рецидива птеригиума |
| UA107560C2 (uk) | 2008-06-06 | 2015-01-26 | Фармацевтична лікарська форма для негайного вивільнення похідної індолінону | |
| RS57142B1 (sr) | 2008-06-06 | 2018-07-31 | Boehringer Ingelheim Int | Farmaceutski dozni oblik u vidu kapsule koji sadrži formulaciju suspenzije indolinon derivata |
| US20100098772A1 (en) | 2008-10-21 | 2010-04-22 | Allergan, Inc. | Drug delivery systems and methods for treating neovascularization |
| US20100185564A1 (en) | 2009-01-21 | 2010-07-22 | Mccormick & Company, Inc. | Method and questionnaire for measuring consumer emotions associated with products |
| US20100247606A1 (en) | 2009-03-25 | 2010-09-30 | Allergan, Inc. | Intraocular sustained release drug delivery systems and methods for treating ocular conditions |
| UY33164A (es) | 2010-01-06 | 2011-08-31 | Glaxo Wellcome Mfg Pte Ltd | Metodo de tratamiento |
| ES2561083T3 (es) | 2010-01-22 | 2016-02-24 | Allergan, Inc. | Implantes intracamerales de agentes terapéuticos de liberación sostenida |
| US20140057908A1 (en) * | 2010-09-27 | 2014-02-27 | Exelixis, Inc. | Method of Treating Cancer |
| CN102018686B (zh) | 2010-12-16 | 2012-12-05 | 浙江大学医学院附属邵逸夫医院 | 含有丝裂霉素的膜剂及其制备方法 |
| EP2663308A1 (en) * | 2011-01-13 | 2013-11-20 | Novartis AG | Bace-2 inhibitors for the treatment of metabolic disorders |
| LT2714735T (lt) | 2011-06-03 | 2021-12-10 | Xoma Technology Ltd. | Tgf beta specifiniai antikūnai |
| US20140296301A1 (en) | 2011-06-28 | 2014-10-02 | Bayer Pharma Aktiengesellschaft | Topical ophthalmological pharmaceutical composition containing regoragenib |
| CN103764118A (zh) | 2011-06-28 | 2014-04-30 | 拜尔健康护理有限责任公司 | 含有索拉非尼的局部眼用药用组合物 |
| US9782397B2 (en) * | 2011-07-04 | 2017-10-10 | Irbm Science Park S.P.A. | Treatment of corneal neovascularization |
| WO2013105895A1 (en) | 2012-01-13 | 2013-07-18 | Xspray Microparticles Ab | A pharmaceutical composition comprising stable, amorphous hybrid nanopraticles of at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix-forming component |
| CN107115294B (zh) * | 2012-01-19 | 2019-10-18 | 北京康弘生物医药有限公司 | 一种含有vegf拮抗剂的滴眼液 |
| EP2817031A4 (en) | 2012-02-22 | 2015-08-05 | Tufts College | COMPOSITIONS AND METHOD FOR THE ORGANIC ADMINISTRATION OF A THERAPEUTIC ACTIVE SUBSTANCE |
| KR102373259B1 (ko) | 2012-05-03 | 2022-03-17 | 칼라 파마슈티컬스, 인크. | 개선된 점막 수송을 나타내는 제약 나노입자 |
| WO2013188279A1 (en) | 2012-06-12 | 2013-12-19 | Bayer Healthcare Llc | Topical ophthalmological pharmaceutical composition containing cediranib |
| US20150164790A1 (en) | 2012-06-12 | 2015-06-18 | Bayer Healthcare Llc | Topical Ophthalmological Pharmaceutical Composition containing Axitinib |
| JP2017512748A (ja) | 2012-06-25 | 2017-05-25 | バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC | スニチニブを含んでいる眼科用局所医薬組成物 |
| JP2015523995A (ja) | 2012-06-25 | 2015-08-20 | バイエル・ヘルスケア・エルエルシーBayer HealthCareLLC | パゾパニブを含んでいる眼科用局所医薬組成物 |
| EP2906145A4 (en) * | 2012-10-11 | 2016-07-06 | Univ Colorado Regents | OKULAR FILTER DEVICES, SYSTEMS AND METHOD |
| EA034963B1 (ru) * | 2012-11-08 | 2020-04-13 | Клиасайд Байомедикал, Инк. | Способ лечения расстройства заднего сегмента глаза |
| CA2926480A1 (en) | 2012-11-15 | 2014-05-22 | Tufts University | Methods, compositions and kits for treating, modulating, or preventing ocular angiogenesis or fibrosis in a subject using a galectin protein inhibitor |
| US8747852B1 (en) | 2012-12-28 | 2014-06-10 | Randal Tanh Hoang Pham | Methods of treating pterygium |
| US20160038760A1 (en) | 2013-03-14 | 2016-02-11 | Massachusetts Eye And Ear Infirmary | Conjunctival diseases |
| CA2908645A1 (en) | 2013-04-01 | 2014-10-09 | Allergan, Inc. | Microsphere drug delivery system for sustained intraocular release |
| CN105246529B (zh) | 2013-05-03 | 2019-06-14 | 科尼尔赛德生物医学公司 | 用于眼部注射的设备和方法 |
| US20140378401A1 (en) | 2013-06-21 | 2014-12-25 | Gnt, Llc | Ophthalmic Lipophilic and Hydrophilic Drug Delivery Vehicle Formulations |
| KR20160126983A (ko) | 2014-01-16 | 2016-11-02 | 온토제네시스, 엘엘씨 | 안내 혈관신생 및/또는 누출 치료용 조성물 및 방법 |
| US10465188B2 (en) * | 2014-08-22 | 2019-11-05 | Auckland Uniservices Limited | Channel modulators |
| CN104448300B (zh) | 2014-12-09 | 2017-01-11 | 西安医学院 | 低分子量l-聚谷氨酸-丝裂霉素c及其合成方法和应用 |
| CA2974702C (en) | 2015-01-26 | 2023-10-10 | University Of Washington | Compositions and methods for treating toxoplasmosis, cryptosporidiosis and other apicomplexan protozoan related diseases |
| KR102643821B1 (ko) | 2015-06-06 | 2024-03-07 | 클라우드브레이크 테라퓨틱스, 엘엘씨 | 익상편을 치료하기 위한 조성물 및 방법 |
| UY36714A (es) | 2015-06-09 | 2016-12-30 | Bayer Pharma Akttiengesellschaft | Moduladores alostéricos positivos del receptor muscarínico m2 |
| TWI664965B (zh) | 2015-06-22 | 2019-07-11 | 新源生物科技股份有限公司 | 酪胺酸激酶抑制劑之眼用調配物、其使用方法、及其製備方法 |
| AU2016297642A1 (en) | 2015-07-22 | 2018-02-15 | Incept, Llc | Coated punctal plug |
| CN108295072A (zh) * | 2015-12-09 | 2018-07-20 | 瑞阳(苏州)生物科技有限公司 | 尼达尼布防治眼部疾病的用途 |
| CN106902117A (zh) * | 2015-12-23 | 2017-06-30 | 瑞阳(苏州)生物科技有限公司 | 一种预防或治疗脉络膜新生血管形成的药物 |
| WO2017120600A1 (en) * | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Compositions and methods of treating wet age-related macular degeneration |
| WO2017136486A1 (en) | 2016-02-04 | 2017-08-10 | Jinsong Ni | Antibody-drug synergism technology for treating diseases |
| MX2018014868A (es) | 2016-06-02 | 2019-09-13 | Cloudbreak Therapeutics Llc | Composiciones y metodos de uso de nintedanib para mejorar el exito de la cirugia del glaucoma. |
| US11278546B2 (en) | 2016-07-22 | 2022-03-22 | Aiviva Biopharma, Inc. | Multikinase inhibitors and uses in ocular fibrosis |
| JP7018939B2 (ja) | 2016-09-26 | 2022-02-14 | ルヤン (スーチョウ) バイオロジー サイエンス アンド テクノロジー カンパニー,リミテッド | 眼疾患の治療のための組成物ならびに使用および調製方法 |
| MX2019003623A (es) | 2016-09-28 | 2019-09-23 | Medicon Pharmaceuticals Inc | Composiciones y metodos para el tratamiento de afecciones oftalmicas. |
| JP7306697B2 (ja) | 2017-03-14 | 2023-07-11 | オールジェネシス バイオセラピューティクス インコーポレイテッド | 3-z-[1-(4-(n-((4-メチル-ピペラジン-1-イル)-メチルカルボニル)-n-メチル-アミノ)-フェニルアミノ)-1-フェニル-メチレン]-6-メトキシカルボニル-2-インドリノンの結晶形 |
| US12156873B2 (en) | 2018-05-25 | 2024-12-03 | Ads Therapeutics Llc | Composition for treating ocular hyperemia and a method for treating ocular hyperemia with the same |
| CN110664757B (zh) | 2018-11-19 | 2022-08-02 | 成都瑞沐生物医药科技有限公司 | 纳米晶滴眼剂、其制备方法及其应用 |
| BR112021026662A2 (pt) | 2019-09-10 | 2022-04-12 | Cloudbreak Therapeutics Llc | Métodos para aliviar a preocupação associada à pterígio sobre a aparência do olho |
| CN119745879A (zh) | 2020-02-19 | 2025-04-04 | 科尼尔赛德生物医学公司 | 包含阿西替尼的组合物和治疗眼部疾病的方法 |
| CN116251186B (zh) | 2021-12-09 | 2025-04-25 | 成都瑞沐生物医药科技有限公司 | 一种酪氨酸激酶抑制剂眼用制剂及其制备方法和用途 |
-
2017
- 2017-05-26 MX MX2018014868A patent/MX2018014868A/es unknown
- 2017-05-26 KR KR1020237003530A patent/KR102657707B1/ko active Active
- 2017-05-26 KR KR1020247011786A patent/KR20240052865A/ko not_active Ceased
- 2017-05-26 BR BR112018074450-6A patent/BR112018074450A2/pt not_active Application Discontinuation
- 2017-05-26 CN CN202411668033.3A patent/CN119656170A/zh active Pending
- 2017-05-26 KR KR1020187037408A patent/KR102408596B1/ko active Active
- 2017-05-26 EP EP23177028.0A patent/EP4248971A3/en active Pending
- 2017-05-26 EP EP17807296.3A patent/EP3463315B1/en not_active Revoked
- 2017-05-26 US US16/306,152 patent/US11246864B2/en active Active
- 2017-05-26 CA CA3025325A patent/CA3025325A1/en active Pending
- 2017-05-26 KR KR1020187037794A patent/KR102496234B1/ko active Active
- 2017-05-26 AU AU2017274197A patent/AU2017274197B2/en active Active
- 2017-05-26 EP EP17807295.5A patent/EP3463225A4/en active Pending
- 2017-05-26 KR KR1020227019229A patent/KR20220080222A/ko not_active Ceased
- 2017-05-26 BR BR112018074454-9A patent/BR112018074454A2/pt not_active Application Discontinuation
- 2017-05-26 CN CN201780033761.9A patent/CN109475506A/zh active Pending
- 2017-05-26 KR KR1020247011013A patent/KR20240049636A/ko not_active Ceased
- 2017-05-26 JP JP2019515767A patent/JP7082115B2/ja active Active
- 2017-05-26 JP JP2019515766A patent/JP7079243B2/ja active Active
- 2017-05-26 WO PCT/US2017/034792 patent/WO2017210130A1/en not_active Ceased
- 2017-05-26 CN CN201780029923.1A patent/CN109561985B/zh active Active
- 2017-05-26 MX MX2018014869A patent/MX389460B/es unknown
- 2017-05-26 CA CA3026118A patent/CA3026118A1/en active Pending
- 2017-05-26 WO PCT/US2017/034795 patent/WO2017210132A1/en not_active Ceased
- 2017-05-26 AU AU2017274195A patent/AU2017274195B2/en active Active
-
2018
- 2018-09-14 US US16/131,945 patent/US10335408B2/en active Active
- 2018-11-30 MX MX2022000754A patent/MX2022000754A/es unknown
- 2018-11-30 MX MX2024007658A patent/MX2024007658A/es unknown
-
2019
- 2019-06-12 US US16/439,469 patent/US10688092B2/en active Active
-
2022
- 2022-01-07 US US17/570,928 patent/US11911379B2/en active Active
- 2022-04-20 AU AU2022202629A patent/AU2022202629B2/en active Active
- 2022-05-26 JP JP2022085867A patent/JP7475395B2/ja active Active
- 2022-06-16 AU AU2022204216A patent/AU2022204216B2/en active Active
-
2024
- 2024-01-18 US US18/416,302 patent/US12491183B2/en active Active
- 2024-04-16 JP JP2024065832A patent/JP2024083587A/ja active Pending
- 2024-09-12 AU AU2024219639A patent/AU2024219639A1/en active Pending
-
2025
- 2025-01-14 AU AU2025200273A patent/AU2025200273A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2024007658A (es) | Composiciones y metodos de uso de nintedanib para mejorar el exito de la cirugia del glaucoma. | |
| WO2015165413A8 (zh) | 一种新型的稳定型抗体药物耦联物及其制备方法和用途 | |
| SG10201808053XA (en) | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders | |
| MX2023003124A (es) | Composiciones farmaceuticas oftalmicas y usos que se relacionan a las mismas. | |
| MX2019003364A (es) | Composiciones oftalmicas que comprenden ciclosporina. | |
| WO2015160975A3 (en) | Combination of a pi3k inhibitor with a bcl-2 inhibitor for use in the treatment of cancer | |
| EP3188688A4 (en) | Methods and biocompatible compositions to achieve sustained drug release in the eye | |
| EP3153170A4 (en) | Methods and uses of quinoline derivatives in the treatment of soft tissue sarcomas and pharmaceutical compositions for treatment of same | |
| EP3137116A4 (en) | Dendrimer compositions and their use in treatment of diseases of the eye | |
| MX2017002374A (es) | Composiciones y metodos para tratar trastornos de la vision. | |
| WO2016025666A8 (en) | Tissue matrices and methods of treatment | |
| EP4324454A3 (en) | Cross-linking agents and associated methods | |
| EP3651747A4 (en) | COMPOSITIONS AND METHODS OF TREATMENT OF EYE DISORDERS | |
| IL282504A (en) | Ocular formulations for drug administration and protection of the front part of the eye | |
| PH12016501371A1 (en) | Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same | |
| WO2016001905A3 (en) | Stable liquid ready-to-use injectable formulation of bortezomib | |
| PH12016502233A1 (en) | (s)-pirlindole or its pharmaceutically acceptable salts for use in medicine | |
| EP4420722A3 (en) | Modified fibroblast growth factors for the treatment of ocular disorders | |
| MX363200B (es) | Composición odontológica de papaína en gel para el tratamiento atraumático de caries y método para prepararla. | |
| PH12016501434A1 (en) | Compositions for use in the treatment of allergic conditions | |
| PH12016502236A1 (en) | (r)-pirlindole and its pharmaceutically acceptable salts for use in medicine | |
| WO2014117010A3 (en) | Composition for ophthalmic administration | |
| TW201613596A (en) | Ophthalmic suspension preparation | |
| MA40369A (fr) | Applications de l'extrait de cistanche tubulosa dans la préparation d'un médicament ou produit de protection les cellules de l'œil | |
| IN2014MU00284A (es) |