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MX2018010718A - Tratamiento de dinitrofenol (dnp) y profarmaco de dinitrofenol (dnp) para enfermedades neuromusculares, neurodegenerativas, autoinmunes, del desarrollo, conmocion, enfermedad del ojo seco y/o metabolicas. - Google Patents

Tratamiento de dinitrofenol (dnp) y profarmaco de dinitrofenol (dnp) para enfermedades neuromusculares, neurodegenerativas, autoinmunes, del desarrollo, conmocion, enfermedad del ojo seco y/o metabolicas.

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Publication number
MX2018010718A
MX2018010718A MX2018010718A MX2018010718A MX2018010718A MX 2018010718 A MX2018010718 A MX 2018010718A MX 2018010718 A MX2018010718 A MX 2018010718A MX 2018010718 A MX2018010718 A MX 2018010718A MX 2018010718 A MX2018010718 A MX 2018010718A
Authority
MX
Mexico
Prior art keywords
dnp
dinitrophenol
neuromuscular
syndrome
concussion
Prior art date
Application number
MX2018010718A
Other languages
English (en)
Inventor
Alonso Robert
Gerard GEISLER John
Anthony Crooks Peter
Reddy Penthala Narsimha
Albayati Zaineb
Original Assignee
Mitochon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitochon Pharmaceuticals Inc filed Critical Mitochon Pharmaceuticals Inc
Publication of MX2018010718A publication Critical patent/MX2018010718A/es

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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/06—Phenols the aromatic ring being substituted by nitro groups
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
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Abstract

La presente invención se refiere a una composición y método de tratamiento de enfermedades neuromuscular, degenerativa neuromuscular, neurodegenerativas, autoinmune, del desarrollo, traumática, pérdida de audición relacionada, y/o metabólicas, que incluye síndrome de atrofia muscular espinal (SMA) (SMA1, SMA2, SMA3, y SMA4, también llamado Tipo I, II, III y IV), lesión traumática cerebral (TBI), conmoción, queratoconjuntivitis sicca (Enfermedad de ojo seco), glaucoma, Síndrome de Sjogren, artritis reumatoide, post-cirugía LASIK, uso de anti-depresivo, Síndrome de Wolfram, y síndrome de Wolcott-Rallison. La composición se selecciona del grupo que consiste de profármacos de 2,3-DNP, 2,4-DNP, 2,5-DNP, 2,6-DNP, 3,4-DNP, o 3,5-DNP, 2,3-dinitrofenol, 2,4-dinitrofenol, 2,5-dinitrofenol, 2,6-dinitrofenol, 3,4-dinitrofenol, o 3,5-dinitrofenol bipartitos (2,3-DNP, 2,4-DNP, 2,5-DNP, 2,6-DNP, 3,4-DNP, o 3,5-DNP); profármacos Géminis, moléculas bioprecursoras, y combinaciones de los mismos.
MX2018010718A 2016-03-07 2017-03-07 Tratamiento de dinitrofenol (dnp) y profarmaco de dinitrofenol (dnp) para enfermedades neuromusculares, neurodegenerativas, autoinmunes, del desarrollo, conmocion, enfermedad del ojo seco y/o metabolicas. MX2018010718A (es)

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US201762460318P 2017-02-17 2017-02-17
PCT/US2017/021080 WO2017155940A1 (en) 2016-03-07 2017-03-07 Dnp and dnp prodrug treatment of neuromuscular, neurodegenerative, autoimmune, developmental, concussion, dry eye disease, and/or metabolic diseases

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MX2022009725A MX2022009725A (es) 2016-03-07 2018-09-05 Tratamiento de dinitrofenol (dnp) y profarmaco de dinitrofenol (dnp) para enfermedades neuromusculares, neurodegenerativas, autoinmunes, del desarrollo, conmocion, enfermedad del ojo seco y/o metabolicas.

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