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MX2018008197A - Composiciones y metodos para cribar mutaciones en el cancer de tiroides. - Google Patents

Composiciones y metodos para cribar mutaciones en el cancer de tiroides.

Info

Publication number
MX2018008197A
MX2018008197A MX2018008197A MX2018008197A MX2018008197A MX 2018008197 A MX2018008197 A MX 2018008197A MX 2018008197 A MX2018008197 A MX 2018008197A MX 2018008197 A MX2018008197 A MX 2018008197A MX 2018008197 A MX2018008197 A MX 2018008197A
Authority
MX
Mexico
Prior art keywords
methods
thyroid cancer
compositions
screening
patient
Prior art date
Application number
MX2018008197A
Other languages
English (en)
Inventor
Qu Kevin
Min Cheng Shih-
J Catanese Joseph
Grupe Andrew
Hantash Feras
M Waldman Frederic
Original Assignee
Quest Diagnostics Invest Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Invest Llc filed Critical Quest Diagnostics Invest Llc
Publication of MX2018008197A publication Critical patent/MX2018008197A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

La presente tecnología se refiere a métodos para determinar si un paciente que tiene nódulos tiroideos con citología indeterminada se beneficiará de una cirugía diagnóstica, por ejemplo, lobectomía. Estos métodos se basan en el cribado de los nódulos tiroideos de un paciente y la detección de alteraciones en las secuencias de ácido nucleico diana que corresponden a una serie específica de genes relacionados con el cáncer de tiroides. También se proveen kits para usarse en la práctica de los métodos.
MX2018008197A 2015-12-31 2016-12-30 Composiciones y metodos para cribar mutaciones en el cancer de tiroides. MX2018008197A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562273783P 2015-12-31 2015-12-31
US201662439572P 2016-12-28 2016-12-28
PCT/US2016/069478 WO2017117523A1 (en) 2015-12-31 2016-12-30 Compositions and methods for screening mutations in thyroid cancer

Publications (1)

Publication Number Publication Date
MX2018008197A true MX2018008197A (es) 2019-02-20

Family

ID=59225391

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018008197A MX2018008197A (es) 2015-12-31 2016-12-30 Composiciones y metodos para cribar mutaciones en el cancer de tiroides.
MX2022012384A MX2022012384A (es) 2015-12-31 2018-06-29 Composiciones y metodos para cribar mutaciones en el cancer de tiroides.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022012384A MX2022012384A (es) 2015-12-31 2018-06-29 Composiciones y metodos para cribar mutaciones en el cancer de tiroides.

Country Status (6)

Country Link
US (2) US11053542B2 (es)
EP (2) EP3397766B1 (es)
CN (1) CN108699553B (es)
CA (1) CA3010013A1 (es)
MX (2) MX2018008197A (es)
WO (1) WO2017117523A1 (es)

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CN109371139A (zh) * 2018-12-29 2019-02-22 杭州迪安医学检验中心有限公司 一种基于高通量测序技术用于检测甲状腺癌致病相关基因变异的引物及其应用
CN109652535A (zh) * 2019-01-30 2019-04-19 上海安甲生物科技有限公司 鉴别人甲状腺结节良恶性的试剂盒及其使用方法和应用
US20210010060A1 (en) * 2019-07-02 2021-01-14 Genenius Genetics Highly Multiplexed PCR with Bioinformatically Optimized Primers to Prepare Targeted Libraries for Next-Generation Sequencing
CN110241215B (zh) * 2019-07-03 2020-05-19 上海润安医学科技有限公司 一种用于检测甲状腺结节良恶性相关基因变异的引物及试剂盒
WO2021016089A1 (en) * 2019-07-19 2021-01-28 Quest Diagnostics Investments Llc Methods for detecting hereditary cancers
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CN113176408B (zh) * 2021-06-02 2022-10-11 四川大学华西医院 一种甲状腺癌预后情况判断的方法
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CN117286247A (zh) * 2022-09-07 2023-12-26 上海医创云康生物科技有限公司 一种甲状腺基因检测试剂盒
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CN119265304B (zh) * 2024-11-13 2025-10-17 广州达健生物科技有限公司 一种用于甲状腺癌检测的组合物、试剂盒及应用

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Also Published As

Publication number Publication date
CN108699553B (zh) 2023-08-04
WO2017117523A1 (en) 2017-07-06
CA3010013A1 (en) 2017-07-06
US20210324468A1 (en) 2021-10-21
EP3397766A1 (en) 2018-11-07
MX2022012384A (es) 2023-01-16
EP4246144A3 (en) 2023-12-20
BR112018013430A2 (pt) 2018-12-18
EP3397766B1 (en) 2023-05-17
CN108699553A (zh) 2018-10-23
EP3397766A4 (en) 2019-10-02
US11053542B2 (en) 2021-07-06
US20190112653A1 (en) 2019-04-18
EP4246144A2 (en) 2023-09-20

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