MX2018007925A - Anticuerpo pcsk9, fragmento de union al antigeno y aplicacion medica del mismo. - Google Patents
Anticuerpo pcsk9, fragmento de union al antigeno y aplicacion medica del mismo.Info
- Publication number
- MX2018007925A MX2018007925A MX2018007925A MX2018007925A MX2018007925A MX 2018007925 A MX2018007925 A MX 2018007925A MX 2018007925 A MX2018007925 A MX 2018007925A MX 2018007925 A MX2018007925 A MX 2018007925A MX 2018007925 A MX2018007925 A MX 2018007925A
- Authority
- MX
- Mexico
- Prior art keywords
- pcsk9 antibody
- antigen
- binding fragment
- antibody
- pcsk9
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 239000012634 fragment Substances 0.000 title abstract 3
- 101150094724 PCSK9 gene Proteins 0.000 title 1
- 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 abstract 6
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 abstract 6
- 239000003524 antilipemic agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención proporciona un anticuerpo PCSK9, un fragmento de unión a antígeno del mismo y una aplicación medicinal del mismo. Se proporciona en la invención un anticuerpo quimérico y un anticuerpo humanizado, ambos que comprenden una CDR del anticuerpo PCSK9, y una composición farmacéutica que comprende el anticuerpo PCSK9 y un fragmento de unión a antígeno del mismo, y una aplicación del anticuerpo PCSK9 como un agente reductor de lípidos. La invención se refiere específicamente a una aplicación de un anticuerpo PCSK9 humanizado para preparar un fármaco para tratar una enfermedad o síntoma inducido por PCSK9.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511024618 | 2015-12-31 | ||
| PCT/CN2016/111053 WO2017114230A1 (zh) | 2015-12-31 | 2016-12-20 | Pcsk9抗体、其抗原结合片段及其医药用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018007925A true MX2018007925A (es) | 2018-08-29 |
Family
ID=59224496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018007925A MX2018007925A (es) | 2015-12-31 | 2016-12-20 | Anticuerpo pcsk9, fragmento de union al antigeno y aplicacion medica del mismo. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10793643B2 (es) |
| EP (1) | EP3398968B1 (es) |
| JP (1) | JP7032662B2 (es) |
| KR (1) | KR102767973B1 (es) |
| CN (1) | CN107406511B (es) |
| AU (1) | AU2016382932B2 (es) |
| BR (1) | BR112018013256A2 (es) |
| CA (1) | CA3009904A1 (es) |
| MX (1) | MX2018007925A (es) |
| RU (1) | RU2739208C2 (es) |
| TW (1) | TWI735499B (es) |
| WO (1) | WO2017114230A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110431153B (zh) * | 2017-06-30 | 2023-09-19 | 苏州盛迪亚生物医药有限公司 | 一种pcsk-9抗体药物组合物及其用途 |
| CN110981962B (zh) * | 2019-12-19 | 2022-07-12 | 中国药科大学 | Pcsk9抗体、其抗原结合片段及其应用 |
| TW202144436A (zh) | 2020-03-19 | 2021-12-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | 膽固醇相關疾病的治療方法 |
| CN114369164A (zh) * | 2020-10-15 | 2022-04-19 | 苏州君盟生物医药科技有限公司 | 抗pcsk9单克隆抗体的生产工艺 |
| WO2023070502A1 (zh) * | 2021-10-29 | 2023-05-04 | 天辰生物医药(苏州)有限公司 | 分离的抗原结合蛋白及其用途 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2118508A1 (en) | 1992-04-24 | 1993-11-11 | Elizabeth S. Ward | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US7658921B2 (en) | 2000-12-12 | 2010-02-09 | Medimmune, Llc | Molecules with extended half-lives, compositions and uses thereof |
| ES2649037T3 (es) | 2000-12-12 | 2018-01-09 | Medimmune, Llc | Moléculas con semividas prolongadas, composiciones y usos de las mismas |
| JP2007538320A (ja) * | 2004-05-18 | 2007-12-27 | シルバーブルック リサーチ ピーティワイ リミテッド | 製品アイテムを追跡する方法およびコンピュータシステム |
| US7572618B2 (en) * | 2006-06-30 | 2009-08-11 | Bristol-Myers Squibb Company | Polynucleotides encoding novel PCSK9 variants |
| JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| AR070315A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Anticuerpos 1b20 antagonistas de pcsk9 |
| TWI445716B (zh) * | 2008-09-12 | 2014-07-21 | Rinat Neuroscience Corp | Ｐｃｓｋ９拮抗劑類 |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| AR079336A1 (es) | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
| AU2011225716A1 (en) | 2010-03-11 | 2012-09-27 | Pfizer Inc. | Antibodies with pH dependent antigen binding |
| WO2012054438A1 (en) | 2010-10-22 | 2012-04-26 | Schering Corporation | Anti-pcsk9 |
| US20140121123A1 (en) | 2010-10-29 | 2014-05-01 | Kevin Caili Wang | Methods for diversifying antibodies, antibodies derived therefrom and uses thereof |
| CA2820953A1 (en) * | 2010-12-22 | 2012-06-28 | Genentech, Inc. | Anti-pcsk9 antibodies and methods of use |
| CN110711248A (zh) | 2011-01-28 | 2020-01-21 | 赛诺菲生物技术公司 | 包含针对pcsk9的人抗体的药物组合物 |
| WO2012109530A1 (en) | 2011-02-11 | 2012-08-16 | Irm Llc | Pcsk9 antagonists |
| JOP20200043A1 (ar) | 2011-05-10 | 2017-06-16 | Amgen Inc | طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول |
| WO2012168491A1 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Pharmaceutical formulations of pcsk9 antagonists |
| WO2012170607A2 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Use of pcsk9 antagonists |
| MX2014000578A (es) | 2011-07-14 | 2014-04-30 | Pfizer | Tratamiento con anticuerpos anti-pcsk9. |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| ES2992345T3 (es) | 2011-09-16 | 2024-12-11 | Regeneron Pharma | Métodos para reducir los niveles de lipoproteína(a) mediante la administración de un inhibidor de la proproteína convertasa subtilisina kexina-9 (PCSK9) |
| AR087715A1 (es) * | 2011-09-16 | 2014-04-09 | Lilly Co Eli | Anticuerpos anti pcsk9 y usos de los mismos |
| US9879093B2 (en) | 2011-12-20 | 2018-01-30 | Adaerata, Limited Partnershp | Single domain antibodies as inhibitors of PCSK9 |
| WO2013148284A1 (en) | 2012-03-29 | 2013-10-03 | Genentech, Inc. | Antibodies that bind to a pcsk9 cleavage site and methods of use |
| US9255154B2 (en) * | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| RU2636820C2 (ru) | 2012-05-17 | 2017-11-28 | Сайон Терапьютикс Инк. | Способы и применения ингибиторов пропротеиновой конвертазы субтилизин кексин типа 9(pcsk9) |
| US9266961B2 (en) | 2012-06-15 | 2016-02-23 | Genentech, Inc. | Anti-PCSK9 antibodies, formulations, dosing, and methods of use |
| AU2014235430A1 (en) * | 2013-03-15 | 2015-09-24 | Amgen Inc. | Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9 (PCSK9) |
| CN105001336A (zh) | 2014-04-18 | 2015-10-28 | 上海复旦张江生物医药股份有限公司 | Pcsk9拮抗剂 |
| WO2015200438A1 (en) * | 2014-06-24 | 2015-12-30 | Eleven Biotherapeutics, Inc. | High affinity antibodies against pcsk9 |
| CN104861071B (zh) * | 2015-04-27 | 2019-04-12 | 南京师范大学 | 针对pcsk9的全人源单克隆抗体的可变区基因及其应用 |
| CN105037554B (zh) * | 2015-06-12 | 2019-04-12 | 成都贝爱特生物科技有限公司 | 抗人pcsk9抗体的制备及其用途 |
-
2016
- 2016-12-20 US US16/066,567 patent/US10793643B2/en active Active
- 2016-12-20 AU AU2016382932A patent/AU2016382932B2/en active Active
- 2016-12-20 KR KR1020187020978A patent/KR102767973B1/ko active Active
- 2016-12-20 RU RU2018125003A patent/RU2739208C2/ru active
- 2016-12-20 WO PCT/CN2016/111053 patent/WO2017114230A1/zh not_active Ceased
- 2016-12-20 BR BR112018013256-0A patent/BR112018013256A2/pt active Search and Examination
- 2016-12-20 JP JP2018533863A patent/JP7032662B2/ja active Active
- 2016-12-20 CA CA3009904A patent/CA3009904A1/en active Pending
- 2016-12-20 CN CN201680013073.1A patent/CN107406511B/zh active Active
- 2016-12-20 EP EP16881019.0A patent/EP3398968B1/en active Active
- 2016-12-20 MX MX2018007925A patent/MX2018007925A/es unknown
- 2016-12-29 TW TW105143912A patent/TWI735499B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016382932A1 (en) | 2018-07-19 |
| EP3398968A1 (en) | 2018-11-07 |
| WO2017114230A1 (zh) | 2017-07-06 |
| RU2018125003A3 (es) | 2020-05-13 |
| AU2016382932B2 (en) | 2022-12-08 |
| EP3398968B1 (en) | 2024-06-12 |
| JP7032662B2 (ja) | 2022-03-09 |
| BR112018013256A2 (pt) | 2018-12-11 |
| CA3009904A1 (en) | 2017-07-06 |
| RU2739208C2 (ru) | 2020-12-21 |
| HK1244828A1 (zh) | 2018-08-17 |
| US20190016825A1 (en) | 2019-01-17 |
| KR20180093068A (ko) | 2018-08-20 |
| TWI735499B (zh) | 2021-08-11 |
| TW201725216A (zh) | 2017-07-16 |
| EP3398968A4 (en) | 2019-08-07 |
| KR102767973B1 (ko) | 2025-02-12 |
| US10793643B2 (en) | 2020-10-06 |
| CN107406511A (zh) | 2017-11-28 |
| CN107406511B (zh) | 2021-01-19 |
| JP2019509254A (ja) | 2019-04-04 |
| RU2018125003A (ru) | 2020-02-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12016501120B1 (en) | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof | |
| MX2018015393A (es) | Anticuerpo lag-3, fragmento de union al antigeno del mismo y aplicacion farmaceutica del mismo. | |
| ZA202004701B (en) | Anti-b7-h4 antibody, antigen-binding fragment thereof and pharmaceutical use thereof | |
| MX2017001976A (es) | Terapia de combinacion de anticuerpos activadores de la cd40 humana y anticuerpos contra el mp-l1 humano. | |
| PH12018500174A1 (en) | Combined use of anti pd-1 and anti m-csf antibodies in the treatment of cancer | |
| UA118453C2 (uk) | Спосіб лікування пухлин у пацієнта | |
| BR112017021245A2 (pt) | Anticorpo anti-c-met e conjugado anticorpo anti- c-met-fármaco citotóxico e uso farmacêutico do mesmo | |
| EA201890162A1 (ru) | Антитела к cd40 с повышенной агонистической активностью | |
| BR112018009064A2 (pt) | anticorpo de pd-l1, fragmento de ligação ao antígeno do mesmo e aplicação médica do mesmo | |
| PH12017500493A1 (en) | Combination therapy | |
| EP4631978A3 (en) | Humanized or chimeric cd3 antibodies | |
| EP4406554A3 (en) | Anti-cd3 antibody formulations | |
| EA201690159A1 (ru) | Способы и композиции для лечения рака | |
| PH12017500002A1 (en) | Anti-cdh6 antibody drug conjugates | |
| MX2015007147A (es) | Metodo de reduccion de placas amiloides de cerebro que usan anticuerpos anti-ab. | |
| MX2020007406A (es) | Anticuerpo pd-l1, fragmento de union al antigeno del mismo y uso farmaceutico del mismo. | |
| MX2019014375A (es) | Anticuerpo anti-cd40, fragmento de union a antigeno del mismo, y uso medico del mismo. | |
| MX2020002750A (es) | Anticuerpo il-6r y fragmento de union a antigeno y uso medico. | |
| MX2018007925A (es) | Anticuerpo pcsk9, fragmento de union al antigeno y aplicacion medica del mismo. | |
| MX2019015914A (es) | Anticuerpos quiméricos para el tratamiento de enfermedades por deposición de amiloide. | |
| MX2018009264A (es) | Anticuerpo de trombina, fragmento de antigeno y sus usos farmaceuticos. | |
| MX2019003779A (es) | Uso médico de un conjugado anticuerpo anti-c-met-fármaco citotóxico. | |
| MX2017001983A (es) | Agentes de union a proteina r-espondina 1 (rspo1) y usos de los mismos. |