MX2018005392A - Acidos nucleicos modificados dirigidos a acidos nucleicos. - Google Patents
Acidos nucleicos modificados dirigidos a acidos nucleicos.Info
- Publication number
- MX2018005392A MX2018005392A MX2018005392A MX2018005392A MX2018005392A MX 2018005392 A MX2018005392 A MX 2018005392A MX 2018005392 A MX2018005392 A MX 2018005392A MX 2018005392 A MX2018005392 A MX 2018005392A MX 2018005392 A MX2018005392 A MX 2018005392A
- Authority
- MX
- Mexico
- Prior art keywords
- polynucleotide sequences
- nucleic
- acid targeting
- modified polynucleotide
- engineered
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title 2
- 108020004707 nucleic acids Proteins 0.000 title 2
- 230000008685 targeting Effects 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 abstract 5
- 108091033319 polynucleotide Proteins 0.000 abstract 5
- 239000002157 polynucleotide Substances 0.000 abstract 5
- 102000011931 Nucleoproteins Human genes 0.000 abstract 1
- 108010061100 Nucleoproteins Proteins 0.000 abstract 1
- 102000044158 nucleic acid binding protein Human genes 0.000 abstract 1
- 108700020942 nucleic acid binding protein Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/51—Physical structure in polymeric form, e.g. multimers, concatemers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/52—Physical structure branched
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente descripción proporciona secuencias de polinucleótidos modificadas que forman andamios y complejos de nucleoproteína que comprenden dichas secuencias de polinucleótidos modificadas que forman andamios y proteínas de unión a ácidos nucleicos. Se describen secuencias de ácidos nucleicos que codifican las secuencias de polinucleótidos modificadas que forman andamios, así como cassettes de expresión, vectores y células que comprenden dichas secuencias de polinucleótidos. También se describe una variedad de métodos para hacer y usar las secuencias de polinucleótidos modificadas que forman andamios.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562263232P | 2015-12-04 | 2015-12-04 | |
| PCT/US2016/064860 WO2017096328A1 (en) | 2015-12-04 | 2016-12-02 | Engineered nucleic-acid targeting nucleic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018005392A true MX2018005392A (es) | 2019-05-30 |
| MX391311B MX391311B (es) | 2025-03-21 |
Family
ID=57750577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018005392A MX391311B (es) | 2015-12-04 | 2016-12-02 | Acidos nucleicos modificados dirigidos a acidos nucleicos. |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9771600B2 (es) |
| EP (2) | EP3371310B1 (es) |
| JP (1) | JP6707133B2 (es) |
| KR (1) | KR102093570B1 (es) |
| CN (1) | CN108473981B (es) |
| AU (2) | AU2016363024B2 (es) |
| CA (1) | CA3004757C (es) |
| DK (1) | DK3371310T3 (es) |
| ES (1) | ES2735773T3 (es) |
| HK (1) | HK1252755B (es) |
| IL (1) | IL259148B (es) |
| MX (1) | MX391311B (es) |
| NZ (2) | NZ756843A (es) |
| RU (1) | RU2018117360A (es) |
| SG (1) | SG11201803593QA (es) |
| WO (1) | WO2017096328A1 (es) |
| ZA (1) | ZA201802968B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3004757C (en) | 2015-12-04 | 2020-07-21 | Caribou Biosciences, Inc. | Engineered nucleic-acid targeting nucleic acids |
| PL3272867T3 (pl) | 2016-06-02 | 2020-01-31 | Sigma-Aldrich Co. Llc | Wykorzystanie programowalnych białek wiążących dna w celu wzmocnienia celowanej modyfikacji genomu |
| EP3555297A1 (en) | 2016-12-19 | 2019-10-23 | Editas Medicine, Inc. | Assessing nuclease cleavage |
| EP3615672A1 (en) | 2017-04-28 | 2020-03-04 | Editas Medicine, Inc. | Methods and systems for analyzing guide rna molecules |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| US11584955B2 (en) * | 2017-07-14 | 2023-02-21 | Shanghai Tolo Biotechnology Company Limited | Application of Cas protein, method for detecting target nucleic acid molecule and kit |
| CN107488710B (zh) | 2017-07-14 | 2020-09-22 | 上海吐露港生物科技有限公司 | 一种Cas蛋白的用途及靶标核酸分子的检测方法和试剂盒 |
| WO2019041296A1 (zh) * | 2017-09-01 | 2019-03-07 | 上海科技大学 | 一种碱基编辑系统及方法 |
| CN118389609A (zh) * | 2017-09-11 | 2024-07-26 | 加利福尼亚大学董事会 | 抗体介导的cas9向哺乳动物细胞的递送 |
| WO2019152941A1 (en) | 2018-02-05 | 2019-08-08 | Caribou Biosciences, Inc. | Engineered gut microbes for reduction of reactivation of detoxified drugs |
| CN111699254A (zh) | 2018-02-08 | 2020-09-22 | 齐默尔根公司 | 使用crispr在棒状杆菌属中进行基因组编辑 |
| WO2019222545A1 (en) | 2018-05-16 | 2019-11-21 | Synthego Corporation | Methods and systems for guide rna design and use |
| CA3104856A1 (en) | 2018-06-29 | 2020-01-02 | Editas Medicine, Inc. | Synthetic guide molecules, compositions and methods relating thereto |
| SG11202101227TA (en) * | 2018-08-09 | 2021-03-30 | G Flas Life Sciences | Novel crispr-associated protein and use thereof |
| CN109517722B (zh) * | 2018-09-28 | 2022-04-01 | 德拜至臻医学科技(杭州)有限公司 | 一种捕获特定微量细胞的装置及其制作和使用方法 |
| JP2022520139A (ja) | 2018-10-12 | 2022-03-29 | セラダプティブ インク | β－リン酸三カルシウム結合配列を含むポリペプチドとその使用 |
| WO2020176389A1 (en) | 2019-02-25 | 2020-09-03 | Caribou Biosciences, Inc. | Plasmids for gene editing |
| EP4048063A4 (en) | 2019-10-23 | 2023-12-06 | Pairwise Plants Services, Inc. | Compositions and methods for rna-templated editing in plants |
| JP7785002B2 (ja) | 2019-11-05 | 2025-12-12 | ペアーワイズ プランツ サービシズ， インコーポレイテッド | 対立遺伝子のｒｎａにコードされたｄｎａの置換のための組成物および方法 |
| WO2021194604A2 (en) * | 2020-03-06 | 2021-09-30 | Theradaptive, Inc. | Therapeutic compositions comprising graft materials and beta-tcp binding peptides and uses thereof |
| US11453907B2 (en) * | 2020-03-23 | 2022-09-27 | The Broad Institute, Inc. | Crispr effector system based coronavirus diagnostics |
| BR112022020809A2 (pt) | 2020-04-15 | 2023-02-23 | Theradaptive Inc | Composições e métodos para entrega terapêutica direcionada ao osso |
| CA3222023A1 (en) | 2021-06-01 | 2022-12-08 | Arbor Biotechnologies, Inc. | Gene editing systems comprising a crispr nuclease and uses thereof |
| CN114540325B (zh) * | 2022-01-17 | 2022-12-09 | 广州医科大学 | 靶向dna去甲基化的方法、融合蛋白及其应用 |
| CN116377104B (zh) * | 2022-11-14 | 2024-01-12 | 海南省农业科学院蔬菜研究所 | 一种快菜高温胁迫内参基因及其引物及应用 |
| AU2024220323A1 (en) | 2023-02-15 | 2025-08-14 | Arbor Biotechnologies, Inc. | Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript |
| WO2025171210A1 (en) | 2024-02-09 | 2025-08-14 | Arbor Biotechnologies, Inc. | Compositions and methods for gene editing via homology-mediated end joining |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10087431B2 (en) | 2010-03-10 | 2018-10-02 | The Regents Of The University Of California | Methods of generating nucleic acid fragments |
| EP3078753B1 (en) | 2010-05-10 | 2018-04-18 | The Regents of The University of California | Methods using endoribonuclease compositions |
| CN103945794A (zh) * | 2011-09-01 | 2014-07-23 | Hip创新科技有限责任公司 | 内衬股骨杯 |
| US9637739B2 (en) * | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
| GB2537000C (en) | 2012-05-25 | 2019-10-09 | Univ California | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| WO2013188638A2 (en) | 2012-06-15 | 2013-12-19 | The Regents Of The University Of California | Endoribonucleases and methods of use thereof |
| EP2880171B1 (en) | 2012-08-03 | 2018-10-03 | The Regents of The University of California | Methods and compositions for controlling gene expression by rna processing |
| EP4556564A3 (en) | 2012-10-23 | 2025-09-03 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| KR20150105635A (ko) | 2012-12-12 | 2015-09-17 | 더 브로드 인스티튜트, 인코퍼레이티드 | 서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물 |
| US20140186919A1 (en) | 2012-12-12 | 2014-07-03 | Feng Zhang | Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation |
| PL2771468T3 (pl) | 2012-12-12 | 2015-07-31 | Broad Inst Inc | Inżynieria systemów, metod i zoptymalizowanych kompozycji kierujących dla manipulacji sekwencjami |
| EP2931898B1 (en) | 2012-12-12 | 2016-03-09 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| AU2014235794A1 (en) * | 2013-03-14 | 2015-10-22 | Caribou Biosciences, Inc. | Compositions and methods of nucleic acid-targeting nucleic acids |
| EP3071695A2 (en) | 2013-11-18 | 2016-09-28 | Crispr Therapeutics AG | Crispr-cas system materials and methods |
| WO2015089364A1 (en) * | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Crystal structure of a crispr-cas system, and uses thereof |
| US20150376587A1 (en) | 2014-06-25 | 2015-12-31 | Caribou Biosciences, Inc. | RNA Modification to Engineer Cas9 Activity |
| SI3250691T1 (sl) * | 2015-01-28 | 2023-10-30 | Caribou Biosciences, Inc. | Hibridni dna/rna-polinukleotidi crispr in postopki za uporabo |
| US9580727B1 (en) * | 2015-08-07 | 2017-02-28 | Caribou Biosciences, Inc. | Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides |
| CA3004757C (en) * | 2015-12-04 | 2020-07-21 | Caribou Biosciences, Inc. | Engineered nucleic-acid targeting nucleic acids |
-
2016
- 2016-12-02 CA CA3004757A patent/CA3004757C/en active Active
- 2016-12-02 SG SG11201803593QA patent/SG11201803593QA/en unknown
- 2016-12-02 AU AU2016363024A patent/AU2016363024B2/en active Active
- 2016-12-02 ES ES16822804T patent/ES2735773T3/es active Active
- 2016-12-02 NZ NZ756843A patent/NZ756843A/en unknown
- 2016-12-02 EP EP16822804.7A patent/EP3371310B1/en active Active
- 2016-12-02 KR KR1020187019090A patent/KR102093570B1/ko active Active
- 2016-12-02 NZ NZ742040A patent/NZ742040A/en unknown
- 2016-12-02 JP JP2018528798A patent/JP6707133B2/ja active Active
- 2016-12-02 CN CN201680071016.9A patent/CN108473981B/zh active Active
- 2016-12-02 EP EP19171356.9A patent/EP3564371B1/en active Active
- 2016-12-02 RU RU2018117360A patent/RU2018117360A/ru not_active Application Discontinuation
- 2016-12-02 DK DK16822804.7T patent/DK3371310T3/da active
- 2016-12-02 WO PCT/US2016/064860 patent/WO2017096328A1/en not_active Ceased
- 2016-12-02 MX MX2018005392A patent/MX391311B/es unknown
- 2016-12-02 US US15/368,570 patent/US9771600B2/en active Active
- 2016-12-02 HK HK18112080.6A patent/HK1252755B/en unknown
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2017
- 2017-09-14 US US15/703,992 patent/US9970029B1/en active Active
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2018
- 2018-05-03 IL IL259148A patent/IL259148B/en unknown
- 2018-05-04 US US15/971,863 patent/US10100333B2/en active Active
- 2018-05-07 ZA ZA2018/02968A patent/ZA201802968B/en unknown
- 2018-10-04 US US16/152,337 patent/US11505808B2/en active Active
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2019
- 2019-10-07 AU AU2019240724A patent/AU2019240724B2/en active Active
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