|
US6867195B1
(en)
|
1989-03-21 |
2005-03-15 |
Vical Incorporated |
Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected
|
|
DE69034078T2
(de)
|
1989-03-21 |
2004-04-01 |
Vical, Inc., San Diego |
Expression von exogenen Polynukleotidsequenzen in Wirbeltieren
|
|
FR2676072B1
(fr)
|
1991-05-03 |
1994-11-18 |
Transgene Sa |
Vecteur de delivrance d'arn.
|
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
EP0855184A1
(en)
|
1997-01-23 |
1998-07-29 |
Grayson B. Dr. Lipford |
Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination
|
|
US6251665B1
(en)
|
1997-02-07 |
2001-06-26 |
Cem Cezayirli |
Directed maturation of stem cells and production of programmable antigen presenting dentritic cells therefrom
|
|
US6261281B1
(en)
|
1997-04-03 |
2001-07-17 |
Electrofect As |
Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
|
|
WO1999018221A1
(en)
|
1997-10-07 |
1999-04-15 |
University Of Maryland Biotechnology Institute |
Method for introducing and expressing rna in animal cells
|
|
US6432925B1
(en)
|
1998-04-16 |
2002-08-13 |
John Wayne Cancer Institute |
RNA cancer vaccine and methods for its use
|
|
EP1574210B1
(en)
|
1999-02-26 |
2016-04-06 |
Novartis Vaccines and Diagnostics, Inc. |
Microemulsions with adsorbed macromolecules
|
|
US6514948B1
(en)
|
1999-07-02 |
2003-02-04 |
The Regents Of The University Of California |
Method for enhancing an immune response
|
|
ATE289630T1
(de)
|
1999-09-09 |
2005-03-15 |
Curevac Gmbh |
Transfer von mrnas unter verwendung von polykationischen verbindungen
|
|
WO2001021810A1
(en)
|
1999-09-17 |
2001-03-29 |
Aventis Pasteur Limited |
Chlamydia antigens and corresponding dna fragments and uses thereof
|
|
US7060291B1
(en)
|
1999-11-24 |
2006-06-13 |
Transave, Inc. |
Modular targeted liposomal delivery system
|
|
AU7569501A
(en)
|
2000-07-21 |
2002-02-05 |
Glaxo Group Ltd |
Codon-optimized papilloma virus sequences
|
|
US6998115B2
(en)
|
2000-10-10 |
2006-02-14 |
Massachusetts Institute Of Technology |
Biodegradable poly(β-amino esters) and uses thereof
|
|
US7708915B2
(en)
|
2004-05-06 |
2010-05-04 |
Castor Trevor P |
Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein
|
|
ES2295351T3
(es)
|
2001-04-21 |
2008-04-16 |
Curevac Gmbh |
Dispositivo para la inyeccion de rnam.
|
|
PT1857122E
(pt)
|
2001-06-05 |
2011-03-07 |
Curevac Gmbh |
Arnm estabilizado com teor de g/c aumentado, codificando para um antigénio viral
|
|
AU2002319668A1
(en)
|
2001-07-27 |
2003-02-17 |
President And Fellows Of Harvard College |
Laminar mixing apparatus and methods
|
|
WO2003028657A2
(en)
|
2001-10-03 |
2003-04-10 |
The Johns Hopkins University |
Compositions for oral gene therapy and methods of using same
|
|
DE10162480A1
(de)
|
2001-12-19 |
2003-08-07 |
Ingmar Hoerr |
Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
|
|
ES2543710T3
(es)
|
2002-04-04 |
2015-08-21 |
Zoetis Belgium S.A. |
Oligorribonucleótidos inmunoestimulantes que contienen G y U
|
|
AU2003217531A1
(en)
|
2002-05-02 |
2003-11-17 |
Massachusetts Eye And Ear Infirmary |
Ocular drug delivery systems and use thereof
|
|
DE10229872A1
(de)
|
2002-07-03 |
2004-01-29 |
Curevac Gmbh |
Immunstimulation durch chemisch modifizierte RNA
|
|
DE60333035D1
(de)
|
2002-12-23 |
2010-07-29 |
Vical Inc |
Impfstoffe gegen infektionen mit dem humanen zytomegalivirus auf grundlage von codonoptimierten polynukleotiden
|
|
ATE432285T1
(de)
|
2003-07-11 |
2009-06-15 |
Alphavax Inc |
Cytomegalovirusimpfstoffe, die auf dem alphavirus basieren
|
|
DE10347710B4
(de)
|
2003-10-14 |
2006-03-30 |
Johannes-Gutenberg-Universität Mainz |
Rekombinante Impfstoffe und deren Verwendung
|
|
WO2005072710A2
(en)
|
2004-01-28 |
2005-08-11 |
Johns Hopkins University |
Drugs and gene carrier particles that rapidly move through mucous barriers
|
|
KR20070044805A
(ko)
|
2004-04-15 |
2007-04-30 |
키아스마, 인코포레이티드 |
생물학적 장벽 투과를 촉진시킬 수 있는 조성물
|
|
EP1856179B1
(en)
|
2004-12-10 |
2013-05-15 |
Kala Pharmaceuticals, Inc. |
Functionalized poly (ether-anhydride) block copolymers
|
|
GB0504436D0
(en)
*
|
2005-03-03 |
2005-04-06 |
Glaxosmithkline Biolog Sa |
Vaccine
|
|
KR101288729B1
(ko)
|
2005-04-01 |
2013-07-23 |
인터자인 테크놀로지스, 인코포레이티드 |
약물 전달용 중합체성 마이셀
|
|
US8273339B2
(en)
|
2005-04-12 |
2012-09-25 |
Nektar Therapeutics |
Polymer-based compositions and conjugates of antimicrobial agents
|
|
EP2279758B1
(en)
|
2005-06-16 |
2015-02-25 |
Nektar Therapeutics |
Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
|
|
ES2937245T3
(es)
|
2005-08-23 |
2023-03-27 |
Univ Pennsylvania |
ARN que contiene nucleósidos modificados y métodos de uso del mismo
|
|
DE102006007433A1
(de)
|
2006-02-17 |
2007-08-23 |
Curevac Gmbh |
Adjuvanz in Form einer Lipid-modifizierten Nukleinsäure
|
|
WO2007098466A2
(en)
|
2006-02-21 |
2007-08-30 |
Nektar Therapeutics Al, Corporation |
Segmented degradable polymers and conjugates made therefrom
|
|
EP2019691B1
(en)
|
2006-05-15 |
2020-08-12 |
Massachusetts Institute of Technology |
Polymers for functional particles
|
|
JP2010507361A
(ja)
|
2006-07-31 |
2010-03-11 |
キュアバック ゲーエムベーハー |
具体的には免疫刺激剤/アジュバントとしての、一般式(I):GlXmGn、または一般式(II):ClXmCnで表される核酸
|
|
CA2663003C
(en)
|
2006-09-08 |
2018-02-13 |
Justin Hanes |
Compositions and methods for enhancing transport through mucus
|
|
DE102006051516A1
(de)
|
2006-10-31 |
2008-05-08 |
Curevac Gmbh |
(Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins
|
|
WO2008082563A2
(en)
|
2006-12-21 |
2008-07-10 |
Stryker Corporation |
Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
|
|
DE102007001370A1
(de)
|
2007-01-09 |
2008-07-10 |
Curevac Gmbh |
RNA-kodierte Antikörper
|
|
EP2175882A4
(en)
*
|
2007-07-19 |
2011-11-30 |
Novavax Inc |
VARICELLA ZOSTER VIRUS VIRUS LIKE PARTICLES (VLP) AND ANTIGENE
|
|
WO2009030254A1
(en)
|
2007-09-04 |
2009-03-12 |
Curevac Gmbh |
Complexes of rna and cationic peptides for transfection and for immunostimulation
|
|
ES2647538T3
(es)
|
2007-09-28 |
2017-12-22 |
Pfizer Inc. |
Direccionamiento a células de cáncer usando nanopartículas
|
|
MX350501B
(es)
|
2007-10-12 |
2017-09-07 |
Massachusetts Inst Technology |
Nanotecnologia de vacuna.
|
|
CA2721333C
(en)
|
2008-04-15 |
2020-12-01 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for nucleic acid delivery
|
|
US8613951B2
(en)
|
2008-06-16 |
2013-12-24 |
Bind Therapeutics, Inc. |
Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
|
|
DK2285350T3
(en)
|
2008-06-16 |
2017-12-11 |
Pfizer |
PROCEDURES FOR THE PREPARATION OF DIBLOCK COPOLYMERS FUNCTIONALIZED WITH TARGETING AGENT FOR USE IN THE MANUFACTURE OF THERAPEUTIC NANOPARTICLES
|
|
US8206747B2
(en)
|
2008-06-16 |
2012-06-26 |
Bind Biosciences, Inc. |
Drug loaded polymeric nanoparticles and methods of making and using same
|
|
WO2010005725A2
(en)
|
2008-06-16 |
2010-01-14 |
Bind Biosciences, Inc. |
Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same
|
|
WO2010030763A2
(en)
|
2008-09-10 |
2010-03-18 |
Bind Biosciences, Inc. |
High throughput fabrication of nanoparticles
|
|
WO2010037408A1
(en)
|
2008-09-30 |
2010-04-08 |
Curevac Gmbh |
Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
|
|
PL2350043T3
(pl)
|
2008-10-09 |
2014-09-30 |
Tekmira Pharmaceuticals Corp |
Ulepszone aminolipidy i sposoby dostarczania kwasów nukleinowych
|
|
WO2010054406A1
(en)
|
2008-11-10 |
2010-05-14 |
Alnylam Pharmaceuticals, Inc. |
Novel lipids and compositions for the delivery of therapeutics
|
|
CA2780482A1
(en)
|
2008-11-17 |
2010-05-10 |
Anil K. Sood |
Hdl particles for delivery of nucleic acids
|
|
ES2776126T3
(es)
|
2008-12-15 |
2020-07-29 |
Pfizer |
Nanopartículas de circulación prolongada para la liberación sostenida de agentes terapéuticos
|
|
WO2010088927A1
(en)
|
2009-02-09 |
2010-08-12 |
Curevac Gmbh |
Use of pei for the improvement of endosomal release and expression of transfected nucleic acids, complexed with cationic or polycationic compounds
|
|
JP5622254B2
(ja)
|
2009-03-31 |
2014-11-12 |
国立大学法人東京大学 |
二本鎖リボ核酸ポリイオンコンプレックス
|
|
AU2010232512B2
(en)
|
2009-04-01 |
2013-07-18 |
University Of Miami |
Vaccine compositions and methods of use thereof
|
|
US8287910B2
(en)
|
2009-04-30 |
2012-10-16 |
Intezyne Technologies, Inc. |
Polymeric micelles for polynucleotide encapsulation
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
US20110300205A1
(en)
|
2009-07-06 |
2011-12-08 |
Novartis Ag |
Self replicating rna molecules and uses thereof
|
|
JP5823405B2
(ja)
|
2009-11-04 |
2015-11-25 |
ザ ユニバーシティ オブ ブリティッシュ コロンビア |
核酸含有脂質粒子および関連方法
|
|
WO2011069529A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
|
|
JP5965844B2
(ja)
|
2009-12-15 |
2016-08-10 |
バインド セラピューティックス インコーポレイテッド |
高いガラス転移温度または高分子量のコポリマーを有する治療用ポリマーナノ粒子組成物
|
|
JP5898627B2
(ja)
|
2009-12-15 |
2016-04-06 |
バインド セラピューティックス インコーポレイテッド |
エポチロンを含む治療用ポリマーナノ粒子ならびにそれを製造および使用する方法
|
|
EP2512487A4
(en)
|
2009-12-15 |
2013-08-07 |
|
THERAPEUTIC POLYMERNANOPARTICLES WITH CORTICOSTEROIDS AND METHOD FOR THE PRODUCTION AND USE THEREOF
|
|
US20130101609A1
(en)
|
2010-01-24 |
2013-04-25 |
Novartis Ag |
Irradiated biodegradable polymer microparticles
|
|
US8207290B2
(en)
|
2010-03-26 |
2012-06-26 |
Cerulean Pharma Inc. |
Methods and systems for generating nanoparticles
|
|
US20110262491A1
(en)
|
2010-04-12 |
2011-10-27 |
Selecta Biosciences, Inc. |
Emulsions and methods of making nanocarriers
|
|
EP2387999A1
(en)
|
2010-05-21 |
2011-11-23 |
CureVac GmbH |
Histidine-containing solution for transfection and/or injection of nucleic acids and uses thereof
|
|
EP2575895A2
(en)
|
2010-05-24 |
2013-04-10 |
Merck Sharp & Dohme Corp. |
Novel amino alcohol cationic lipids for oligonucleotide delivery
|
|
WO2011163483A2
(en)
|
2010-06-25 |
2011-12-29 |
Massachusetts Institute Of Technology |
Polymers for biomaterials and therapeutics
|
|
RU2625546C2
(ru)
|
2010-07-06 |
2017-07-14 |
Новартис Аг |
Катионные эмульсии "масло-в-воде"
|
|
HUE026646T2
(en)
|
2010-07-06 |
2016-07-28 |
Glaxosmithkline Biologicals Sa |
Preferred liposomes containing lipids of PKA value for delivery of RNA
|
|
US9192661B2
(en)
|
2010-07-06 |
2015-11-24 |
Novartis Ag |
Delivery of self-replicating RNA using biodegradable polymer particles
|
|
HRP20161352T1
(hr)
*
|
2010-07-06 |
2016-12-02 |
Glaxosmithkline Biologicals Sa |
Čestice nalik na virione za unos samoreplicirajućih molekula rna
|
|
ES2586580T3
(es)
|
2010-07-06 |
2016-10-17 |
Glaxosmithkline Biologicals Sa |
Inmunización de mamíferos grandes con dosis bajas de ARN
|
|
ES2558106T3
(es)
|
2010-07-30 |
2016-02-02 |
Curevac Ag |
Formación de complejos de ácidos nucleicos con componentes catiónicos disulfuro-reticulados para la transfección e inmunoestimulación
|
|
US8822663B2
(en)
|
2010-08-06 |
2014-09-02 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
WO2012019630A1
(en)
|
2010-08-13 |
2012-02-16 |
Curevac Gmbh |
Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
|
|
US20120058153A1
(en)
*
|
2010-08-20 |
2012-03-08 |
Selecta Biosciences, Inc. |
Synthetic nanocarrier vaccines comprising proteins obtained or derived from human influenza a virus hemagglutinin
|
|
CN103384515B
(zh)
|
2010-08-31 |
2017-02-15 |
诺华有限公司 |
适用于脂质体递送编码蛋白质的rna的脂质
|
|
EP4043040B1
(en)
|
2010-08-31 |
2023-01-11 |
GlaxoSmithKline Biologicals SA |
Small liposomes for delivery of immunogen-encoding rna
|
|
DK4226941T3
(da)
|
2010-08-31 |
2024-12-02 |
Glaxosmithkline Biologicals Sa |
Pegylerede liposomer til levering af immunogen-kodende rna
|
|
US10307372B2
(en)
|
2010-09-10 |
2019-06-04 |
The Johns Hopkins University |
Rapid diffusion of large polymeric nanoparticles in the mammalian brain
|
|
CA2821992A1
(en)
|
2010-10-01 |
2012-04-05 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
KR102266691B1
(ko)
*
|
2010-10-11 |
2021-06-23 |
노파르티스 아게 |
항원 전달 플랫폼
|
|
WO2012054923A2
(en)
|
2010-10-22 |
2012-04-26 |
Bind Biosciences, Inc. |
Therapeutic nanoparticles with high molecular weight copolymers
|
|
EP2635254B1
(en)
|
2010-11-05 |
2019-05-15 |
The John Hopkins University |
Compositions and methods relating to reduced mucoadhesion
|
|
WO2012075040A2
(en)
|
2010-11-30 |
2012-06-07 |
Shire Human Genetic Therapies, Inc. |
mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
|
|
WO2012089225A1
(en)
|
2010-12-29 |
2012-07-05 |
Curevac Gmbh |
Combination of vaccination and inhibition of mhc class i restricted antigen presentation
|
|
US20120189700A1
(en)
|
2011-01-19 |
2012-07-26 |
Zoraida Aguilar |
Nanoparticle Based Immunological Stimulation
|
|
JP6099573B2
(ja)
*
|
2011-01-31 |
2017-03-22 |
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア |
新規なヘルペス抗原をコードする核酸分子、それを含むワクチン及びその使用方法
|
|
US20140066363A1
(en)
|
2011-02-07 |
2014-03-06 |
Arun K. Bhunia |
Carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide
|
|
WO2012116715A1
(en)
|
2011-03-02 |
2012-09-07 |
Curevac Gmbh |
Vaccination in newborns and infants
|
|
WO2012113413A1
(en)
|
2011-02-21 |
2012-08-30 |
Curevac Gmbh |
Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates
|
|
WO2012116714A1
(en)
|
2011-03-02 |
2012-09-07 |
Curevac Gmbh |
Vaccination in elderly patients
|
|
AU2012237262A1
(en)
|
2011-03-31 |
2013-11-14 |
Ingell Technologies Holding B.V. |
Biodegradable compositions suitable for controlled release
|
|
DE12722942T1
(de)
|
2011-03-31 |
2021-09-30 |
Modernatx, Inc. |
Freisetzung und formulierung von manipulierten nukleinsäuren
|
|
CA2831469C
(en)
|
2011-03-31 |
2020-02-18 |
Ingell Technologies Holding B.V. |
Biodegradable compositions suitable for controlled release
|
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
|
US20140206752A1
(en)
|
2011-05-17 |
2014-07-24 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof for non-human vertebrates
|
|
US20140308363A1
(en)
|
2011-05-31 |
2014-10-16 |
Bind Therapeutics, Inc. |
Drug loaded polymeric nanoparticles and methods of making and using same
|
|
DK2714017T3
(en)
|
2011-06-02 |
2018-09-03 |
Univ California |
MEMBRANE-WRAPPED NANOPARTICLES AND METHOD OF USE
|
|
CN103764121A
(zh)
*
|
2011-07-06 |
2014-04-30 |
诺华股份有限公司 |
用于递送rna分子的具有有用n:p比的脂质体
|
|
RU2649133C2
(ru)
*
|
2011-07-06 |
2018-03-29 |
Новартис Аг |
Катионные эмульсии масло-в-воде
|
|
EP2729168A2
(en)
|
2011-07-06 |
2014-05-14 |
Novartis AG |
Immunogenic compositions and uses thereof
|
|
US11896636B2
(en)
|
2011-07-06 |
2024-02-13 |
Glaxosmithkline Biologicals Sa |
Immunogenic combination compositions and uses thereof
|
|
CN103732211B
(zh)
|
2011-07-21 |
2017-03-01 |
禾大国际股份公开有限公司 |
支化的聚醚‑聚酰胺嵌段共聚物及其制造与使用方法
|
|
CN104024328A
(zh)
|
2011-08-26 |
2014-09-03 |
箭头研究公司 |
用于体内核酸递送的聚(乙烯基酯)聚合物
|
|
JP2014527071A
(ja)
|
2011-08-31 |
2014-10-09 |
マリンクロッド エルエルシー |
H−ホスホネートによるナノ粒子pegの改変
|
|
JP2014525435A
(ja)
|
2011-09-02 |
2014-09-29 |
ノバルティス アーゲー |
Hsf1関連疾患を処置するための有機組成物
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
EP3384938A1
(en)
|
2011-09-12 |
2018-10-10 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
US20150017245A1
(en)
|
2011-09-22 |
2015-01-15 |
Bind Therapeutics, Inc. |
Methods of treating cancers with therapeutic nanoparticles
|
|
US9375388B2
(en)
|
2011-09-23 |
2016-06-28 |
Indian Institute Of Technology, Bombay |
Nanoparticle based cosmetic composition
|
|
CA2872033A1
(en)
*
|
2011-10-11 |
2013-04-18 |
Novartis Ag |
Recombinant self-replicating polycistronic rna molecules
|
|
AU2012323937A1
(en)
|
2011-10-14 |
2014-06-05 |
Stc.Unm |
Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof
|
|
CA2852917C
(en)
|
2011-10-18 |
2020-07-07 |
Dicerna Pharmaceuticals, Inc. |
Amine cationic lipids and uses thereof
|
|
PE20181541A1
(es)
|
2011-10-27 |
2018-09-26 |
Massachusetts Inst Technology |
Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco
|
|
WO2013078199A2
(en)
|
2011-11-23 |
2013-05-30 |
Children's Medical Center Corporation |
Methods for enhanced in vivo delivery of synthetic, modified rnas
|
|
WO2013086373A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Lipids for the delivery of active agents
|
|
EP2791364A4
(en)
|
2011-12-14 |
2015-11-11 |
Moderna Therapeutics Inc |
PROCESS FOR RESPONSE TO A BIOLOGICAL THREAT
|
|
SI2791160T1
(sl)
|
2011-12-16 |
2022-07-29 |
Modernatx, Inc. |
Sestave modificirane MRNA
|
|
RU2014129863A
(ru)
|
2011-12-21 |
2016-02-10 |
Модерна Терапьютикс, Инк. |
Способы повышения жизнеспособности или увеличения продолжительности жизни органа или экспланта органа
|
|
WO2013110028A1
(en)
|
2012-01-19 |
2013-07-25 |
The Johns Hopkins University |
Nanoparticle formulations with enhanced mucosal penetration
|
|
WO2013113325A1
(en)
|
2012-01-31 |
2013-08-08 |
Curevac Gmbh |
Negatively charged nucleic acid comprising complexes for immunostimulation
|
|
AU2013214799B2
(en)
|
2012-02-03 |
2016-05-12 |
Rutgers, The State Of University Of New Jersey |
Polymeric biomaterials derived from phenolic monomers and their medical uses
|
|
CN104105750A
(zh)
|
2012-02-10 |
2014-10-15 |
纳幕尔杜邦公司 |
高-x两嵌段共聚物的制备、纯化和使用
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
AU2013243952A1
(en)
|
2012-04-02 |
2014-10-30 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
US10501512B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides
|
|
US10501513B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides for the production of oncology-related proteins and peptides
|
|
EP2854857B1
(en)
|
2012-05-25 |
2018-11-28 |
CureVac AG |
Reversible immobilization and/or controlled release of nucleic acid containing nanoparticles by (biodegradable) polymer coatings
|
|
BR112014030677A2
(pt)
|
2012-06-08 |
2022-07-19 |
Shire Human Genetic Therapies |
distribuição pulmonar de mrna para células-alvo não-pulmonares
|
|
US9512456B2
(en)
|
2012-08-14 |
2016-12-06 |
Modernatx, Inc. |
Enzymes and polymerases for the synthesis of RNA
|
|
WO2014093924A1
(en)
*
|
2012-12-13 |
2014-06-19 |
Moderna Therapeutics, Inc. |
Modified nucleic acid molecules and uses thereof
|
|
WO2014071963A1
(en)
|
2012-11-09 |
2014-05-15 |
Biontech Ag |
Method for cellular rna expression
|
|
AU2013343864B2
(en)
|
2012-11-09 |
2019-04-04 |
BioNTech SE |
Method for cellular RNA expression
|
|
SMT202200337T1
(it)
|
2012-11-26 |
2022-09-14 |
Modernatx Inc |
Rna modificato al livello del terminale
|
|
AU2013355258A1
(en)
|
2012-12-07 |
2015-06-11 |
Alnylam Pharmaceuticals, Inc. |
Improved nucleic acid lipid particle formulations
|
|
EP3628335B1
(en)
*
|
2012-12-07 |
2023-11-08 |
Translate Bio, Inc. |
Lipidic nanoparticles for mrna delivery in the lungs
|
|
WO2014093574A1
(en)
|
2012-12-13 |
2014-06-19 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for altering cell phenotype
|
|
ES2649180T3
(es)
|
2013-02-22 |
2018-01-10 |
Curevac Ag |
Combinación de vacunación e inhibición de la ruta PD-1
|
|
EA201891018A1
(ru)
*
|
2013-03-08 |
2018-09-28 |
Новартис Аг |
Липиды и липидные композиции для доставки активных агентов
|
|
EP3932947A1
(en)
|
2013-03-14 |
2022-01-05 |
Translate Bio MA, Inc. |
Methods and compositions for delivering mrna coded antibodies
|
|
EP2971010B1
(en)
|
2013-03-14 |
2020-06-10 |
ModernaTX, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
|
WO2014160243A1
(en)
|
2013-03-14 |
2014-10-02 |
The Trustees Of The University Of Pennsylvania |
Purification and purity assessment of rna molecules synthesized with modified nucleosides
|
|
WO2014144039A1
(en)
|
2013-03-15 |
2014-09-18 |
Moderna Therapeutics, Inc. |
Characterization of mrna molecules
|
|
WO2014152027A1
(en)
|
2013-03-15 |
2014-09-25 |
Moderna Therapeutics, Inc. |
Manufacturing methods for production of rna transcripts
|
|
HUE071526T2
(hu)
|
2013-03-15 |
2025-09-28 |
Translate Bio Inc |
Nukleinsavak bejuttatásának szinergista fokozása kevert kiszerelésekkel
|
|
US10077439B2
(en)
|
2013-03-15 |
2018-09-18 |
Modernatx, Inc. |
Removal of DNA fragments in mRNA production process
|
|
WO2014144767A1
(en)
|
2013-03-15 |
2014-09-18 |
Moderna Therapeutics, Inc. |
Ion exchange purification of mrna
|
|
WO2014152031A1
(en)
|
2013-03-15 |
2014-09-25 |
Moderna Therapeutics, Inc. |
Ribonucleic acid purification
|
|
WO2014144711A1
(en)
|
2013-03-15 |
2014-09-18 |
Moderna Therapeutics, Inc. |
Analysis of mrna heterogeneity and stability
|
|
TW201534578A
(zh)
|
2013-07-08 |
2015-09-16 |
Daiichi Sankyo Co Ltd |
新穎脂質
|
|
EP3677279A1
(en)
|
2013-07-25 |
2020-07-08 |
Calder Biosciences Inc. |
Conformationally stabilized rsv pre-fusion f proteins
|
|
MX369469B
(es)
|
2013-08-21 |
2019-11-08 |
Curevac Ag |
Vacuna contra el virus respiratorio sincitial.
|
|
SG10201801428RA
(en)
|
2013-08-21 |
2018-03-28 |
Curevac Ag |
Method for increasing expression of rna-encoded proteins
|
|
EP3052511A4
(en)
|
2013-10-02 |
2017-05-31 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
WO2015058069A1
(en)
|
2013-10-18 |
2015-04-23 |
Moderna Therapeutics, Inc. |
Compositions and methods for tolerizing cellular systems
|
|
WO2015130584A2
(en)
*
|
2014-02-25 |
2015-09-03 |
Merck Sharp & Dohme Corp. |
Lipid nanoparticle vaccine adjuvants and antigen delivery systems
|
|
SG10201912038TA
(en)
|
2014-04-23 |
2020-02-27 |
Modernatx Inc |
Nucleic acid vaccines
|
|
CA2951430A1
(en)
|
2014-06-13 |
2015-12-17 |
Glaxosmithkline Biologicals Sa |
Immunogenic combinations
|
|
WO2015196128A2
(en)
|
2014-06-19 |
2015-12-23 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules and uses thereof
|
|
EP3169783A4
(en)
|
2014-07-17 |
2018-10-03 |
Modernatx, Inc. |
Terminal modifications of polynucleotides
|
|
EP3233118A1
(en)
*
|
2014-12-18 |
2017-10-25 |
GlaxoSmithKline Biologicals S.A. |
Vaccination
|
|
WO2016118724A1
(en)
|
2015-01-21 |
2016-07-28 |
Moderna Therapeutics, Inc. |
Lipid nanoparticle compositions
|
|
WO2016164762A1
(en)
|
2015-04-08 |
2016-10-13 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor egf-a and intracellular domain mutants and methods of using the same
|
|
US20180303925A1
(en)
|
2015-04-27 |
2018-10-25 |
The Trustees Of The University Of Pennsylvania |
Nucleoside-Modified RNA For Inducing an Adaptive Immune Response
|
|
EP3307305A4
(en)
|
2015-06-10 |
2019-05-22 |
Modernatx, Inc. |
TARGETED ADAPTIVE VACCINES
|
|
EP3310384A1
(en)
|
2015-06-17 |
2018-04-25 |
CureVac AG |
Vaccine composition
|
|
MA42502A
(fr)
|
2015-07-21 |
2018-05-30 |
Modernatx Inc |
Vaccins contre une maladie infectieuse
|
|
WO2017015457A1
(en)
|
2015-07-21 |
2017-01-26 |
Modernatx, Inc. |
Ebola vaccine
|
|
US20190008887A1
(en)
|
2015-07-30 |
2019-01-10 |
ModernaTX Inc. |
Multimeric mrna
|
|
WO2017020026A1
(en)
|
2015-07-30 |
2017-02-02 |
Modernatx, Inc. |
Concatemeric peptide epitopes rnas
|
|
WO2017031232A1
(en)
|
2015-08-17 |
2017-02-23 |
Modernatx, Inc. |
Methods for preparing particles and related compositions
|
|
US20180237849A1
(en)
|
2015-08-17 |
2018-08-23 |
Modernatx, Inc. |
Rna mapping/fingerprinting
|
|
CA2998810A1
(en)
|
2015-09-17 |
2017-03-23 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of therapeutic agents
|
|
AU2016336344A1
(en)
|
2015-10-05 |
2018-04-19 |
Modernatx, Inc. |
Methods for therapeutic administration of messenger ribonucleic acid drugs
|
|
WO2017066789A1
(en)
|
2015-10-16 |
2017-04-20 |
Modernatx, Inc. |
Mrna cap analogs with modified sugar
|
|
EP4349405A3
(en)
|
2015-10-22 |
2024-06-19 |
ModernaTX, Inc. |
Respiratory virus vaccines
|
|
CN109310751A
(zh)
|
2015-10-22 |
2019-02-05 |
摩登纳特斯有限公司 |
广谱流感病毒疫苗
|
|
US20180318409A1
(en)
|
2015-10-22 |
2018-11-08 |
Modernatx, Inc. |
Cancer vaccines
|
|
EA201890999A1
(ru)
|
2015-10-22 |
2018-12-28 |
МОДЕРНАТиЭкс, ИНК. |
Вакцина против вируса простого герпеса
|
|
AU2016341311B2
(en)
|
2015-10-22 |
2023-11-16 |
Modernatx, Inc. |
Respiratory syncytial virus vaccine
|
|
EP3364950A4
(en)
|
2015-10-22 |
2019-10-23 |
ModernaTX, Inc. |
VACCINES AGAINST TROPICAL DISEASES
|
|
WO2017070613A1
(en)
|
2015-10-22 |
2017-04-27 |
Modernatx, Inc. |
Human cytomegalovirus vaccine
|
|
EP3364982A4
(en)
|
2015-10-22 |
2019-04-17 |
ModernaTX, Inc. |
VACCINES AGAINST SEXUALLY TRANSMITTED DISEASES
|
|
EA201891001A1
(ru)
*
|
2015-10-22 |
2018-11-30 |
МОДЕРНАТиЭкс, ИНК. |
Вакцины на основе нуклеиновых кислот против вируса ветряной оспы (vzv)
|
|
ES2924407T3
(es)
|
2015-12-10 |
2022-10-06 |
Modernatx Inc |
Composiciones y procedimientos para el suministro de agentes terapéuticos
|
|
CA3007108A1
(en)
|
2015-12-17 |
2017-06-22 |
Modernatx, Inc. |
Polynucleotides encoding methylmalonyl-coa mutase
|
|
US10465190B1
(en)
|
2015-12-23 |
2019-11-05 |
Modernatx, Inc. |
In vitro transcription methods and constructs
|
|
US20210206818A1
(en)
|
2016-01-22 |
2021-07-08 |
Modernatx, Inc. |
Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof
|
|
AU2017268394A1
(en)
|
2016-05-18 |
2019-01-03 |
Modernatx, Inc. |
Polynucleotides encoding relaxin
|
|
EP3458108A4
(en)
|
2016-05-18 |
2020-04-22 |
ModernaTX, Inc. |
POLYNUCLEOTIDES ENCODING A CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR FOR THE TREATMENT OF CYSTIC FIBROSIS
|
|
MA45037A
(fr)
|
2016-05-18 |
2019-03-27 |
Modernatx Inc |
Polythérapie à base d'arnm pour le traitement du cancer
|
|
US12123030B2
(en)
|
2016-05-18 |
2024-10-22 |
Modernatx, Inc. |
Polynucleotides encoding lipoprotein lipase for the treatment of hyperlipidemia
|
|
MA45032A
(fr)
|
2016-05-18 |
2019-03-27 |
Fundacion Para La Investig Medica Aplicada |
Polynucléotides codant pour la porphobilinogène désaminase destinés au traitement de la porphyrie intermittente aiguë
|
|
US20190298657A1
(en)
|
2016-05-18 |
2019-10-03 |
Modernatx, Inc. |
Polynucleotides Encoding Acyl-CoA Dehydrogenase, Very Long-Chain for the Treatment of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency
|
|
MA45041A
(fr)
|
2016-05-18 |
2019-03-27 |
Modernatx Inc |
Polynucléotides codant pour la galactose-1-phosphate uridylyltransférase destinés au traitement de la galactosémie de type 1
|
|
SG11201810162PA
(en)
|
2016-05-18 |
2018-12-28 |
Modernatx Inc |
Polynucleotides encoding citrin for the treatment of citrullinemia type 2
|
|
US20190382774A1
(en)
|
2016-05-18 |
2019-12-19 |
Modernatx, Inc. |
Polyribonucleotides containing reduced uracil content and uses thereof
|
|
EP3896164A1
(en)
|
2016-05-18 |
2021-10-20 |
ModernaTX, Inc. |
Polynucleotides encoding alpha-galactosidase a for the treatment of fabry disease
|
|
EP3458107B1
(en)
|
2016-05-18 |
2024-03-13 |
ModernaTX, Inc. |
Polynucleotides encoding jagged1 for the treatment of alagille syndrome
|
|
WO2017218704A1
(en)
|
2016-06-14 |
2017-12-21 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
|
CN109937253B
(zh)
|
2016-09-14 |
2023-06-30 |
摩登纳特斯有限公司 |
高纯度rna组合物及其制备方法
|
|
MA46584A
(fr)
|
2016-10-21 |
2019-08-28 |
Modernatx Inc |
Vaccin contre le cytomégalovirus humain
|
|
IL317855A
(en)
|
2016-10-26 |
2025-02-01 |
Acuitas Therapeutics Inc |
mRNA vaccines with lipid nanoparticles
|
|
EP3532613A4
(en)
|
2016-10-26 |
2020-05-06 |
ModernaTX, Inc. |
METHOD AND COMPOSITIONS FOR RNA MAPPING
|
|
CN110402145A
(zh)
|
2016-10-26 |
2019-11-01 |
莫得纳特斯公司 |
用于增强免疫应答的信使核糖核酸及其使用方法
|
|
EP3538146A4
(en)
|
2016-11-11 |
2020-07-15 |
ModernaTX, Inc. |
INFLUENZA VACCINE
|
|
MA50335A
(fr)
|
2016-12-08 |
2020-08-19 |
Modernatx Inc |
Vaccins à acide nucléique contre des virus respiratoires
|
|
US11384352B2
(en)
|
2016-12-13 |
2022-07-12 |
Modernatx, Inc. |
RNA affinity purification
|
|
US20180243225A1
(en)
|
2017-01-25 |
2018-08-30 |
Modernatx, Inc. |
Ebola/marburg vaccines
|
|
CN110505877A
(zh)
|
2017-02-01 |
2019-11-26 |
摩登纳特斯有限公司 |
Rna癌症疫苗
|
|
US20190351039A1
(en)
|
2017-02-01 |
2019-11-21 |
Modernatx, Inc. |
Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides
|
|
WO2018144778A1
(en)
|
2017-02-01 |
2018-08-09 |
Modernatx, Inc. |
Polynucleotide secondary structure
|
|
EP3582790A4
(en)
|
2017-02-16 |
2020-11-25 |
ModernaTX, Inc. |
VERY POWERFUL IMMUNOGENIC COMPOSITIONS
|
|
WO2018157009A1
(en)
|
2017-02-24 |
2018-08-30 |
Modernatx, Inc. |
Nucleic acid-based therapy of muscular dystrophies
|
|
WO2018170270A1
(en)
|
2017-03-15 |
2018-09-20 |
Modernatx, Inc. |
Varicella zoster virus (vzv) vaccine
|
|
EP3595713A4
(en)
|
2017-03-15 |
2021-01-13 |
ModernaTX, Inc. |
Respiratory syncytial virus vaccine
|
|
US11752206B2
(en)
|
2017-03-15 |
2023-09-12 |
Modernatx, Inc. |
Herpes simplex virus vaccine
|
|
US11576961B2
(en)
|
2017-03-15 |
2023-02-14 |
Modernatx, Inc. |
Broad spectrum influenza virus vaccine
|
|
EP3596041B1
(en)
|
2017-03-15 |
2022-11-02 |
ModernaTX, Inc. |
Compound and compositions for intracellular delivery of therapeutic agents
|
|
EP3595676A4
(en)
|
2017-03-17 |
2021-05-05 |
Modernatx, Inc. |
RNA VACCINES AGAINST ZOONOSES
|
|
WO2018175783A1
(en)
|
2017-03-22 |
2018-09-27 |
Modernatx, Inc. |
Rna bacterial vaccines
|
|
EP3607074A4
(en)
|
2017-04-05 |
2021-07-07 |
Modernatx, Inc. |
REDUCTION OR ELIMINATION OF IMMUNE RESPONSES TO NON-INTRAVENOUS THERAPEUTIC PROTEINS, FOR EXAMPLE SUBCUTANEOUSLY
|
|
EP3641810A4
(en)
|
2017-04-26 |
2021-08-18 |
Modernatx, Inc. |
VACCINES AGAINST HERPES SIMPLEX VIRUS
|
|
WO2018232357A1
(en)
|
2017-06-15 |
2018-12-20 |
Modernatx, Inc. |
Rna formulations
|
|
WO2018232355A1
(en)
|
2017-06-15 |
2018-12-20 |
Modernatx, Inc. |
Rna antibodies
|
|
EP3668977A4
(en)
|
2017-08-18 |
2021-04-21 |
Modernatx, Inc. |
HPLC ANALYTICAL PROCESSES
|
|
US20200254086A1
(en)
|
2017-08-18 |
2020-08-13 |
Moderna TX, Inc. |
Efficacious mrna vaccines
|
|
EP3668979A4
(en)
|
2017-08-18 |
2021-06-02 |
Modernatx, Inc. |
METHOD OF HPLC ANALYSIS
|
|
EP4397757A3
(en)
|
2017-08-18 |
2024-10-23 |
ModernaTX, Inc. |
Rna polymerase variants
|
|
EP3681514A4
(en)
|
2017-09-14 |
2021-07-14 |
ModernaTX, Inc. |
RNA VACZINE AGAINST ZIKA VIRUS
|
|
US20190192646A1
(en)
|
2017-11-03 |
2019-06-27 |
Modernatx, Inc. |
Salmonella vaccines
|
|
WO2019103993A1
(en)
|
2017-11-21 |
2019-05-31 |
Modernatx, Inc. |
Epstein-barr virus vaccines
|
|
MA54676A
(fr)
|
2018-01-29 |
2021-11-17 |
Modernatx Inc |
Vaccins à base d'arn contre le vrs
|
|
KR20210038886A
(ko)
|
2018-06-27 |
2021-04-08 |
모더나티엑스, 인크. |
개인화된 암 백신 에피토프 선택
|
|
EP3863645A4
(en)
|
2018-09-13 |
2022-11-16 |
ModernaTX, Inc. |
MODIFIED mRNA FOR THE TREATMENT OF FAMILY PROGRESSIVE INTRAHEPATIC CHOLESTASIS DISORDERS
|
|
WO2020061367A1
(en)
|
2018-09-19 |
2020-03-26 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of therapeutic agents
|
|
WO2020061284A1
(en)
|
2018-09-19 |
2020-03-26 |
Modernatx, Inc. |
Peg lipids and uses thereof
|
|
JP7640452B2
(ja)
|
2018-09-19 |
2025-03-05 |
モデルナティエックス インコーポレイテッド |
高純度peg脂質及びそれらの使用
|
|
MA54192A
(fr)
|
2018-11-07 |
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Modernatx Inc |
Vaccins à arn contre le cancer
|
|
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(fr)
|
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Modernatx Inc |
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|
|
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(es)
|
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Modernatx Inc |
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|
|
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(en)
|
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Modernatx, Inc. |
HIV RNA vaccines
|
|
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(fr)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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Moderna TX, Inc. |
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|