MX2018003592A - Sales y formas solidas de un antibiotico de monobactam. - Google Patents
Sales y formas solidas de un antibiotico de monobactam.Info
- Publication number
- MX2018003592A MX2018003592A MX2018003592A MX2018003592A MX2018003592A MX 2018003592 A MX2018003592 A MX 2018003592A MX 2018003592 A MX2018003592 A MX 2018003592A MX 2018003592 A MX2018003592 A MX 2018003592A MX 2018003592 A MX2018003592 A MX 2018003592A
- Authority
- MX
- Mexico
- Prior art keywords
- salts
- solid forms
- monobactam
- antibiotic
- oxo
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 title 1
- 229960003644 aztreonam Drugs 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 title 1
- -1 2-aminothiazol-4-yl Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- YMGUBTXCNDTFJI-UHFFFAOYSA-N cyclopropanecarboxylic acid Chemical compound OC(=O)C1CC1 YMGUBTXCNDTFJI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La invención proporciona nuevas formas sólidas, sales y polimorfos del ácido 1- (((Z) - (1- (2-aminotiazol-4-il) -2-oxo-2 - (((3S, 4R) -2- ácido oxo-4 - ((2-oxooxazolidin-3-il) metil) -1-sulfoazetidin-3-il) amino) etiliden) amino) oxi) ciclopropanocarboxílico (al que se hace referencia en este documento como Compuesto X), composiciones farmacéuticas que los contienen, y procesos para su fabricación y uso en terapia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222430P | 2015-09-23 | 2015-09-23 | |
| PCT/CN2016/099482 WO2017050218A1 (en) | 2015-09-23 | 2016-09-20 | Salts and solid forms of monobactam antibiotic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018003592A true MX2018003592A (es) | 2018-06-18 |
| MX377532B MX377532B (es) | 2025-03-10 |
Family
ID=58385723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018003592A MX377532B (es) | 2015-09-23 | 2016-09-20 | Sales y formas sólidas de un antibiótico de monobactam. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10919887B2 (es) |
| EP (1) | EP3353175B1 (es) |
| JP (1) | JP6837480B2 (es) |
| KR (1) | KR102749337B1 (es) |
| CN (1) | CN108137573B (es) |
| AU (1) | AU2016327264B2 (es) |
| CA (1) | CA2999794C (es) |
| CL (2) | CL2018000745A1 (es) |
| CY (1) | CY1123509T1 (es) |
| DK (1) | DK3353175T3 (es) |
| EA (2) | EA202092620A1 (es) |
| ES (1) | ES2817537T3 (es) |
| HR (1) | HRP20201423T1 (es) |
| HU (1) | HUE050849T2 (es) |
| IL (1) | IL258254B (es) |
| LT (1) | LT3353175T (es) |
| MA (1) | MA42946B1 (es) |
| MX (1) | MX377532B (es) |
| PH (1) | PH12018500653B1 (es) |
| PL (1) | PL3353175T3 (es) |
| PT (1) | PT3353175T (es) |
| RS (1) | RS60805B1 (es) |
| RU (1) | RU2754180C2 (es) |
| SI (1) | SI3353175T1 (es) |
| SM (1) | SMT202000480T1 (es) |
| WO (1) | WO2017050218A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3661933B1 (en) | 2017-08-02 | 2022-03-23 | Novartis AG | Process for preparing 1-(((z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3s,4r)-2-oxo-4-((2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3- yl)amino)ethylidene)amino)oxy)cyclopropane carboxylic acid |
| JP7120516B2 (ja) * | 2017-08-16 | 2022-08-17 | エルジー・ケム・リミテッド | Ｚｉｆ系粉末を含む白色顔料、高分子樹脂フィルムおよび白色顔料を使用して媒質の色を変更する方法 |
| US20200360349A1 (en) * | 2017-11-10 | 2020-11-19 | Novartis Ag | Administration of monobactam for the treatment of urinary tract infection |
| JP7280273B2 (ja) * | 2018-01-29 | 2023-05-23 | メッドシャイン ディスカバリー インコーポレイテッド | 細菌感染を治療するための単環β－ラクタム化合物 |
| JP7179185B2 (ja) * | 2018-12-18 | 2022-11-28 | メッドシャイン ディスカバリー インコーポレイテッド | 医薬の製造おける単環式β－ラクタム化合物の使用 |
| JP7446424B2 (ja) * | 2019-11-22 | 2024-03-08 | スージョウ アーイェ ファーマシューティカル カンパニー リミテッド | スルホニル尿素環置換単環式β－ラクタム系抗生物質 |
| EP4079305A4 (en) | 2019-12-19 | 2024-01-10 | Shenzhen Optimum Biological Technology Co., Ltd | APPLICATION OF A COMPOUND IN THE PREPARATION OF DRUG |
| CN113754651B (zh) | 2020-06-02 | 2023-04-18 | 中国医学科学院医药生物技术研究所 | 一种β-内酰胺化合物、其用途及其制备方法 |
| US20230150996A1 (en) * | 2020-08-06 | 2023-05-18 | Ningxia Academy Of Agriculture And Forestry Sciences | B-lactam compounds, their preparation and use as antibacterial agents |
| WO2022185240A1 (en) | 2021-03-04 | 2022-09-09 | Bp Asset Vi, Inc. | Formulation of a monobactam antibiotic |
| WO2022185241A1 (en) | 2021-03-04 | 2022-09-09 | Bp Asset Vi, Inc. | Process for manufacturing a monobactam antibiotic |
| CN115304594B (zh) * | 2022-10-12 | 2023-02-14 | 苏州二叶制药有限公司 | 磺酰脲环取代的化合物的盐型及其晶型 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ196202A (en) | 1980-02-07 | 1984-07-31 | Squibb & Sons Inc | Beta-lactam antibiotics (of azetidine-sulphonic acid type) |
| US4775670A (en) | 1980-09-29 | 1988-10-04 | E. R. Squibb & Sons, Inc. | 2-oxo-1-azetidinesulfonic acid salts |
| EP0048953B1 (en) | 1980-09-29 | 1988-03-09 | E.R. Squibb & Sons, Inc. | Beta-lactam antibiotics |
| WO1982001873A1 (en) | 1980-12-05 | 1982-06-10 | Takeda Chemical Industries Ltd | 1-sulfo-2-oxoazetidine derivatives and process for their preparation |
| US4782147A (en) | 1980-12-05 | 1988-11-01 | Takeda Chemical Industries, Ltd. | 1-sulfo-2-oxoazetidine derivatives and their production |
| CA1262128A (en) | 1981-08-27 | 1989-10-03 | Christian N. Hubschwerlen | .beta.-lactams |
| IL67451A (en) | 1981-12-25 | 1987-10-20 | Takeda Chemical Industries Ltd | 4-cyano-2-azetidinones and production thereof and process for the preparation of 4-carbamoyl-2-azetidinones using them |
| AU564150B2 (en) | 1982-04-30 | 1987-08-06 | Takeda Chemical Industries Ltd. | 1-sulfo-2-azetidinone derivatives |
| KR900005112B1 (ko) | 1982-05-31 | 1990-07-19 | 반유세이야꾸 가부시끼가이샤 | 2-옥소-1-아제티딘술폰산 유도체의 제조방법 |
| DE3377061D1 (en) | 1982-06-03 | 1988-07-21 | Hoffmann La Roche | Process for the preparation of 1-sulfo-2-oxoazetidine derivatives |
| JPS6153282A (ja) | 1984-08-22 | 1986-03-17 | Banyu Pharmaceut Co Ltd | 単環β−ラクタム誘導体 |
| JPS6153283A (ja) | 1984-08-24 | 1986-03-17 | Banyu Pharmaceut Co Ltd | ２−オキソ−１−アゼチジンスルホン酸誘導体 |
| US4610824A (en) | 1984-10-09 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Hydrazide derivatives of monocyclic beta-lactam antibiotics |
| US5112968A (en) | 1989-07-28 | 1992-05-12 | E. R. Squibb & Sons, Inc. | Monobactam hydrazide derivatives |
| LT2960244T (lt) | 2008-10-31 | 2016-11-25 | Shionogi & Co., Ltd. | Cefalosporinas, turintis katecholio grupę |
| SG171781A1 (en) * | 2008-12-19 | 2011-07-28 | Pfizer | Monocarbams |
| AU2011336209B2 (en) * | 2010-11-29 | 2015-03-19 | Pfizer Inc. | Monobactams |
| UY34585A (es) * | 2012-01-24 | 2013-09-02 | Aicuris Gmbh & Co Kg | Compuestos b-lactámicos sustituidos con amidina, su preparación y uso |
| CN103044416A (zh) | 2012-12-17 | 2013-04-17 | 浙江华方药业有限责任公司 | 一种卡芦莫南钠的合成方法 |
| US20160326157A1 (en) | 2014-01-06 | 2016-11-10 | President And Fellows Of Harvard College | Monobactams and methods of their synthesis and use |
| HRP20190501T1 (hr) * | 2014-03-24 | 2019-05-03 | Novartis Ag | Monobaktam organski spojevi za liječenje bakterijskih infekcija |
-
2016
- 2016-09-20 PT PT168480994T patent/PT3353175T/pt unknown
- 2016-09-20 ES ES16848099T patent/ES2817537T3/es active Active
- 2016-09-20 PL PL16848099.4T patent/PL3353175T3/pl unknown
- 2016-09-20 DK DK16848099.4T patent/DK3353175T3/da active
- 2016-09-20 SI SI201630906T patent/SI3353175T1/sl unknown
- 2016-09-20 MA MA42946A patent/MA42946B1/fr unknown
- 2016-09-20 EP EP16848099.4A patent/EP3353175B1/en active Active
- 2016-09-20 PH PH1/2018/500653A patent/PH12018500653B1/en unknown
- 2016-09-20 US US15/762,724 patent/US10919887B2/en active Active
- 2016-09-20 RU RU2018114480A patent/RU2754180C2/ru active
- 2016-09-20 EA EA202092620A patent/EA202092620A1/ru unknown
- 2016-09-20 HU HUE16848099A patent/HUE050849T2/hu unknown
- 2016-09-20 WO PCT/CN2016/099482 patent/WO2017050218A1/en not_active Ceased
- 2016-09-20 LT LTEP16848099.4T patent/LT3353175T/lt unknown
- 2016-09-20 MX MX2018003592A patent/MX377532B/es active IP Right Grant
- 2016-09-20 RS RS20201038A patent/RS60805B1/sr unknown
- 2016-09-20 EA EA201890771A patent/EA037569B1/ru not_active IP Right Cessation
- 2016-09-20 AU AU2016327264A patent/AU2016327264B2/en active Active
- 2016-09-20 JP JP2018515607A patent/JP6837480B2/ja active Active
- 2016-09-20 KR KR1020187011354A patent/KR102749337B1/ko active Active
- 2016-09-20 CN CN201680055680.4A patent/CN108137573B/zh active Active
- 2016-09-20 HR HRP20201423TT patent/HRP20201423T1/hr unknown
- 2016-09-20 SM SM20200480T patent/SMT202000480T1/it unknown
- 2016-09-20 CA CA2999794A patent/CA2999794C/en active Active
-
2018
- 2018-03-20 IL IL258254A patent/IL258254B/en active IP Right Grant
- 2018-03-21 CL CL2018000745A patent/CL2018000745A1/es unknown
-
2019
- 2019-11-20 CL CL2019003324A patent/CL2019003324A1/es unknown
-
2020
- 2020-09-07 CY CY20201100840T patent/CY1123509T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |