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MX2018003456A - Combinacion farmaceutica en la forma de comprimidos en bicapa que comprende ketorolaco trometamina y tramadol clorhidrato, y su uso para el tratamiento del dolor. - Google Patents

Combinacion farmaceutica en la forma de comprimidos en bicapa que comprende ketorolaco trometamina y tramadol clorhidrato, y su uso para el tratamiento del dolor.

Info

Publication number
MX2018003456A
MX2018003456A MX2018003456A MX2018003456A MX2018003456A MX 2018003456 A MX2018003456 A MX 2018003456A MX 2018003456 A MX2018003456 A MX 2018003456A MX 2018003456 A MX2018003456 A MX 2018003456A MX 2018003456 A MX2018003456 A MX 2018003456A
Authority
MX
Mexico
Prior art keywords
pharmaceutical combination
tablet form
bilayer tablet
tramadol hydrochloride
ketorolac tromethamine
Prior art date
Application number
MX2018003456A
Other languages
English (en)
Inventor
Margoth Riera Cabuyales Sonia
Alejandro Cardenas Mendieta Ivan
Augusto Estevez Valencia Cesar
Jose CUENCA AVILA Juan
Del Carmen Beltrán Apablaza Marianela
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2018003456A publication Critical patent/MX2018003456A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Una combinación farmacéutica en la forma de comprimido en bicapa de liberación inmediata que comprende: i) una primera capa que contiene entre 1.0% y 6.0% p/p de ketorolaco trometamina; ii) una segunda capa que contiene entre 4.0% y 11.0% p/p de tramadol clorhidrato; y iii) un recubrimiento opcional que no modifica la liberación de los ingredientes farmacéuticamente activos. La presente invención proporciona métodos para prevenir y tratar el dolor, tal como el dolor agudo, y el uso de la combinación farmacéutica para la prevención y el tratamiento del dolor, tal como el dolor agudo.
MX2018003456A 2017-12-21 2017-12-21 Combinacion farmaceutica en la forma de comprimidos en bicapa que comprende ketorolaco trometamina y tramadol clorhidrato, y su uso para el tratamiento del dolor. MX2018003456A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2017/058310 WO2019122982A1 (en) 2017-12-21 2017-12-21 Pharmaceutical combination in a bilayer tablet form comprising ketorolac tromethamine and tramadol hydrochloride, and its use in pain treatment

Publications (1)

Publication Number Publication Date
MX2018003456A true MX2018003456A (es) 2019-09-06

Family

ID=61148269

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018003456A MX2018003456A (es) 2017-12-21 2017-12-21 Combinacion farmaceutica en la forma de comprimidos en bicapa que comprende ketorolaco trometamina y tramadol clorhidrato, y su uso para el tratamiento del dolor.

Country Status (4)

Country Link
AR (1) AR114006A1 (es)
MX (1) MX2018003456A (es)
UY (1) UY38028A (es)
WO (1) WO2019122982A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116115581A (zh) * 2023-03-21 2023-05-16 中国人民解放军中部战区总医院 酮咯酸氨丁三醇双相控释片及其制备方法
WO2024211978A1 (en) * 2023-04-13 2024-10-17 Aché Laboratórios Farmacêuticos S.A. Oral pharmaceutical composition, process for the production of granules or an oral pharmaceutical composition, oral pharmaceutical granule, use of the pharmaceutical composition and method for treating inflammatory conditions, pain and/or avoiding the use of perioperative opioid

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516803A (en) 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
MXPA02010828A (es) * 2002-11-04 2004-07-16 Leopoldo Espinosa Abdala Composicion farmaceutica en capsulas que comprende un antiinflamatorio no esteroideo y un analgesico opiaceo para el manejo del dolor.
BRPI0700133A (pt) 2007-01-29 2008-09-16 Incrementha P D & I Pesquisa D composição farmacêutica compreendendo tramadol e cetoprofeno em combinação
MX2007003948A (es) 2007-04-02 2009-02-25 World Trade Imp Export Wtie Ag Composicion farmaceutica en forma de tableta sublingual que comprende un antiinflamatorio no esteroideo y un analgesico opiaceo para el manejo del dolor.
WO2009087658A2 (en) 2007-11-07 2009-07-16 Sun Pharma Advanced Research Company Limited Composition suitable for parenteral administration
PL2596784T3 (pl) 2007-11-23 2017-06-30 Grünenthal GmbH Kompozycje tapentadolu
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
MX2010011193A (es) 2010-10-12 2012-04-18 World Trade Imp Exp Wtie Ag Composicion farmaceutica liquida para el tratamiento y prevencion del dolor.
KR102165246B1 (ko) 2011-04-05 2020-10-13 옵토솔브 리서치 앤드 디벨롭먼트 리미티드 안과 치료제
WO2013163142A1 (en) 2012-04-25 2013-10-31 Yung Shin Pharm. Ind. Co., Ltd. Liquid pharmaceutical formulation containing ketorolac and tramadol
MX2014005153A (es) 2014-04-29 2015-10-28 Liomont S A De C V Lab Proceso de obtencion y composicion farmaceutica de ketorolaco trometamina y clorhidrato de tramadol sublingual usado para el dolor.
MX2014005152A (es) 2014-04-29 2015-10-28 Liomont S A De C V Lab Composicion farmaceutica para el tratamiento de alopatias relacionadas con el dolor, usando como agente activo al ketorolaco trometamina y clorhidrato de tramadol.

Also Published As

Publication number Publication date
AR114006A1 (es) 2020-07-08
WO2019122982A1 (en) 2019-06-27
UY38028A (es) 2019-07-31

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