MX2018002479A - Derivados antibacterianos pirrolidin-2-ona anulados. - Google Patents
Derivados antibacterianos pirrolidin-2-ona anulados.Info
- Publication number
- MX2018002479A MX2018002479A MX2018002479A MX2018002479A MX2018002479A MX 2018002479 A MX2018002479 A MX 2018002479A MX 2018002479 A MX2018002479 A MX 2018002479A MX 2018002479 A MX2018002479 A MX 2018002479A MX 2018002479 A MX2018002479 A MX 2018002479A
- Authority
- MX
- Mexico
- Prior art keywords
- antibacterial
- annulated
- pyrrolidin
- derivatives
- phosphonooxymethyl
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- HNJBEVLQSNELDL-YZRHJBSPSA-N pyrrolidin-2-one Chemical class O=C1CC[14CH2]N1 HNJBEVLQSNELDL-YZRHJBSPSA-N 0.000 title 1
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 phosphonooxymethyl Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
Abstract
La invención se refiere a compuestos antibacterianos de fórmula l (ver Fórmula) donde X representa azufre o CH=CH; R1 representa H, PO3H2, SO3H, fosfonooximetilo o el grupo -CO- R2 donde R2 es tal como se definió en las reivindicaciones, M es uno de los grupos MA y MB representados a continuación(ver Fórmula) donde A representa un enlace o C?C y R1A, R2A, R3A y R1B son tal como se definió en las reivindicaciones; y a sales de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2015069757 | 2015-08-28 | ||
| PCT/EP2016/070203 WO2017036968A1 (en) | 2015-08-28 | 2016-08-26 | Antibacterial annulated pyrrolidin-2-one derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018002479A true MX2018002479A (es) | 2018-06-15 |
Family
ID=56801557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018002479A MX2018002479A (es) | 2015-08-28 | 2016-08-26 | Derivados antibacterianos pirrolidin-2-ona anulados. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20190031676A1 (es) |
| EP (1) | EP3341378A1 (es) |
| JP (1) | JP2018531902A (es) |
| KR (1) | KR20180041231A (es) |
| CN (1) | CN107922433A (es) |
| AR (1) | AR105839A1 (es) |
| AU (1) | AU2016314963A1 (es) |
| CA (1) | CA2991281A1 (es) |
| EA (1) | EA201890600A1 (es) |
| MA (1) | MA42679A (es) |
| MX (1) | MX2018002479A (es) |
| TW (1) | TW201718484A (es) |
| WO (1) | WO2017036968A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| WO2019086452A1 (en) | 2017-10-31 | 2019-05-09 | Idorsia Pharmaceuticals Ltd | Antibacterial heteroaromatic compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR097617A1 (es) * | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| CA2933604A1 (en) * | 2013-12-19 | 2015-06-25 | Actelion Pharmaceuticals Ltd | Antibacterial 1h-indazole and 1h-indole derivatives |
| AR099612A1 (es) * | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| KR20170005105A (ko) * | 2014-05-16 | 2017-01-11 | 액테리온 파마슈티칼 리미티드 | 항균성 퀴나졸린-４(３ｈ)-온 유도체 |
-
2016
- 2016-08-26 AU AU2016314963A patent/AU2016314963A1/en not_active Abandoned
- 2016-08-26 EA EA201890600A patent/EA201890600A1/ru unknown
- 2016-08-26 MA MA042679A patent/MA42679A/fr unknown
- 2016-08-26 AR ARP160102619A patent/AR105839A1/es unknown
- 2016-08-26 EP EP16757255.1A patent/EP3341378A1/en not_active Withdrawn
- 2016-08-26 CA CA2991281A patent/CA2991281A1/en not_active Abandoned
- 2016-08-26 CN CN201680048835.1A patent/CN107922433A/zh active Pending
- 2016-08-26 US US15/755,893 patent/US20190031676A1/en not_active Abandoned
- 2016-08-26 WO PCT/EP2016/070203 patent/WO2017036968A1/en not_active Ceased
- 2016-08-26 JP JP2018511143A patent/JP2018531902A/ja active Pending
- 2016-08-26 TW TW105127566A patent/TW201718484A/zh unknown
- 2016-08-26 MX MX2018002479A patent/MX2018002479A/es unknown
- 2016-08-26 KR KR1020187008393A patent/KR20180041231A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN107922433A (zh) | 2018-04-17 |
| AU2016314963A1 (en) | 2018-04-19 |
| WO2017036968A1 (en) | 2017-03-09 |
| EA201890600A1 (ru) | 2018-09-28 |
| KR20180041231A (ko) | 2018-04-23 |
| AR105839A1 (es) | 2017-11-15 |
| MA42679A (fr) | 2018-07-04 |
| EP3341378A1 (en) | 2018-07-04 |
| JP2018531902A (ja) | 2018-11-01 |
| TW201718484A (zh) | 2017-06-01 |
| CA2991281A1 (en) | 2017-03-09 |
| US20190031676A1 (en) | 2019-01-31 |
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