[go: up one dir, main page]

MX2017015752A - Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo. - Google Patents

Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo.

Info

Publication number
MX2017015752A
MX2017015752A MX2017015752A MX2017015752A MX2017015752A MX 2017015752 A MX2017015752 A MX 2017015752A MX 2017015752 A MX2017015752 A MX 2017015752A MX 2017015752 A MX2017015752 A MX 2017015752A MX 2017015752 A MX2017015752 A MX 2017015752A
Authority
MX
Mexico
Prior art keywords
cognitive impairment
compositions
age
impairment
disorders
Prior art date
Application number
MX2017015752A
Other languages
English (en)
Other versions
MX384734B (es
Inventor
Mekonnen Belew
A Butera John
Huang Jianxing
Original Assignee
Agenebio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agenebio Inc filed Critical Agenebio Inc
Publication of MX2017015752A publication Critical patent/MX2017015752A/es
Publication of MX384734B publication Critical patent/MX384734B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Esta invención se refiere a derivados de benzodiazepina, a composiciones que comprenden cantidades terapéuticamente efectivas de esos derivados de benzodiazepina y a métodos para usar esos derivados o composiciones en el tratamiento del deterioro cognitivo asociado con trastornos del sistema nervioso central (SNC). En particular, se refiere al uso de un agonista del receptor GABAA que contiene a5 (por ejemplo, un modulador alostérico positivo para el receptor GABAA que contiene a5) como el descrito en la presente para tratar el deterioro cognitivo asociado con trastornos del sistema nervioso central (SNC) en un sujeto en necesidad o en riesgo, incluyendo, sin limitación, sujetos que tienen o están en riesgo de deterioro cognitivo relacionado con la edad, deterioro cognitivo leve (MCI), MCI amnésico (aMCI), deterioro de la memoria asociado a la edad (AAMI), deterioro cognitivo relacionado con la edad (ARCD), demencia, enfermedad de Alzheimer (AD), AD prodrómica, trastorno de estrés postraumático (PTSD), esquizofrenia, trastorno bipolar, esclerosis lateral amiotrófica (ALS), deterioro cognitivo relacionado con el tratamiento del cáncer, retraso mental, enfermedad de Parkinson (PD), trastornos del espectro autista, trastorno X frágil, síndrome de Rett, comportamiento compulsivo y adicción a sustancias.
MX2017015752A 2015-06-19 2016-06-17 Derivados de benzodiazepina, composiciones y métodos para tratar deterioro cognitivo. MX384734B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562182336P 2015-06-19 2015-06-19
PCT/US2016/038224 WO2016205739A1 (en) 2015-06-19 2016-06-17 Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment

Publications (2)

Publication Number Publication Date
MX2017015752A true MX2017015752A (es) 2018-04-13
MX384734B MX384734B (es) 2025-03-14

Family

ID=57546444

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020013374A MX392119B (es) 2015-06-19 2016-06-17 Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo
MX2017015752A MX384734B (es) 2015-06-19 2016-06-17 Derivados de benzodiazepina, composiciones y métodos para tratar deterioro cognitivo.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020013374A MX392119B (es) 2015-06-19 2016-06-17 Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo

Country Status (12)

Country Link
US (3) US10815242B2 (es)
EP (1) EP3310785B1 (es)
JP (2) JP6987384B2 (es)
CN (2) CN108026107B (es)
AU (2) AU2016279052A1 (es)
CA (1) CA2990004C (es)
EA (1) EA036844B1 (es)
IL (1) IL256354B (es)
MA (1) MA42624A (es)
MX (2) MX392119B (es)
WO (1) WO2016205739A1 (es)
ZA (1) ZA201800360B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ722077A (en) 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN108026107B (zh) 2015-06-19 2021-07-30 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
IL279530B1 (en) 2018-06-19 2025-09-01 Agenebio Inc Benzodiazepine history, preparations, and methods for treating cognitive disorder
CA3129749A1 (en) * 2019-02-13 2020-08-20 Centre For Addiction And Mental Health Compositions and methods relating to use of agonists of alpha5-containing gabaa receptors
JP7737721B2 (ja) * 2019-12-19 2025-09-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
JP2023534190A (ja) * 2020-07-10 2023-08-08 エージンバイオ， インコーポレイテッド ＧＡＢＡＡα５アゴニストの多形および認知障害の処置において使用する方法
AU2023324882A1 (en) 2022-08-19 2025-03-20 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment
WO2024196801A1 (en) * 2023-03-17 2024-09-26 LAPKO INC, dba AFECTA PHARMACEUTICALS Methods for treating aberrant behavior and motor activity

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3391142A (en) 1966-02-09 1968-07-02 Lilly Co Eli Adamantyl secondary amines
US3539573A (en) 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
CH603545A5 (es) 1972-04-20 1978-08-31 Merz & Co
NL7605526A (nl) 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
JPS54130587A (en) 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE2856393C2 (de) 1978-12-27 1983-04-28 Merz + Co GmbH & Co, 6000 Frankfurt Arzneimittel zur Behandlung von Morbus Parkinson
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
IE58370B1 (en) 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8607684D0 (en) 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
US4816456A (en) 1986-10-01 1989-03-28 Summers William K Administration of monoamine acridines in cholinergic neuronal deficit states
HU201906B (en) 1987-03-04 1991-01-28 Sandoz Ag Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them
FI95572C (fi) 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
US4831031A (en) 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5006528A (en) 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
CA2000786C (en) 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
US5043345A (en) 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
ES2059602T3 (es) 1989-04-14 1994-11-16 Merz & Co Gmbh & Co Uso de derivados de adamantano para la prevencion y tratamiento de isquemia cerebral.
ES2076253T3 (es) 1989-05-19 1995-11-01 Hoechst Roussel Pharma N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos.
US5229382A (en) 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
JP2807577B2 (ja) 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
JP2800953B2 (ja) 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
ATE180475T1 (de) 1990-09-21 1999-06-15 Rohm & Haas Dihydropyridazinone und pyridazinone als fungizide
US5190951A (en) 1990-10-19 1993-03-02 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
EP0781768B1 (en) 1991-05-24 2001-11-21 E.I. Du Pont De Nemours And Company Arthropodicidal anilides
US5106856A (en) 1991-06-07 1992-04-21 Hoechst-Roussel Pharmaceuticals Inc. [(Arylalkylpiperidin-4-yl)methyl]-2a,3,4,5-tetrahydro-1(2H)-acenaphthylen-1-ones and related compounds
TW201311B (es) * 1991-06-17 1993-03-01 Hoffmann La Roche
US5312925A (en) 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
HU225051B1 (en) 1994-03-02 2006-05-29 Organon Ireland Ltd Sublingual or buccal pharmaceutical compositions containing trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
US6479523B1 (en) 1997-08-26 2002-11-12 Emory University Pharmacologic drug combination in vagal-induced asystole
AU1041599A (en) 1997-11-13 1999-06-07 Jose Luis Castro Pineiro Therapeutic uses of triazolo-pyridazine derivatives
US6391922B1 (en) 1998-01-13 2002-05-21 Synchroneuron, Llc Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders
US6294583B1 (en) 1998-01-13 2001-09-25 Synchroneuron, Llc Methods of treating tardive dyskinesia and other movement disorders
AU1816900A (en) 1998-11-12 2000-05-29 Merck & Co., Inc. Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
WO2000051985A1 (en) 1999-03-03 2000-09-08 Eisai Co., Ltd. Fluorides of 4-substituted piperidine derivatives
GB9911803D0 (en) 1999-05-20 1999-07-21 Merck Sharp & Dohme Therapeutic combination
GB9911802D0 (en) 1999-05-20 1999-07-21 Merck Sharp & Dohme Therapeutic combination
GB9911804D0 (en) 1999-05-20 1999-07-21 Merck Sharp & Dohme Therapeutic combination
GB9929569D0 (en) 1999-12-14 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0004297D0 (en) 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
US20020151591A1 (en) 2000-10-17 2002-10-17 Anabella Villalobos Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
TWI239333B (en) * 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
EP1363606A1 (en) 2001-03-01 2003-11-26 Pfizer Products Inc. Use of gaba[a] inverse agonists in combination with nicotine receptor partial agonists, estrogen, selective estrogen modulators or vitamin e for the treatment of coginitive disorders
US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
WO2003025122A2 (en) 2001-08-13 2003-03-27 University Of Kentucky Research Foundation Gene expression profile biomarkers and therapeutic targets for brain aging and age-related cognitive impairment
EP1471909A4 (en) 2002-01-16 2007-07-25 Endo Pharmaceuticals Inc PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM
CA2495285A1 (en) 2002-08-13 2004-02-19 Merck Sharp & Dohme Limited Phenylpyridazine derivatives as ligands for gaba receptors
GB0218876D0 (en) 2002-08-13 2002-09-25 Merck Sharp & Dohme Therapeutic agents
US7635709B2 (en) 2002-09-26 2009-12-22 The United States Of America As Represented By The Department Of Veterans Affairs Compositions and methods for bowel care in individuals with chronic intestinal pseudo-obstruction
CN100339070C (zh) 2002-10-24 2007-09-26 莫茨药物股份两合公司 包含1－氨基环己烷衍生物类和乙酰胆碱酯酶抑制剂类的药物组合物
US20040191803A1 (en) 2002-11-22 2004-09-30 Michela Gallagher Target for therapy of cognitive impairment
CN1870984A (zh) 2003-10-22 2006-11-29 莫茨药物股份两合公司 1－氨基环己烷衍生物用于调节淀粉样病变中原纤维生成Aβ肽的沉积的用途
CN101374525A (zh) 2004-09-23 2009-02-25 莫茨药物股份两合公司 美金刚治疗儿童行为障碍
CN101039678B (zh) 2004-10-12 2011-06-15 弗·哈夫曼-拉罗切有限公司 用于治疗认知障碍的咪唑并[1,5-a]三唑并[1,5-d]苯并二氮杂䓬衍生物
NZ554556A (en) 2004-10-20 2009-11-27 Hoffmann La Roche Halogen substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepines
EP1805184B1 (en) * 2004-10-20 2013-01-09 F. Hoffmann-La Roche AG Imidazo-benzodiazepine derivatives
ATE396998T1 (de) * 2004-12-14 2008-06-15 Hoffmann La Roche Tetrazyklische imidazobenzodiazepine als gaba- rezeptormodulatoren
US20060205822A1 (en) 2004-12-22 2006-09-14 Forest Laboratories, Inc. 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
EP1888594A2 (en) 2005-05-16 2008-02-20 Wisys Technology Foundation, Inc. Gabaergic agents to treat memory deficits
EP2682481A3 (en) 2005-08-03 2014-09-17 The Johns-Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
CN101287738B (zh) * 2005-10-11 2011-08-10 弗·哈夫曼-拉罗切有限公司 咪唑并苯并二氮杂*衍生物
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US8486979B2 (en) 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
US7943619B2 (en) 2007-12-04 2011-05-17 Hoffmann-La Roche Inc. Isoxazolo-pyridazine derivatives
EP2318005B1 (en) 2008-08-01 2017-11-01 Lixte Biotechnology, Inc. Neuroprotective agents for the prevention and treatment of neurodegenerative diseases
EP2330891A1 (en) 2008-09-24 2011-06-15 E. I. du Pont de Nemours and Company Fungicidal pyridazines
EP2348834B1 (en) 2008-09-25 2018-04-18 Vive Crop Protection Inc. Methods to produce polymer nanoparticles and formulations of active ingredients
JP2012524065A (ja) 2009-04-17 2012-10-11 ゼノポート，インコーポレーテッド ＧＡＢＡＢ受容体リガンドとしてのγ−アミノ酪酸誘導体
WO2011085406A1 (en) 2010-01-11 2011-07-14 Mithridion, Inc. Compounds and compositions for cognition-enhancement, methods of making, and methods of treating
WO2012059482A1 (en) 2010-11-05 2012-05-10 F. Hoffmann-La Roche Ag Use of active pharmaceutical compounds for the treatment of central nervous system conditions
AU2011329068A1 (en) * 2010-11-15 2013-06-06 Agenebio, Inc. Benzodiazepine derivatives, compositions and methods for treating cognitive impairment
BR112013012062B1 (pt) 2010-11-15 2020-06-02 Agenebio, Inc Composto derivado da piridazina ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e uso do composto
WO2012161133A1 (ja) 2011-05-20 2012-11-29 日産化学工業株式会社 置換ピリダジン化合物及び農園芸用殺菌剤
US20150374705A1 (en) * 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
EP2892521A4 (en) 2012-09-10 2016-06-29 Ophirex Inc ADMINISTRATION OF ACETYLCHOLINESTERASE INHIBITORS FOR THE ALLOCATION OF NEUROTOXININDUCED FLUCTUATIONS AND THE REMAINING NEUROMUSCULAR BLOCKADES
NZ722077A (en) * 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN108026107B (zh) 2015-06-19 2021-07-30 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN108567787A (zh) 2017-03-10 2018-09-25 辛衍雪 一种治疗慢性阻塞性肺病的药物组合物
IL279530B1 (en) 2018-06-19 2025-09-01 Agenebio Inc Benzodiazepine history, preparations, and methods for treating cognitive disorder

Also Published As

Publication number Publication date
JP2021152071A (ja) 2021-09-30
US20220274996A1 (en) 2022-09-01
CN108026107B (zh) 2021-07-30
EA201890090A1 (ru) 2018-09-28
AU2016279052A1 (en) 2018-02-15
CN113264939A (zh) 2021-08-17
AU2021200164B2 (en) 2022-09-08
EP3310785B1 (en) 2024-11-20
WO2016205739A1 (en) 2016-12-22
CA2990004A1 (en) 2016-12-22
HK1254362A1 (zh) 2019-07-19
MX2020013374A (es) 2022-05-06
IL256354B (en) 2022-09-01
JP2018521034A (ja) 2018-08-02
NZ739092A (en) 2024-07-05
AU2021200164A1 (en) 2021-03-18
US10815242B2 (en) 2020-10-27
ZA201800360B (en) 2023-03-29
US20190055258A1 (en) 2019-02-21
CN108026107A (zh) 2018-05-11
US11312721B2 (en) 2022-04-26
US12024525B2 (en) 2024-07-02
US20210009602A1 (en) 2021-01-14
IL256354A (en) 2018-02-28
JP6987384B2 (ja) 2021-12-22
EP3310785A4 (en) 2018-12-26
MX384734B (es) 2025-03-14
EA036844B1 (ru) 2020-12-28
CA2990004C (en) 2024-04-23
EP3310785A1 (en) 2018-04-25
MA42624A (fr) 2021-04-28
MX392119B (es) 2025-03-11

Similar Documents

Publication Publication Date Title
MX2017015752A (es) Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo.
MX2019010577A (es) Derivados de benzodiazepina, composiciones, y metodos para tratar el deterioro cognitivo.
MX2019007338A (es) Derivados de benzodiazepina, composiciones y métodos para tratar deterioro cognitivo.
EA202190076A1 (ru) Производные бензодиазепина, композиции и способы лечения когнитивных нарушений
MX2018011453A (es) Moduladores alostericos de receptores de acetilcolina nicotinicos.
MX346185B (es) Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo.
EA201390710A1 (ru) Производные бензодиазепина, композиции и способы для лечения когнитивного нарушения
CL2019001092A1 (es) Tratamientos de combinación que comprenden la administración de imidazopirazinonas.
BR112018013247A2 (pt) tratamentos de combinação compreendendo imidazopirazinonas para o tratamento de distúrbios psiquiátricos e/ou cognitivos
ECSP12012023A (es) 3,6-diazabiciclo [3.1.1] heptanos como ligandos de receptores nicotínicos neuronales de acetilcolina
MX2021008289A (es) Composiciones farmaceuticas de levetiracetam de liberacion extendida.
MX2019007100A (es) Derivados de tiazina y oxazina biciclicos como inhibidores de beta-secretasa y metodos de uso.
MX2022007725A (es) Derivados de benzodiazepinas, composiciones y metodos para tratar deterioro cognitivo.
CO2020013462A2 (es) Moduladores alostéricos de espiropiperidina de receptores nicotínicos de acetilcolina
CL2018003113A1 (es) Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular.
EA201691290A1 (ru) Бензодиазепиновые производные, композиции и способы для лечения когнитивного нарушения
WO2015189830A9 (en) Dual inhibitor compounds for use in the treatment of neurodegenerative disorders and alzheimer's disease
CL2009000149A1 (es) Compuestos heterociclos que incluyen un grupo ciclobutoxi sustituido ligandos del receptor h3 composicion farmaceutica que los comprende utiles para tratar enfermedades del sistema nervioso central, tales como deterioro cognitivo leve, alzheimer, trastornos de la memoria, enfermedad de parkinson, esquizofrenia y demencia.
CL2012000539A1 (es) Compuestos derivados de acido 3-(morfolin-4-il)-propionico, moduladores de s1p; composicion farmaceutica; utiles en el tratamiento, alivio o prvencion de enfermedades del sistema nervioso central, tales como trastornos neurodegenerativas, enfermedades de alzheimer, depresion mayor, autismo, entre otras.
EA201892113A1 (ru) Аллостерические модуляторы никотиновых ацетилхолиновых рецепторов
BR112017023539A2 (pt) composições para limpeza de cólon e tratamento de distúrbios gastrointestinais
CL2012000650A1 (es) Compuestos derivados de dihidro- benzocicloalquiloximetil- oxazolopirimidonas sustituidas, moduladores alosterocos de receptores metabortropicos de glutamato ( mglur); composicion famaceutica que los comprende; y uso para el tratamiento y/o prevencion de enfermedades asociadas del snc, como ansiedad, migraña, dolor, entre otras.
HK1220364A1 (zh) 用於改善認知功能的方法和組合物